Mus musculus (house mouse): 54721 Help Entry 54721             CDS       T01002                                  Symbol Tyk2, JTK1 Name (RefSeq) tyrosine kinase 2   KO K11219   non-receptor tyrosine-protein kinase TYK2 [EC:2.7.10.2] Organism mmu  Mus musculus (house mouse) Pathway mmu04217   Necroptosis mmu04380   Osteoclast differentiation mmu04620   Toll-like receptor signaling pathway mmu04621   NOD-like receptor signaling pathway mmu04630   JAK-STAT signaling pathway mmu04658   Th1 and Th2 cell differentiation mmu04659   Th17 cell differentiation mmu05145   Toxoplasmosis mmu05160   Hepatitis C mmu05161   Hepatitis B mmu05162   Measles mmu05164   Influenza A mmu05165   Human papillomavirus infection mmu05167   Kaposi sarcoma-associated herpesvirus infection mmu05168   Herpes simplex virus 1 infection mmu05169   Epstein-Barr virus infection mmu05171   Coronavirus disease - COVID-19 Brite KEGG Orthology (KO) [BR:mmu00001]  09130 Environmental Information Processing   09132 Signal transduction    04630 JAK-STAT signaling pathway     54721 (Tyk2)  09140 Cellular Processes   09143 Cell growth and death    04217 Necroptosis     54721 (Tyk2)  09150 Organismal Systems   09151 Immune system    04620 Toll-like receptor signaling pathway     54721 (Tyk2)    04621 NOD-like receptor signaling pathway     54721 (Tyk2)    04658 Th1 and Th2 cell differentiation     54721 (Tyk2)    04659 Th17 cell differentiation     54721 (Tyk2)   09158 Development and regeneration    04380 Osteoclast differentiation     54721 (Tyk2)  09160 Human Diseases   09172 Infectious disease: viral    05161 Hepatitis B     54721 (Tyk2)    05160 Hepatitis C     54721 (Tyk2)    05171 Coronavirus disease - COVID-19     54721 (Tyk2)    05164 Influenza A     54721 (Tyk2)    05162 Measles     54721 (Tyk2)    05168 Herpes simplex virus 1 infection     54721 (Tyk2)    05167 Kaposi sarcoma-associated herpesvirus infection     54721 (Tyk2)    05169 Epstein-Barr virus infection     54721 (Tyk2)    05165 Human papillomavirus infection     54721 (Tyk2)   09174 Infectious disease: parasitic    05145 Toxoplasmosis     54721 (Tyk2)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:mmu01001]     54721 (Tyk2) Enzymes [BR:mmu01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.2  non-specific protein-tyrosine kinase      54721 (Tyk2) Protein kinases [BR:mmu01001]  Non-receptor tyrosine kinases   JAK family [OT]    54721 (Tyk2) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  PK_Tyr_Ser-Thr Pkinase Jak1_Phl FERM_F2 FERM_F1 SH2_1 Kinase-like Kdo Motif Other DBs NCBI-GeneID:  