Mus musculus (house mouse): 20191 Help Entry 20191             CDS       T01002                                  Symbol Ryr2, 9330127I20Rik, RYR-2 Name (RefSeq) ryanodine receptor 2, cardiac   KO K04962   ryanodine receptor 2 Organism mmu  Mus musculus (house mouse) Pathway mmu04020   Calcium signaling pathway mmu04024   cAMP signaling pathway mmu04260   Cardiac muscle contraction mmu04261   Adrenergic signaling in cardiomyocytes mmu04371   Apelin signaling pathway mmu04713   Circadian entrainment mmu04911   Insulin secretion mmu04921   Oxytocin signaling pathway mmu04972   Pancreatic secretion mmu05020   Prion disease mmu05022   Pathways of neurodegeneration - multiple diseases mmu05410   Hypertrophic cardiomyopathy mmu05412   Arrhythmogenic right ventricular cardiomyopathy mmu05414   Dilated cardiomyopathy mmu05415   Diabetic cardiomyopathy Brite KEGG Orthology (KO) [BR:mmu00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     20191 (Ryr2)    04020 Calcium signaling pathway     20191 (Ryr2)    04024 cAMP signaling pathway     20191 (Ryr2)  09150 Organismal Systems   09152 Endocrine system    04911 Insulin secretion     20191 (Ryr2)    04921 Oxytocin signaling pathway     20191 (Ryr2)   09153 Circulatory system    04260 Cardiac muscle contraction     20191 (Ryr2)    04261 Adrenergic signaling in cardiomyocytes     20191 (Ryr2)   09154 Digestive system    04972 Pancreatic secretion     20191 (Ryr2)   09159 Environmental adaptation    04713 Circadian entrainment     20191 (Ryr2)  09160 Human Diseases   09164 Neurodegenerative disease    05020 Prion disease     20191 (Ryr2)    05022 Pathways of neurodegeneration - multiple diseases     20191 (Ryr2)   09166 Cardiovascular disease    05410 Hypertrophic cardiomyopathy     20191 (Ryr2)    05412 Arrhythmogenic right ventricular cardiomyopathy     20191 (Ryr2)    05414 Dilated cardiomyopathy     20191 (Ryr2)    05415 Diabetic cardiomyopathy     20191 (Ryr2)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:mmu04040]     20191 (Ryr2)    04990 Domain-containing proteins not elsewhere classified [BR:mmu04990]     20191 (Ryr2) Ion channels [BR:mmu04040]  Voltage-gated cation channels   Ryanodine receptor    20191 (Ryr2) Domain-containing proteins not elsewhere classified [BR:mmu04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    20191 (Ryr2) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY Ins145_P3_rec MIR RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_8 Motif Other DBs NCBI-GeneID:  20191 NCBI-ProteinID:  NP_076357 MGI:  99685 Ensembl:  ENSMUSG00000021313 UniProt:  E9Q401 Q80ZZ5 Q60835 Structure PDBPDBj LinkDB All DBs Position 13:complement(11567985..12121831) Genome browser AA seq 4966 aa AA seqDB search MADAGEGEDEIQFLRTDDEVVLQCTATIHKEQQKLCLAAEGFGNRLCFLESTSNSKNVPP DLSICTFVLEQSLSVRALQEMLANTVEKSEGQVDVEKWKFMMKTAQGGGHRTLLYGHAIL LRHSYSGMYLCCLSTSRSSTDKLAFDVGLQEDTTGEACWWTIHPASKQRSEGEKVRVGDD