Mus musculus (house mouse): 20425
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Entry
20425 CDS
T01002
Symbol
Shmt1, Shmt, mshmt, mshmt1, mshmt2
Name
(RefSeq) serine hydroxymethyltransferase 1 (soluble)
KO
K00600
glycine hydroxymethyltransferase [EC:
2.1.2.1
]
Organism
mmu
Mus musculus (house mouse)
Pathway
mmu00260
Glycine, serine and threonine metabolism
mmu00630
Glyoxylate and dicarboxylate metabolism
mmu00670
One carbon pool by folate
mmu01100
Metabolic pathways
mmu01200
Carbon metabolism
mmu01230
Biosynthesis of amino acids
mmu01240
Biosynthesis of cofactors
mmu01523
Antifolate resistance
Module
mmu_M00141
C1-unit interconversion, eukaryotes
Brite
KEGG Orthology (KO) [BR:
mmu00001
]
09100 Metabolism
09101 Carbohydrate metabolism
00630 Glyoxylate and dicarboxylate metabolism
20425 (Shmt1)
09105 Amino acid metabolism
00260 Glycine, serine and threonine metabolism
20425 (Shmt1)
09108 Metabolism of cofactors and vitamins
00670 One carbon pool by folate
20425 (Shmt1)
09160 Human Diseases
09176 Drug resistance: antineoplastic
01523 Antifolate resistance
20425 (Shmt1)
Enzymes [BR:
mmu01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.2 Hydroxymethyl-, formyl- and related transferases
2.1.2.1 glycine hydroxymethyltransferase
20425 (Shmt1)
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Gene cluster
GFIT
Motif
Pfam:
SHMT
Aminotran_1_2
Motif
Other DBs
NCBI-GeneID:
20425
NCBI-ProteinID:
NP_033197
MGI:
98299
Ensembl:
ENSMUSG00000020534
UniProt:
P50431
Structure
PDB
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All DBs
Position
11:complement(60679723..60702062)
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AA seq
478 aa
AA seq
DB search
MADRDATLWASHEKMLSQPLKDSDAEVYSIIKKESNRQRVGLELIASENFASRAVLEALG
SCLNNKYSEGYPGQRYYGGTEFIDELEMLCQKRALQAYHLDPQCWGVNVQPYSGSPANFA
VYTALVEPHGRIMGLDLPDGGHLTHGFMTDKKKISATSIFFESMPYKVYPETGYINYDQL
EENASLFHPKLIIAGTSCYSRNLDYARLRKIADDNGAYLMADMAHISGLVAAGVVPSPFE
HCHVVTTTTHKTLRGCRAGMIFYRKGVRSVDPKTGKETYYELESLINSAVFPGLQGGPHN
HAIAGVAVALKQAMTTEFKIYQLQVLANCRALSDALTELGYKIVTGGSDNHLILMDLRSK
GTDGGRAEKVLEACSIACNKNTCPGDKSALRPSGLRLGTPALTSRGLLEEDFQKVAHFIH
RGIELTLQIQSHMATKATLKEFKEKLAGDEKIQSAVATLREEVENFASNFSLPGLPDF
NT seq
1437 nt
NT seq
+upstream
nt +downstream
nt
atggcagacagggatgccaccctgtgggcttctcatgagaagatgttgtcgcagcccctc
aaggacagtgatgccgaggtttacagcatcattaaaaaggagagcaaccggcagagggtc
ggattagagctgattgcctcggagaattttgccagccgagctgtgttggaggccctggga
tcttgcttaaataacaaatactctgagggatatccaggccaaaggtattatggcgggacc
gagttcatcgatgagctggagatgctgtgtcagaagcgtgcattacaggcctaccatctg
gatcctcagtgctggggtgtcaatgtccagccttattcaggctcccctgcaaactttgct
gtgtatactgccctggtagagcctcatgggcgaatcatgggcttggacctgccagacggt
ggccatctgacccatggcttcatgacagacaagaagaaaatctctgccacatctatcttc
tttgaatccatgccttataaggtgtacccagagactgggtacatcaactatgaccagctg
gaggagaatgccagcctcttccacccgaagctgatcatcgcagggaccagctgctactcc
cggaacctggactacgcacggctgcggaagattgcggatgataatggggcgtatctcatg
gcagacatggcacatatcagtgggctcgtggcagctggggtggtgccctccccctttgaa
cactgccatgtagtgaccactacaacccacaagaccctgagaggctgccgtgctggtatg
atattctacagaaagggtgtgcgcagtgtggatcccaagactggcaaagagacttactat
gaactggagtccctcatcaactctgccgtgttcccaggccttcaggggggtcctcacaac
catgccattgctggtgttgctgtggccctgaagcaagccatgactacagaattcaaaatc
taccagctccaggtgttggccaactgcagggctctgtctgatgcactcacagagctaggc
tacaaaatagtcacaggtggctctgataatcacttgatcctaatggatctgcgttctaag
ggtactgatggtggaagggctgagaaggtactagaagcctgttctatcgcctgcaacaag
aatacctgcccaggtgacaagagcgcgttacggcccagtggactgcgactggggactcca
gcattgacatcccgaggacttttggaagaagacttccaaaaagtagcacactttatccac
agggggatagagttgacactgcagattcagagccacatggccacgaaggccacactgaaa
gagttcaaagagaagctggcaggagatgagaagatccagagtgctgtggcaactctccgg
gaagaagtggagaactttgcttccaacttctcactacctggccttcctgacttctga
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