Mus musculus (house mouse): 66725
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Entry
66725 CDS
T01002
Symbol
Lrrk2, 4921513O20Rik, 9330188B09Rik, D630001M17Rik, Gm927, cI-46
Name
(RefSeq) leucine-rich repeat kinase 2
KO
K08844
leucine-rich repeat kinase 2 [EC:
2.7.11.1
]
Organism
mmu
Mus musculus (house mouse)
Pathway
mmu05012
Parkinson disease
mmu05022
Pathways of neurodegeneration - multiple diseases
Brite
KEGG Orthology (KO) [BR:
mmu00001
]
09160 Human Diseases
09164 Neurodegenerative disease
05012 Parkinson disease
66725 (Lrrk2)
05022 Pathways of neurodegeneration - multiple diseases
66725 (Lrrk2)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
mmu01001
]
66725 (Lrrk2)
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:
mmu04131
]
66725 (Lrrk2)
09183 Protein families: signaling and cellular processes
04147 Exosome [BR:
mmu04147
]
66725 (Lrrk2)
Enzymes [BR:
mmu01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.1 non-specific serine/threonine protein kinase
66725 (Lrrk2)
Protein kinases [BR:
mmu01001
]
Serine/threonine kinases: TKL group
LRRK family
66725 (Lrrk2)
Membrane trafficking [BR:
mmu04131
]
Exocytosis
Calcium ion-dependent exocytosis
Kinases and associated proteins
66725 (Lrrk2)
Exosome [BR:
mmu04147
]
Exosomal proteins
Exosomal proteins of other body fluids (saliva and urine)
66725 (Lrrk2)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
ARM_LRRK2
Beta-prop_LRRK2
ANK_LRRK2
Pkinase
PK_Tyr_Ser-Thr
LRR_8
LRR_4
Roc
COR-B
Ras
COR-A
LRR_1
LRR_14
WD40_CDC20-Fz
Beta-prop_RSE1_2nd
WDR55
Beta-prop_WDR36-Utp21_1st
LRR_NXF1-5
Arf
LRR_9
Beta-prop_EML_2
Ank_2
ABC_tran
LRR_13
T2SSE
AAA_22
Ank_3
PduV-EutP
Beta-prop_WDR5
MMR_HSR1
nSTAND3
GTP_EFTU
G-alpha
AAA_16
AAA_7
Kdo
Arm
TniB
MobB
WD40_Prp19
WD40_WDHD1_1st
NACHT
AAA_29
NB-ARC
FtsK_SpoIIIE
TrwB_AAD_bind
cobW
AAA_18
nSTAND_NTPase5
Ank_5
LRR_6
ARM_CUL7_CUL9
Motif
Other DBs
NCBI-GeneID:
66725
NCBI-ProteinID:
NP_080006
MGI:
1913975
Ensembl:
ENSMUSG00000036273
UniProt:
Q5S006
Q9CQG8
LinkDB
All DBs
Position
15:91556994..91700327
Genome browser
AA seq
2527 aa
AA seq
DB search
MASGACQGCEEEEEEEALKKLIVRLNNVQEGKQIETLLQLLEDMLVFTYSDRASKLFEDK
NFHVPLLIVLDSYMRVASVQQAGWSLLCKLIEVCPGTLQSLIGPQDIGNDWEVLGIHRLI
LKMLTVHHANVNLSIVGLKALDLLLDSGKLTLLILDEECDIFLLIFDAMHRYSANDEVQK
LGCKALHVLFERVSEEQLTEFVENKDYTILLSTFGSFRRDKEIVYHVLCCLHSLAVTCSN
VEVLMSGNVRCYNLVVEAMKAFPTNENIQEVSCSLFQKLTLGNFFNILVLNEVHVFVVKA
VRQYPENAALQISALSCLALLTETIFLNQDLEERSETQEQSEEEDSEKLFWLEPCYKALV
RHRKDKHVQEAACWALNNLLMYQNSLHEKIGDEDGQFPAHREVMLSMLMHSSSKDVFQAA