LILVSVSSERYLHLSYGNSSWHVDAAFQQTLWSVAPISSGSEAAQGYLIGGDVLRLLHGH MDECLTVPSGEHGEEQRRTVHYEGGAVSVHARSLWRLETLRVAWSGSHIRWGQPFRLRHV TTGKYLSLMEDKNLLLMDKEKADVKSTAFAFRSSKEKLDVGVRKEVDGMGTSEIKYGDSI CYIQHVDTGLWLTYQAVDVKSARMGSIQRKAIMHHEGHMDDGLNLSRSQHEESRTARVIR STVFLFNRFIRGLDALSKKVKLPTIDLPIESVSLSLQDLIGYFHPPDEHLEHEDKQNRLR ALKNRQNLFQEEGMINLVLECIDRLHVYSSAAHFADVAGREAGESWKSILNSLYELLAAL IRGNRKNCAQFSGSLDWLISRLERLEASSGILEVLHCVLVESPEALNIIKEGHIKSIISL LDKHGRNHKVLDVLCSLCVCHGVAVRSNQHLICDNLLPGRDLLLQTRLVNHVSSMRPNIF LGVSEGSAQYKKWYYELMVDHTEPFVTAEATHLRVGWASTEGYSPYPGGGEEWGGNGVGD DLFSYGFDGLHLWSGCIARTVSSPNQHLLRTDDVISCCLDLSAPSISFRINGQPVQGMFE NFNIDGLFFPVVSFSAGIKVRFLLGGRHGEFKFLPPPGYAACYEAVLPKEKLKVEHSREY KQERTYTRDLLGPTVSLTQAAFTPVPVDTSQIVLPPHLERIRERLAENIHELWVMNKIEL GWQYGPVRDDNKRQHPCLVEFCKLPEQERNYNLQMSLETLKTLLALGCHVGIADEHAEEK VKKMKLPKNYQLTSGYKPAPMDLSFIKLTPSQEAMVDKLAENAHNVWARDRIRQGWTYGI QQDVKNRRNPRLVPYTLLDDRTKKSNKDSLREAVRTLLGYGYHLEAPDQDHASRAEVCSG TGERFRIFRAEKTYAVKAGRWYFEFEAVTAGDMRVGWSRPGCQPDLELGSDDRAFAFDGF KAQRWHQGNEHYGRSWQAGDVVGCMVDMNEHTMMFTLNGEILLDDSGSELAFKDFDVGDG FIPVCSLGVAQVGRMNFGKDVSTLKYFTICGLQEGYEPFAVNTNRDITMWLSKRLPQFLQ VPSNHEHIEVTRIDGTIDSSPCLKVTQKSFGSQNNNTDIMFYRLSMPIECAEVFSKSVAG GLPGAGFYGPKNDLEDFDVDSDFEVLMKTAHGHLVPDRIDKDKETPKPEFNNHKDYAQEK PSRLKQRFLLRRTKPDYSTGHSARLTEDVLADDRDDYEYLMQTSTYYYSVRIFPGQEPAN VWVGWITSDFHQYDTGFDLDRVRTVTVTLGDEKGKVHESIKRSNCYMVCAGESMSPGQGR NNSNGLEIGCVVDAASGLLTFIANGKELSTYYQVEPSTKLFPAVFAQATSPNVFQFELGR IKNVMPLSAGLFKSEHKNPVPQCPPRLHVQFLSHVLWSRMPNQFLKVDVSRISERQGWLV QCLDPLQFMSLHIPEENRSVDILELTEQEELLQFHYHTLRLYSAVCALGNHRVAHALCSH VDEPQLLYAIENKYMPGLLRAGYYDLLIDIHLSSYATARLMMNNEFIVPMTEETKSITLF PDENKKHGLPGIGLSTSLRPRMRFSSPSFVSISNDCYQYSPEFPLDILKAKTIQMLTEAV KEGSLHARDPVGGTTEFLFVPLIKLFYTLLIMGIFHNEDLKHILQLIEPSVFKEAAVPEE EGGTPEKEISIEDAKLEGEEEAKGGKRPKEGLLQMKLPEPVKLQMCLLLQYLCDCQVRHR IEAIVAFSDDFVAKLQDNQRFRYNEVMQALNMSAALTARKTREFRSPPQEQINMLLNFKD DKSECPCPEEIRDQLLDFHEDLMTHCGIELDEDGSLDGSNDLTIRGRLLSLVEKVTYLKK KQAEKPVASDSRKCSSLQQLISETMVRWAQESVIEDPELVRAMFVLLHRQYDGIGGLVRA LPKTYTINGVSVEDTINLLASLGQIRSLLSVRMGKEEEKLMIRGLGDIMNNKVFYQHPNL MRALGMHETVMEVMVNVLGGGESKEITFPKMVANCCRFLCYFCRISRQNQKAMFDHLSYL LENSSVGLASPAMRGSTPLDVAAASVMDNNELALALREPDLEKVVRYLAGCGLQSCQMLV SKGYPDIGWNPVEGERYLDFLRFAVFCNGESVEENANVVVRLLIRRPECFGPALRGEGGN GLLAAMEEAIKIAEDPSRDGPSPTSGSSKTLDIEEEEDDTIHMGNAIMTFYAALIDLLGR CAPEMHLIHAGKGEAIRIRSILRSLIPLGDLVGVISIAFQMPTIAKDGKVVEPDMSAGFC PDHKAAMVLFLDRVYGIEVQDFLLHLLEVGFLPDLRAAASLDTAALSATDMALALNRYLC TAVLPLLTRCAPLFAGTEHHASLIDSLLHTVYRLSKGCSLTKAQRDSIEVCLLSICGQLR PSMMQHLLRRLVFDVPLLNEHAKMPLKLLTNHYERCWKYYCLPGGWGNFGAASEEELHLS RKLFWGIFDALSQKKYEQELFKLALPCLSAVAGALPPDYMESNYVSMMEKQSSMDSEGNF NPQPVDTSNITIPEKLEYFINKYAEHSHDKWSMDKLANGWIYGEIYSDSSKIQPLMKPYK LLSEKEKEIYRWPIKESLKTMLAWGWRIERTREGDSMALYNRTRRISQTSQVSIDAAHGY SPRAIDMSNVTLSRDLHAMAEMMAENYHNIWAKKKKLELESKGGGNHPLLVPYDTLTAKE KAKDREKAQDIFKFLQISGYVVSRGFKDLDLDTPSIEKRFAYSFLQQLIRYVDEAHQYIL EFDGGSRSKGEHFPYEQEIKFFAKVVLPLIDQYFKNHRLYFLSAASRPLCTGGHASNKEK