Mus musculus (house mouse): 21973
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Entry
21973 CDS
T01002
Symbol
Top2a, Top-2
Name
(RefSeq) topoisomerase (DNA) II alpha
KO
K03164
DNA topoisomerase II [EC:
5.6.2.2
]
Organism
mmu
Mus musculus (house mouse)
Pathway
mmu01524
Platinum drug resistance
Brite
KEGG Orthology (KO) [BR:
mmu00001
]
09160 Human Diseases
09176 Drug resistance: antineoplastic
01524 Platinum drug resistance
21973 (Top2a)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03032 DNA replication proteins [BR:
mmu03032
]
21973 (Top2a)
03036 Chromosome and associated proteins [BR:
mmu03036
]
21973 (Top2a)
Enzymes [BR:
mmu01000
]
5. Isomerases
5.6 Isomerases altering macromolecular conformation
5.6.2 Enzymes altering nucleic acid conformation
5.6.2.2 DNA topoisomerase (ATP-hydrolysing)
21973 (Top2a)
DNA replication proteins [BR:
mmu03032
]
Eukaryotic type
DNA Topoisomerases
21973 (Top2a)
Chromosome and associated proteins [BR:
mmu03036
]
Eukaryotic type
Chromosome condensation proteins
Other regulators of chromosome condensation
21973 (Top2a)
Centrosome formation proteins
Centriole proteins
21973 (Top2a)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
DNA_topoisoIV
TOPRIM_C
DNA_gyraseB
DTHCT
HATPase_c
Toprim
Microp_apicomplexa_20
Motif
Other DBs
NCBI-GeneID:
21973
NCBI-ProteinID:
NP_035753
MGI:
98790
Ensembl:
ENSMUSG00000020914
UniProt:
Q01320
LinkDB
All DBs
Position
11:complement(98883773..98915037)
Genome browser
AA seq
1528 aa
AA seq
DB search
MELSPLQPVNENMLMNKKKNEDGKKRLSIERIYQKKTQLEHILLRPDTYIGSVELVTQQM
WVYDEDVGINYREVTFVPGLYKIFDEILVNAADNKQRDPKMSCIRVTIDPENNVISIWNN
GKGIPVVEHKVEKIYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVET
ASREYKKMFKQTWMDNMGRAGDMELKPFSGEDYTCITFQPDLSKFKMQSLDKDIVALMVR
RAYDIAGSTKDVKVFLNGNSLPVKGFRSYVDLYLKDKVDETGNSLKVIHEQVNPRWEVCL
TMSERGFQQISFVNSIATSKGGRHVDYVADQIVSKLVDVVKKKNKGGVAVKAHQVKNHMW
IFVNALIENPTFDSQTKENMTLQAKSFGSTCQLSEKFIKAAIGCGIVESILNWVKFKAQI
QLNKKCSAVKHTKIKGIPKLDDANDAGSRNSTECTLILTEGDSAKTLAVSGLGVVGRDKY
GVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKNYEDEDSLKTLRYGKIMIMTD
QDQDGSHIKGLLINFIHHNWPSLLRHRFLEEFITPIVKVSKNKQEIAFYSLPEFEEWKSS
TPNHKKWKVKYYKGLGTSTSKEAKEYFADMKRHRIQFKYSGPEDDAAISLAFSKKQVDDR
KEWLTNFMEDRRQRKLLGLPEDYLYGQSTSYLTYNDFINKELILFSNSDNERSIPSMVDG
LKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSSYHHGEMSLMMTIINLAQNFVGSNNL
NLLQPIGQFGTRLHGGKDSASPRYIFTMLSPLARLLFPPKDDHTLRFLYDDNQRVEPEWY
IPIIPMVLINGAEGIGTGWSCKIPNFDVREVVNNIRRLLDGEEPLPMLPSYKNFKGTIEE
LASNQYVINGEVAILDSTTIEISELPIRTWTQTYKEQVLEPMLNGTEKTPSLITDYREYH
TDTTVKFVIKMTEEKLAEAERVGLHKVFKLQSSLTCNSMVLFDHVGCLKKYDTVLDILRD
FFELRLKYYGLRKEWLLGMLGAESSKLNNQARFILEKIDGKIVIENKPKKELIKVLIQRG