AHALSTLLEQNVNFRKILLAKGVYLNVLELMQKHAHAPEVAESGCKMLSHLFEGSNPSLD
TMAAVVPKILTVMKAHGTSLSVQLEALRAILHFVVPGLLEESREDSQCRPNVLRKQCFRT
DIHKLVLVALNRFIGNPGIQKCGLKVISSLAHLPDATETLSLQGAVDSVLHTLQMYPDDQ
EIQCLGLHLMGCLMTKKNFCIGTGHLLAKILASTLQRFKDVAEVQTTGLQTTLSILELSV
SFSKLLVHYSFDVVIFHQMSSSVVEQKDEQFLNLCCKCFAKVAVDDELKNTMLERACDQN
NSIMVECLLLLGADANQVKGATSLIYQVCEKESSPKLVELLLNGGCREQDVRKALTVSIQ
KGDSQVISLLLRKLALDLANNSICLGGFGIGKIDPSWLGPLFPDKSSNLRKQTNTGSVLA
RKVLRYQMRNTLQEGVASGSDGKFSEDALAKFGEWTFIPDSSMDSVFGQSDDLDSEGSES
SFLVKRKSNSISVGEVYRDLALQRCSPNAQRHSNSLGPVFDHEDLLRRKRKILSSDESLR
SSRLPSHMRQSDSSSSLASEREHITSLDLSANELKDIDALSQKCCLSSHLEHLTKLELHQ
NSLTSFPQQLCETLKCLIHLDLHSNKFTSFPSFVLKMPRITNLDASRNDIGPTVVLDPAM
KCPSLKQLNLSYNQLSSIPENLAQVVEKLEQLLLEGNKISGICSPLSLKELKILNLSKNH
IPSLPGDFLEACSKVESFSARMNFLAAMPALPSSITSLKLSQNSFTCIPEAIFSLPHLRS
LDMSHNNIECLPGPAHWKSLNLRELIFSKNQISTLDFSENPHVWSRVEKLHLSHNKLKEI
PPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPLDGLHLNFDFKHVGCKAKDIIR
FLQQRLKKAVPYNRMKLMIVGNTGSGKTTLLQQLMKMKKPELGMQGATVGIDVRDWSIQI
RGKRRKDLVLNVWDFAGREEFYSTHPHFMTQRALYLAVYDLSKGQAEVDAMKPWLFNIKA
RASSSPVILVGTHLDVSDEKQRKACISKITKELLNKRGFPTIRDYHFVNATEESDALAKL
RKTIINESLNFKIRDQPVVGQLIPDCYVELEKIILSERKAVPTEFPVINRKHLLQLVNEH
QLQLDENELPHAVHFLNESGVLLHFQDPALQLSDLYFVEPKWLCKVMAQILTVKVDGCLK
HPKGIISRRDVEKFLSKKKRFPKNYMMQYFKLLEKFQIALPIGEEYLLVPSSLSDHRPVI
ELPHCENSEIIIRLYEMPYFPMGFWSRLINRLLEISPFMLSGRERALRPNRMYWRQGIYL
NWSPEAYCLVGSEVLDNRPESFLKITVPSCRKGCILLGRVVDHIDSLMEEWFPGLLEIDI
CGEGETLLKKWALYSFNDGEEHQKILLDELMKKAEEGDLLINPDQPRLTIPISQIAPDLI
LADLPRNIMLNNDELEFEEAPEFLLGDGSFGSVYRAAYEGEEVAVKIFNKHTSLRLLRQE
LVVLCHLHHPSLISLLAAGIRPRMLVMELASKGSLDRLLQQDKASLTRTLQHRIALHVAD
GLRYLHSAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRA
PEVARGNVIYNQQADVYSFGLLLHDIWTTGSRIMEGLRFPNEFDELAIQGKLPDPVKEYG
CAPWPMVEKLITKCLKENPQERPTSAQVFDILNSAELICLMRHILIPKNIIVECMVATNL
NSKSATLWLGCGNTEKGQLSLFDLNTERYSYEEVADSRILCLALVHLAAEKESWVVCGTQ
SGALLVINVEEETKRHTLEKMTDSVTCLHCNSLAKQSKQSNFLLVGTADGNLMIFEDKAV
KCKGAAPLKTLHIGDVSTPLMCLSESLNSSERHITWGGCGTKVFSFSNDFTIQKLIETKT
NQLFSYAAFSDSNIIALAVDTALYIAKKNSPVVEVWDKKTEKLCELIDCVHFLKEVMVKL
NKESKHQLSYSGRVKALCLQKNTALWIGTGGGHILLLDLSTRRVIRTIHNFCDSVRAMAT
AQLGSLKNVMLVLGYKRKSTEGIQEQKEIQSCLSIWDLNLPHEVQNLEKHIEVRTELADK
MRKTSVE
NT seq
7584 nt
NT seq
+upstream
nt +downstream
nt
atggccagtggcgcctgtcagggctgcgaagaggaagaggaggaggaggctctgaagaag
ttgatagtcaggctgaataatgtccaggaaggcaagcagatcgagacgttgcttcagctc
ctggaggacatgctggtgttcacctactcggaccgcgcctccaagttatttgaagataaa
aatttccacgtgcctctgttgattgtcctggactcctacatgagagttgccagtgtacag