EMVTSLFCKLGVLVRHRISLFGNDATSIVNCLHILGQTLDARTVMKTGLDSVKSALRAFL DNAAEDLEKTMENLKQGQFTHTRSQPKGVTQIINYTTVALLPMLSSLFEHIGQHQFGEDL ILEDVQVSCYRILTSLYALGTSKSIYVERQRSALGECLAAFAGAFPIAFLETHLDKHNVY SIYNTRSSRERAALSLPANVEDVCPNIPSLEKLMTEIIELAESGIRYTQMPYMMEVVLPM LCSYMSRWWEHGPENHPERAEMCCTALNSEHMNTLLGNILKIIYNNLGIDEGAWMKRLAV FSQPIINKVKPQLLKTHFLPLMEKLKKKAAMVVSEEDHLKAEARGDMSEAELLILDEFTT LARDLYAFYPLLIRFVDYNRAKWLKEPNPEAEELFRMVAEVFIYWSKSHNFKREEQNFVV QNEINNMSFLITDTKSKMSKAAISDQERKKMKRKGDRYSMQTSLIVAALKRLLPIGLNIC APGDQELIALAKNRFSLKDTEEEVRDIIRSNIHLQGKLEDPAIRWQMALYKDLPNRTEDP SDPERTVERVLGIANVLFHLEQKSKYTGRGYFSLVEHPQRSKKAVWHKLLSKQRKRAVVA CFRMAPLYNLPRHRAVNLFLQGYEKSWIETEEHYFEDKLIEDLAKPGAELPEEDEAMKRV DPLHQLILLFSRTALTEKCKLEEDFLYMAYADIMAKSCHDEEDDDGEEEVKSFEEKEMEK QKLLYQQARLHDRGAAEMVLQTISASKGETGPMVAATLKLGIAILNGGNSTVQQKMLDYL KEKKDVGFFQSLAGLMQSCSVLDLNAFERQNKAEGLGMVTEEGSGEKVLQDDEFTCDLFR FLQLLCEGHNSDFQNYLRTQTGNNTTVNIIISTVDYLLRVQESISDFYWYYSGKDIIDEQ GQRNFSKAIQVAKQVFNTLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMQMKLSQD SSQIELLKELMDLQKDMVVMLLSMLEGNVVNGTIGKQMVDMLVESSNNVEMILKFFDMFL KLKDLTSSDTFKEYDPDGKGVISKRDFHKAMESHKHYTQSETEFLLSCAETDENETLDYE EFVKRFHEPAKDIGFNVAVLLTNLSEHMPNDTRLQTFLELAESVLNYFQPFLGRIEIMGS AKRIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGEKEKMELFVNFCEDTIFEMQ LAAQISESDLNERLANKEESEKERPEEQAPRMGFFSLLTIQSALFALRYNVLTLVRMLSL KSLKKQMKRMKKMTVKDMVLAFFSSYWSVFVTLLHFVASVCRGFFRIVSSLLLGGSLVEG AKKIKVAELLANMPDPTQDEVRGDEEEGERKPLESALPSEDLTDLKELTEESDLLSDIFG LDLKREGGQYKLIPHNPNAGLSDLMTNPVPVPEVQEKFQEQKAKEEKEEKEETKSEPEKA EGEDGEKEEKAKDEKSKQKLRQLHTHRYGEPEVPESAFWKKIIAYQQKLLNYFARNFYNM RMLALFVAFAINFILLFYKVSTSSVVEGKELPTRTSSDTAKVTNSLDSSPHRIIAVHYVL EESSGYMEPTLRILAILHTIISFFCIIGYYCLKVPLVIFKREKEVARKLEFDGLYITEQP SEDDIKGQWDRLVINTQSFPNNYWDKFVKRKVMDKYGEFYGRDRISELLGMDKAALDFSD AREKKKPKKDSSLSAVLNSIDVKYQMWKLGVVFTDNSFLYLAWYMTMSVLGHYNNFFFAA HLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSEDGDT PDMKCDDMLTCYMFHMYVGVRAGGGIGDEIEDPAGDEYEIYRIIFDITFFFFVIVILLAI IQGLIIDAFGELRDQQEQVKEDMETKCFICGIGNDYFDTVPHGFETHTLQEHNLANYLFF LMYLINKDETEHTGQESYVWKMYQERCWEFFPAGDCFRKQYEDQLN NT seq 14901 nt NT seq  +upstreamnt  +downstreamnt atggctgatgcgggcgaaggcgaggatgagatccagttcctgagaactgatgatgaggtg gttctgcagtgcacggcgaccatccacaaagaacagcagaagctgtgcttggcagcagaa ggatttggcaacagactttgttttttggagtctacttccaattccaagaatgttcccccg gacctgtctatctgcacctttgtgctggagcagtccctgtcagtacgggccctgcaggag atgctggccaacacagtggaaaagtcagaagggcaggtggatgtggaaaagtggaagttc atgatgaagactgctcaaggtggaggccaccggacactcctctatggacacgccatattg ctacgccattcctacagtggtatgtatctttgctgtctctccacctcccggtcttccact gacaaactggccttcgatgttggccttcaagaggataccacaggggaggcttgctggtgg accatacatcctgcctctaagcagagatcagaaggagaaaaagtgcgtgttggagatgat ctcatcttggtcagcgtgtcctcagaaaggtacttgcacttgtcatatggcaacagcagc tggcatgtggatgctgccttccagcagaccctctggagcgtggcccctatcagctcagga agtgaagcagcccaaggctatctcattggcggtgatgttctccggctgctgcatgggcac atggatgaatgtctcactgtcccttcaggagagcatggtgaagaacagcggagaacagtt