Mus musculus (house mouse): 234779 Help Entry 234779            CDS       T01002                                  Symbol Plcg2, PLC-gamma-2, PLCgamma2, Plcg-2 Name (RefSeq) phospholipase C, gamma 2   KO K05859   phosphatidylinositol phospholipase C, gamma-2 [EC:3.1.4.11] Organism mmu  Mus musculus (house mouse) Pathway mmu00562   Inositol phosphate metabolism mmu01100   Metabolic pathways mmu01521   EGFR tyrosine kinase inhibitor resistance mmu04012   ErbB signaling pathway mmu04014   Ras signaling pathway mmu04020   Calcium signaling pathway mmu04062   Chemokine signaling pathway mmu04064   NF-kappa B signaling pathway mmu04066   HIF-1 signaling pathway mmu04070   Phosphatidylinositol signaling system mmu04072   Phospholipase D signaling pathway mmu04360   Axon guidance mmu04370   VEGF signaling pathway mmu04380   Osteoclast differentiation mmu04611   Platelet activation mmu04613   Neutrophil extracellular trap formation mmu04625   C-type lectin receptor signaling pathway mmu04650   Natural killer cell mediated cytotoxicity mmu04662   B cell receptor signaling pathway mmu04664   Fc epsilon RI signaling pathway mmu04666   Fc gamma R-mediated phagocytosis mmu04670   Leukocyte transendothelial migration mmu04722   Neurotrophin signaling pathway mmu04750   Inflammatory mediator regulation of TRP channels mmu04919   Thyroid hormone signaling pathway mmu04933   AGE-RAGE signaling pathway in diabetic complications mmu04935   Growth hormone synthesis, secretion and action mmu05167   Kaposi sarcoma-associated herpesvirus infection mmu05169   Epstein-Barr virus infection mmu05170   Human immunodeficiency virus 1 infection mmu05171   Coronavirus disease - COVID-19 mmu05200   Pathways in cancer mmu05205   Proteoglycans in cancer mmu05206   MicroRNAs in cancer mmu05214   Glioma mmu05223   Non-small cell lung cancer mmu05225   Hepatocellular carcinoma Module mmu_M00130   Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4 Brite KEGG Orthology (KO) [BR:mmu00001]  09100 Metabolism   09101 Carbohydrate metabolism    00562 Inositol phosphate metabolism     234779 (Plcg2)  09130 Environmental Information Processing   09132 Signal transduction    04012 ErbB signaling pathway     234779 (Plcg2)    04014 Ras signaling pathway     234779 (Plcg2)    04370 VEGF signaling pathway     234779 (Plcg2)    04064 NF-kappa B signaling pathway     234779 (Plcg2)    04066 HIF-1 signaling pathway     234779 (Plcg2)    04020 Calcium signaling pathway     234779 (Plcg2)    04070 Phosphatidylinositol signaling system     234779 (Plcg2)    04072 Phospholipase D signaling pathway     234779 (Plcg2)  09150 Organismal Systems   09151 Immune system    04611 Platelet