54721 NCBI-ProteinID:  NP_061263 MGI:  1929470 Ensembl:  ENSMUSG00000032175 UniProt:  Q9R117 Structure PDBPDBj LinkDB All DBs Position 9:complement(21015364..21042689) Genome browser AA seq 1184 aa AA seqDB search MVGTMPLCGRRAILEDSKADGTEAQPLVPTGCLMVLLHWPGPEGGEPWVTFSQTSLTAEE VCIHIAHKVGITPPCLNLFALYNAQAKVWLPPNHILDTSQDMNLYFRMRFYFRNWHGMNP QEPAVYRCGFPGAETSSDRAEQGVQLLDSASFEYLFEQGKHEFMNDVVSLRDLSSEEEIH HFKNESLGMAFLHLCHLALSRGVPLEEMAREISFKNCIPHSFRQHIRQHNVLTRLRLHRV FRRFLRAFRPGHLSQQVVMVKYLATLERLAPRFGSERIPVCHLEVLAQPERDPCYIQNSG QTAGDPGPELPSGPPTHEVLVTGTGGIQWHPLQTQESERGNSRGNPHGSRSGKKPKAPKA GEHLTESPQEPPWTYFCDFQDISHVVLKERRVHIHLQDNKCLLLCLCSQAEALSFVALVD GYFRLTADSSHYLCHEVAPPRLVTSIQNGIHGPLMDPFVQAKLWPEDGLYLIQWSTSHLH RLILTVAHRNPAFSNGPRGLRLRKFPITQQPGAFVLDGWGRSFASLGDLRLALQGCSLRA GDDCFPLHHCCLPRPREISNLVIMRGSRAHTRPLNLSQLSFHRVHQDEITQLSHLGQGTR TNVYEGLLRVGGPDEGKVDNGCPPEPGGTSGQQLRVVLKVLDPSHHDIALAFYETASLMS QVSHMHLAFLHGVCVRGSENIIVTEFVEHGPLDVWLRRQRGQVPMTWKMVVAQQLASALS YLEDKNLVHGNVCGRNILLARLGLEEGTNPFIKLSDPGVGQGALSREERVERIPWTAPEC LSGGTSSLGTATDMWGFGATLLEICFDGEAPLQGRGPSEKERFYTKKHQLPEPSSPELAT LTRQCLTYEPAQRPSFRTILRDLTRLQPQNLVGTSAVNSDSPASDPTVFHKRYLKKIRDL GEGHFGKVSLYCYDPTNDGTGEMVAVKALKEGCGPQLRSGWQREIEILRTLYHEHIVKYK GCCEDQGEKSVQLVMEYVPLGSLRDYLPRHCVGLAQLLLFAQQICEGMAYLHAQHYIHRD LAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKECKFYYASD VWSFGVTLYELLTYCDSNQSPHMKFTELIGHTQGQMTVLRLTELLERGERLPRPDRCPCE IYHLMKNCWETEASFRPTFQNLVPILQTAQEKYQGQVPSVFSVC NT seq 3555 nt NT seq  +upstreamnt  +downstreamnt atggtggggaccatgcctctgtgtgggcggagagccatcttggaagacagcaaggcagat ggcacagaagctcagcccctggtgcccacaggatgcttgatggtgctactgcattggcct gggcctgagggcggggagccctgggtcaccttcagccagacatctctgactgcagaggag gtctgcatccacatcgcacacaaagtcggcatcactccaccctgcttgaatctcttcgca ctctacaatgcacaggctaaggtctggctgcccccaaaccatattctggatacatcccaa gacatgaacctctattttcgaatgaggttttacttccggaactggcatggcatgaatccc caggagccagctgtataccggtgtggtttcccaggggcagagacttcctcagaccgggca gagcaaggtgtacagctcttggactctgcctcgtttgaatacctttttgagcagggaaag catgagttcatgaacgatgtggtgtctctgcgggacctgtctagcgaggaggagatccac cactttaagaatgagagcttaggcatggccttcctgcacctgtgtcaccttgctctcagc cgaggcgtccccctggaggagatggccagagagatcagcttcaagaactgcatccctcat tccttccgacagcacatccggcagcacaatgtgctcacacgcctgcggctccacagagtc ttccgccgcttcctgcgggccttccggcctggccacctctcccagcaggttgtgatggtg aagtacttggctaccctggagcggctggctccgcgctttggctcagagcgcatacctgtg tgtcatctggaggtcctggcacagcccgagagggacccctgctacatccagaacagtggg cagaccgctggggatccaggcccagagctgccttccgggcctcccacccacgaggtactg gtgacaggcaccggaggtatccagtggcatccgctgcagacccaggaatctgagagaggt aacagcagagggaatccccacggcagccggtcggggaagaagcccaaagcccccaaggct