cattatgaaggtggtgccgtatcagttcatgcccgctccctctggagactagagacccta agagtcgcgtggagtggaagccacataagatggggccagccattccgactccggcatgtc acgacaggaaaatacttaagcctcatggaagacaagaacctcctactcatggacaaagag aaagcagatgtaaaatcaacagcgtttgccttccggtcttccaaggaaaaattggacgtg ggggtgaggaaagaagtcgatggcatgggaacctcagaaatcaagtatggagactccatt tgctacatacaacatgtggatacaggcctgtggctaacctaccaggctgtggatgtgaaa tcagcacgaatgggatccatccagcgtaaggctatcatgcaccacgaaggccacatggac gatggtttgaacttatccagatcacagcatgaggagtcccgcactgcccgcgtcattcgg agcacagtgttcctctttaataggttcataaggggcctggatgctctcagcaagaaagta aagctgcccaccattgacttgcccatcgagtctgtgagcctgagtttgcaggacctcatc ggctacttccaccccccagatgagcacttggagcatgaggacaagcagaacaggctgcga gccctgaagaacaggcagaatctcttccaggaagagggaatgatcaacctggttctggag tgcatcgaccgcctgcatgtctacagcagtgcagcccactttgcagatgtcgcaggacga gaagcaggagagtcttggaaatccatcctgaattctctgtatgagttgctggcggcccta attagaggaaatcgtaaaaactgtgctcagttttctggttccctcgactggctgatcagc agactggaaagactggaagcatcctcaggtatcctggaggtcctccactgtgtgttagtg gagagcccagaagctctgaatatcatcaaagaagggcatatcaagtccattatctcgctt ttagacaagcatgggagaaaccacaaggtcctggatgtgctgtgttctctctgtgtatgc catggagttgctgtccgctctaatcagcacctcatctgtgataatctcctgccaggacga gatctcttactgcagacccgtcttgtgaatcatgtcagcagcatgaggcctaatattttc ctgggtgtcagcgaaggatcagcacagtataagaagtggtactacgagctcatggtggac cacacggaaccctttgtgacggcagaagccactcacctgcgagtgggctgggcttccact gaagggtattctccatacccaggtgggggtgaagagtggggtggcaatggcgttggtgac gacctcttctcctatgggtttgatggccttcacctctggtcaggttgtatagctcggacc gtgagctcccccaaccagcacctgctgagaactgacgatgtcatcagttgttgtttagat ctaagtgcccccagcatctcgtttcgcattaatggacaaccggtgcaagggatgtttgag aacttcaatatcgatggcctgttctttccagttgtcagtttctctgcaggaataaaggtt cgctttttgcttggggggagacatggagaattcaagtttctccctccacctggctatgca gcttgctatgaagctgtactacccaaagagaaattgaaggtggaacacagccgagaatat aagcaggagaggacatacacacgagacctgctggggcctacagtgtccctgacccaagct gccttcacacctgttcctgtggacaccagccagattgtgttgcctcctcacctggaaagg ataagagaaagactggcagagaatatccatgagctctgggttatgaataaaattgagctt ggctggcagtatggtccggttagagatgacaacaagagacagcacccatgtctggtggag ttctgcaagcttccagaacaggaacgcaactataatttgcagatgtcgcttgaaaccctc aagactttgctggcattgggatgtcacgtgggtatagctgatgaacatgctgaagagaag gtgaagaaaatgaaactgcctaagaattaccagctgaccagcggatacaagcctgcccca atggatctgagctttataaaactaaccccgtctcaggaagcaatggtggacaagttggct gaaaatgctcacaatgtgtgggcccgggaccgaatccggcaaggctggacttacggcatc cagcaggatgtaaagaatagaagaaaccctcgtctcgtcccctacactcttctggatgac agaaccaagaagtccaacaaagacagtctccgagaggcagtgcgcacactgctgggctac ggctaccacctggaagctcctgatcaggaccatgcctcgagagccgaggtgtgcagcggt actggggagaggttccgcatcttcagggcagagaagacctatgcggtgaaggctgggcgc tggtactttgaatttgaggctgtcactgctggagacatgcgggtgggctggagcaggcca ggctgccaaccagatctagaactgggttctgatgaccgtgcctttgcttttgatggcttt aaggcacagcggtggcaccagggcaatgaacactacgggcgctcatggcaagctggtgac gtcgtgggctgcatggttgatatgaatgaacacaccatgatgttcactctgaacggcgag atcctgctggatgattcaggctctgagctggcattcaaggactttgatgttggtgatgga