caggcggggtggtcacttctgtgcaaattaatagaagtctgtccagggacattgcaaagc
ttaataggaccccaggatattggaaatgattgggaagtccttggtattcaccggctgatt
cttaaaatgttaactgttcatcacgccaatgtaaacctgtcaatagttggactaaaagcc
ttggatctcctcctagattcaggtaaactcaccttgctgatactggatgaagaatgtgat
attttcttgttaatttttgatgccatgcacagatattcagccaatgatgaagtccaaaaa
ctgggatgcaaagctttacacgtgctttttgagagagtttccgaggaacagctgactgag
tttgtggagaacaaagattacacgatactgctgagtacgttcggcagcttcagaagggac
aaggagattgtgtaccacgtactttgctgcttgcattccctggcggttacatgcagcaat
gtagaggtcctcatgagtgggaatgtccggtgctacaatcttgtggtggaggccatgaaa
gccttccccaccaatgaaaacatccaagaggtgagctgctccttgttccagaagcttaca
ttaggtaactttttcaacatcctggtgttgaacgaagtgcatgtctttgtggtgaaagcg
gtccgacagtatcctgagaacgcagccttacagatctctgcactcagctgtttagcactc
ctcactgagactattttcttaaaccaagacttggaggaaagaagtgagactcaagagcag
agcgaagaggaagacagtgagaagcttttctggctggaaccctgctataaagccctggtg
cgccatcgaaaggacaaacacgtgcaggaggctgcctgctgggcactaaataacctcctt
atgtaccagaacagtttgcatgagaagatcggagatgaagatggccagttccctgcgcac
agggaagtgatgctgtctatgctgatgcactcttcttccaaagatgtcttccaagcagct
gcacatgctctgtccactctcttggaacaaaatgttaatttcaggaaaatcctgctggca
aaaggagtatacctgaatgtcttggaattgatgcagaagcatgcccatgcgcctgaggtg
gcagagagtggctgcaagatgctgagtcacctgtttgaaggaagtaacccttctctggat
acaatggcagcagtggtccctaaaatactaacagtgatgaaagcccacggaacgtctctg
tcagtccagctggaggcgctgcgagctatcttgcatttcgttgtgccaggactattggaa
gaatccagggaggactctcaatgcagaccaaatgtgctcagaaaacagtgtttcaggact
gacatccacaagctggttctagtcgctctgaacaggttcattgggaatcctgggattcag
aaatgtggattgaaagtaatctcttctctcgcgcaccttcctgatgccacagagacattg
tccctgcaaggagcagttgactcagtcctccacaccttacagatgtatccagatgaccaa
gaaattcagtgtctgggcttacaccttatgggatgcttgatgacaaagaagaatttctgc
atagggacagggcacctcctggcaaaaattctggcttccactttgcagcgctttaaagat
gttgctgaggtgcagactacaggattacagacaaccctgtcaatacttgagctgtcagta
tctttctccaagctgctagtgcactattcctttgatgtggtgatatttcatcagatgtct
tccagtgttgtagaacaaaaggatgagcagttcctcaatctatgttgcaaatgctttgca
aaagtggccgtggatgatgagctgaaaaacaccatgctagagagagcctgcgatcagaat
aacagcatcatggttgaatgtttgctcctcttgggagctgatgccaaccaagtgaagggg
gcaacttctttaatctatcaggtatgtgagaaagagagcagtcctaaattggtggaactg
ttgcttaatggtggttgtcgtgaacaagatgtacggaaggccctgaccgtaagcatccaa
aagggcgacagccaggtcatcagcttgctcctcaggaaacttgccctggacctggccaac
aacagcatttgccttggaggatttggcataggaaaaattgatccttcttggcttggtcct
ttatttccagataagtcatccaatttaaggaagcaaacaaacacaggatctgtcctagcg
aggaaagtgctccggtatcagatgagaaacacccttcaagaaggcgtggcctcaggcagt
gacggcaagttttctgaagacgcgctggcgaaatttggagaatggacctttattcccgac
tcttctatggacagtgtgtttggccagagcgatgatctggatagcgaaggcagcgagagc
