Mus musculus (house mouse): 26419
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Entry
26419 CDS
T01002
Symbol
Mapk8, JNK, JNK1, Prkm8, SAPK1
Name
(RefSeq) mitogen-activated protein kinase 8
KO
K04440
mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase) [EC:
2.7.11.24
]
Organism
mmu
Mus musculus (house mouse)
Pathway
mmu01522
Endocrine resistance
mmu04010
MAPK signaling pathway
mmu04012
ErbB signaling pathway
mmu04014
Ras signaling pathway
mmu04024
cAMP signaling pathway
mmu04068
FoxO signaling pathway
mmu04071
Sphingolipid signaling pathway
mmu04137
Mitophagy - animal
mmu04140
Autophagy - animal
mmu04141
Protein processing in endoplasmic reticulum
mmu04210
Apoptosis
mmu04215
Apoptosis - multiple species
mmu04217
Necroptosis
mmu04310
Wnt signaling pathway
mmu04380
Osteoclast differentiation
mmu04510
Focal adhesion
mmu04530
Tight junction
mmu04620
Toll-like receptor signaling pathway
mmu04621
NOD-like receptor signaling pathway
mmu04622
RIG-I-like receptor signaling pathway
mmu04625
C-type lectin receptor signaling pathway
mmu04657
IL-17 signaling pathway
mmu04658
Th1 and Th2 cell differentiation
mmu04659
Th17 cell differentiation
mmu04660
T cell receptor signaling pathway
mmu04664
Fc epsilon RI signaling pathway
mmu04668
TNF signaling pathway
mmu04722
Neurotrophin signaling pathway
mmu04723
Retrograde endocannabinoid signaling
mmu04728
Dopaminergic synapse
mmu04750
Inflammatory mediator regulation of TRP channels
mmu04910
Insulin signaling pathway
mmu04912
GnRH signaling pathway
mmu04914
Progesterone-mediated oocyte maturation
mmu04917
Prolactin signaling pathway
mmu04920
Adipocytokine signaling pathway
mmu04926
Relaxin signaling pathway
mmu04930
Type II diabetes mellitus
mmu04931
Insulin resistance
mmu04932
Non-alcoholic fatty liver disease
mmu04933
AGE-RAGE signaling pathway in diabetic complications
mmu04935
Growth hormone synthesis, secretion and action
mmu04936
Alcoholic liver disease
mmu05010
Alzheimer disease
mmu05012
Parkinson disease
mmu05016
Huntington disease
mmu05017
Spinocerebellar ataxia
mmu05020
Prion disease
mmu05022
Pathways of neurodegeneration - multiple diseases
mmu05132
Salmonella infection
mmu05133
Pertussis
mmu05135
Yersinia infection
mmu05142
Chagas disease
mmu05145
Toxoplasmosis
mmu05152
Tuberculosis
mmu05161
Hepatitis B
mmu05162
Measles
mmu05166
Human T-cell leukemia virus 1 infection
mmu05167
Kaposi sarcoma-associated herpesvirus infection
mmu05169
Epstein-Barr virus infection
mmu05170
Human immunodeficiency virus 1 infection
mmu05171
Coronavirus disease - COVID-19
mmu05200
Pathways in cancer
mmu05208
Chemical carcinogenesis - reactive oxygen species
mmu05210
Colorectal cancer
mmu05212
Pancreatic cancer
mmu05231
Choline metabolism in cancer
mmu05415
Diabetic cardiomyopathy
mmu05417
Lipid and atherosclerosis
mmu05418
Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:
mmu00001
]
09120 Genetic Information Processing
09123 Folding, sorting and degradation
04141 Protein processing in endoplasmic reticulum
26419 (Mapk8)
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
