Mus musculus (house mouse): 269254
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Entry
269254 CDS
T01002
Symbol
Setx, A130090N03, A930037J23Rik, AOA2, Als4, SCAR1, Sen1, mKIAA0625
Name
(RefSeq) senataxin
KO
K10706
ATP-dependent RNA/DNA helicase, senataxin [EC:
5.6.2.5
5.6.2.3
]
Organism
mmu
Mus musculus (house mouse)
Pathway
mmu05014
Amyotrophic lateral sclerosis
Brite
KEGG Orthology (KO) [BR:
mmu00001
]
09160 Human Diseases
09164 Neurodegenerative disease
05014 Amyotrophic lateral sclerosis
269254 (Setx)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03021 Transcription machinery [BR:
mmu03021
]
269254 (Setx)
Enzymes [BR:
mmu01000
]
5. Isomerases
5.6 Isomerases altering macromolecular conformation
5.6.2 Enzymes altering nucleic acid conformation
5.6.2.3 DNA 5'-3' helicase
269254 (Setx)
5.6.2.5 RNA 5'-3' helicase
269254 (Setx)
Transcription machinery [BR:
mmu03021
]
Eukaryotic type
RNA polymerase II system
Other transcription-related factors
Transcription termination factor
269254 (Setx)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
AAA_11
AAA_12
AAA_19
UvrD-helicase
AAA_30
AAA_22
ResIII
NAT10_TcmA_helicase
AAA_16
SLFN-g3_helicase
nSTAND3
Motif
Other DBs
NCBI-GeneID:
269254
NCBI-ProteinID:
NP_932150
MGI:
2443480
Ensembl:
ENSMUSG00000043535
UniProt:
A2AKX3
LinkDB
All DBs
Position
2:29013600..29072483
Genome browser
AA seq
2646 aa
AA seq
DB search
MSTCCWCTPGGSSTIDVLKRYASSTGSSEFQTADEDLCYCLECVAEYHRARDEVPFLHEV
LWELETLRLVSHFEKSMKAEAEDDDDLYIVDNNGEEQLFDCSGQDFENKLRVPLFEILKY
PYLLLHERVNELCVEALCRMEQNNCSFQVFDKYPGIYLFLVHPNEMVRRWAILTARNLGK
VDRDDYYDLQEVLTCLFKVIELGLLESPDIYTSSVLEKGKLILLPAHMYDTTNYKNYWLG
ICMLLTILEEQAMDSLLLGSDKQNDFMQSILHTMEKQSDDDSMDPFWPALHCFMVILDRL
GSKVWGQLIDPIEAFQTIINNESYNREIQNIRNSSIRTKLEPEPHFDDMVTCSQIVYNFN
PEKTKKDSGWRSAICPDYCPNMYEEMETLANVLQSDIGQDMRVHNSTFLWFIPFVQSLMD
LKDLGVAYIVEVIHHLYSEVKDVLNQTDAVCDKVTEFFILILISVIELHRNKKCLHLLWV
SSQQWVEAVVKCAKLPTTAFVRSCEKSPGSTSRGAAIMSSLALHSVQSNSVQLACVQLIR
GLLKEGYQLGQQTLCKRFWDKLNLFLRGNLSLGWQLTGQETHELQMCLKQIIRNIKFKMP
QYSTFGDSTSTFKTPPSFKEESDKIDRKHKKNIYCLENCSPVSSKEPMKADTHRVLMKVN
TTEEENFKQHYIDLNEEEQEPLPAELCLKQKSEALFSESAQEQVKISAEKSGKESSSYAP
SNSTSRNGPEWGCDRGVIMSAHSLTDSSSDFMEQVSTSNEDVSLKDGSVGKTSKPSFKLQ
KDEICAKLSHVIKKQIRKSTLVDNIIDLEENTAISDLENCSGTDGGALKEDSIGHNVPSD
PVLDDKHEEQKSQNSSLFKKEIKSEELDNSSSDDEDKLQIQEGRADDDLVSFTEVTDTLV
KAPCEGHVKMVVESRDKEMRESTALTSNLVEGQVPHDSSKPLVAGRQIDLCNITLISQTT
VIQFPSGLSKQNSFQLQKGDKRCLTANQNSAATCRGQVIVISDSDEEEDEDEDERSSSEE