activation     234779 (Plcg2)    04613 Neutrophil extracellular trap formation     234779 (Plcg2)    04625 C-type lectin receptor signaling pathway     234779 (Plcg2)    04650 Natural killer cell mediated cytotoxicity     234779 (Plcg2)    04662 B cell receptor signaling pathway     234779 (Plcg2)    04664 Fc epsilon RI signaling pathway     234779 (Plcg2)    04666 Fc gamma R-mediated phagocytosis     234779 (Plcg2)    04670 Leukocyte transendothelial migration     234779 (Plcg2)    04062 Chemokine signaling pathway     234779 (Plcg2)   09152 Endocrine system    04935 Growth hormone synthesis, secretion and action     234779 (Plcg2)    04919 Thyroid hormone signaling pathway     234779 (Plcg2)   09156 Nervous system    04722 Neurotrophin signaling pathway     234779 (Plcg2)   09157 Sensory system    04750 Inflammatory mediator regulation of TRP channels     234779 (Plcg2)   09158 Development and regeneration    04360 Axon guidance     234779 (Plcg2)    04380 Osteoclast differentiation     234779 (Plcg2)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     234779 (Plcg2)    05206 MicroRNAs in cancer     234779 (Plcg2)    05205 Proteoglycans in cancer     234779 (Plcg2)   09162 Cancer: specific types    05225 Hepatocellular carcinoma     234779 (Plcg2)    05214 Glioma     234779 (Plcg2)    05223 Non-small cell lung cancer     234779 (Plcg2)   09172 Infectious disease: viral    05170 Human immunodeficiency virus 1 infection     234779 (Plcg2)    05171 Coronavirus disease - COVID-19     234779 (Plcg2)    05167 Kaposi sarcoma-associated herpesvirus infection     234779 (Plcg2)    05169 Epstein-Barr virus infection     234779 (Plcg2)   09167 Endocrine and metabolic disease    04933 AGE-RAGE signaling pathway in diabetic complications     234779 (Plcg2)   09176 Drug resistance: antineoplastic    01521 EGFR tyrosine kinase inhibitor resistance     234779 (Plcg2)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    04131 Membrane trafficking [BR:mmu04131]     234779 (Plcg2) Enzymes [BR:mmu01000]  3. Hydrolases   3.1  Acting on ester bonds    3.1.4  Phosphoric-diester hydrolases     3.1.4.11  phosphoinositide phospholipase C      234779 (Plcg2) Membrane trafficking [BR:mmu04131]  Exocytosis   Calcium ion-dependent exocytosis    Phospholipases     234779 (Plcg2)  Endocytosis   Macropinocytosis    Phospholipase C     234779 (Plcg2) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  PI-PLC-X SH2 PI-PLC-Y EF-hand_PLCG2 C2 SH3_1 SH3_9 PH PH_12 EF-hand_PLCG1 SH2_1 SH3_2 PH_14 GDPD EF-hand_like Motif Other DBs NCBI-GeneID:  234779 NCBI-ProteinID:  NP_758489 MGI:  97616 Ensembl:  ENSMUSG00000034330 UniProt:  Q8CIH5 Structure