Mus musculus (house mouse): 18795 Help Entry 18795             CDS       T01002                                  Symbol Plcb1, 3110043I21Rik, Plcb, mKIAA0581 Name (RefSeq) phospholipase C, beta 1   KO K05858   phosphatidylinositol phospholipase C, beta [EC:3.1.4.11] Organism mmu  Mus musculus (house mouse) Pathway mmu00562   Inositol phosphate metabolism mmu01100   Metabolic pathways mmu04015   Rap1 signaling pathway mmu04020   Calcium signaling pathway mmu04022   cGMP-PKG signaling pathway mmu04062   Chemokine signaling pathway mmu04070   Phosphatidylinositol signaling system mmu04071   Sphingolipid signaling pathway mmu04072   Phospholipase D signaling pathway mmu04261   Adrenergic signaling in cardiomyocytes mmu04270   Vascular smooth muscle contraction mmu04310   Wnt signaling pathway mmu04371   Apelin signaling pathway mmu04540   Gap junction mmu04611   Platelet activation mmu04613   Neutrophil extracellular trap formation mmu04621   NOD-like receptor signaling pathway mmu04713   Circadian entrainment mmu04720   Long-term potentiation mmu04723   Retrograde endocannabinoid signaling mmu04724   Glutamatergic synapse mmu04725   Cholinergic synapse mmu04726   Serotonergic synapse mmu04728   Dopaminergic synapse mmu04730   Long-term depression mmu04742   Taste transduction mmu04750   Inflammatory mediator regulation of TRP channels mmu04911   Insulin secretion mmu04912   GnRH signaling pathway mmu04915   Estrogen signaling pathway mmu04916   Melanogenesis mmu04918   Thyroid hormone synthesis mmu04919   Thyroid hormone signaling pathway mmu04921   Oxytocin signaling pathway mmu04922   Glucagon signaling pathway mmu04924   Renin secretion mmu04925   Aldosterone synthesis and secretion mmu04926   Relaxin signaling pathway mmu04927   Cortisol synthesis and secretion mmu04928   Parathyroid hormone synthesis, secretion and action mmu04929   GnRH secretion mmu04933   AGE-RAGE signaling pathway in diabetic complications mmu04934   Cushing syndrome mmu04935   Growth hormone synthesis, secretion and action mmu04961   Endocrine and other factor-regulated calcium reabsorption mmu04970   Salivary secretion mmu04971   Gastric acid secretion mmu04972   Pancreatic secretion mmu04973   Carbohydrate digestion and absorption mmu05010   Alzheimer disease mmu05016   Huntington disease mmu05017   Spinocerebellar ataxia mmu05022   Pathways of neurodegeneration - multiple diseases mmu05142   Chagas disease mmu05143   African trypanosomiasis mmu05146   Amoebiasis mmu05163   Human cytomegalovirus infection mmu05200   Pathways in cancer mmu05415   Diabetic cardiomyopathy mmu05417   Lipid and atherosclerosis Module mmu_M00130   Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4 Brite KEGG Orthology (KO) [BR:mmu00001]  09100 Metabolism   09101 Carbohydrate metabolism    00562 Inositol phosphate metabolism     18795 (Plcb1)  09130 Environmental Information Processing   09132 Signal transduction    04015 Rap1 signaling pathway     18795 (Plcb1)    04310 Wnt signaling pathway     18795 (Plcb1)    04371 Apelin signaling pathway     18795 (Plcb1)    04020 Calcium signaling pathway     18795 (Plcb1)    04070 Phosphatidylinositol signaling system     18795 (Plcb1)    04072 Phospholipase D signaling pathway     18795 (Plcb1)    04071 Sphingolipid signaling pathway     18795 (Plcb1)    04022 cGMP-PKG signaling pathway     18795 (Plcb1)  09140 Cellular Processes   09144 Cellular community - eukaryotes    04540 Gap junction     18795 (Plcb1)  09150 Organismal Systems   09151 Immune system    04611 Platelet activation     18795 (Plcb1)    04613 Neutrophil extracellular trap formation     18795 (Plcb1)    04621 NOD-like receptor signaling pathway     18795 (Plcb1)    04062 Chemokine signaling pathway     18795 (Plcb1)   09152 Endocrine system    04911 Insulin secretion     18795 (Plcb1)    04922 Glucagon signaling pathway     18795 (Plcb1)    04929 GnRH secretion     18795 (Plcb1)    04912 GnRH signaling pathway     18795 (Plcb1)    04915 Estrogen signaling pathway     18795 (Plcb1)    04921 Oxytocin signaling pathway     18795 (Plcb1)    04926 Relaxin signaling pathway     18795 (Plcb1)    04935 Growth hormone synthesis, secretion and action     18795 (Plcb1)    04918 Thyroid hormone synthesis     18795 (Plcb1)    04919 Thyroid hormone signaling pathway     18795 (Plcb1)    04928 Parathyroid hormone synthesis, secretion and action     18795 (Plcb1)    04916 Melanogenesis     18795 (Plcb1)    04924 Renin secretion     18795 (Plcb1)    04925 Aldosterone synthesis and secretion     18795 (Plcb1)    04927 Cortisol synthesis and secretion     18795 (Plcb1)   09153 Circulatory system    04261 Adrenergic signaling in cardiomyocytes     18795 (Plcb1)    04270 Vascular smooth muscle contraction     18795 (Plcb1)   09154 Digestive system    04970 Salivary secretion     18795 (Plcb1)    04971 Gastric acid secretion     18795 (Plcb1)    04972 Pancreatic secretion     18795 (Plcb1)    04973 Carbohydrate digestion and absorption     18795 (Plcb1)   09155 Excretory system    04961 Endocrine and other factor-regulated calcium reabsorption     18795 (Plcb1)   09156 Nervous system    04724 Glutamatergic synapse     18795 (Plcb1)    04725 Cholinergic synapse     18795 (Plcb1)    04728 Dopaminergic synapse     18795 (Plcb1)    04726 Serotonergic synapse     18795 (Plcb1)    04720 Long-term potentiation     18795 (Plcb1)    04730 Long-term depression     18795 (Plcb1)    04723 Retrograde endocannabinoid signaling     18795 (Plcb1)   09157 Sensory system    04742 Taste transduction     18795 (Plcb1)    04750 Inflammatory mediator regulation of TRP channels     18795 (Plcb1)   09159 Environmental adaptation    04713 Circadian entrainment     18795 (Plcb1)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     18795 (Plcb1)   09172 Infectious disease: viral    05163 Human cytomegalovirus infection     18795 (Plcb1)   09174 Infectious disease: parasitic    05146 Amoebiasis     18795 (Plcb1)    05142 Chagas disease     18795 (Plcb1)    05143 African trypanosomiasis     18795 (Plcb1)   09164 Neurodegenerative disease    05010 Alzheimer disease     18795 (Plcb1)    05016 Huntington disease     18795 (Plcb1)    05017 Spinocerebellar ataxia     