YDSDPVKAWKEAQQKVPDEEENEESDTETSTSDSAAEAGPTFNYLLDMPLWYLTKEKKDE
LCKQRNEKEQELNTLKQKSPSDLWKEDLAVFIEELEVVEAKEKQDEQVGLPGKAGKAKGK
KAQMCADVLPSPRGKRVIPQVTVEMKAEAEKKIRKKIKSENVEGTPAEDGAEPGSLRQRI
EKKQKKEPGAKKQTTLPFKPVKKGRKKNPWSDSESDVSSNESNVDVPPRQKEQRSAAAKA
KFTVDLDSDEDFSGLDEKDEDEDFLPLDATPPKAKIPPKNTKKALKTQGSSMSVVDLESD
VKDSVPASPGVPAADFPAETEQSKPSKKTVGVKKTATKSQSSVSTAGTKKRAAPKGTKSD
SALSARVSEKPAPAKAKNSRKRKPSSSDSSDSDFERAISKGATSKKAKGEEQDFPVDLED
TIAPRAKSDRARKPIKYLEESDDDDDLF
NT seq
4587 nt
NT seq
+upstream
nt +downstream
nt
atggagttgtcaccgctgcagcctgtaaatgaaaatatgctaatgaacaaaaagaagaat
gaagatggcaagaaaagattgtctattgaaagaatctatcagaaaaaaacacaactggaa
catatactgctccgcccagatacctacattggctctgtggagttagtgacccagcaaatg
tgggtttacgatgaagatgttggcattaactacagggaagtcacttttgttcctggtttg
tataaaatctttgatgagattctagttaatgctgctgataacaaacaaagggacccaaaa
atgtcttgtattagagtcacaattgatccagaaaataatgtaattagcatctggaataat
gggaaaggaatccctgttgttgaacacaaagttgagaaaatatatgtcccagctctcata
tttggacaactcctgacctccagtaactatgacgacgatgagaagaaagtgacaggtggt
cgaaatggctatggagctaaactgtgtaacatattcagcaccaaatttactgtggaaaca
gccagtagagagtacaagaaaatgttcaaacagacgtggatggataacatggggagagct
ggtgacatggaactcaagccctttagtggagaagattatacatgtatcaccttccagcct
gacttatctaagtttaaaatgcaaagcctggacaaagatattgttgcactgatggtcaga
agagcatatgatatcgctggctccactaaagatgtcaaagtctttcttaatggaaatagt
ctgccagtgaaaggattccgcagttacgtggatttgtatttgaaggataaggtagatgaa
actgggaattcactgaaggtgatacatgaacaggtcaatccccggtgggaagtgtgctta
acaatgagcgagagaggcttccagcagattagcttcgtcaacagcattgcgacttctaag
ggcggcagacatgtcgattatgtagctgatcagattgtgagcaaactcgttgatgtggtg
aaaaagaagaacaagggcggggttgcagtgaaggctcatcaggtgaaaaatcacatgtgg
atttttgtaaatgccttaattgaaaacccaacctttgactctcaaacaaaagaaaacatg
actttacaagccaagagctttggatcaacatgtcaattaagtgaaaagttcatcaaagct
gcaattggttgtggtattgtggaaagcatactaaactgggtgaagttcaaggctcaaatc
caactgaacaagaagtgttcagctgtaaaacataccaaaatcaagggaatccccaaactt
gatgatgccaacgatgcagggagccgaaactctactgaatgcacacttatcctgactgag
ggagactcagcaaaaactctagccgtttcaggccttggagtggttggaagagacaaatat
ggggtgttccctcttagaggaaagatactcaatgtgcgagaagcctctcataaacagatc
atggaaaatgctgaaattaacaatatcatcaagattgtgggtctccagtacaagaaaaac
tatgaagatgaagattcattgaaaactcttcgttatgggaagatcatgattatgacagat
caggaccaagatggttcccacatcaaaggcttgctgatcaattttatccatcacaattgg
ccatctcttctgcgacatcgttttctagaagaatttatcactcccattgtaaaggtgtcc
aaaaataagcaagaaatagcattctatagtcttcccgagtttgaagaatggaaaagttcg
actccgaatcataaaaagtggaaagtcaaatactacaaaggtttgggcaccagcacatca
aaggaagctaaggaatattttgcagatatgaaacgacatcgtattcagttcaaatactct
ggccctgaagatgatgctgcgatcagcctggcctttagtaaaaaacaagttgatgatcga
aaggaatggttaactaattttatggaagacagaagacagcggaagttacttggccttcct
gaggattatttgtatggacaaagcacttcgtacctgacctataatgacttcataaacaag