PDBPDBj LinkDB All DBs Position 8:118225014..118361881 Genome browser AA seq 1265 aa AA seqDB search MTTMVNVDTLPEYEKSQIKRALELGTVMTVFNARKSTPERRTVQMIMETRQVAWSKTADK IEGFLDIMEIKEIRPGKNSKDFERAKAVRHKAECCFTILYGTQFVLSTLSLATDSKEDAV KWLSGLKILHQEAMSASTPTMIESWLRKQIYSVDQTRRNSISLRELKTILPLVNFKVSGI KFLKDKLVEIGAQKDELSFEQFHLFYKKLMFDQQKSILDEFKKDSSVFILGNTDRPDASA VYLQDFQRFLLHEQQELWAQDLNKVRERMTKFIDDTMRETAEPFLFVDEFLTYLFSRENS IWDEKYDAVDMQDMNNPLSHYWISSSHNTYLTGDQLRSESSTEAYIRCLRAGCRCIELDC WDGPDGKPIIYHGWTRTTKIKFDDVVQAIRDHAFVTSSFPVILSIEEHCSVEQQRHMAKV FKEVLGDMLLTKPTEASADQLPSPSQLREKIIIKHKKLGPKGDVDVNVEDKKDEHKPQGE LYMWDSIDQKWTRHYCAIADAKLSFGDDIEQAVEEEPVQDTPPTELHFGEKWFHKKVESR TSAEKLLQEYCAETGAKDGTFLVRESETFPNDYTLSFWRSGRVQHCRIRSTMENGVMKYY LTDNLTFNSIYALIQHYREAHLRCAEFELRLTDPVPNPNPHESKPWYYDSLSRGEAEDML MRIPRDGAFLIRKREGTNSYAITFRARGKVKHCRINRDGRHFVLGTSAYFESLVELVSYY EKHALYRKMRLRYPVTPELLERYNMERDINSLYDVSRMYVDPSEINPSMPQRTVKALYDY KAKRSDELTFCRGALIHNVSKEPGGWWKGDYGTRIQQYFPSNYVEDISAGDAEEMEKQII EDNPLGSLCKGILDLNTYNVVKAPQGKNQKAFVFILEPKKQGDPPVEFATDRVEELFEWF QSIREITWKMDTKENNMKYWERNQSIAIELSDLVVYCKPTSKTKDHLENPDFREIRSFVE TKADSIVRQKPVDLLRYNQKGLTRVYPKGQRVDSSNYDPFRLWLCGSQMVALNFQTPDKY MQMNHALFSLNGRTGYVLQPESMRSEKYDPMPLESQRKILMTLTVKVLGARHLPKLGRSI ACPFVEVEICGAEYDSNKFKTTVVNDNGLSPVWAPTQEKVTFEIYDPNLAFLRFVVYEED MFSDPNFLAHATYPIKGIKSGFRSVPLKNGYSEDIELASLLVFCEMRPVLESEEELYSSC RQLRRRQEELNNQLFLYDTHQNLRGANRDALVKEFNVNENQLQLYQEKCNRRLREKRVSN SRFYS NT seq 3798 nt NT seq  +upstreamnt  +downstreamnt atgaccaccatggtcaacgtggacacccttccagaatatgagaagagtcagatcaagaga gcgctggagttagggacggtgatgaccgtgttcaacgcccgcaaatccaccccagagcgg aggacagtacagatgatcatggagactcggcaggtggcatggagcaagaccgcagacaag attgaaggcttcctggacatcatggagataaaggaaatccgtccggggaagaactccaag gactttgagcgagccaaggctgtccgccacaaggcagaatgttgcttcaccatcctctac ggcacccagtttgtcctcagcacgctcagtttggcaacggactcaaaggaggatgcggtg aagtggctctctggtttgaagatcctacaccaggaagcgatgagtgcatccacccccaca atgattgagagttggctgagaaaacagatttattcagtagatcaaacccgaagaaacagc atcagcctccgggagctgaagaccatcttgcccctggtcaacttcaaagtgagcggcatc aagtttctcaaggacaagctggtggaaatcggcgcacagaaagatgagctcagctttgaa cagttccatctcttctataagaaactcatgtttgaccagcaaaaatcgatacttgacgaa ttcaaaaaagactcctccgtgttcatcctaggaaacacagaccggccggatgcctcggct gtctacctgcaggacttccaaaggtttcttttacatgaacagcaggagctatgggctcag gatctgaacaaagtccgggagcggatgaccaagtttatcgacgacacaatgagagagacc gcagagcccttcttatttgtggatgagttcctcacgtatctgttctcccgggagaacagc atctgggacgagaagtacgatgcagtggacatgcaggacatgaacaaccccttgtcccac tactggatctcctcttcccacaacacgtacctcactggggaccagctgcgtagtgagtcc tccacggaagcgtatatccgctgtctgcgcgctggttgccgctgcattgagctggactgc tgggacgggcctgatgggaagcccattatctaccacggctggacacggaccaccaagatc aagtttgatgatgttgttcaggccatccgagaccacgcctttgttacctccagcttcccc