ggagagcacctgacagagagccctcaggaaccaccttggacctacttctgtgacttccag gacatttcccacgtggtgctaaaggagcgtcgcgtgcacatccacctccaagacaacaag tgcttgttgctgtgcctctgttcccaggctgaggccctgtcctttgtggccctggtcgat ggctatttccgcttgactgctgactccagccactatctgtgccatgaggtggcacccccg aggctggtgactagcatccagaacggcatccatgggcccctgatggatccgtttgtacag gccaagctgtggccagaggacggcctctacctgattcagtggagcaccagccacctgcac cgcctgatccttaccgtggcccatcgaaacccggctttcagtaatggccctcggggcctg cgcctgcgaaagttccccatcacacagcagcctggagcctttgtgctggatggctggggc cgctcctttgccagcttgggggaccttcggctcgccttgcagggctgctcgttgcgggcc ggtgatgactgtttccccctgcaccactgctgcctgccccggccaagagaaatctccaac ctcgtcatcatgcgggggtctagggcccacacccggcctctcaacctcagtcagctcagc ttccacagggttcaccaggatgaaatcacccagctgtcccacttgggccaaggcacaagg accaatgtgtatgagggccttctaagagtgggaggccccgatgagggcaaagtggacaat ggatgtccccctgagcctggtgggactagtgggcagcagcttcgagtggtgctcaaagtt ctcgaccccagtcaccatgatatcgccttggccttctatgagactgctagcctcatgagc caggtgtcacacatgcacctggctttcctgcatggtgtttgcgtgcgtggctcagagaat atcattgtgacagaattcgtagaacatggtcccttggatgtgtggttacggcgacagagg ggccaagtgcccatgacctggaagatggtcgtggctcagcagctggccagcgccctcagc tacctggaggacaagaatctggttcacgggaatgtatgtggccggaacatcctgctggct cgcctggggttggaggagggtaccaaccccttcatcaagctaagtgatcctggtgtgggc cagggtgccctctccagggaagagcgggtggagcgcatcccctggacagctcccgagtgc ctgtctggagggaccagtagcttgggtactgccacggacatgtggggctttggtgccacc cttcttgagatctgctttgatggggaggcacccctgcagggtcgtggtccctctgagaaa gaacggttctacacaaagaaacatcagctgcctgaaccctcatccccagagctggccaca ctcacccgccagtgcctgacctatgaaccagcacagcggccatccttccgcaccattttg cgggacctcacaaggctgcagccacagaatctagtcggcacttcggctgtgaactcagac tcaccagcatcagaccccactgttttccacaagcgctatttgaaaaagatccgggatttg ggtgagggtcactttggcaaggtcagcctgtactgctacgacccaaccaatgacggcact ggcgagatggtggccgtgaaggccctgaaggaagggtgcggtccccagctccgctcaggc tggcagcgggagatcgagatcctgcggacgctgtaccacgaacatattgtcaagtataaa ggctgctgtgaggaccaaggagagaagtctgtacagctggtcatggagtacgtccctctg ggcagcctccgagactacctgccaaggcactgcgtagggctggcgcagctcctgctgttt gcccagcagatctgcgagggcatggcctacctgcacgctcagcactacattcaccgagac ctcgccgcgcgcaacgtgctgctggacaacgacaggctggtcaagattggagactttggc ctagccaaggctgtacctgaaggccacgagtactaccgagtgcgcgaggacggggacagc ccagtgttctggtatgccccagaatgcctgaaggagtgcaaattttactatgcatctgat gtctggtccttcggggtaactctgtatgagttgttgacatactgtgactctaaccagagt ccccatatgaaattcaccgagctcatcggccatacccagggccagatgaccgtgctgagg ctcacagagctgctggaacgaggagagaggctgcctcggcctgacaggtgtccctgtgag atctatcacctcatgaagaactgctgggagacagaggcctccttccggcccaccttccag aatcttgtgcccatcctccagacagcacaggagaagtaccaaggtcaggtgccttccgtg ttcagcgtgtgctga

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