Mus musculus (house mouse): 20963
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Entry
20963 CDS
T01002
Symbol
Syk, Sykb
Name
(RefSeq) tyrosine-protein kinase SYK
KO
K05855
spleen tyrosine kinase [EC:
2.7.10.2
]
Organism
mmu
Mus musculus (house mouse)
Pathway
mmu04064
NF-kappa B signaling pathway
mmu04072
Phospholipase D signaling pathway
mmu04145
Phagocytosis
mmu04151
PI3K-Akt signaling pathway
mmu04380
Osteoclast differentiation
mmu04611
Platelet activation
mmu04613
Neutrophil extracellular trap formation
mmu04625
C-type lectin receptor signaling pathway
mmu04650
Natural killer cell mediated cytotoxicity
mmu04662
B cell receptor signaling pathway
mmu04664
Fc epsilon RI signaling pathway
mmu04666
Fc gamma R-mediated phagosome formation
mmu05152
Tuberculosis
mmu05167
Kaposi sarcoma-associated herpesvirus infection
mmu05168
Herpes simplex virus 1 infection
mmu05169
Epstein-Barr virus infection
mmu05171
Coronavirus disease
mmu05203
Viral carcinogenesis
Brite
KEGG Orthology (KO) [BR:
mmu00001
]
09130 Environmental Information Processing
09132 Signal transduction
04064 NF-kappa B signaling pathway
20963 (Syk)
04072 Phospholipase D signaling pathway
20963 (Syk)
04151 PI3K-Akt signaling pathway
20963 (Syk)
09140 Cellular Processes
09141 Transport and catabolism
04145 Phagocytosis
20963 (Syk)
09150 Organismal Systems
09151 Immune system
04611 Platelet activation
20963 (Syk)
04613 Neutrophil extracellular trap formation
20963 (Syk)
04625 C-type lectin receptor signaling pathway
20963 (Syk)
04650 Natural killer cell mediated cytotoxicity
20963 (Syk)
04662 B cell receptor signaling pathway
20963 (Syk)
04664 Fc epsilon RI signaling pathway
20963 (Syk)
04666 Fc gamma R-mediated phagosome formation
20963 (Syk)
09158 Development and regeneration
04380 Osteoclast differentiation
20963 (Syk)
09160 Human Diseases
09161 Cancer: overview
05203 Viral carcinogenesis
20963 (Syk)
09172 Infectious disease: viral
05171 Coronavirus disease
20963 (Syk)
05168 Herpes simplex virus 1 infection
20963 (Syk)
05167 Kaposi sarcoma-associated herpesvirus infection
20963 (Syk)
05169 Epstein-Barr virus infection
20963 (Syk)
09171 Infectious disease: bacterial
05152 Tuberculosis
20963 (Syk)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
mmu01001
]
20963 (Syk)
Enzymes [BR:
mmu01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.10 Protein-tyrosine kinases
2.7.10.2 non-specific protein-tyrosine kinase
20963 (Syk)
Protein kinases [BR:
mmu01001
]
Non-receptor tyrosine kinases
SYK family
20963 (Syk)
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
PK_Tyr_Ser-Thr
Pkinase
SH2
Kdo
ABC1
DUF7145
SH2_1
Motif
Other DBs
NCBI-GeneID:
20963
NCBI-ProteinID:
NP_001185906
MGI:
99515
Ensembl:
ENSMUSG00000021457
UniProt:
P48025
Q3UPF7
Q6P1E0
Structure
PDB
PDBj
LinkDB
All DBs
Position
13:52736670..52802828
Genome browser
AA seq
629 aa
AA seq
DB search
MAGSAVDSANHLTYFFGNITREEAEDYLVQGGMTDGLYLLRQSRNYLGGFALSVAHNRKA
HHYTIERELNGTYAISGGRAHASPADLCHYHSQEPDGLICLLKKPFNRPPGVQPKTGPFE
DLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGNISRDESEQT
VLIGSKTNGKFLIRARDNSGSYALCLLHEGKVLHYRIDRDKTGKLSIPEGKKFDTLWQLV
EHYSYKPDGLLRVLTVPCQKIGAQMGHPGSPNAHPVTWSPGGIISRIKSYSFPKPGHKKP
APPQGSRPESTVSFNPYEPTGGPWGPDRGLQREALPMDTEVYESPYADPEEIRPKEVYLD
RSLLTLEDNELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQ
LDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHIKDKNIIELVHQVSMGMKYLE
ESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINY
YKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMN
LCWTYDVENRPGFTAVELRLRNYYYDVVN
NT seq
1890 nt
NT seq
+upstream
nt +downstream
nt
atggcgggaagtgctgtggacagcgccaaccacctgacctacttttttggcaacatcacc
cgggaagaggctgaagactacctggtccagggaggcatgaccgatgggctctacctgcta
cgccagagccgcaattacctgggtggttttgctttgtcggtggctcacaacaggaaggca
caccactacaccatcgagagggaacttaatggcacctacgccatctccgggggcagggcc
catgccagcccagcagacctctgccattaccactcccaggaacctgatggccttatctgc
ctccttaagaagcccttcaaccggcccccgggagtacagcccaagaccggaccctttgag
gacctgaaggagaacctcatcagggaatatgtgaaacagacctggaaccttcagggccag
gctctggagcaagccatcatcagccagaagccccagctggagaagctgatcgccaccacg
gcccatgagaagatgccctggttccatggcaacatctccagagatgaatcagagcagacg
gtcctcatagggtcaaagaccaatggaaaattcctgatcagggccagagacaacagcggc
tcctatgctctgtgcctgctgcacgaagggaaagtattgcactaccgcattgacagggac
aagaccgggaagctctccattcctgaggggaagaagtttgacaccctctggcagctagtg
gaacattactcttacaagccagatgggctactaagagtcctcacggtaccatgccaaaag
attggtgcacagatgggccacccaggaagcccaaatgcccatcccgtgacttggtcaccg
ggtggaataatctcaaggatcaaatcctactccttcccaaagcctggccacaaaaagcct
gccccaccccaagggagccgtccagagagcactgtgtccttcaacccctatgagccaacg
ggagggccctggggcccagacagaggccttcagagagaagccctgcccatggacacagag
gtgtacgagagcccttatgctgaccctgaagagatccggcccaaagaggtctacctggac
aggagcctgctgaccctggaggacaatgaactgggctccggtaacttcgggactgtgaaa
aagggatactaccaaatgaaaaaagttgtgaaaaccgtggctgtgaaaatcctgaagaac
gaggccaacgacccggctttgaaggacgagctgctggcagaggcgaacgtcatgcagcag
ctggacaacccctacattgtgcgcatgatcggaatctgcgaggcggagtcctggatgctg
gtgatggagatggcggagctggggccgctcaacaagtacctgcagcagaacaggcacatt
aaggataagaacatcatagagctggttcaccaggtttccatggggatgaagtatttggaa
gagagcaactttgtgcacagagatctggctgcgcggaacgtgcttctggtcacacagcac
tatgccaagatcagcgatttcggtctttccaaagccctgcgtgctgatgaaaactactac
aaggcccagacccacgggaagtggcccgtgaagtggtacgcccccgaatgcatcaactac
tacaagttctccagtaagagtgacgtctggagcttcggagtcctgatgtgggaagcgttc
tcctatgggcagaagccctacagagggatgaaagggagcgaagtgaccgccatgctggag
aaaggagagcggatggggtgccctgcaggatgcccgagagagatgtacgacctgatgaac
ctgtgctggacttacgatgtggagaacaggccaggattcacagctgtggaactgaggctt
cgcaattactactacgacgtggttaactaa
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