NIKQSKACIGKDCSEHRSLAVNASVEKQLVKEEERYPVEFEDSESQVFEFESSSEVFSVW
QDHKIDSKNSLQGEQKSYVTHVADSTNNNLGCGDSVSEEVVRNKAEGVKEHAGPHSSVSA
EEFCKTGVKKPKRKRYDKVTAEDPQRPSSSVGTDQLPDRRDLTESDLKSADMGMATPSSS
VERDSTILQKSTKSRTHSKPVRKVPASKATKKTHSDTRRGQSKSSCYISCRTSPAIVPPK
KLRQCPEPTSTVEKLGLKKAPRKAFELSQRSLECIVQLRDHGKTVGVVDAPKKAKLISPQ
TLSIKNNKKLLTSQDLQFQRLMRSRSHKKRDFDYKNTDTVRVSRIVQGSDVLEADSDEPD
DHRVSEPLAISNEKQLAKCMLSKTEVAEASSDPWVTGITCLVNQCESRVLSGGVPTDVVM
VSASEDPVDGGAVTVQVGEVASVKAAEPASSSDTDDDDNLFLTQHDPQDMDLCSQLENKT
IIVAHKKDTVQREDSLSRPQLESLSITKCKYKDCVETTKNQGEYCPRHSEAKAADDGLFR
KPGLPLSVARPLRPTTTKIFSSSSASRTANLSKSLESTTLQQSALKNKSSGAQPNLKVTP
PSSMGSQKPVAEVKSLCNIFHFQTPSSSSKQSCKLTFSENRPTSAASPVNILLPSQSIFD
TFIKEVLKWKYQMFLNFDKCGAPTSLCQSISRPVPVRFQDCAEYFNVFLPLIILNAFETV
AQEWLSSPNKENFYQLQLRKFPADYKKYWEFLIYLNESELAKQLHPKENDLVFLAPEKSY
MDRHGMQDCSHYYCGYVHKFRRTSVMRSGKAECSLCIQTQDTLPASVKNLTRCIVISSLV
TTQRKLKAMSLLSSRNQLARAVLNPNPMDFCTKDLLTTTSERIVAYLKDFNEDQKKAIET
AYAMVKHSPSVAKICLIHGPPGTGKSKTIVGLLYRLLTENQRKGHSDENFNAKIKQNRVL
VCAPSNAAVDELMKKIILEFKEKCKDKKNPLGNCGDINLVRLGPEKSINTEVLKFSLDSQ
VNHRMKKDLPSHIQEMLRRKEILDAQLDELSRQRALCRGGREMQRQELDEHIAIVSKERQ
ELASKIKEVQGRPQRAQNTIILESHVICCTLSTSGGLLLESAFRGQGGVPFSCVIVDEAG
QSCEVETLSPLIHRCNKLILVGDPKQLPPTVISMKAQEYGYDQSMMARFCKLLEENVEQN
MIGRLPVLQLTIQYRMHPDICLFPSNYVYNKNLKTNRLTESIRCSSEWPFQPYLVFDVGD
GSERRDNDSYINVQEIKLVMEIIKLIKEKRKDISFRNIGIITHYKAQKTMIQKDLEKEFD
KKGPAEVDTVDAFQGRQKDCIIVTCVRASAVQGSIGFLASLQRLNVTITRAKYSLFILGH
LRTLMENQHWYELIQDAQKRGAIIKTSDPNYRHDAMKILKLKPVLQRSLTHPPATAPEAP
RPQGGLPSNRLDSGLATTSFAASLYHTPSDTVTSKGPERPLLQDRLRDPRLLRRLDAEAK
GTFLKDPQPVSPQLPGVVHLLGEPGFPVVFQDLGFVVPPSTAIVAPLGSHRSPMQAEPPP
AHPAAAASTSKRKYSDPDAGLSHKREPRAFSGEQGRHGSVTHHVLRSTDWDRRRLDDSSA
KRRQFL
NT seq
7941 nt
NT seq
+upstream
nt +downstream
nt
atgagcacatgctgttggtgtactccaggtgggtcttccaccattgatgtcctaaagcgc
tatgcatctagcactgggtcaagtgaatttcagacagctgatgaagacctctgctactgc
ttagagtgtgtggctgagtaccaccgagccagagatgaggtgccgttcttgcacgaggtt
ttatgggagctagaaaccttacgcctcgtaagtcactttgagaagtccatgaaggcagaa
gctgaagatgacgatgatttatatatagtagacaacaatggagaggaacagctgtttgac
tgtagtggccaagattttgaaaataagcttcgagttcctctttttgaaatactgaagtac
ccttacttgcttctgcatgagcgtgttaatgaactgtgtgtggaagcgctttgccgaatg
gaacaaaacaattgctcctttcaggtttttgacaaatatccaggcatctatttgtttttg
gttcatcccaatgaaatggttcggcgatgggctattctgactgcaagaaacctggggaag
gtggacagagatgactattatgacttacaggaagttttaacttgcctttttaaagtcatt
gagctggggcttttggaaagtccagacatttacacatcttctgtgcttgaaaaaggcaaa
ctgatccttttgcctgcacacatgtatgatactaccaactacaaaaactattggctaggt
atttgcatgttgttgactattcttgaggagcaagccatggattcactgttgctgggctca