gaactcatcctcttctccaactctgataatgaaaggtctatcccatccatggtagacggt
ttgaaaccaggtcagagaaaggttttgtttacttgtttcaaacggaatgacaagcgagaa
gtgaaggttgcccagttagctgggtcagtggcagaaatgtcctcttatcaccatggtgag
atgtcactgatgatgaccattatcaatttggcgcagaattttgtgggtagcaataatttg
aaccttttacagcccattggtcagtttggaaccaggctgcatggtggcaaggactcagct
agtcctaggtacatctttacaatgctcagccctttggctcggttgttgtttcctccaaaa
gatgatcacacattacggtttctatatgatgacaaccaacgtgttgagcctgaatggtac
attcctataatacccatggtgctgataaatggtgctgagggaattggtactgggtggtcc
tgcaaaatccccaactttgatgtgcgtgaagttgtgaataatatcagacggcttctggat
ggagaggagcccctacccatgctcccaagttataagaatttcaaaggtactattgaagaa
ctggcttcaaatcagtatgtgattaatggagaagtagctattctggattctacaaccatt
gaaatctcagagcttcccatccgaacgtggactcagacatataaagaacaggttctagaa
cccatgttgaatggaactgagaagacaccctctctaataacagactatagggaataccat
acagataccactgtgaagtttgtcataaagatgactgaagaaaaactggcagaggcagag
agagtcggcctacacaaagtcttcaaactccagagtagtctcacttgcaactctatggtg
ctttttgaccatgtaggttgcttaaagaaatatgacactgtgttggatattctaagagac
ttctttgagctcaggcttaaatattatggattaagaaaagaatggcttctaggaatgctt
ggtgcagaatcttctaaactgaataatcaagctcgctttatattagagaaaatagatggc
aaaatagtcattgaaaataaacctaaaaaagaattaattaaagttctgattcagagaggc
tacgactctgaccctgtgaaagcctggaaagaagctcagcagaaggttccagatgaagaa
gaaaatgaagaaagtgacactgaaaccagcaccagtgactctgcagccgaggctgggccg
accttcaactaccttctcgacatgcccctgtggtatctgaccaaggagaagaaggatgag
ctgtgcaaacaaagaaacgagaaggaacaagagctcaacacattaaagcaaaagagtcca
tcagatctgtggaaggaagatctggctgtttttattgaagaactggaggttgtcgaggcc
aaggaaaagcaggatgaacaagtgggccttcctggaaaggcggggaaagcaaaggggaag
aaagcacagatgtgtgctgacgtcttgccttctcctcggggcaaaagagtcatcccccaa
gtgactgtggagatgaaagctgaggcagagaagaaaattaggaagaaaattaagagtgaa
aacgttgagggtacccctgctgaggatggtgcggaaccaggaagcctccggcaacgaata
gagaagaagcagaagaaagagccaggtgcaaagaagcagactacattgccgtttaagcct
gtcaaaaaagggaggaagaaaaacccctggtctgactctgagtcagacgtgagcagtaat
gaaagtaacgttgatgtccctcctcgacaaaaagagcaaagaagtgctgcagcaaaagcc
aaattcacagtggatttagactcggatgaagatttctcaggtttggatgagaaggatgag
gatgaagatttcctcccattagatgctactccacctaaggccaaaatccccccaaaaaat
actaaaaaagcactgaagacccagggaagctccatgtcggtagttgatcttgaaagtgat
gttaaggacagtgtgccagcttctccaggcgttcctgctgctgacttcccagcggaaact
gaacagtcaaagccatccaaaaagaccgtgggagtgaagaagacagcaaccaaaagccag
tcttcagtctccactgctggtaccaaaaagagagctgcgccaaagggaaccaaatcagat
tcagccttgagtgctcgtgtctcggaaaaacctgctcctgccaaagccaagaacagtcgc
aaaaggaagccatcttcttctgatagctctgactctgattttgagagagcaatttctaaa
ggtgccacgagcaagaaagcaaagggagaggaacaggacttccctgtggacttggaagac
acgatagctcctcgagccaaatctgaccgggcgaggaagccaattaagtacctggaggag
tccgatgacgatgacgacctcttctga
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integrated database retrieval system
