Mus musculus (house mouse): 20963 Help Entry 20963             CDS       T01002                                  Symbol Syk, Sykb Name (RefSeq) spleen tyrosine kinase   KO K05855   spleen tyrosine kinase [EC:2.7.10.2] Organism mmu  Mus musculus (house mouse) Pathway mmu04064   NF-kappa B signaling pathway mmu04072   Phospholipase D signaling pathway mmu04151   PI3K-Akt signaling pathway mmu04380   Osteoclast differentiation mmu04611   Platelet activation mmu04613   Neutrophil extracellular trap formation mmu04625   C-type lectin receptor signaling pathway mmu04650   Natural killer cell mediated cytotoxicity mmu04662   B cell receptor signaling pathway mmu04664   Fc epsilon RI signaling pathway mmu04666   Fc gamma R-mediated phagocytosis mmu05152   Tuberculosis mmu05167   Kaposi sarcoma-associated herpesvirus infection mmu05168   Herpes simplex virus 1 infection mmu05169   Epstein-Barr virus infection mmu05171   Coronavirus disease - COVID-19 mmu05203   Viral carcinogenesis Brite KEGG Orthology (KO) [BR:mmu00001]  09130 Environmental Information Processing   09132 Signal transduction    04064 NF-kappa B signaling pathway     20963 (Syk)    04072 Phospholipase D signaling pathway     20963 (Syk)    04151 PI3K-Akt signaling pathway     20963 (Syk)  09150 Organismal Systems   09151 Immune system    04611 Platelet activation     20963 (Syk)    04613 Neutrophil extracellular trap formation     20963 (Syk)    04625 C-type lectin receptor signaling pathway     20963 (Syk)    04650 Natural killer cell mediated cytotoxicity     20963 (Syk)    04662 B cell receptor signaling pathway     20963 (Syk)    04664 Fc epsilon RI signaling pathway     20963 (Syk)    04666 Fc gamma R-mediated phagocytosis     20963 (Syk)   09158 Development and regeneration    04380 Osteoclast differentiation     20963 (Syk)  09160 Human Diseases   09161 Cancer: overview    05203 Viral carcinogenesis     20963 (Syk)   09172 Infectious disease: viral    05171 Coronavirus disease - COVID-19     20963 (Syk)    05168 Herpes simplex virus 1 infection     20963 (Syk)    05167 Kaposi sarcoma-associated herpesvirus infection     20963 (Syk)    05169 Epstein-Barr virus infection     20963 (Syk)   09171 Infectious disease: bacterial    05152 Tuberculosis     20963 (Syk)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:mmu01001]     20963 (Syk) Enzymes [BR:mmu01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.2  non-specific protein-tyrosine kinase      20963 (Syk) Protein kinases [BR:mmu01001]  Non-receptor tyrosine kinases   SYK family    20963 (Syk) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  PK_Tyr_Ser-Thr Pkinase SH2 Kdo ABC1 Motif Other DBs NCBI-GeneID:  20963 NCBI-ProteinID:  NP_001185906 MGI:  99515 Ensembl:  ENSMUSG00000021457 UniProt:  P48025 Q3UPF7 Q6P1E0 Structure PDB LinkDB All DBs Position 13:52736670..52802828 Genome browser AA seq 629 aa AA seqDB search MAGSAVDSANHLTYFFGNITREEAEDYLVQGGMTDGLYLLRQSRNYLGGFALSVAHNRKA HHYTIERELNGTYAISGGRAHASPADLCHYHSQEPDGLICLLKKPFNRPPGVQPKTGPFE DLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGNISRDESEQT VLIGSKTNGKFLIRARDNSGSYALCLLHEGKVLHYRIDRDKTGKLSIPEGKKFDTLWQLV EHYSYKPDGLLRVLTVPCQKIGAQMGHPGSPNAHPVTWSPGGIISRIKSYSFPKPGHKKP APPQGSRPESTVSFNPYEPTGGPWGPDRGLQREALPMDTEVYESPYADPEEIRPKEVYLD RSLLTLEDNELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQ LDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHIKDKNIIELVHQVSMGMKYLE ESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINY YKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMN LCWTYDVENRPGFTAVELRLRNYYYDVVN NT seq 1890 nt NT seq  +upstreamnt  +downstreamnt atggcgggaagtgctgtggacagcgccaaccacctgacctacttttttggcaacatcacc cgggaagaggctgaagactacctggtccagggaggcatgaccgatgggctctacctgcta cgccagagccgcaattacctgggtggttttgctttgtcggtggctcacaacaggaaggca caccactacaccatcgagagggaacttaatggcacctacgccatctccgggggcagggcc catgccagcccagcagacctctgccattaccactcccaggaacctgatggccttatctgc ctccttaagaagcccttcaaccggcccccgggagtacagcccaagaccggaccctttgag gacctgaaggagaacctcatcagggaatatgtgaaacagacctggaaccttcagggccag gctctggagcaagccatcatcagccagaagccccagctggagaagctgatcgccaccacg gcccatgagaagatgccctggttccatggcaacatctccagagatgaatcagagcagacg gtcctcatagggtcaaagaccaatggaaaattcctgatcagggccagagacaacagcggc tcctatgctctgtgcctgctgcacgaagggaaagtattgcactaccgcattgacagggac aagaccgggaagctctccattcctgaggggaagaagtttgacaccctctggcagctagtg gaacattactcttacaagccagatgggctactaagagtcctcacggtaccatgccaaaag attggtgcacagatgggccacccaggaagcccaaatgcccatcccgtgacttggtcaccg ggtggaataatctcaaggatcaaatcctactccttcccaaagcctggccacaaaaagcct gccccaccccaagggagccgtccagagagcactgtgtccttcaacccctatgagccaacg ggagggccctggggcccagacagaggccttcagagagaagccctgcccatggacacagag gtgtacgagagcccttatgctgaccctgaagagatccggcccaaagaggtctacctggac aggagcctgctgaccctggaggacaatgaactgggctccggtaacttcgggactgtgaaa aagggatactaccaaatgaaaaaagttgtgaaaaccgtggctgtgaaaatcctgaagaac gaggccaacgacccggctttgaaggacgagctgctggcagaggcgaacgtcatgcagcag ctggacaacccctacattgtgcgcatgatcggaatctgcgaggcggagtcctggatgctg gtgatggagatggcggagctggggccgctcaacaagtacctgcagcagaacaggcacatt aaggataagaacatcatagagctggttcaccaggtttccatggggatgaagtatttggaa gagagcaactttgtgcacagagatctggctgcgcggaacgtgcttctggtcacacagcac tatgccaagatcagcgatttcggtctttccaaagccctgcgtgctgatgaaaactactac aaggcccagacccacgggaagtggcccgtgaagtggtacgcccccgaatgcatcaactac tacaagttctccagtaagagtgacgtctggagcttcggagtcctgatgtgggaagcgttc tcctatgggcagaagccctacagagggatgaaagggagcgaagtgaccgccatgctggag aaaggagagcggatggggtgccctgcaggatgcccgagagagatgtacgacctgatgaac ctgtgctggacttacgatgtggagaacaggccaggattcacagctgtggaactgaggctt cgcaattactactacgacgtggttaactaa

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