18795 (Plcb1)    05022 Pathways of neurodegeneration - multiple diseases     18795 (Plcb1)   09166 Cardiovascular disease    05417 Lipid and atherosclerosis     18795 (Plcb1)    05415 Diabetic cardiomyopathy     18795 (Plcb1)   09167 Endocrine and metabolic disease    04933 AGE-RAGE signaling pathway in diabetic complications     18795 (Plcb1)    04934 Cushing syndrome     18795 (Plcb1)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    04131 Membrane trafficking [BR:mmu04131]     18795 (Plcb1) Enzymes [BR:mmu01000]  3. Hydrolases   3.1  Acting on ester bonds    3.1.4  Phosphoric-diester hydrolases     3.1.4.11  phosphoinositide phospholipase C      18795 (Plcb1) Membrane trafficking [BR:mmu04131]  Exocytosis   Calcium ion-dependent exocytosis    Phospholipases     18795 (Plcb1)  Endocytosis   Macropinocytosis    Phospholipase C     18795 (Plcb1) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  PI-PLC-X PLC-beta_C PH_14 PI-PLC-Y PLCB1-4-like_EFh EF-hand_like Motif Other DBs NCBI-GeneID:  18795 NCBI-ProteinID:  NP_001139302 MGI:  97613 Ensembl:  ENSMUSG00000051177 UniProt:  Q9Z1B3 Q3UPW0 LinkDB All DBs Position 2:134628084..135317178 Genome browser AA seq 1216 aa AA seqDB search MAGAQPGVHALQLKPVCVSDSLKKGTKFVKWDDDSTIVTPIILRTDPQGFFFYWTDQNKE TELLDLSLVKDARCGKHAKAPKDPKLRELLDVGNIGHLEQRMITVVYGPDLVNISHLNLV AFQEEVAKEWTNEVFSLATNLLAQNMSRDAFLEKAYTKLKLQVTPEGRIPLKNIYRLFSA DRKRVETALEACSLPSSRNDSIPQEDFTPDVYRVFLNNLCPRPEIDNIFSEFGAKSKPYL TVDQMMDFINLKQRDPRLNEILYPPLKQEQVQVLIEKYEPNSSLAKKGQMSVDGFMRYLS GEENGVVSPEKLDLNEDMSQPLSHYFINSSHNTYLTAGQLAGNSSVEMYRQVLLSGCRCV ELDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPFPILLSFENHVDSPKQ QAKMAEYCRLIFGDALLMEPLEKYPLESGVPLPSPMDLMYKILVKNKKKSHKSSEGSGKK KLSEQASNTYSDSSSVFEPSSPGAGEADTESDDDDDDDDCKKSSMDEGTAGSEAMATEEM SNLVNYIQPVKFESFEISKKRNKSFEMSSFVETKGLEQLTKSPVEFVEYNKMQLSRIYPK GTRVDSSNYMPQLFWNAGCQMVALNFQTVDLAMQINMGMYEYNGKSGYRLKPEFMRRPDK HFDPFTEGIVDGIVANTLSVKIISGQFLSDKKVGTYVEVDMFGLPVDTRRKAFKTKTSQG NAVNPVWEEEPIVFKKVVLPSLACLRIAAYEEGGKFIGHRILPVQAIRPGYHYICLRNER NQPLTLPAVFVYIEVKDYVPDTYADVIEALSNPIRYVNLMEQRAKQLAALTLEDEEEVKK EADPGETSSEAPSETRTTPAENGVNHTASLAPKPPSQAPHSQPAPGSVKAPAKTEDLIQS VLTEVEAQTIEELKQQKSFVKLQKKHYKEMKDLVKRHHKKTTELIKEHTTKYNEIQNDYL RRRAALEKSAKKDSKKKSEPSSPDHGSSAIEQDLAALDAEMTQKLIDLKDKQQQQLLNLR QEQYYSEKYQKREHIKLLIQKLTDVAEECQNNQLKKLKEICEKEKKELKKKMDKKRQEKI TEAKSKDKSQMEEEKTEMIRSYIQEVVQYIKRLEEAQSKRQEKLVEKHNEIRQQILDEKP KLQTELEQEYQDKFKRLPLEILEFVQEAMKGKISEDSNHGSAPPSLASDAAKVNLKSPSS EEIERENPGREFDTPL NT seq 3651 nt NT seq  +upstreamnt  +downstreamnt atggctggggctcagcccggagtgcacgccttgcaactcaagcccgtgtgcgtgtccgac agcctcaagaagggcaccaaattcgtcaagtgggatgatgactccactattgttactcca attattttgaggactgatcctcagggatttttcttttactggacagaccagaataaggag acggagctgttagatctcagccttgtcaaggatgccaggtgtgggaagcacgccaaagct cccaaggaccccaagttgcgtgaacttctggatgttgggaacatcggacacttggaacag cgcatgataactgtggtgtatggaccagacctggtgaacatttcccacttgaatcttgtg gcttttcaagaggaagtagccaaggaatggacaaatgaggttttcagcttggcaacaaac ctgctggctcagaacatgtccagggacgcatttctggagaaagcatatactaagctcaag ctccaggtcaccccagaaggccgcattcctcttaaaaacatctatcgattgttctcagca gaccggaagcgcgttgaaactgcactagaggcttgtagtcttccatcttcgaggaatgac tccattccccaagaggacttcactccagatgtatacagagttttcctgaacaatctctgt ccccgacctgaaattgataacatcttttctgaatttggtgccaaaagcaaaccgtacctg acggttgatcagatgatggattttatcaaccttaagcagagagatccccggctcaatgaa atcctttacccacctctgaagcaggagcaggtccaagtgttgattgagaaatatgagccc aacagcagcctcgccaagaaagggcagatgtcagtggatggattcatgcgctacctgagc ggagaagaaaatggagtcgtttcacctgagaaactggatttgaacgaagacatgtctcag cccctgtctcactatttcatcaattcctcgcacaacacctacctcacagctggccagttg gctgggaactcgtctgtagagatgtatcgccaggtgcttctgtctggatgtcgctgtgtg gagctggactgctggaagggaaggaccgctgaggaagagcctgtcattacccatggattc accatgacaacagaaatatccttcaaggaagtcatagaagccatcgcagagtgtgcgttc aagacgtctcctttccccatcctcctttcctttgagaaccacgtggattccccgaagcaa caagccaagatggccgagtattgccgattaatctttggtgatgccctcctgatggaacca ctggaaaaatacccactggaatctggggtacctcttccaagccctatggatttaatgtat aaaatcttggtgaaaaacaagaagaagtcgcacaagtcgtcagagggaagtggtaagaag aagctttcagagcaagcttccaacacctacagcgactcctccagtgtgttcgagccttcg tctccaggagctggggaagcagatacggagagtgatgacgatgacgacgacgatgactgt aaaaagtcttccatggatgaggggacagctggcagcgaagccatggccacagaagagatg tctaacctggtgaactatattcagcctgtcaagtttgagtcctttgaaatttcaaaaaaa agaaataaaagctttgaaatgtcttccttcgtggaaaccaaaggacttgaacaacttaca aagtctccggtggaatttgtagaatacaacaagatgcaacttagcaggatatatcccaag ggaacacgtgtggattcatccaactacatgcctcaactcttctggaatgctggctgtcag atggtggcgctcaacttccagacagtggatctagctatgcagataaacatgggcatgtat gagtacaatgggaagagcggctataggctgaagccagagttcatgaggaggccggacaag cattttgatccatttactgaaggaatcgtagatgggatagtggccaacactctatctgtt aagattatttcaggtcagttcctctctgataagaaagttgggacttatgtggaagtggat atgtttggcttgcctgtggacacaaggaggaaggcatttaaaaccaagacatcccaagga aatgctgtaaaccctgtctgggaagaagaacctattgtattcaaaaaggtagttctacct tctctggcctgtttgaggatagcagcatatgaagagggaggcaaatttattggccaccgg atattgcctgtgcaggctattcggccaggctatcactacatctgcctgcggaatgagagg aaccagcccctgacgctgccagctgtctttgtctacatagaagtcaaagattatgtgcca gacacgtatgcagatgtaatcgaagctctatcaaacccaatccgatatgtcaatctgatg gaacagagagctaagcagctggctgcgttgaccctggaggatgaagaggaagtaaagaag gaggctgaccctggagaaacatcttccgaggctccaagcgaaaccaggacaacgccagca gagaatggggtgaatcacaccgcatcccttgcacccaagccgccttcccaggctccacac agccagcctgctccagggtctgtgaaggcacctgccaaaacagaagatctgatccagagc gtgttaacagaagtagaggcgcaaaccatcgaagagctcaagcaacagaaatcgttcgtg aaacttcaaaagaaacactacaaagaaatgaaagacctggtgaagagacaccacaagaaa accacggagctcattaaggagcacacgaccaagtacaacgagattcagaatgactacctg agaaggagggcagccttggagaagtccgccaaaaaggacagcaagaagaaatctgaaccc agcagccctgaccacggctcatcagccattgagcaagacctcgctgccctggatgcagaa atgactcagaagttgatagacttgaaagacaagcaacaacagcagctgcttaatcttcgg caagagcagtattacagcgagaagtaccaaaagcgagaacacattaaactgcttattcag aagttgacagatgttgcagaagagtgtcagaacaatcagttaaagaagctgaaggaaatc tgcgagaaagagaagaaggaattaaagaagaaaatggataagaagaggcaagagaagata acagaagccaagtccaaagacaaaagccagatggaagaggagaagacagagatgatccga tcgtacatccaggaggtggttcagtacatcaagaggttagaggaagcacaaagtaaaaga caagaaaaactcgtggagaaacacaatgagatccgccagcagatcctcgatgagaagccc aagctgcagacggagctggagcaagaataccaagacaagttcaaaaggctgcccctggag attctggagtttgtacaggaagccatgaaagggaagatcagcgaggacagcaatcacggc tctgcccctccctctctggcctcagatgctgcaaaggtgaacctcaagtctccctccagt gaggagatagaaagagagaacccaggaagagagtttgatactcctctgtga