gacaagcaaaatgattttatgcaatcaattcttcacaccatggagaagcaatcggatgat
gatagcatggatcctttttggccagcattacactgtttcatggtgattcttgatcgcctt
ggatctaaggtatggggtcaacttattgaccctattgaagcatttcaaaccatcattaac
aacgagagctacaacagagagatccagaatatacggaacagctccataaggaccaagtta
gaaccggagccacattttgatgatatggtgacgtgcagccagattgtttataactttaat
cctgaaaagaccaaaaaggattctgggtggagatcagccatttgtccagattattgtcca
aacatgtatgaagaaatggaaacattagccaatgtacttcagtcagatattggtcaagat
atgcgtgttcataacagcacctttctgtggttcataccttttgttcagtcactcatggat
cttaaggatttgggtgtggcttacatagtagaagttattcatcatctatactcagaagtc
aaagatgtcctcaaccagacagatgctgtgtgtgacaaagtcactgaattttttattctg
attttaatatcagtgattgagctgcatagaaataaaaaatgcttgcatctgctgtgggtg
agttctcagcagtgggtagaagctgttgtgaagtgtgccaagcttcctactaccgcattt
gtccggagttgtgagaagtcacctggaagtacctccagaggagcagcaataatgtcgtcc
ttggcgttgcattcggtgcagtctaactctgtccagcttgcttgtgtacagttgattaga
ggtctcctcaaagaaggttatcagcttggtcagcaaacactttgtaagcggttctgggat
aagcttaacttattccttcgaggaaatttgtctctgggttggcaattgactggtcaagaa
acccatgagttacaaatgtgtttgaaacaaataattagaaacataaaattcaaaatgccc
caatatagcacttttggggattcaacttctacatttaaaacccctccatcttttaaagaa
gaaagtgataaaatagacaggaagcataaaaaaaacatttattgtttggaaaattgcagt
ccagtgtcttctaaagagccaatgaaagctgacacccatcgagtattgatgaaagtaaat
actacagaagaggagaacttcaagcagcattacattgatttgaatgaagaagagcaagag
cctcttccagctgagttgtgcttgaagcagaaaagtgaggcccttttttctgaaagtgct
caagagcaagttaaaattagcgcagagaagtctgggaaagaaagctcttcatatgcacca
tcaaatagtacttcaagaaatggtccagaatggggatgtgacagaggagtgataatgtca
gcacattcattgactgattctagcagtgattttatggaacaggtatctacatcaaatgaa
gatgtctcattaaaggatggctctgttggtaaaacttcaaaaccaagtttcaaattacag
aaagatgaaatttgtgcaaagttatcacatgtcataaagaagcaaatcaggaaaagtact
ttggtagataatattatcgatctagaggaaaatacagctatatctgaccttgagaactgt
tcaggaacagatggaggagctctaaaggaagatagtattggacacaatgtcccttcagac
cctgttctggatgacaagcatgaagagcaaaaatctcaaaacagttcattattcaagaaa
gagataaagagtgaggagttggataatagtagttctgatgatgaagacaagcttcaaatc
caggaaggccgtgctgacgatgatttggtatcatttacagaagttactgatacactggtg
aaagctccatgtgagggtcatgtaaagatggtagttgaatcaagagataaggaaatgaga
gagagtacagcgttgacttctaacttggtagaaggacaggtgcctcatgacagtagcaag
cctttggttgcaggtcgtcaaatagacctctgtaacataactttaatatctcaaaccact
gttattcaatttccatcaggtttaagtaaacagaattcatttcagctacaaaaaggtgat
aaaagatgtttgacagctaaccaaaacagtgctgccacctgccgtggacaagttattgtg
atttcagattctgacgaagaagaggatgaggatgaagatgaaagaagtagtagtgaggaa
aacatcaaacagagtaaagcatgcatagggaaagactgctcagagcatcgtagcttggca
gttaatgccagtgtggagaagcagcttgtaaaagaggaagaaaggtaccctgtagaattt