tcatttctcgtgaagaggaagtccaactcaattagtgtaggggaagtttacagagatcta
gctctgcagcgctgctcaccaaatgctcagaggcattccaattcgctgggtcctgttttt
gaccatgaagacttactgagacgaaaaagaaaaatactgtcttcagatgagtctctcagg
tcctcaaggctgccgtcccatatgaggcaatcagatagctcttcttccctggcttctgag
agagaacacatcacgtcgttagacctatctgccaacgaactcaaagatattgatgctctg
agccagaagtgttgcctcagtagccacctggaacatctcaccaaactggaacttcaccag
aattcactcacgagcttcccacagcagctgtgtgagactctgaagtgtttgatacacttg
gatttgcacagtaacaaattcacctcatttccctctttcgtgttgaaaatgccacgtatc
accaacctagatgcctctcgaaatgacatcgggccaacagtagttttagaccctgcgatg
aagtgtccaagcctcaaacagttgaatctgtcctataaccagctctcttcaatcccagag
aatcttgcccaagtggtggagaaacttgagcagctcctactggaaggaaataaaatatcc
gggatttgctctcccctgagcctgaaggaactgaagattttaaatcttagtaaaaatcac
attccatccctacctggagattttcttgaggcttgttcaaaagtcgagagtttcagtgct
cgcatgaattttcttgctgcaatgcctgccttaccttcttccataacgagcttaaaattg
tctcagaactctttcacgtgcattccagaagcgattttcagtcttccgcacttgcggtcc
ttggatatgagccacaacaacattgaatgtctgccgggacctgcacattggaagtctctg
aacttaagggaactcatttttagcaagaatcagatcagcaccttagactttagtgagaac
ccacacgtgtggtcaagagtagagaaactgcatctctctcataataaactgaaagagatt
cctccagaaattggctgccttgaaaatctgacgtctctcgacgtcagttacaacttggaa
ctgaggtccttcccaaatgaaatggggaagttgagcaagatatgggatcttcccttggac
ggactgcatctgaattttgactttaagcacgtaggatgcaaggccaaagacatcataagg
tttctacaacaacgtctgaaaaaggctgtaccctacaaccgaatgaagctcatgattgtg
ggaaatacggggagcggtaagaccactttactgcaacaactcatgaaaatgaagaaacca
gaacttggcatgcagggtgccacagtcggcatagacgtgcgagactggtccatccaaata
cggggcaaaaggagaaaggacctggttctaaacgtgtgggattttgcaggtcgtgaggaa
ttctacagcactcacccccacttcatgacccagagagccctctacctggctgtctatgat
ctcagcaaggggcaggcagaggtggacgccatgaagccctggctcttcaatatcaaggct
cgtgcctcttcttccccggtgattctggtgggcacacatttggatgtttctgatgagaag
cagcggaaagcgtgcataagcaaaatcacgaaggaactcctaaataagcgaggattcccc
accatccgggactaccactttgtgaatgccaccgaggagtcagatgcgctggcaaagctt
cggaaaaccatcataaatgagagccttaatttcaagatccgagatcagcctgtggttggg
cagctaattccagattgctacgtagaactggagaaaatcattttatcagagcggaaagct
gtgccgactgagtttcctgtgattaaccggaaacacctgttacagctcgtgaacgaacat
cagctgcagctggatgagaacgagctcccacacgccgttcacttcctaaatgagtcggga
gttcttctgcattttcaagaccctgccctgcagctaagtgacctgtactttgtggaaccc
aagtggctttgtaaagtcatggcacagatcttgacagtgaaggtagacggctgtctgaaa
catcctaagggcatcatttcccggagagatgtggaaaaattcctttcaaagaagaagcga
ttcccgaagaactatatgatgcaatactttaaactattagaaaaatttcagatcgcattg
ccaataggggaagaatatcttctggttccaagcagcttgtctgaccacaggccagtgata
gagctcccccactgtgagaactctgagatcatcatccggctgtacgaaatgccgtacttt
cccatgggattttggtcaagattgattaaccgattacttgaaatctcacccttcatgctt