Mus musculus (house mouse): 18796 Help Entry 18796             CDS       T01002                                  Symbol Plcb2, B230205M18Rik, B230399N12 Name (RefSeq) phospholipase C, beta 2   KO K05858   phosphatidylinositol phospholipase C, beta [EC:3.1.4.11] Organism mmu  Mus musculus (house mouse) Pathway mmu00562   Inositol phosphate metabolism mmu01100   Metabolic pathways mmu04015   Rap1 signaling pathway mmu04020   Calcium signaling pathway mmu04022   cGMP-PKG signaling pathway mmu04062   Chemokine signaling pathway mmu04070   Phosphatidylinositol signaling system mmu04071   Sphingolipid signaling pathway mmu04072   Phospholipase D signaling pathway mmu04261   Adrenergic signaling in cardiomyocytes mmu04270   Vascular smooth muscle contraction mmu04310   Wnt signaling pathway mmu04371   Apelin signaling pathway mmu04540   Gap junction mmu04611   Platelet activation mmu04613   Neutrophil extracellular trap formation mmu04621   NOD-like receptor signaling pathway mmu04713   Circadian entrainment mmu04720   Long-term potentiation mmu04723   Retrograde endocannabinoid signaling mmu04724   Glutamatergic synapse mmu04725   Cholinergic synapse mmu04726   Serotonergic synapse mmu04728   Dopaminergic synapse mmu04730   Long-term depression mmu04742   Taste transduction mmu04750   Inflammatory mediator regulation of TRP channels mmu04911   Insulin secretion mmu04912   GnRH signaling pathway mmu04915   Estrogen signaling pathway mmu04916   Melanogenesis mmu04918   Thyroid hormone synthesis mmu04919   Thyroid hormone signaling pathway mmu04921   Oxytocin signaling pathway mmu04922   Glucagon signaling pathway mmu04924   Renin secretion mmu04925   Aldosterone synthesis and secretion mmu04926   Relaxin signaling pathway mmu04927   Cortisol synthesis and secretion mmu04928   Parathyroid hormone synthesis, secretion and action mmu04929   GnRH secretion mmu04933   AGE-RAGE signaling pathway in diabetic complications mmu04934   Cushing syndrome mmu04935   Growth hormone synthesis, secretion and action mmu04961   Endocrine and other factor-regulated calcium reabsorption mmu04970   Salivary secretion mmu04971   Gastric acid secretion mmu04972   Pancreatic secretion mmu04973   Carbohydrate digestion and absorption mmu05010   Alzheimer disease mmu05016   Huntington disease mmu05017   Spinocerebellar ataxia mmu05022   Pathways of neurodegeneration - multiple diseases mmu05142   Chagas disease mmu05143   African trypanosomiasis mmu05146   Amoebiasis mmu05163   Human cytomegalovirus infection mmu05200   Pathways in cancer mmu05415   Diabetic cardiomyopathy mmu05417   Lipid and atherosclerosis Module mmu_M00130   Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4 Brite KEGG Orthology (KO) [BR:mmu00001]  09100 Metabolism   09101 Carbohydrate metabolism    00562 Inositol phosphate metabolism     18796 (Plcb2)  09130 Environmental Information Processing   09132 Signal transduction    04015 Rap1 signaling pathway     18796 (Plcb2)    04310 Wnt signaling pathway     18796 (Plcb2)    04371 Apelin signaling pathway     18796 (Plcb2)    04020 Calcium signaling pathway     18796 (Plcb2)    04070 Phosphatidylinositol signaling system     18796 (Plcb2)    04072 Phospholipase D signaling pathway     18796 (Plcb2)    04071 Sphingolipid signaling pathway     18796 (Plcb2)    04022 cGMP-PKG signaling pathway     18796 (Plcb2)  09140 Cellular Processes   09144 Cellular community - eukaryotes    04540 Gap junction     18796 (Plcb2)  09150 Organismal Systems   09151 Immune system    04611 Platelet activation     18796 (Plcb2)    04613 Neutrophil extracellular trap formation     18796 (Plcb2)    04621 NOD-like receptor signaling pathway     18796 (Plcb2)    04062 Chemokine signaling pathway     18796 (Plcb2)   09152 Endocrine system    04911 Insulin secretion     18796 (Plcb2)    04922 Glucagon signaling pathway     18796 (Plcb2)    04929 GnRH secretion     18796 (Plcb2)    04912 GnRH signaling pathway     18796 (Plcb2)    04915 Estrogen signaling pathway     18796 (Plcb2)    04921 Oxytocin signaling pathway     18796 (Plcb2)    04926 Relaxin signaling pathway     18796 (Plcb2)    04935 Growth hormone synthesis, secretion and action     18796 (Plcb2)    04918 Thyroid hormone synthesis     18796 (Plcb2)    04919 Thyroid hormone signaling pathway     18796 (Plcb2)    04928 Parathyroid hormone synthesis, secretion and action     18796 (Plcb2)    04916 Melanogenesis     18796 (Plcb2)    04924 Renin secretion     18796 (Plcb2)    04925 Aldosterone synthesis and secretion     18796 (Plcb2)    04927 Cortisol synthesis and secretion     18796 (Plcb2)   09153 Circulatory system    04261 Adrenergic signaling in cardiomyocytes     18796 (Plcb2)    04270 Vascular smooth muscle contraction     18796 (Plcb2)   09154 Digestive system    04970 Salivary secretion     18796 (Plcb2)    04971 Gastric acid secretion     18796 (Plcb2)    04972 Pancreatic secretion     18796 (Plcb2)    04973 Carbohydrate digestion and absorption     18796 (Plcb2)   09155 Excretory system    04961 Endocrine and other factor-regulated calcium reabsorption     18796 (Plcb2)   09156 Nervous system    04724 Glutamatergic synapse     18796 (Plcb2)    04725 Cholinergic synapse     18796 (Plcb2)    04728 Dopaminergic synapse     18796 (Plcb2)    04726 Serotonergic synapse     18796 (Plcb2)    04720 Long-term potentiation     18796 (Plcb2)    04730 Long-term depression     18796 (Plcb2)    04723 Retrograde endocannabinoid signaling     18796 (Plcb2)   09157 Sensory system    04742 Taste transduction     18796 (Plcb2)    04750 Inflammatory mediator regulation of TRP channels     18796 (Plcb2)   09159 Environmental adaptation    04713 Circadian entrainment     18796 (Plcb2)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     18796 (Plcb2)   09172 Infectious disease: viral    05163 Human cytomegalovirus infection     18796 (Plcb2)   09174 Infectious disease: parasitic    05146 Amoebiasis     18796 (Plcb2)    05142 Chagas disease     18796 (Plcb2)    05143 African trypanosomiasis     18796 (Plcb2)   09164 Neurodegenerative disease    05010 Alzheimer disease     18796 (Plcb2)    05016 Huntington disease     18796 (Plcb2)    