26419 (Mapk8)
04012 ErbB signaling pathway
26419 (Mapk8)
04014 Ras signaling pathway
26419 (Mapk8)
04310 Wnt signaling pathway
26419 (Mapk8)
04668 TNF signaling pathway
26419 (Mapk8)
04068 FoxO signaling pathway
26419 (Mapk8)
04071 Sphingolipid signaling pathway
26419 (Mapk8)
04024 cAMP signaling pathway
26419 (Mapk8)
09140 Cellular Processes
09141 Transport and catabolism
04140 Autophagy - animal
26419 (Mapk8)
04137 Mitophagy - animal
26419 (Mapk8)
09143 Cell growth and death
04210 Apoptosis
26419 (Mapk8)
04215 Apoptosis - multiple species
26419 (Mapk8)
04217 Necroptosis
26419 (Mapk8)
09144 Cellular community - eukaryotes
04510 Focal adhesion
26419 (Mapk8)
04530 Tight junction
26419 (Mapk8)
09150 Organismal Systems
09151 Immune system
04620 Toll-like receptor signaling pathway
26419 (Mapk8)
04621 NOD-like receptor signaling pathway
26419 (Mapk8)
04622 RIG-I-like receptor signaling pathway
26419 (Mapk8)
04625 C-type lectin receptor signaling pathway
26419 (Mapk8)
04660 T cell receptor signaling pathway
26419 (Mapk8)
04658 Th1 and Th2 cell differentiation
26419 (Mapk8)
04659 Th17 cell differentiation
26419 (Mapk8)
04657 IL-17 signaling pathway
26419 (Mapk8)
04664 Fc epsilon RI signaling pathway
26419 (Mapk8)
09152 Endocrine system
04910 Insulin signaling pathway
26419 (Mapk8)
04920 Adipocytokine signaling pathway
26419 (Mapk8)
04912 GnRH signaling pathway
26419 (Mapk8)
04914 Progesterone-mediated oocyte maturation
26419 (Mapk8)
04917 Prolactin signaling pathway
26419 (Mapk8)
04926 Relaxin signaling pathway
26419 (Mapk8)
04935 Growth hormone synthesis, secretion and action
26419 (Mapk8)
09156 Nervous system
04728 Dopaminergic synapse
26419 (Mapk8)
04723 Retrograde endocannabinoid signaling
26419 (Mapk8)
04722 Neurotrophin signaling pathway
26419 (Mapk8)
09157 Sensory system
04750 Inflammatory mediator regulation of TRP channels
26419 (Mapk8)
09158 Development and regeneration
04380 Osteoclast differentiation
26419 (Mapk8)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
26419 (Mapk8)
05208 Chemical carcinogenesis - reactive oxygen species
26419 (Mapk8)
05231 Choline metabolism in cancer
26419 (Mapk8)
09162 Cancer: specific types
05210 Colorectal cancer
26419 (Mapk8)
05212 Pancreatic cancer
26419 (Mapk8)
09172 Infectious disease: viral
05166 Human T-cell leukemia virus 1 infection
26419 (Mapk8)
05170 Human immunodeficiency virus 1 infection
26419 (Mapk8)
05161 Hepatitis B
26419 (Mapk8)
05171 Coronavirus disease - COVID-19
26419 (Mapk8)
05162 Measles
26419 (Mapk8)
05167 Kaposi sarcoma-associated herpesvirus infection
26419 (Mapk8)
05169 Epstein-Barr virus infection
26419 (Mapk8)
09171 Infectious disease: bacterial
05132 Salmonella infection
26419 (Mapk8)
05135 Yersinia infection
26419 (Mapk8)
05133 Pertussis
26419 (Mapk8)
05152 Tuberculosis
26419 (Mapk8)
09174 Infectious disease: parasitic
05145 Toxoplasmosis
26419 (Mapk8)
05142 Chagas disease
26419 (Mapk8)
09164 Neurodegenerative disease
05010 Alzheimer disease
26419 (Mapk8)
05012 Parkinson disease
26419 (Mapk8)
05016 Huntington disease