gtcatcttgtctatcgaggagcactgcagtgtggagcagcaacgtcacatggccaaggtg ttcaaggaagtgttaggagacatgctgttgacgaagcccacagaggccagtgctgaccag ctgccctcgcccagtcagcttcgtgagaagatcattatcaagcataagaagctgggtccc aagggtgatgtcgacgtcaacgtggaggacaagaaagatgagcacaagccccagggcgag ctgtatatgtgggactccatcgaccagaaatggacgcgccactactgtgccattgctgac gccaagctgtccttcggtgatgacattgaacaggctgtggaggaggagccggtccaggac actccccccacggagctgcattttggggagaaatggttccacaagaaggtggagagtagg accagtgcggagaagctgctgcaagagtactgtgctgagaccggggccaaggacggcacc ttcctggtgcgggagagcgagaccttccccaatgactacacactctccttctggcggtct ggccgggtgcagcactgccggatccggtctactatggagaatggggtcatgaagtactac ctgaccgacaacctcacgttcaacagcatctacgccctcatccagcactaccgtgaggca cacctgcgctgcgcggagttcgagctgcggctcacagacccggtgcccaaccccaaccca cacgagtccaagccgtggtactatgacagtctgagcaggggggaagcggaggacatgctg atgcggatcccccgagatggagccttcctcatccggaagagggaggggaccaactcctac gccatcaccttcagggccaggggcaaggtgaaacattgtcgcatcaaccgggacggacgc cacttcgtgctgggcacctctgcctactttgagagcctggtggagcttgtcagctactac gagaagcacgcgctctatcgcaagatgaggcttcgataccccgtgaccccggagctcctg gagcgatataatatggaaagagacatcaactctctttatgacgtcagcaggatgtatgtg gacccaagtgagatcaacccttccatgcctcagaggaccgtgaaagcgctctatgactac aaagccaagcgcagcgacgagctgaccttctgccgcggtgccctcatccacaatgtctcc aaggagcccgggggatggtggaaaggggactacgggacccggatccagcagtacttcccg tccaactatgtcgaggatatctcggcaggcgatgctgaggagatggaaaagcagattatt gaagacaatcccctcgggtctctctgcaaaggcatattggatcttaatacctacaacgtt gtgaaggccccccaggggaaaaaccagaaagccttcgtctttatcctggagcctaagaaa cagggagatcctcccgtggagttcgcgaccgaccgtgtggaggagctgtttgagtggttt cagagcatacgggagatcacttggaagatggacaccaaggagaacaacatgaagtactgg gagaggaaccagtccatcgccattgagctctcggacttggttgtatactgcaagccaact agcaaaaccaaggaccatttggaaaatcccgacttccgagaaatccgctcttttgtggag acgaaggcagacagcattgtcaggcaaaaacctgtcgatctattgcgatacaatcagaag ggcctgacccgagtctaccccaagggacagagagttgactcttcgaactatgaccccttc cgtctgtggctgtgcggctcccagatggtggcactcaatttccagactccagacaaatac atgcagatgaaccacgcgctgttttcgctcaatgggcgaacaggctacgtcctgcagcct gagagcatgcgctctgagaagtatgatccgatgcccctggagtcccagaggaagatcctg atgacactcactgtcaaggttcttggtgcacgccacctccctaaactagggcggagtatt gcctgtccttttgtggaggtggaaatctgcggggctgagtatgacagcaacaaattcaag acgacggttgtgaatgacaatggcctcagccctgtctgggctccaactcaggagaaggtg acatttgagatctatgatccaaaccttgccttcctacgctttgtggtctacgaagaagac atgttcagtgatcccaacttcctggctcatgccacgtaccccattaaaggcatcaaatcc gggtttagatcagtccctctgaagaatgggtacagtgaagacatcgagctggcatccctc ctggttttctgtgagatgaggccagtcctggagagtgaagaggaactctattcctcctgt cgccaactgcggaggcggcaagaagagctcaacaaccagctcttcctttacgacacgcac cagaacctgcgcggagccaaccgtgatgccctggtgaaggagttcaatgttaacgagaat cagctgcagctgtaccaggagaagtgcaaccggaggctgagagagaagagagtaagcaac agcaggttctactcctag

DBGET integrated database retrieval system