05017 Spinocerebellar ataxia     18796 (Plcb2)    05022 Pathways of neurodegeneration - multiple diseases     18796 (Plcb2)   09166 Cardiovascular disease    05417 Lipid and atherosclerosis     18796 (Plcb2)    05415 Diabetic cardiomyopathy     18796 (Plcb2)   09167 Endocrine and metabolic disease    04933 AGE-RAGE signaling pathway in diabetic complications     18796 (Plcb2)    04934 Cushing syndrome     18796 (Plcb2)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    04131 Membrane trafficking [BR:mmu04131]     18796 (Plcb2) Enzymes [BR:mmu01000]  3. Hydrolases   3.1  Acting on ester bonds    3.1.4  Phosphoric-diester hydrolases     3.1.4.11  phosphoinositide phospholipase C      18796 (Plcb2) Membrane trafficking [BR:mmu04131]  Exocytosis   Calcium ion-dependent exocytosis    Phospholipases     18796 (Plcb2)  Endocytosis   Macropinocytosis    Phospholipase C     18796 (Plcb2) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  PLC-beta_C PI-PLC-X PH_14 PI-PLC-Y PLCB1-4-like_EFh EF-hand_like C2 Spike_torovirin Motif Other DBs NCBI-GeneID:  18796 NCBI-ProteinID:  NP_808236 MGI:  107465 Ensembl:  ENSMUSG00000040061 UniProt:  A3KGF7 LinkDB All DBs Position 2:complement(118535484..118559140) Genome browser AA seq 1181 aa AA seqDB search MSLLNPVLLPPNVKAYLSQGERFIKWDDETSIASPVILRVDPKGYYLYWTYQNQEMEFLD VTSIRDTRFGKFAKIPKSQKLREVFNMDFPDNHFLLKTLTVVSGPDMVDLTFYNFVSYKE NVGKDWAEDVLALAKHPMTVNAPRSTFLDKILVKLKMQLNPEGKIPVKNFFQMFPADRKR VEAALGACHLAKGKNDAINPEDFPESVYKSFLMSLCPRPEIDEIFTSYHSKAKPYMTKEH LTKFINQKQRDPRLNSLLFPPARPEQVQVLIDKYEPSGINVQRGQLSPEGMVWFLCGPEN SVLAHDTLLIHQDMTQPLNHYFINSSHNTYLTAGQFSGLSSAEMYRQVLLSGCRCVELDC WKGKPPDEEPIITHGFTMTTDILFKEAIEAIAESAFKTSPYPVILSFENHVDSPRQQAKM AEYCRSMFGETLLTDPLENFPLKPGIPLPSPEDLRGKILIKNKKNQFSGPASPSKKPGGV AEGSLPSSVPVEEDTGWTAEDRTEVEEEEVVEEEEEEESGNLDEEEIKKMQSDEGTAGLE VTAYEEMSSLVNYIQPTKFISFEFSAQKNRSYVVSSFTELKAYELLSKASMQFVDYNKRQ MSRVYPKGTRMDSSNYMPQMFWNAGCQMVALNFQTMDLPMQQNMALFEFNGQSGYLLKHE FMRRLDKQFNPFSVDRIDVVVATTLSITIISGQFLSERSVRTYVEVELFGLPGDPKRRYR TKLSPTANSINPVWKEEPFIFEKILMPELASLRIAVMEEGSKFLGHRIIPINALHSGYHH LCLRSESNMALTMPALFVFLEMKDYIPDTWADLTVALANPIKYFNAQDKKSVKLKGVTGS LPEKLFSGTPVASQSNGAPVSAGNGSTAPGTKATGEEATKEVTEPQTASLEELRELKGVV KLQRRHEKELRELERRGARRWEELLQRGAAQLAELQTQAAGCKLRPGKGSRKKRTLPCEE TVVAPSEPHDRADPRVQELKDRLEQELQQQGEEQYRSVLKRKEQHVTEQIAKMMELAREK QAAELKTFKETSETDTKEMKKKLEAKRLERIQAMTKVTTDKVAQERLKREINNSHIQEVV QAVKQMTETLERHQEKLEERQTACLEQIQAMEKQFQEKALAEYEAKMKGLEAEVKESVRA YFKDCFPTEAEDKPERSCEASEESCPQEPLVSKADTQESRL NT seq 3546 nt NT seq  +upstreamnt  +downstreamnt atgtctttgctcaaccctgttctattgccccctaacgtgaaggcatatctgagccaaggg gagcgcttcatcaagtgggacgatgaaacttcaatagcctctcctgttatcctccgtgtg gatcccaagggctattacttatactggacatatcaaaatcaggagatggagttcctggat gtcacgagtatccgagatactcgctttgggaagtttgcaaagatacccaagagccagaaa ctccgggaggtcttcaacatggactttccagacaaccacttcctgctgaaaacactcaca gtggtgtccggccctgacatggtggacctcaccttctacaactttgtctcttacaaggag aacgtaggcaaggactgggctgaggacgtgctagctctcgccaaacacccgatgacagtc aatgctcctcgaagcacattcctggacaagatcctggtgaagcttaagatgcagctcaac cctgaagggaagattcccgtgaagaattttttccagatgtttcctgctgatcgaaaacgg gtggaagctgccctcggtgcttgtcaccttgcaaaaggcaaaaatgatgctatcaaccca gaggacttcccagaatccgtgtacaagagcttcctcatgagcctctgtcctcggccagaa atcgacgagatcttcacttcctaccactctaaagctaagccctacatgaccaaggaacac ctgaccaaattcatcaatcagaagcagcgagaccctcgactcaactccttgctgttccca ccagcccggcctgagcaagttcaagtgctcattgacaagtacgaacccagcggcatcaat gtgcagaggggccagctgtcaccagaggggatggtctggtttctctgtggaccagagaac agtgtgctggcccacgatacactgctgatccaccaagacatgacacaaccactgaatcac tatttcatcaactcctcacacaacacctacctgacagccggccagttctcaggcctttcc tcggctgagatgtaccgccaggtgctgctgtctggctgccggtgtgtagagttagactgt tggaagggcaagccccctgacgaagagcccattatcacccacggcttcaccatgaccaca gatatcttgttcaaggaagcaattgaagccattgcagaaagtgcctttaagacctccccg tatcctgtcatcctatcatttgaaaaccatgtagactcaccccggcaacaggctaagatg gctgagtactgcaggagcatgtttggagagaccttgctcacagatcccctggaaaatttc cctctgaaacctggcatccctctgcccagccccgaggacctccggggcaagatcctcatt aagaataagaagaaccagttttctgggccagcatcccccagcaagaagcctggtggggtg gctgagggcagcctcccgtctagtgtccctgtagaagaggacacggggtggactgctgag gaccggactgaggtggaggaggaggaggtggtggaagaggaggaagaggaggagtcagga aacctggatgaagaagaaattaagaagatgcagtcggatgagggcacagcaggcctggag gtgacagcttatgaggaaatgtccagccttgtcaattatatccagcccaccaagtttatc tccttcgagttctctgcacagaagaacagaagttacgttgtctcttccttcacggagctc aaggcctacgagctgctctccaaggcctccatgcagtttgtggactataataaacgccag atgagccgtgtgtaccccaagggcacacgcatggactcttccaactacatgccccagatg ttctggaatgctggatgtcagatggttgccctcaatttccagacaatggacctgcccatg cagcagaacatggcactgtttgagttcaacgggcagagtggctacctcctaaagcacgag ttcatgcgcagactggacaagcagttcaaccccttctcagtggaccgcattgatgtggtg gtagccaccaccctttccattacgatcatctctgggcagttcctgtcagagcgcagtgta cgcacctatgtggaagtggaactgtttggcctcccaggggaccccaagaggcggtatcga accaagctgtcacctactgctaactccatcaatcctgtctggaaagaggaaccctttatc tttgagaagatcttgatgcctgagctggcctccctcaggatagctgtgatggaagaaggc agcaaatttcttggacaccgcatcatccccatcaatgccttacattctggataccaccat ctgtgcctgcgcagtgagagcaacatggcccttaccatgccagctctctttgtcttcctg gagatgaaggactacatacctgacacctgggcagatcttacagtagcccttgccaacccc atcaagtacttcaatgcccaggataagaagtccgtgaagctcaaaggagtgacaggaagt ctgcccgagaaactcttctctgggacacctgttgccagtcagtccaatggggcgccagtc tcggcaggcaatgggtcaacagcgcctgggaccaaggccacgggggaagaagctacgaaa gaagtgacagagccacagaccgccagcttggaagagttgcgggaactgaagggcgtggtg aaactgcagcgaagacatgagaaggagcttcgagagttggagcgccgtggagcccggcgc tgggaggaactgctgcagcgtggcgccgcacagctggcggagctccagacccaggcagca ggctgcaagctccgcccaggcaagggctcccgcaagaagaggaccctgccctgtgaggag accgtcgtggcgcctagcgagccccacgaccgggcggacccgcgcgtgcaggagctgaag gacaggctggagcaggagctgcagcagcaaggcgaggagcagtaccgctccgtcctcaag cgcaaggagcagcacgtgaccgagcaaatcgccaagatgatggagctggccagagagaaa caggctgctgaactcaagaccttcaaggagacctcagaaactgacaccaaagaaatgaag aaaaaactggaggccaagaggctggaacggatccaagccatgaccaaggtcaccacagac aaggtggcccaggagaggctcaagagagaaattaacaactcccacatccaggaagtggtc caggctgtcaagcagatgacagagaccctggagcgtcaccaggagaagctggaagagagg cagacagcctgcctggagcagatccaggcaatggaaaagcagttccaggagaaggcgctg gcagagtatgaggccaagatgaagggcctggaggctgaagtaaaggagtcggtgcgggcc tacttcaaggactgcttccccaccgaagcagaagacaagcctgagaggtcctgtgaggcc tctgaggagtcgtgtccacaggaaccacttgtgagcaaggcagacactcaggagagccgc ctctga