26419 (Mapk8)
05017 Spinocerebellar ataxia
26419 (Mapk8)
05020 Prion disease
26419 (Mapk8)
05022 Pathways of neurodegeneration - multiple diseases
26419 (Mapk8)
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
26419 (Mapk8)
05418 Fluid shear stress and atherosclerosis
26419 (Mapk8)
05415 Diabetic cardiomyopathy
26419 (Mapk8)
09167 Endocrine and metabolic disease
04930 Type II diabetes mellitus
26419 (Mapk8)
04936 Alcoholic liver disease
26419 (Mapk8)
04932 Non-alcoholic fatty liver disease
26419 (Mapk8)
04931 Insulin resistance
26419 (Mapk8)
04933 AGE-RAGE signaling pathway in diabetic complications
26419 (Mapk8)
09176 Drug resistance: antineoplastic
01522 Endocrine resistance
26419 (Mapk8)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
mmu01001
]
26419 (Mapk8)
Enzymes [BR:
mmu01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.24 mitogen-activated protein kinase
26419 (Mapk8)
Protein kinases [BR:
mmu01001
]
Serine/threonine kinases: CMGC group
MAPK family [OT]
26419 (Mapk8)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Pkinase
PK_Tyr_Ser-Thr
Kdo
ABC1
RIO1
Kinase-like
FTA2
APH
Motif
Other DBs
NCBI-GeneID:
26419
NCBI-ProteinID:
NP_057909
MGI:
1346861
Ensembl:
ENSMUSG00000021936
UniProt:
Q91Y86
Q544A0
LinkDB
All DBs
Position
14:complement(33099855..33169213)
Genome browser
AA seq
384 aa
AA seq
DB search
MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP
FQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ
MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF
MMTPYVVTRYYRAPEVILGMGYKENVDLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQ
LGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSK
MLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEV
MDLEERTKNGVIRGQPSPLAQVQQ
NT seq
1155 nt
NT seq
+upstream
nt +downstream
nt
atgagcagaagcaaacgtgacaacaatttttatagtgtagagattggagattctacattc
acagtcctaaaacgataccagaatttaaagcctataggctcaggagctcaaggaatagtg
tgtgcagcttatgatgccattcttgaaagaaatgttgcaatcaagaagctcagccggcca
tttcagaatcagacccatgctaagcgcgcctaccgagaactagttcttatgaagtgtgtt
aatcacaaaaatataattggccttttgaatgttttcacaccacagaaatccctagaagaa
tttcaagatgtttacatagtcatggagctcatggatgcaaatctttgccaagtgattcag
atggagttagatcatgaaagaatgtcctaccttctctatcaaatgctgtgtggaatcaag
caccttcactctgctggaattattcatcgggacttaaagcctagtaatatagtagtcaaa
tcagactgcactttgaagattcttgattttggactggcgaggactgcaggaacgagtttt
atgatgacgccttatgtggtgactcgctactacagagcaccagaggtcattctcggcatg
ggctacaaggagaacgtggacttatggtctgtggggtgcattatgggagaaatggtttgc
cacaaaatcctctttccaggaagggactatattgatcagtggaataaagttattgaacag
ctcggaacaccttgtcctgaattcatgaagaaactacaaccaacagtaaggacttatgtt
gaaaacaggcctaaatacgctggatatagctttgagaaactgttccccgatgtgcttttc
ccagctgactcagagcataacaaacttaaagccagtcaggcaagagatttgttatccaaa
atgctagtaatagatgcatccaaaaggatctccgtagatgaagctctccagcacccatac
atcaacgtctggtatgatccttcagaagcagaagccccaccaccaaagatcccggacaag
cagttagatgagagggagcacacaatagaggagtggaaagaactgatatacaaggaggta
atggatttggaggaacgaactaagaatggagtcataagagggcagccgtctcctttagca
caggtgcagcaatga
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integrated database retrieval system
