KEGG   Mus musculus (house mouse): 218461
Entry
218461            CDS       T01002                                 
Symbol
Pde8b, B230331L10Rik, C030047E14Rik
Name
(RefSeq) phosphodiesterase 8B
  KO
K18437  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8 [EC:3.1.4.53]
Organism
mmu  Mus musculus (house mouse)
Pathway
mmu00230  Purine metabolism
mmu01100  Metabolic pathways
mmu04927  Cortisol synthesis and secretion
mmu04934  Cushing syndrome
mmu05032  Morphine addiction
Brite
KEGG Orthology (KO) [BR:mmu00001]
 09100 Metabolism
  09104 Nucleotide metabolism
   00230 Purine metabolism
    218461 (Pde8b)
 09150 Organismal Systems
  09152 Endocrine system
   04927 Cortisol synthesis and secretion
    218461 (Pde8b)
 09160 Human Diseases
  09165 Substance dependence
   05032 Morphine addiction
    218461 (Pde8b)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    218461 (Pde8b)
Enzymes [BR:mmu01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.53  3',5'-cyclic-AMP phosphodiesterase
     218461 (Pde8b)
SSDB
Motif
Pfam: PDEase_I PDE8A_N PDE8 DUF2722 DHH
Other DBs
NCBI-GeneID: 218461
NCBI-ProteinID: NP_001164140
MGI: 2443999
Ensembl: ENSMUSG00000021684
UniProt: E9PYP0
LinkDB
Position
13:complement(95160962..95386904)
AA seq 788 aa
MGCAPSIHVSQSGVIYCRDSDESNSPRQTSSVSQGPTAPLHGLFVQTDAADAMPPSRAAG
PPGAVRVRRSRAELGSGSSTGSSGPATTTCRGRRRHCCSSAEAETQTSYTSVKQVSSAEV
RIGPMRLTQDPIQVLLIFAKEDSQSDGFWWACDRAGYRCNIARTPESALECFLDKHHEII
VIDHRQSRNFDAEAVCRSIRATNPSEHTVILAVVSQASDDHEEASVLPLLHAGFNRRFME
NSSIIACYNELIQIEHGEVRSQFKLRACNSVFTALDHCHEAIEITSDDHVIQIHRIHRDS
GDNSQTEPHSFRHKSRRKESIDVKSISSRGSDAPSLQNRRYPSMARIHSMTIEAPITKVI
NIINAAQENSPVTVAEALDRVLEILRTTELYSPQLGTKDEDPHTSDLVGGLMTDGLRRLS
GNEYVFTKNVHHSHSHLSMPITINDVPPSIAQLLDNEESWDFNIFELEAVTHKRPLVYLG
LKVFSRFGVCEFLNCTETTLRAWLQVIEANYHSSNAYHNSTHAADVLHATAFFLGKERVK
GSLDQLDEVAALIAATVHDVDHPGRTNSFLCNAGSELAVLYNDTAVLESHHTALAFQLTV
KDTKCNIFKNIDRNHYRTLRQAIIDMVLATEMTKHFEHVNKFVNSINKPLAAESEGSDCE
CNPTGKNFPENQILIKRMMIKCADVANPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPV
VMPVFDRNTCSIPKSQISFIDYFITDMFDAWDAFAHLPALMQHLADNYKHWKTLDDLKCK
TLRLPSDS
NT seq 2367 nt   +upstreamnt  +downstreamnt
atgggctgcgcccccagcatccatgtctcgcagagcggtgtgatctactgccgggactcg
gatgagtccaactcgccccgccagaccagcagcgtgtcgcagggccccacggcgcccctg
cacggcctcttcgtgcagaccgacgccgccgacgccatgcccccgagtcgcgcggcggga
cccccgggcgctgtccgagtccgcagatcccgggctgaactgggcagcggcagcagcacg
gggtcctcgggccccgccacgaccacctgccggggccggaggcgccactgctgcagcagc
gccgaggccgagacccagactagctacaccagcgtcaagcaggtgtcttctgcagaggtg
cgcattgggcccatgagactgacacaggaccctatccaggttctgctaatcttcgcaaag
gaagatagccagagtgatggcttctggtgggcctgtgacagagctggctacagatgcaac
atcgctcgcactccagagtcggccctcgagtgctttctggacaagcatcatgaaattatt
gtgatcgatcacaggcagagccggaactttgatgcagaagccgtgtgcaggtcaatccgg
gccacgaacccctctgagcacacggtgatcctggctgtcgtttcacaagcatctgatgac
catgaagaggcctcagtccttcctcttcttcatgcaggcttcaaccggagatttatggag
aacagcagcataattgcttgctataatgaactgattcaaatagaacacggggaagttcgc
tcacagttcaaattacgggcctgtaattcagtgtttacagcgttagaccactgtcacgaa
gccatagaaataacaagtgatgaccatgtgattcagattcaccggattcatcgtgactcc
ggggacaactctcagacagagcctcattcgttcagacacaagagcaggaggaaagagtcc
attgatgtgaaatcaatatcttctcggggcagtgatgcgccaagcctacagaatcgccgc
tacccctccatggccaggatccactccatgaccattgaggctcccatcacaaaggttata
aatataatcaatgcagctcaggagaacagcccagttacagtagcagaggccttggacaga
gtcctagaaattttacggaccacagaactgtattcccctcagctgggaaccaaagatgag
gatccccacaccagtgaccttgttgggggcctgatgactgatggcttgaggagactgtca
gggaacgagtatgtgtttacaaagaatgtgcaccacagtcacagtcacctctcgatgccc
atcaccatcaatgatgtccccccaagtatcgcccagctccttgataatgaggaaagctgg
gacttcaacatctttgaattggaagccgttacacataaaaggccacttgtgtacctgggc
ttaaaggtcttctctcggtttggagtatgtgaatttttaaactgtactgaaaccactctt
cgggcctggctgcaagtgattgaagccaactaccactcctccaacgcctaccacaactcc
acccatgctgccgatgtactgcatgccacggctttcttccttggaaaggaaagagtgaag
ggaagcctggaccagctggatgaggtggctgctctgattgctgccacagtccacgacgtg
gatcaccccggaaggaccaactctttcctgtgcaacgccggcagcgagctcgctgtgctc
tacaatgacactgcagtcttggagagtcaccacacagccctggccttccagctcacagtc
aaggacaccaagtgcaacattttcaagaatattgacaggaaccactatcgaacgctgcgc
caggctattatcgacatggttttggctacagagatgacaaaacacttcgagcacgtgaac
aaattcgtgaacagcatcaacaagccactggcagctgagagtgagggcagtgattgtgaa
tgcaaccctaccgggaagaactttcctgagaaccaaatcctcatcaaacgcatgatgatt
aagtgtgccgacgtggccaacccgtgccggcccttggacctgtgcattgaatgggctgga
aggatctccgaggagtactttgctcagactgatgaagagaagaggcaggggctgcctgtg
gtgatgccagtgttcgaccgcaatacctgcagcatccccaagtcccagatctccttcatc
gactacttcataacagacatgtttgatgcttgggatgccttcgctcacctgcctgccctg
atgcagcacctggccgataactataaacactggaagacactggatgacctcaagtgcaaa
actctgagacttccatctgacagctga

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