Mus musculus (house mouse): 18797 Help Entry 18797             CDS       T01002                                  Symbol Plcb3, mKIAA4098 Name (RefSeq) phospholipase C, beta 3   KO K05858   phosphatidylinositol phospholipase C, beta [EC:3.1.4.11] Organism mmu  Mus musculus (house mouse) Pathway mmu00562   Inositol phosphate metabolism mmu01100   Metabolic pathways mmu04015   Rap1 signaling pathway mmu04020   Calcium signaling pathway mmu04022   cGMP-PKG signaling pathway mmu04062   Chemokine signaling pathway mmu04070   Phosphatidylinositol signaling system mmu04071   Sphingolipid signaling pathway mmu04072   Phospholipase D signaling pathway mmu04261   Adrenergic signaling in cardiomyocytes mmu04270   Vascular smooth muscle contraction mmu04310   Wnt signaling pathway mmu04371   Apelin signaling pathway mmu04540   Gap junction mmu04611   Platelet activation mmu04613   Neutrophil extracellular trap formation mmu04621   NOD-like receptor signaling pathway mmu04713   Circadian entrainment mmu04720   Long-term potentiation mmu04723   Retrograde endocannabinoid signaling mmu04724   Glutamatergic synapse mmu04725   Cholinergic synapse mmu04726   Serotonergic synapse mmu04728   Dopaminergic synapse mmu04730   Long-term depression mmu04742   Taste transduction mmu04750   Inflammatory mediator regulation of TRP channels mmu04911   Insulin secretion mmu04912   GnRH signaling pathway mmu04915   Estrogen signaling pathway mmu04916   Melanogenesis mmu04918   Thyroid hormone synthesis mmu04919   Thyroid hormone signaling pathway mmu04921   Oxytocin signaling pathway mmu04922   Glucagon signaling pathway mmu04924   Renin secretion mmu04925   Aldosterone synthesis and secretion mmu04926   Relaxin signaling pathway mmu04927   Cortisol synthesis and secretion mmu04928   Parathyroid hormone synthesis, secretion and action mmu04929   GnRH secretion mmu04933   AGE-RAGE signaling pathway in diabetic complications mmu04934   Cushing syndrome mmu04935   Growth hormone synthesis, secretion and action mmu04961   Endocrine and other factor-regulated calcium reabsorption mmu04970   Salivary secretion mmu04971   Gastric acid secretion mmu04972   Pancreatic secretion mmu04973   Carbohydrate digestion and absorption mmu05010   Alzheimer disease mmu05016   Huntington disease mmu05017   Spinocerebellar ataxia mmu05022   Pathways of neurodegeneration - multiple diseases mmu05142   Chagas disease mmu05143   African trypanosomiasis mmu05146   Amoebiasis mmu05163   Human cytomegalovirus infection mmu05200   Pathways in cancer mmu05415   Diabetic cardiomyopathy mmu05417   Lipid and atherosclerosis Module mmu_M00130   Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4 Brite KEGG Orthology (KO) [BR:mmu00001]  09100 Metabolism   09101 Carbohydrate metabolism    00562 Inositol phosphate metabolism     18797 (Plcb3)  09130 Environmental Information Processing   09132 Signal transduction    04015 Rap1 signaling pathway     18797 (Plcb3)    04310 Wnt signaling pathway     18797 (Plcb3)    04371 Apelin signaling pathway     18797 (Plcb3)    04020 Calcium signaling pathway     18797 (Plcb3)    04070 Phosphatidylinositol signaling system     18797 (Plcb3)    04072 Phospholipase D signaling pathway     18797 (Plcb3)    04071 Sphingolipid signaling pathway     18797 (Plcb3)    04022 cGMP-PKG signaling pathway     18797 (Plcb3)  09140 Cellular Processes   09144 Cellular community - eukaryotes    04540 Gap junction     18797 (Plcb3)  09150 Organismal Systems   09151 Immune system    04611 Platelet activation     18797 (Plcb3)    04613 Neutrophil extracellular trap formation     18797 (Plcb3)    04621 NOD-like receptor signaling pathway     18797 (Plcb3)    04062 Chemokine signaling pathway     18797 (Plcb3)   09152 Endocrine system    04911 Insulin secretion     18797 (Plcb3)    04922 Glucagon signaling pathway     18797 (Plcb3)    04929 GnRH secretion     18797 (Plcb3)    04912 GnRH signaling pathway     18797 (Plcb3)    04915 Estrogen signaling pathway     18797 (Plcb3)    04921 Oxytocin signaling pathway     18797 (Plcb3)    04926 Relaxin signaling pathway     18797 (Plcb3)    04935 Growth hormone synthesis, secretion and action     18797 (Plcb3)    04918 Thyroid hormone synthesis     18797 (Plcb3)    04919 Thyroid hormone signaling pathway     18797 (Plcb3)    04928 Parathyroid hormone synthesis, secretion and action     18797 (Plcb3)    04916 Melanogenesis     18797 (Plcb3)    04924 Renin secretion     18797 (Plcb3)    04925 Aldosterone synthesis and secretion     18797 (Plcb3)    04927 Cortisol synthesis and secretion     18797 (Plcb3)   09153 Circulatory system    04261 Adrenergic signaling in cardiomyocytes     18797 (Plcb3)    04270 Vascular smooth muscle contraction     18797 (Plcb3)   09154 Digestive system    04970 Salivary secretion     18797 (Plcb3)    04971 Gastric acid secretion     18797 (Plcb3)    04972 Pancreatic secretion     18797 (Plcb3)    04973 Carbohydrate digestion and absorption     18797 (Plcb3)   09155 Excretory system    04961 Endocrine and other factor-regulated calcium reabsorption     18797 (Plcb3)   09156 Nervous system    04724 Glutamatergic synapse     18797 (Plcb3)    04725 Cholinergic synapse     18797 (Plcb3)    04728 Dopaminergic synapse     18797 (Plcb3)    04726 Serotonergic synapse     18797 (Plcb3)    04720 Long-term potentiation     18797 (Plcb3)    04730 Long-term depression     18797 (Plcb3)    04723 Retrograde endocannabinoid signaling     18797 (Plcb3)   09157 Sensory system    04742 Taste transduction     18797 (Plcb3)    04750 Inflammatory mediator regulation of TRP channels     18797 (Plcb3)   09159 Environmental adaptation    04713 Circadian entrainment     18797 (Plcb3)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     18797 (Plcb3)   09172 Infectious disease: viral    05163 Human cytomegalovirus infection     18797 (Plcb3)   09174 Infectious disease: parasitic    05146 Amoebiasis     18797 (Plcb3)    05142 Chagas disease     18797 (Plcb3)    05143 African trypanosomiasis     18797 (Plcb3)   09164 Neurodegenerative disease    05010 Alzheimer disease     18797 (Plcb3)    05016 Huntington disease     18797 (Plcb3)    05017 Spinocerebellar ataxia     18797 (Plcb3)    05022 Pathways of neurodegeneration - multiple diseases     18797 (Plcb3)   