ttcatccctgtgtgtagcctcggggtggcacaagtaggcaggatgaactttggaaaggac gtcagcactttgaaatattttaccatctgtggcttacaagaaggctatgagccatttgcc gttaatacaaatagggacatcaccatgtggctgagcaagcggcttcctcagttcctccag gtcccatcaaaccacgaacacattgaggtgaccagaatagatggtaccatagacagttct ccatgtctgaaggtcactcagaagtcctttggttctcagaacaacaacactgacatcatg ttttaccgcctgagtatgcccattgaatgtgccgaggtcttctcaaagtcggtggcggga gggcttcctggtgccggcttctacgggcccaagaatgatttggaggactttgatgtggac tctgactttgaggttctgatgaagacagctcatggtcatcttgtgcctgaccgcatcgac aaggacaaagagacccctaagccagagttcaataaccacaaagattatgctcaggaaaag ccctcacgactaaagcaaagattcttacttagaaggaccaagccagattacagcacaggc cactctgcaagactcactgaagatgtccttgctgatgaccgggatgactacgagtacctg atgcagacgtccacatactattactcggtgaggatctttcctggacaagaaccagctaat gtctgggtgggctggattacatctgacttccaccagtacgacacaggctttgatttggac agagtgcgcacagtgacggtcaccctaggagatgaaaaaggaaaagtgcatgagagcatc aaacgcagcaactgctatatggtgtgtgcaggagagagcatgagccccgggcaaggacga aacaacagcaacgggctggagattggctgtgtggtggatgctgccagtgggctgctcaca ttcatagccaatggcaaggagctaagcacttactatcaggtggagccaagcacaaagctc tttcctgcggttttcgcgcaagctacgagtcccaatgttttccagtttgagttgggcaga ataaagaatgtaatgcctctctccgcgggactgtttaagagcgagcacaaaaaccccgtg ccccagtgtcctccacgtctgcatgtgcagttcctgtcccatgtcctgtggagccggatg cccaaccagttcttgaaggtggacgtctctcgaatcagtgaacgccaaggctggctggtg cagtgtctagatcctctgcagttcatgtccctccatatacctgaggagaacagatctgtt gacatcttagagctgacagagcaggaggagttgttgcagtttcactatcacaccctccgc ctctactctgctgtctgcgcccttgggaatcatcgggtggctcacgccctgtgcagccac gtggacgaacctcagctgctctacgccattgagaacaagtacatgcctggcttgctgcga gctggctactatgacctgctgattgacatccacctcagctcctatgccaccgccaggctc atgatgaacaacgaattcatcgtccctatgacagaggagacaaagagcatcaccctcttc cctgatgagaataagaaacatggcctcccaggcataggccttagcacctccctccggcct cggatgcgtttttcctccccgagtttcgtgagcattagcaacgactgttatcagtacagt cccgagtttcctctggacatcctcaaggccaagaccatccagatgctcacagaagccgtg aaggagggcagcctccacgctcgggatcctgtgggtgggaccacggagttcctctttgtg cccctcatcaagctgttctacaccctgctcatcatgggcatctttcacaatgaggatttg aaacacatcctgcagttgatcgagcccagtgtgtttaaggaagctgccgttccagaggag gaaggaggcaccccggagaaggagatcagtatagaagacgccaagctggaaggcgaagaa gaagccaaagggggtaaaaggcccaaggaaggcttgctccagatgaaactcccggagcca gttaaactacagatgtgcctcttgcttcagtacctctgtgactgccaggttaggcaccgg atcgaagccattgtagccttttcagatgactttgtagctaaactccaagacaaccaacgg ttcaggtataatgaagtcatgcaagccttaaacatgtctgccgcactcactgccaggaaa accagggagttccggtcaccaccgcaggagcagattaacatgcttctcaattttaaggat gacaaaagtgaatgcccctgccctgaagaaatccgagaccaactcctagatttccacgag gacctgatgactcactgtggaattgaactggacgaggatggatccctagatggaagcaat gacttaacaatcagaggacgtctgttgtctctggtagaaaaggtgacctacctgaagaag aagcaagctgaaaaaccagttgcaagtgactccagaaagtgctccagcctccagcaactc atttctgagactatggtacggtgggctcaagagtctgtcattgaggaccctgagctggtg agggccatgtttgtgctgctacatcggcagtatgatggcatcgggggtctagtccgagcg ctgccaaagacctacactatcaacggggtctctgtggaggacaccatcaatctgcttgct tcgctcggtcagatccgatctctgctgagtgtgaggatgggcaaagaagaggagaagctg