Mus musculus (house mouse): 26410
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Entry
26410 CDS
T01002
Symbol
Map3k8, Cot, Cot/Tpl2, Est, Estf, Tpl-2, Tpl2, c-COT
Name
(RefSeq) mitogen-activated protein kinase kinase kinase 8
KO
K04415
mitogen-activated protein kinase kinase kinase 8 [EC:
2.7.11.25
]
Organism
mmu
Mus musculus (house mouse)
Pathway
mmu04010
MAPK signaling pathway
mmu04620
Toll-like receptor signaling pathway
mmu04660
T cell receptor signaling pathway
mmu04668
TNF signaling pathway
Brite
KEGG Orthology (KO) [BR:
mmu00001
]
09130 Environmental Information Processing
09132 Signal transduction
04668 TNF signaling pathway
26410 (Map3k8)
09150 Organismal Systems
09151 Immune system
04620 Toll-like receptor signaling pathway
26410 (Map3k8)
04660 T cell receptor signaling pathway
26410 (Map3k8)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
mmu01001
]
26410 (Map3k8)
Enzymes [BR:
mmu01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.25 mitogen-activated protein kinase kinase kinase
26410 (Map3k8)
Protein kinases [BR:
mmu01001
]
Serine/threonine kinases: STE group
Other
26410 (Map3k8)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Pkinase
PK_Tyr_Ser-Thr
Pkinase_fungal
HTH_8
ABC1
RIO1
Motif
Other DBs
NCBI-GeneID:
26410
NCBI-ProteinID:
NP_031772
MGI:
1346878
Ensembl:
ENSMUSG00000024235
UniProt:
Q07174
Q3UEB8
LinkDB
All DBs
Position
18:complement(4331325..4352978)
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AA seq
467 aa
AA seq
DB search
MEYMSTGSDEKEEIDLLIKHLNVSEVIDIMENLYASEEPGVYEPSLMTMYPDSNQNEERS
ESLLRSGQEVPWLSSVRYGTVEDLLAFANHVSNMTKHFYGRRPQECGILLNMVISPQNGR
YQIDSDVLLVPWKLTYRNIGSGFVPRGAFGKVYLAQDMKTKKRMACKLIPIDQFKPSDVE
IQACFRHENIAELYGAVLWGDTVHLFMEAGEGGSVLEKLESCGPMREFEIIWVTKHILKG
LDFLHSKKVIHHDIKPSNIVFMSTKAVLVDFGLSVKMTEDVYLPKDLRGTEIYMSPEVIL
CRGHSTKADIYSLGATLIHMQTGTPPWVKRYPRSAYPSYLYIIHKQAPPLEDIAGDCSPG
MRELIEAALERNPNHRPKAADLLKHEALNPPREDQPRCQSLDSALFERKRLLSRKELQLP
ENIADSSCTGSTEESEVLRRQRSLYIDLGALAGYFNIVRGPPTLEYG
NT seq
1404 nt
NT seq
+upstream
nt +downstream
nt
atggagtacatgagcactggaagtgacgagaaagaagaaattgatttattaattaagcat
ttaaacgtgtcagaagtcatagacataatggagaacctttatgcaagtgaagagccagga
gtgtatgagcccagtctgatgaccatgtatccagacagcaatcaaaatgaggaacgttcg
gagtcactgcttcggagtggccaggaggttccctggctgtcatctgtcagatatgggacc
gtggaggatctgcttgcatttgcaaaccatgtctccaatatgacaaagcatttttatgga
cgtcgaccacaagaatgtggaattttattaaatatggtaatcagtccccagaatggccgc
taccaaatcgattcggatgttctccttgttccttggaagctgacatacaggaacatcggc
tctggtttcgttcctcggggggcctttggaaaagtatacttagcccaagacatgaagaca
aagaaaagaatggcgtgcaaactgatccctatagatcagtttaagccatcggatgtggaa
atccaggcctgtttccggcatgagaacattgctgagttatatggtgccgtcctatggggc
gatactgtccatctctttatggaagccggcgagggagggtctgttctggagaaactggag
agttgtgggcccatgagagaatttgaaattatttgggtgacgaagcacattctcaaggga
cttgattttctgcactccaagaaagtgatccaccatgatattaaacctagcaacattgta
ttcatgtctacaaaagctgttttggtagattttggcctgagtgttaagatgactgaagat
gtctatcttcccaaggacctccggggaacagagatatacatgagcccagaggtgatccta
tgtcggggccattccacaaaagccgacatctacagccttggagccacactcatccacatg
cagacaggcaccccaccctgggtgaagcgctaccctcgatcagcctatccctcctaccta
tacattatccacaagcaggcacctcccctggaagacatcgctggtgactgcagtccaggc
atgagggagctgatagaagctgccctggagaggaaccccaaccaccgccccaaagcagca
gacctactgaaacatgaagccctgaatcccccaagagaggaccagccacgatgtcagagt
ctggactctgccctctttgaacggaagaggctgctgagcaggaaggaactacaacttcct
gagaacattgctgattcatcatgcacaggcagcaccgaagagtctgaagtgctcaggaga
cagcgttccctctacattgacctcggagctctggctggctacttcaatattgttcgtggg
ccaccaaccctggaatacggctga
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