09166 Cardiovascular disease    05417 Lipid and atherosclerosis     18797 (Plcb3)    05415 Diabetic cardiomyopathy     18797 (Plcb3)   09167 Endocrine and metabolic disease    04933 AGE-RAGE signaling pathway in diabetic complications     18797 (Plcb3)    04934 Cushing syndrome     18797 (Plcb3)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    04131 Membrane trafficking [BR:mmu04131]     18797 (Plcb3) Enzymes [BR:mmu01000]  3. Hydrolases   3.1  Acting on ester bonds    3.1.4  Phosphoric-diester hydrolases     3.1.4.11  phosphoinositide phospholipase C      18797 (Plcb3) Membrane trafficking [BR:mmu04131]  Exocytosis   Calcium ion-dependent exocytosis    Phospholipases     18797 (Plcb3)  Endocytosis   Macropinocytosis    Phospholipase C     18797 (Plcb3) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  PLC-beta_C PI-PLC-X PI-PLC-Y PH_14 PLCB1-4-like_EFh EF-hand_like C2 Motif Other DBs NCBI-GeneID:  18797 NCBI-ProteinID:  NP_001277278 MGI:  104778 Ensembl:  ENSMUSG00000024960 UniProt:  P51432 LinkDB All DBs Position 19:complement(6931081..6951738) Genome browser AA seq 1234 aa AA seqDB search MAGARPGVHALQLEPPTVVETLRRGSKFIKWDEEASSRNLVTLRVDPNGFFLYWTGPNME VDTLDISSIRDTRTGRYARLPKDPKIREVLGFGGPDTRLEEKLMTVVAGPDPVNTTFLNF MAVQDDTVKVWSEELFKLAMNILAQNASRNTFLRKAYTKLKLQVNQDGRIPVKNILKMFS ADKKRVETALESCGLNFNRSESIRPDEFPLEIFERFLNKLCLRPDIDKILLEIGAKGKPY LTLEQLMDFINQKQRDPRLNEVLYPPLRSSQARLLIEKYETNKQFLERDQMSMEGFSRYL GGEENGILPLEALDLSMDMTQPLSAYFINSSHNTYLTAGQLAGPSSVEMYRQALLWGCRC VELDVWKGRPPEEEPFITHGFTMTTEVPLRDVLEAIAEAAFKTSPYPVILSFENHVDSAK QQAKMAEYCRSIFGDALLIDPLDKYPLSAGIPLPSPQDLMGRILVKNKKRHRPSTGVPDS SVRKRPLEQSNSALSESSAATEPSSPQLGSPSSDSCPGLSNGEEVGLEKTSLEPQKSLGE ESLSREPNVPMPDRDREDEEEDEEEEETTDPKKPTTDEGTASSEVNATEEMSTLVNYVEP VKFKSFEAARKRNKCFEMSSFVETKAMEQLTKSPMEFVEYNKQQLSRIYPKGTRVDSSNY MPQLFWNVGCQLVALNFQTLDLPMQLNAGVFEYNGRSGYLLKPEFMRRPDKSFDPFTEVI VDGIVANALRVKVISGQFLSDKKVGIYVEVDMFGLPVDTRRKYRTRTSQGNSFNPVWDEE PFDFPKVVLPTLASLRIAAFEEGGKFVGHRILPVSAIRSGYHYVCLRNEANQPLCLPALL IYTEASDYIPDDHQDYAEALINPIKHVSLMDQRAKQLAALIGESEAQASTETYQETPCQQ PGSQLPSNPTPNPLDASPRWPPGPTTSSTSSSLSSPGQRDDLIASILSEVTPTPLEELRS HKAMVKLRSRQDRDLRELHKKHQRKAVALTRRLLDGLAQARAEGKCRPSPSALGKATNSE DVKEEEEAKQYREFQNRQVQSLLELREAQADVETKRKLEHLRQAHQRLKEVVLDTHTTQF KRLKELNEREKKELQKILDRKRNNSISEAKTREKHKKEVELTEINRRHITESVNSIRRLE EAQKQRHERLVAGQQQVLQQLEEEEPKLLAQLTQECQEQRERLPQEIRRCLLGETAEGLG DGPLVACASNGHAPGSGGHLSSADSESQEENTQL NT seq 3705 nt NT seq  +upstreamnt  +downstreamnt atggcgggcgcgaggcccggcgtccacgcgctgcagctggagccgcccaccgtggtggag accctgcggcgcgggagtaagttcatcaaatgggacgaggaggcctccagtcggaacctg gtgaccctgcgtgtggaccctaatggcttcttcttgtactggacaggacccaacatggag gtggacacactggacatcagctccatcagggacacaaggacaggtcgttatgcccgcctg cccaaggaccctaagattcgagaagtactgggctttggaggtcctgacacccggctggag gagaaactgatgacagtggtggccgggccagatccagtaaataccacattcttgaacttc atggccgtgcaagatgacacagtcaaggtctggtcagaggagttgtttaaactggccatg aacatattggctcagaacgcctcccggaacaccttcctgcggaaagcatacacgaagctg aagctgcaggtgaaccaggatggacggattccggtcaagaacattctgaagatgttctcg gcggacaagaagcgggtggagacggcgctggagtcctgtggcctcaacttcaaccgaagt gagtccattcgccctgatgagtttcccttggaaatttttgagcggttcttgaataaactg tgtctgcgcccggatattgacaagatcctgctggagataggtgccaagggcaagccgtac ctcactctggagcagctcatggactttatcaaccagaagcagagagacccgagactcaac gaagtgctgtacccgccacttcggtcctcacaggctcggctgctcattgagaagtacgag acgaacaaacagttcctggagcgcgaccagatgtctatggagggcttcagccgctacctg ggaggggaggagaatggtatcctgcctctggaggccctggatctgagcatggacatgacc cagccactgagcgcatattttatcaactcctcacacaacacctatctcactgcgggccag ctggctggaccatcatcggtggagatgtaccgccaggcactgctgtggggctgccgctgt gtggagctggatgtatggaagggacggccaccggaggaagagcctttcatcactcatggt ttcaccatgaccactgaggtgccattgcgtgatgtgctagaggccatcgctgaggcagcc ttcaagacctcgccctaccctgtcatcctctcctttgagaaccatgtcgactcggcaaag cagcaggccaagatggctgagtactgccgctctatctttggggatgcgctgctcattgac cctctcgacaaatacccgctatctgcgggcatccccctgcctagtccacaggacctgatg ggccgtatcctggtgaagaataagaagcgacatcggcccagcacaggtgtccctgacagc tcagtgcgcaagcggcctctggaacagagcaactcggccttgagtgagagctcggccgcc acagagccctcctcacctcagcttgggtcccccagctccgacagctgccctggcctaagc aatggggaggaggtgggactcgagaagaccagcctggagcctcagaagtctctaggtgag gagagcctcagccgggaacctaatgtgcccatgcctgaccgtgaccgagaggatgaggag gaagatgaagaagaagaggaaacaacggatccaaaaaagcccaccactgatgagggcaca gccagcagtgaggtcaatgccacggaggagatgtcaacgctcgtcaactacgttgagccc gtcaagttcaagtccttcgaggctgctcgaaaaaggaacaagtgcttcgagatgtcatcc ttcgtggagaccaaggcaatggagcaactgaccaagagtcctatggagtttgtggaatac aacaaacagcagctcagccgcatctaccctaagggcacacgagtggactcctccaactac atgcctcagctcttctggaacgtgggttgccagcttgttgccctcaacttccagaccttg gatttgccaatgcagctcaacgcaggcgtgtttgagtacaatgggcgcagcgggtacttg ctcaagcccgagtttatgcggcggccggacaagtcttttgatcccttcactgaggtcatc gtagatggcatagtggccaacgccttgcgggtcaaggtgatttcggggcagttcctgtct gacaagaaggtgggcatctacgtcgaggtggacatgtttggcctcccagttgacacaaga cgcaaatatcgtacccggacatcccaggggaactcattcaaccctgtgtgggacgaggaa ccctttgacttccccaaggttgtgctgcccacgctggcctcacttcgcatcgcagccttt gaggagggtggcaaatttgttgggcaccgtatcctgcctgtctctgctatccgctcagga taccactatgtctgcctgcgaaacgaggccaaccaacctttgtgcctgcctgccctgctt atctacactgaagcttctgactacatcccagatgaccaccaggactatgcggaggccttg attaaccccatcaagcacgtaagcctaatggaccagcgggccaagcaactagccgctctc attggggagagtgaggctcaggccagcacagagacatatcaggagaccccgtgtcaacag ccagggtcacagctcccctccaaccccacacctaacccactggatgcctcacctcgctgg ccccccggtcctaccacttcctccactagctcctccctcagtagcccagggcagcgagat gatttgattgccagcatcctctctgaggtgacccctacacctctagaggagctcagaagc cacaaggctatggtgaagctacggagccggcaggatcgagacctgcgggagttgcataag aagcaccagcgcaaggctgtggccctcacccgccgccttctggatggcctggcccaggcc agggctgaggggaagtgccggccctcccccagtgccctgggcaaggccaccaactcggag gacgtgaaggaggaagaggaggccaaacagtatcgagagttccagaaccgacaagtacag agcctgttggagctgagggaagcccaggcagatgtggagaccaagcggaagctggagcat ctacgacaggctcatcagcggctcaaggaggttgtcctggatacacacacaacacagttc aagaggctgaaggagctgaatgaaagggagaagaaggaactccagaagatcctggacagg aagcgcaacaacagcatctcagaggccaagacaagggagaaacacaagaaggaggtggaa ctgacagagattaatcggcggcacatcactgagtcggtaaactccatcagacggctggaa gaggcccagaagcagcgccatgaacgcctggtggcagggcaacagcaagtcctccagcag ctagaggaagaggaacccaagctgctggcccagctgacccaggagtgtcaggaacagcga gagaggttgccccaggagatccgtcggtgcctgctgggcgagacagcagagggactgggg gacggccccctggtggcctgtgccagcaatggtcatgcacctgggagtggtgggcacctg tccagcgctgactcggagagccaggaggagaacacccagctttga