atgatccgtggactaggggatatcatgaataacaaagtgttttaccagcatcccaatctc atgcgggcccttgggatgcatgagacagtgatggaagtcatggtgaatgtccttggaggt ggcgagtccaaggaaatcaccttccccaagatggtggccaactgctgccgttttctctgt tacttctgtcgtataagtagacagaatcaaaaagccatgtttgatcatctcagttactta ctggaaaacagcagtgttggtcttgcatcaccagccatgagaggttcaactcctttagac gtggccgcagcttcagtgatggataacaatgagcttgcccttgctctacgagagccggat ctggagaaggtagttcgctatctggctggctgtggtctgcagagctgtcagatgctggtg tctaagggttacccagacattgggtggaatccagttgaaggagagcgataccttgacttt ctcagatttgcagtcttctgtaacggggagagtgtggaagagaatgcaaatgttgtggtg aggctgctcatccggagacccgagtgctttggtcctgccttgagaggagaaggtggtaat ggtctccttgcagccatggaagaagccataaaaatagctgaggatccttctagagatggt ccctctccaaccagtggctccagcaaaacccttgatatagaagaggaggaagatgatacc atccacatggggaacgcgatcatgaccttctacgcagctttgattgacctgcttggtcgc tgtgctcctgaaatgcacttgattcatgctggaaagggagaagccatccgaattaggtcc attttgcgatctctgattccattgggagacttggtgggcgtcatcagcattgcatttcag atgccaacaatagccaaagatgggaaggtggtggagcctgacatgtccgcggggttttgc ccagatcacaaggcagccatggttttgttccttgacagggtctatggaattgaggtgcaa gatttcctcctccatctccttgaggttggctttctgccagatcttcgagctgctgcctct ctagacacggctgcactaagtgctacagacatggccttggccctcaaccggtacctctgc acagctgtcctacctttgttaacgaggtgtgctcccctgtttgctggaacagagcaccat gcttccctcattgactctctgctacacactgtatatagactctctaagggatgctccctt accaaagctcagcgggactccatagaagtgtgcctgctctctatatgtggccaactgaga ccatctatgatgcaacacctactccgaaggctggtgtttgatgttccactgttgaatgag catgcaaagatgcctctgaagctgctgaccaatcattatgaaagatgctggaaatattat tgcctccctggagggtggggcaactttggtgctgcctcggaagaagaacttcatttatca agaaaattattttggggcatctttgatgctttgtctcaaaagaaatatgaacaagaactt ttcaaactggccctgccttgcctgagtgcagttgcgggagctttacctccagactacatg gagtcaaactatgtcagtatgatggaaaaacagtcatccatggattctgaagggaacttt aacccacaacctgttgatacctcaaacattacaattccagagaagttggaatacttcatt aacaaatatgcagaacattcccatgataaatggtccatggacaagttggcgaatggatgg atttatggggaaatatattcagactcttctaagatccaaccgctaatgaagccatataaa ctcttgtctgaaaaggaaaaagaaatttatcgttggccaatcaaggagtctttgaaaacg atgctggcttggggttggagaattgagagaacacgggagggggacagcatggccctttat aaccggactcgacgaatttctcagacaagccaggtgtctatagatgctgcacatggatac agcccccgtgctattgacatgagtaatgtgacactctctcgagacctgcatgctatggca gagatgatggctgaaaactaccacaacatatgggccaagaaaaagaaactggagctggaa tccaaaggaggaggaaaccaccccctcctggtgccttatgacacactgacagccaaggag aaagccaaggacagagaaaaagcccaagacatcttcaagttcctacagatcagtggttat gtggtatccagagggttcaaagacctggatctagatacaccttcgattgagaagcgattt gcctatagtttcctgcagcagctgatccgatacgtggatgaggcgcatcagtacatcctg gagtttgatggtggcagcagaagcaaaggagaacacttcccgtacgagcaagaaatcaag ttctttgccaaagttgttcttcctttaattgatcagtatttcaaaaaccaccgcctgtac ttcttgtctgctgcaagcaggcctctctgcactggaggacatgcatccaacaaagagaag gagatggtgacaagcctgttctgcaaacttggagttcttgtcaggcataggatctcactg tttgggaatgatgccacctcaattgtgaactgtctgcacattttgggtcagactttggat gcaaggactgtgatgaagacgggcctagacagtgtgaaaagtgctcttagggcctttctg gacaatgctgcagaggatttggaaaagacaatggaaaacctgaagcagggccagtttact cacaccaggagccagcccaagggggtgactcagatcatcaactacaccactgtggctctc