tctggcagagagagagcactacgccctaacaggatgtattggcggcaaggcatctacttg
aattggtctccagaagcatactgtctggtaggctctgaagtcttagacaatcgacctgag
agtttcttgaaaatcacagttccgtcttgtagaaaaggttgtattcttctgggccgagtt
gtggatcatattgactcactcatggaagaatggtttcccgggttactggagattgacatt
tgtggggaaggagaaactctgttgaagaaatgggcattgtacagttttaatgatggtgaa
gaacatcagaagatcttgcttgatgagttgatgaagaaggctgaagaaggagacctgtta
ataaatccagaccaaccaaggctcactattccaatatcccagattgctccggacttgatc
ttggctgacctgcctagaaatatcatgttgaacaatgatgagttggaatttgaggaagca
ccagagtttctcttaggcgatggaagttttggatccgtttatcgagctgcctacgaagga
gaggaagtggctgtgaagatttttaataagcacacatctcttaggctgttaagacaagag
ttggtggtcctttgtcaccttcaccaccccagcctgatatccttgctggcggctggtatt
cgtcctcggatgttggtaatggagttggcctccaaaggttccttggatcgcctgctgcag
caggacaaagccagcctcaccagaaccctccagcacaggatcgcgttgcatgtggccgac
ggcctgaggtatctccactcagccatgattatttaccgtgacctgaagccccacaatgtg
ctgctttttaccctgtatcccaatgctgccatcattgcgaagattgcggactacgggatc
gcacagtactgctgcaggatgggaataaagacatcagagggcaccccagggttccgggca
cctgaagttgccagggggaatgtcatttataaccaacaggccgatgtttattcttttggc
ttactacttcacgatatttggacaactgggagtaggattatggagggtttgaggttccca
aatgagtttgatgagttagccatacaagggaagttgccagatccagttaaagaatatggc
tgtgccccatggcctatggttgagaagttaattacaaagtgtttgaaagaaaatcctcaa
gaaagacccacttctgcccaggtctttgacattttgaattcggctgaattaatttgcctc
atgcgacacattttaatacctaagaacatcattgttgaatgcatggttgccacgaatctc
aatagcaagagtgcgactctctggttgggatgtgggaacacagaaaaaggacagctttcc
ttatttgacttaaacacggaaagatacagctatgaggaagttgctgatagtagaatactg
tgcttggctttggtgcatctcgctgctgagaaagagagctgggttgtgtgcgggacacag
tctggggctctcctggtcatcaatgttgaagaggagacaaagagacacaccctggaaaag
atgactgattctgtcacttgtttgcattgcaattcccttgccaagcagagcaagcaaagt
aactttcttttggtgggaactgctgatggtaacttaatgatatttgaagataaagccgtt
aagtgtaaaggagctgcccccttgaagacactacacataggcgatgtcagtacgcccctg
atgtgcctgagcgagtccctgaattcatctgaaagacacatcacatggggagggtgtggc
acaaaggtcttctccttttccaatgatttcaccattcagaaactcatcgagacaaaaacc
aaccagctgttttcttacgcagctttcagcgattctaacatcatagcgctggcagtagac
acagccctgtatattgccaagaaaaacagccctgtcgtagaggtgtgggacaagaaaaca
gaaaagctctgtgaattaatagactgtgtgcacttcttaaaggaggtgatggtaaaacta
aacaaggaatcgaaacatcagctgtcctactctgggagggtgaaggccctctgcctgcag
aagaacacggctctctggatcggaactggaggaggccacatcttactcctggatctttct
actcggcgagttatccgcaccattcacaatttctgtgattctgtgagagccatggccaca
gcacaattaggaagccttaagaatgtcatgctggttttggggtacaagcggaagagtaca
gagggtatccaagaacaaaaagagatacaatcttgtttgtctatttgggacctcaatctt
ccacacgaggtgcaaaatttagaaaaacacattgaagtaagaacagaattagctgataaa
atgaggaaaacatctgttgaatag
DBGET
integrated database retrieval system