Mus musculus (house mouse): 18798 Help Entry 18798             CDS       T01002                                  Symbol Plcb4, A930039J07Rik, C230058B11Rik Name (RefSeq) phospholipase C, beta 4   KO K05858   phosphatidylinositol phospholipase C, beta [EC:3.1.4.11] Organism mmu  Mus musculus (house mouse) Pathway mmu00562   Inositol phosphate metabolism mmu01100   Metabolic pathways mmu04015   Rap1 signaling pathway mmu04020   Calcium signaling pathway mmu04022   cGMP-PKG signaling pathway mmu04062   Chemokine signaling pathway mmu04070   Phosphatidylinositol signaling system mmu04071   Sphingolipid signaling pathway mmu04072   Phospholipase D signaling pathway mmu04261   Adrenergic signaling in cardiomyocytes mmu04270   Vascular smooth muscle contraction mmu04310   Wnt signaling pathway mmu04371   Apelin signaling pathway mmu04540   Gap junction mmu04611   Platelet activation mmu04613   Neutrophil extracellular trap formation mmu04621   NOD-like receptor signaling pathway mmu04713   Circadian entrainment mmu04720   Long-term potentiation mmu04723   Retrograde endocannabinoid signaling mmu04724   Glutamatergic synapse mmu04725   Cholinergic synapse mmu04726   Serotonergic synapse mmu04728   Dopaminergic synapse mmu04730   Long-term depression mmu04742   Taste transduction mmu04750   Inflammatory mediator regulation of TRP channels mmu04911   Insulin secretion mmu04912   GnRH signaling pathway mmu04915   Estrogen signaling pathway mmu04916   Melanogenesis mmu04918   Thyroid hormone synthesis mmu04919   Thyroid hormone signaling pathway mmu04921   Oxytocin signaling pathway mmu04922   Glucagon signaling pathway mmu04924   Renin secretion mmu04925   Aldosterone synthesis and secretion mmu04926   Relaxin signaling pathway mmu04927   Cortisol synthesis and secretion mmu04928   Parathyroid hormone synthesis, secretion and action mmu04929   GnRH secretion mmu04933   AGE-RAGE signaling pathway in diabetic complications mmu04934   Cushing syndrome mmu04935   Growth hormone synthesis, secretion and action mmu04961   Endocrine and other factor-regulated calcium reabsorption mmu04970   Salivary secretion mmu04971   Gastric acid secretion mmu04972   Pancreatic secretion mmu04973   Carbohydrate digestion and absorption mmu05010   Alzheimer disease mmu05016   Huntington disease mmu05017   Spinocerebellar ataxia mmu05022   Pathways of neurodegeneration - multiple diseases mmu05142   Chagas disease mmu05143   African trypanosomiasis mmu05146   Amoebiasis mmu05163   Human cytomegalovirus infection mmu05200   Pathways in cancer mmu05415   Diabetic cardiomyopathy mmu05417   Lipid and atherosclerosis Module mmu_M00130   Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4 Brite KEGG Orthology (KO) [BR:mmu00001]  09100 Metabolism   09101 Carbohydrate metabolism    00562 Inositol phosphate metabolism     18798 (Plcb4)  09130 Environmental Information Processing   09132 Signal transduction    04015 Rap1 signaling pathway     18798 (Plcb4)    04310 Wnt signaling pathway     18798 (Plcb4)    04371 Apelin signaling pathway     18798 (Plcb4)    04020 Calcium signaling pathway     18798 (Plcb4)    04070 Phosphatidylinositol signaling system     18798 (Plcb4)    04072 Phospholipase D signaling pathway     18798 (Plcb4)    04071 Sphingolipid signaling pathway     18798 (Plcb4)    04022 cGMP-PKG signaling pathway     18798 (Plcb4)  09140 Cellular Processes   09144 Cellular community - eukaryotes    04540 Gap junction     18798 (Plcb4)  09150 Organismal Systems   09151 Immune system    04611 Platelet activation     18798 (Plcb4)    04613 Neutrophil extracellular trap formation     18798 (Plcb4)    04621 NOD-like receptor signaling pathway     18798 (Plcb4)    04062 Chemokine signaling pathway     18798 (Plcb4)   09152 Endocrine system    04911 Insulin secretion     18798 (Plcb4)    04922 Glucagon signaling pathway     18798 (Plcb4)    04929 GnRH secretion     18798 (Plcb4)    04912 GnRH signaling pathway     18798 (Plcb4)    04915 Estrogen signaling pathway     18798 (Plcb4)    04921 Oxytocin signaling pathway     18798 (Plcb4)    04926 Relaxin signaling pathway     18798 (Plcb4)    04935 Growth hormone synthesis, secretion and action     18798 (Plcb4)    04918 Thyroid hormone synthesis     18798 (Plcb4)    04919 Thyroid hormone signaling pathway     18798 (Plcb4)    04928 Parathyroid hormone synthesis, secretion and action     18798 (Plcb4)    04916 Melanogenesis     18798 (Plcb4)    04924 Renin secretion     18798 (Plcb4)    04925 Aldosterone synthesis and secretion     18798 (Plcb4)    04927 Cortisol synthesis and secretion     18798 (Plcb4)   09153 Circulatory system    04261 Adrenergic signaling in cardiomyocytes     18798 (Plcb4)    04270 Vascular smooth muscle contraction     18798 (Plcb4)   09154 Digestive system    04970 Salivary secretion     18798 (Plcb4)    04971 Gastric acid secretion     18798 (Plcb4)    04972 Pancreatic secretion     18798 (Plcb4)    04973 Carbohydrate digestion and absorption     18798 (Plcb4)   09155 Excretory system    04961 Endocrine and other factor-regulated calcium reabsorption     18798 (Plcb4)   09156 Nervous system    04724 Glutamatergic synapse     18798 (Plcb4)    04725 Cholinergic synapse     18798 (Plcb4)    04728 Dopaminergic synapse     18798 (Plcb4)    04726 Serotonergic synapse     18798 (Plcb4)    04720 Long-term potentiation     18798 (Plcb4)    04730 Long-term depression     18798 (Plcb4)    04723 Retrograde endocannabinoid signaling     18798 (Plcb4)   09157 Sensory system    04742 Taste transduction     18798 (Plcb4)    04750 Inflammatory mediator regulation of TRP channels     18798 (Plcb4)   09159 Environmental adaptation    04713 Circadian entrainment     18798 (Plcb4)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     18798 (Plcb4)   09172 Infectious disease: viral    05163 Human cytomegalovirus infection     18798 (Plcb4)   09174 Infectious disease: parasitic    05146 Amoebiasis     18798 (Plcb4)    05142 Chagas disease     18798 (Plcb4)    05143 African trypanosomiasis     18798 (Plcb4)   09164 Neurodegenerative disease    05010 Alzheimer disease     18798 (Plcb4)    05016 Huntington disease     18798 (Plcb4)    05017 Spinocerebellar ataxia     