ctgcccatgctctcctccctgtttgaacacatcggccagcatcagtttggagaagatctg atattggaggatgtacaggtgtcttgttatagaatcctgaccagcttgtatgccctggga accagcaagagcatctacgtggagaggcaacgatctgcacttggggaatgcttagctgcc tttgctggtgccttccctatcgcctttttggaaacccacctggacaaacataacgtttac tccatctacaacaccagatcttcacgagaaagagcagctctcagtttacctgcaaatgtg gaggatgtctgcccaaatataccatccctggagaagcttatgactgagataatagagctg gcagagtcaggaatccgctacactcagatgccatacatgatggaggttgtactgcccatg ttatgcagctacatgtcaaggtggtgggaacacggtcctgagaaccatccagagagggct gagatgtgctgcacagccctcaactcagagcacatgaacacgctgctgggcaacattctc aaaatcatctacaacaacctggggattgatgaaggagcctggatgaagcgcttggccgtg ttttcacagcctatcatcaacaaagtgaaacctcagctcttgaaaactcatttcttaccc ttgatggagaagctaaagaaaaaggctgctatggtagtgtctgaggaagaccacctgaaa gccgaagccagaggggacatgtctgaggccgagctgctcattctagatgagttcaccaca ctggccagggatctctatgccttctacccactcctgatccgatttgtggactataacagg gcaaagtggctgaaggagcccaacccagaagcagaggagctatttcgaatggtggctgaa gtcttcatctactggtccaaatcccataatttcaaaagagaagaacagaactttgtggtg cagaatgaaatcaacaacatgtccttcctcatcactgacacaaagtccaagatgtccaag gcagccatttctgatcaagaaaggaagaaaatgaagcgcaaaggggaccggtattctatg cagacatctttgatcgtggcagctctgaagagattactacccattgggctgaacatctgt gcccctggtgaccaagagctcattgctttggccaaaaatagatttagcttgaaagacacc gaggaggaagtacgtgatataatccgcagtaatatacacttacaaggcaagctggaagac cctgcaatcaggtggcagatggctctctacaaagacttgccaaacaggacagaagacccc tcagacccagagaggacagtcgagcgtgtcctgggtatagcaaatgtgctttttcacctt gagcagaaatctaagtatactggccggggatatttcagcctggtggaacatcctcaaaga tcaaagaaagctgtgtggcacaaactactctctaagcagagaaaaagagctgttgtggcc tgcttccggatggcccccttgtacaatctgccaaggcatcgggcggtcaatctttttctt cagggatatgaaaagtcttggattgaaacagaagaacattactttgaggataaattgatt gaagatttagcgaaaccaggggctgagctcccagaagaagatgaagccatgaaaagggtt gatcccctccatcaacttattcttctgttcagccgcacagccctaacggagaaatgcaaa ctggaggaagattttctatacatggcgtatgcagacattatggcaaagagttgtcacgat gaagaagatgatgatggtgaagaagaagtgaagagctttgaagaaaaggaaatggaaaag cagaaacttctgtaccagcaagccagactgcatgaccgcggggcagcagagatggtcctg cagactatcagtgccagcaaaggtgaaactggaccaatggtggctgctactttgaagctg ggcattgcgattttaaatggtggcaactccacggtgcagcagaagatgctggattacctg aaggaaaaaaaggatgtaggcttcttccagagtctggcaggcctcatgcagtcctgcagt gtcctggacctgaatgcatttgagagacaaaacaaagcagaaggacttgggatggtgact gaggaaggatcaggggagaaggttctgcaggatgacgagttcacctgtgacctcttccga ttcctgcagctgctttgtgaggggcacaactcagactttcagaattacctgagaactcag accggcaacaacaccacagttaatatcatcatctctactgtggactacctccttcgagtg caggagtccattagtgatttctattggtactactctggcaaggacatcatagatgagcag gggcagcgtaacttttccaaagccattcaagtggcgaagcaggtgttcaacacgctcacg gagtacatccagggcccttgtactggaaatcagcagagcctggcacacagcaggctgtgg gatgctgttgtgggcttccttcatgtatttgcacacatgcaaatgaagctgtctcaggat tccagccagattgagctcttaaaagaacttatggatctccagaaggacatggtggtcatg ctgctgtctatgctagaaggtaatgtggtgaacggaacaataggcaaacagatggtggac atgcttgtggagtcgtccaacaacgtggagatgatcctcaagttctttgacatgtttctg aagctgaaggacttaacatcctctgacacattcaaagagtatgaccctgatggcaaaggg