gaagactctgaatctcaggtttttgagtttgaaagctcatctgaagtcttttcagtttgg
caagatcataaaatagacagcaaaaactcccttcaaggggaacagaagagctatgtaact
catgtagctgatagtacaaacaataacttgggttgtggtgactctgtgtctgaagaggtt
gttagaaacaaagcagagggagttaaagagcatgcaggaccacatagtagtgtttctgct
gaggaattttgtaaaactggagtaaaaaaacctaagaggaaacgctatgacaaagttaca
gctgaagatcctcagaggccttcctcttctgttggaactgatcaattgcctgatcgcaga
gatcttactgaaagtgatttaaagagtgcagacatggggatggcaactcccagttcaagt
gttgagagagattctacaattttacagaagtctacaaaatctcgaactcactcaaaacct
gttaggaaagttccagcctctaaggcaactaagaaaacacattcagacaccagaagagga
cagtctaagagttcatgttacataagttgtagaacttctcctgctattgtgccaccaaag
aagcttcgtcagtgtccagagccaacttcaacagttgaaaaacttggtctgaaaaaagcc
cctaggaaggcatttgagttgtcccagaggtctctggagtgtatagtccaattacgtgac
cacgggaagactgttggagtagttgacgcccccaagaaagctaaattaatttctcctcag
actctttctatcaaaaataataagaagcttctgacaagccaggatcttcaatttcaaagg
cttatgagatccagatcacataaaaaacgagactttgattacaaaaatactgatactgta
agagtgtcacgcatagtacagggatcagatgtacttgaagcagactctgatgagccagat
gatcatagagtaagtgagccacttgccatcagtaatgaaaaacagttagcaaaatgcatg
ctttccaaaacagaagtggcagaagcctcttctgatccttgggtgacaggtataacttgt
cttgtgaaccagtgtgaatctagagtgttaagtggaggagtgccaacagatgtggtgatg
gtctctgcttcagaggaccctgtggatggaggtgctgtcacagttcaagttggggaggtg
gcatctgtgaaagctgcagagccagcgtctagtagtgatacagatgatgatgacaactta
ttcctaacacaacatgatcctcaagatatggatctgtgctcacagttggaaaataaaacc
attatcgtggctcataaaaaagatacagttcagagagaagattctttaagtcggcctcag
ttggagtctttgagtatcacaaagtgtaaatacaaagactgtgtcgaaactacaaaaaac
cagggtgaatactgcccaagacactctgaagctaaagcagcagatgacggcctgttccgt
aaacctggcttgcctctttctgtagccaggcccttgagacctactactaccaagatattt
agctcaagcagcgcttcacgaactgccaatctttccaagtctttggaaagtactacactt
cagcagtcagcactaaaaaataagtcaagtggagcgcagcctaatttgaaggtgacacca
ccctcttccatgggttctcagaagccagtggctgaggtgaaaagtctatgcaatattttt
cattttcagactccaagcagttccagcaaacagagttgcaagcttacatttagtgagaac
aggcctacatcagctgcttctccagtgaatattctcttgccatcgcagtctatctttgac
accttcattaaagaggtcttaaaatggaaataccaaatgtttttgaactttgataagtgt
ggtgctccaacaagtctctgtcagtctatctcaagacctgtgcctgtccgatttcaagat
tgtgcagaatattttaatgtttttctacctttgattatattgaatgcttttgaaacagtg
gcacaggaatggctgagctctccaaataaagagaatttctatcagttgcaattacgaaaa
tttccagctgactataaaaaatactgggagtttctgatttacttgaacgaatctgaactt
gctaaacagcttcacccaaaggaaaatgatctggtgtttctggctcctgagaagagttat
atggacaggcatggcatgcaagattgcagtcactattactgtggctatgttcataagttt
cgtcgcacttcagttatgcgcagtgggaaagctgagtgttcattatgcatacagacacaa
gataccttgccagccagtgtaaaaaatcttacaagatgcattgtgatcagttctctggta