18798 (Plcb4)    05022 Pathways of neurodegeneration - multiple diseases     18798 (Plcb4)   09166 Cardiovascular disease    05417 Lipid and atherosclerosis     18798 (Plcb4)    05415 Diabetic cardiomyopathy     18798 (Plcb4)   09167 Endocrine and metabolic disease    04933 AGE-RAGE signaling pathway in diabetic complications     18798 (Plcb4)    04934 Cushing syndrome     18798 (Plcb4)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    04131 Membrane trafficking [BR:mmu04131]     18798 (Plcb4) Enzymes [BR:mmu01000]  3. Hydrolases   3.1  Acting on ester bonds    3.1.4  Phosphoric-diester hydrolases     3.1.4.11  phosphoinositide phospholipase C      18798 (Plcb4) Membrane trafficking [BR:mmu04131]  Exocytosis   Calcium ion-dependent exocytosis    Phospholipases     18798 (Plcb4)  Endocytosis   Macropinocytosis    Phospholipase C     18798 (Plcb4) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  PI-PLC-X PH_14 PI-PLC-Y PLCB1-4-like_EFh EF-hand_like C2 PLC-beta_C EF-hand_6 EF-hand_7 Motif Other DBs NCBI-GeneID:  18798 NCBI-ProteinID:  NP_001342082 MGI:  107464 Ensembl:  ENSMUSG00000039943 LinkDB All DBs Position 2:135500523..135856522 Genome browser AA seq 1194 aa AA seqDB search MAKPYEFNWQKEVPSFLQEGAVFDRYEEESFVFEPNCLFKVDEFGFFLTWKSEGKEGQVL ECSLINSIRQAAIPKDPKILAALEAVGKSENDLEGRILCVCSGTDLVNIGFTYMVAENPE VTKQWVEGLRSIIHNFRANNVSPMTCLKKHWMKLAFLTNTTGKIPVRSITRTFASGKTEK VIFQALKELGLPSGKNDEIEPAAFTYEKFYELTQKICPRTDIEDLFKKINGDKTDYLTVD QLVSFLNEHQRDPRLNEILFPFYDAKRAMQIIEMYEPDEELKKKGLISSDGFCRYLMSDE NAPVFLDRLELYQEMDHPLAHYFISSSHNTYLTGRQFGGKSSVEMYRQVLLAGCRCVELD CWDGKGEDQEPIITHGKAMCTDILFKDVIQAIKETAFVTSEYPVILSFENHCSKYQQYKM SKYCEDLFGDLLLKQALESHPLEPGRPLPSPNDLKRKILIKNKRLKPEVEKKQLEALKSM MEAGESAAPASILEDDNEEEIESADQEEEAHPEYKFGNELSADDYSHKEAVANSVKKGLV TVEDEQAWMASYKYVGATTNIHPYLSTMINYAQPVKFQGFHVAEERNIHYNMSSFNESVG LGYLKTHAIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQMVSLNYQTPDLAMQL NQGKFEYNGSCGYLLKPDFMRRPDRTFDPFSETPVDGVIAATCSVQVISGQFLSDKKIGT YVEVDMYGLPTDTIRKEFRTRMVMNNGLNPVYNEESFVFRKVILPDLAVLRIAVYDDNNK LIGQRILPLDGLQAGYRHISLRNEGNKPLSLPTIFCNIVLKTYVPDGFGDIVDALSDPKK FLSITEKRADQMRAMGIETSDIADVPSDTSKNDKKGKANPAKANVTPQSSSELRPTTTAA LGSGQEAKKGIELIPQVRIEDLKQMKAYLKHLKKQQKELNSLKKKHAKEHSTMQKLHCTQ VDKIVAQYDKEKSTHEKILEKAMKKKGGSNCLEIKKETEIKIQTLTTDHKSKVKEIVAQH TKEWSEMINTHSAEEQEIRDLHLSQQCELLRKLLINAHEQQTQQLKLSHDRESKEMRAHQ AKISMENSKAISQDKSIKNKAERERRVRELNSSNTKKFLEERKRLAMKQSKEMDQLKKVQ LEHLEFLEKQNEQLLKSCHAVSQTQGEGDAADGEIGSRDGPQTSNSSMKLQSAN NT seq 3585 nt NT seq  +upstreamnt  +downstreamnt atggccaaaccttacgaatttaactggcagaaggaagtgccctctttcttgcaagaagga gcagtttttgacagatacgaagaggaatcttttgtgtttgagcccaactgcctcttcaaa gtagatgaattcggcttcttcctgacgtggaagagtgaaggcaaggaaggacaagtgcta gaatgttccctcatcaacagtattcgccaagcagccataccaaaggatcccaaaatcctg gctgctctcgaagctgttggaaaatctgaaaatgatctggaagggcggatattgtgtgtc tgcagcggcacggatctggtgaatatcggcttcacttacatggtggctgaaaatccagaa gtaactaagcaatgggtagaaggcctgagatcgatcattcacaacttcagggcaaacaac gtcagtccgatgacatgcctcaagaaacactggatgaaactggcctttctgaccaacaca actggtaaaatcccagtgaggagtatcactagaaccttcgcatcagggaaaacagaaaag gtgatctttcaagccctcaaggaactaggtcttcccagtggaaagaatgatgaaattgaa cctgctgcatttacttatgaaaagttctatgaactgacacaaaagatttgtcctcggaca gatatagaagatctttttaaaaaaatcaatggagacaaaactgattatttaacggtagac caattagtgagctttctaaacgaacatcagcgagatcctcggctgaatgaaattttattc ccattttatgatgctaaaagagcaatgcagatcattgaaatgtatgagcctgatgaagag ctgaagaaaaaaggcctcatatccagtgatggattctgcagatatctgatgtcagatgaa aatgcccctgtcttcttagatcgcttagaactttaccaggagatggaccacccgctggct cattacttcatcagttcctcccacaacacctatctcactggccggcaatttggaggaaag tcttcagtggaaatgtacagacaagttctcctggctggttgcaggtgtgttgaacttgac tgttgggatggaaaaggtgaagatcaggaaccgataataactcacggaaaagcaatgtgt acagacatcctttttaaggatgtaatccaggccatcaaggaaacggcgtttgtcacatca gaataccctgtcattctctccttcgaaaaccactgcagcaaatatcaacagtacaagatg tccaagtattgtgaagatctatttggggatctcctgttgaaacaagcacttgagtcgcat ccacttgaaccaggaaggcccttgccgtctcctaatgacctcaaaagaaaaatactcatc aagaataagaggctgaagcctgaagttgaaaagaaacagcttgaagctttgaaaagcatg atggaagctggagagtcagccgccccagctagcatcttggaagacgacaatgaagaggaa atagaaagtgctgatcaagaggaagaagcccaccctgaatacaaatttggaaatgaactt tctgccgatgactacagtcacaaggaagcggttgcaaacagcgtcaagaagggcctggtc accgtagaggatgagcaagcatggatggcatcttataaatacgtaggtgctaccacgaac atccatccgtacttgtccacgatgatcaactatgcccagcccgtgaagtttcaaggtttc cacgtggctgaagagcgcaatattcactataacatgtcttcttttaacgagtcggttggc cttggctacttgaagacgcacgcgattgagtttgtaaattacaataagcgacaaatgagc cgcatttaccccaagggaggccgagttgattccagtaattacatgcctcagattttctgg aacgctggttgccagatggtttcactgaactatcaaaccccagatttagcgatgcaattg aatcaaggaaaatttgagtataatggatcatgcgggtaccttctcaagccagatttcatg aggcggcctgatcggacatttgaccccttctctgaaacccctgtggacggggttattgca gccacgtgctcagtgcaggttatatcagggcagttcctctcagataagaagatcgggaca tacgtggaagtcgatatgtacgggctgcccaccgacaccatacggaaagagttccgaacc cgcatggttatgaacaatggactcaacccagtgtataatgaagaatcgtttgtgtttcga aaggtgatcctgcctgacctagctgtcctgagaatcgcagtctacgatgacaacaacaag ctaattggccagaggatccttcctttggatggtctccaagcaggctaccgacacatctcc ctgagaaacgagggaaacaaaccattatcactgccaacaattttctgcaatattgttctt aaaacatacgtgcctgatggatttggagatattgtggatgctttatccgatccaaagaaa tttctttcaatcacagagaagagagcagaccaaatgagagcaatgggcattgaaactagt gacatagcagatgtgcccagtgacacttccaaaaatgacaagaaaggcaaggccaaccca gccaaagcgaacgtgacccctcagagcagctctgagctcagaccaaccaccacagccgcc ctgggctctggccaggaagccaagaaaggtattgaacttatccctcaagtgaggatagaa gatttaaagcaaatgaaggcttacttgaagcatttaaagaaacaacagaaggagttaaac tctttaaagaagaaacatgcaaaggagcacagtaccatgcagaagttacactgcacacaa gttgacaaaatcgtggcccagtatgacaaagagaagtcgactcatgagaaaatcctagag aaggcgatgaagaagaaggggggaagtaattgtcttgaaataaaaaaagaaacagaaatt aaaattcagaccctgacaacggatcacaaatctaaggtcaaagagattgtggcccagcac acaaaggagtggtcagaaatgatcaacactcacagtgcggaggagcaggaaatccgggat ctgcacctgagccagcagtgtgagctgctgagaaagctgctcatcaatgctcatgagcag cagacccagcagctgaaactctcccatgacagggaaagcaaggagatgagagcccatcag gctaagatttctatggaaaatagcaaggccatcagtcaagataaatctatcaagaacaag gcagaacgggaaaggcgagtcagggagttgaacagcagcaacactaagaagttcctagaa gaaagaaagagactggcgatgaagcagtcaaaagaaatggatcagttgaaaaaagtccag ctggagcacctagaattcctagagaaacagaacgagcagcttttgaaatcctgtcatgca gtgtcccaaacacaaggcgaaggagatgcagcagatggtgaaattggaagccgagatgga ccgcagaccagcaacagtagtatgaaactccagagtgcaaactga

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