gtcatttccaagagagacttccacaaagccatggagagccacaagcactacacccagtca gagactgagttcctgctgtcctgtgcagagacagatgaaaacgagacacttgactatgaa gagtttgtcaagaggttccatgagcctgccaaggacatcggcttcaacgtggctgttctg ctgaccaacctctcagagcacatgcccaatgacacgaggctgcagaccttcttggagttg gcagagagtgtcctcaactacttccaacctttcctgggtcgcattgagatcatgggcagt gccaagcgcatcgaaagggtctattttgagatcagcgaatccagccgaacccagtgggag aaaccccaggttaaggagtccaagaggcagttcatattcgatgtggtcaatgagggcggg gagaaggagaagatggagctctttgtgaacttctgtgaggacaccatctttgagatgcag ttggcagctcagatctcagagtctgatctgaatgagaggttggctaataaagaagagagt gagaaggagaggccagaggagcaggccccacgaatgggcttcttctccctcctcaccatc cagtcagccctgtttgctctcaggtacaatgtcctaaccctcgtgaggatgctcagcctg aagagcctgaagaagcagatgaagaggatgaagaagatgacagtgaaggacatggtcttg gccttcttctcatcctactggagtgtgtttgtcaccctcttgcacttcgtggccagtgtc tgcaggggcttctttcgcattgtctccagcctgttgctggggggcagcctggtggaaggt gctaagaaaatcaaagtggcagaacttctagctaacatgccagaccccactcaggatgag gtgcgaggagatgaggaggagggagagaggaagcctttagagtcagccctgccctctgaa gacctgacagacttgaaggaactgacagaggagagtgatcttctttctgacatattcggc ttggatctgaagagagaaggagggcagtacaaactaattcctcacaacccaaatgccggc ctcagtgacctcatgaccaaccctgtccctgtccctgaggtacaagaaaagtttcaggag cagaaggcgaaagaggaaaaggaagaaaaggaagaaaccaagtcggaaccagagaaagct gaaggggaggatggagaaaaagaagaaaaagccaaagatgagaagagcaaacagaagttg aggcagcttcatacacatcgctatggggagccggaagtgcctgagtcagcattctggaag aaaatcatagcctaccaacagaagctgctgaactattttgctcgcaacttttacaacatg agaatgctggccttgtttgttgccttcgccatcaatttcatcctgctcttctacaaggtc tccacttcttctgtggttgaaggaaaggagctgcctacccgaacctccagcgatactgct aaagtgaccaacagcctagacagcagcccccacaggatcattgcggttcactatgtcctg gaggagagcagcggctacatggaacccaccctgcgcatcttagccatcctccacaccatc atctccttcttttgcatcatcggatactactgcttgaaagtccccttggttatttttaag cgagagaaggaagtggcacggaagttggagtttgacggactttatataacagagcagcca tcggaagatgatatcaaaggccagtgggacagacttgtgatcaacacacagtcatttccc aataactactgggataaatttgtgaaaagaaaggtaatggataaatatggagagttttat gggagagacagaatcagtgagttactgggcatggataaggctgcactagatttcagcgat gcaagagagaagaagaagcccaagaaagacagctccttgtctgctgtattgaattctatt gacgtgaagtaccagatgtggaaacttggagtcgtgttcacagacaattccttcctctac ctagcctggtacatgaccatgtctgttcttggacattataacaactttttttttgctgct cacctccttgacatcgcgatgggattcaagaccttgagaactatcctgtcctcagttacc cataatggcaaacagctcgtgttaactgttggcttattggctgttgttgtgtacctgtac actgtcgtggcgttcaatttcttccgaaaattctacaataaaagtgaggatggtgacacg ccagacatgaagtgtgatgacatgctgacgtgttacatgttccacatgtatgtgggcgtc cgtgctggagggggcattggtgatgaaattgaagacccagcaggagacgagtatgagatc taccgcatcatctttgacatcacattcttcttcttcgtgattgtcatccttttggctatc atacaaggtttgatcattgatgcttttggagaactcagagaccaacaagagcaagtcaag gaagacatggagaccaagtgcttcatctgtgggattggcaacgattattttgatacagtg ccacatggctttgaaacccatactttacaggaacacaacctggccaactacctgtttttt ctgatgtatctcataaacaaggatgaaacagaacacacaggacaggaatcttacgtctgg aagatgtaccaagagaggtgttgggaatttttcccagcaggggactgtttccggaaacag tatgaagaccagttaaattag

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