actacacagaggaaattgaaagccatgtctctgttgagtagtcggaaccagttggccaga
gctgttctaaatccaaaccccatggacttctgtaccaaagatctactaactacaacttct
gaaagaattgttgcctacttaaaagactttaatgaagaccaaaagaaagccatagaaact
gcatatgccatggtgaaacactcaccatccgttgccaaaatctgtctgattcatggacca
cctggaacaggaaaatccaaaactattgttggtctcttgtaccgcttactgacagagaac
cagaggaagggccattcagatgaaaatttcaatgccaaaatcaaacaaaatcgagtcctc
gtgtgtgcaccttccaatgcggcggttgatgaacttatgaaaaaaattatcctcgaattt
aaagaaaaatgtaaagacaagaagaatcctttgggaaactgtggagatataaatttagta
cgactaggtccagaaaagtctattaatacagaggtcttaaaattcagtttggacagccaa
gtcaaccatagaatgaaaaaagacttgccttctcatattcaagaaatgcttagaagaaaa
gaaattctagatgctcaacttgatgagctttctcgtcagcgagctctgtgccgaggtggg
cgggagatgcagaggcaagaattagatgaacacattgccatagtctcaaaagaaaggcaa
gaacttgcttcgaaaattaaagaggttcagggacgcccacagagagcacagaataccatc
atcttggagtcccatgtcatctgctgcacattgagcactagtggtggtttattgcttgag
tctgcttttcgagggcaagggggtgtccccttcagttgtgtcatcgtagatgaggctggg
cagtcttgtgaagttgagacactttctccactcatccaccgctgcaataaacttatccta
gtaggagaccccaaacagctccctcccacagtcatctctatgaaagcacaggagtatggc
tatgaccagtcgatgatggcccgattctgcaagctgctggaagagaatgtggagcagaac
atgattggcaggctgccggtgttacagcttaccattcagtacaggatgcatccagacata
tgtcttttcccttctaattacgtttataacaaaaacctgaagacaaatagattgactgaa
tccattcgatgttcatcagagtggccatttcagccctacctcgtgtttgatgttggagat
ggttcagaacgacgggataatgactcatatataaatgttcaagaaataaagttggtgatg
gaaataattaaacttattaaagagaaaagaaaagatatttccttccgaaatattggcata
ataacccattacaaggctcagaagacgatgatccagaaggatttggagaaagaatttgat
aagaaaggacctgcagaagtggacacagtagatgccttccagggccggcagaaagactgt
atcatcgttacctgtgtcagggcaagtgctgtgcaaggctcaataggattcctggcaagt
ttgcagagattgaatgtcaccattacacgagccaagtatagcctctttatccttggacat
ttgaggactctgatggaaaaccagcattggtatgaactgattcaggatgctcagaagcgt
ggggccattattaagaccagtgacccaaactatagacatgacgcaatgaagattctgaaa
ctgaagcctgtgctacagaggagtctgacccatcccccagccactgccccggaggcaccc
agaccccagggtggcttgcccagcaacagactggacagtggacttgccacaacatctttt
gctgcttctttgtatcacacaccctctgatactgtcacttcaaagggacctgaaaggcca
cttcttcaagaccgacttcgagatccacgactactcaggagattggatgctgaagccaag
ggaacattcctgaaggatccacagcccgttagcccccagctccccggggtagttcatctc
ttgggagagcctggcttccctgtggttttccaggacctaggttttgttgtgccgccatcc
actgccattgttgctcctctgggcagccacaggtcacctatgcaggctgagccaccacct
gctcaccctgctgctgccgcctccacaagtaagaggaagtacagtgacccagatgctggg
ctcagccacaaaagagaacccagggccttcagtggagagcaggggaggcatggctctgtg
actcatcacgtgctgagaagcactgactgggacaggaggaggctggatgacagcagtgcc
aagaggagacaatttctatag
DBGET
integrated database retrieval system
