Mus musculus (house mouse): 78943
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Entry
78943 CDS
T01002
Symbol
Ern1, 9030414B18Rik, Ire1a, Ire1alpha, Ire1p
Name
(RefSeq) endoplasmic reticulum to nucleus signalling 1
KO
K08852
serine/threonine-protein kinase/endoribonuclease IRE1 [EC:
2.7.11.1
3.1.26.-]
Organism
mmu
Mus musculus (house mouse)
Pathway
mmu04140
Autophagy - animal
mmu04141
Protein processing in endoplasmic reticulum
mmu04210
Apoptosis
mmu04932
Non-alcoholic fatty liver disease
mmu05010
Alzheimer disease
mmu05012
Parkinson disease
mmu05014
Amyotrophic lateral sclerosis
mmu05016
Huntington disease
mmu05017
Spinocerebellar ataxia
mmu05022
Pathways of neurodegeneration - multiple diseases
mmu05417
Lipid and atherosclerosis
Brite
KEGG Orthology (KO) [BR:
mmu00001
]
09120 Genetic Information Processing
09123 Folding, sorting and degradation
04141 Protein processing in endoplasmic reticulum
78943 (Ern1)
09140 Cellular Processes
09141 Transport and catabolism
04140 Autophagy - animal
78943 (Ern1)
09143 Cell growth and death
04210 Apoptosis
78943 (Ern1)
09160 Human Diseases
09164 Neurodegenerative disease
05010 Alzheimer disease
78943 (Ern1)
05012 Parkinson disease
78943 (Ern1)
05014 Amyotrophic lateral sclerosis
78943 (Ern1)
05016 Huntington disease
78943 (Ern1)
05017 Spinocerebellar ataxia
78943 (Ern1)
05022 Pathways of neurodegeneration - multiple diseases
78943 (Ern1)
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
78943 (Ern1)
09167 Endocrine and metabolic disease
04932 Non-alcoholic fatty liver disease
78943 (Ern1)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
mmu01001
]
78943 (Ern1)
Enzymes [BR:
mmu01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.1 non-specific serine/threonine protein kinase
78943 (Ern1)
Protein kinases [BR:
mmu01001
]
Serine/threonine kinases: Other
IRE family
78943 (Ern1)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Pkinase
Ribonuc_2-5A
PK_Tyr_Ser-Thr
PQQ_2
PQQ
Pkinase_fungal
Kdo
APH
Motif
Other DBs
NCBI-GeneID:
78943
NCBI-ProteinID:
NP_076402
MGI:
1930134
Ensembl:
ENSMUSG00000020715
UniProt:
Q9EQY0
Structure
PDB
PDBj
LinkDB
All DBs
Position
11:complement(106285474..106378701)
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AA seq
977 aa
AA seq
DB search
MPARWLLLLLALLLPPPGPGSFGRTSTVTLPETLLFVSTLDGSLHAVSKRTGSIKWTLKE
DPVLQVPTHVEEPAFLPDPNDGSLYTLGGKNNEGLTKLPFTIPELVQASPCRSSDGILYM
GKKQDIWYVIDLLTGEKQQTLSSAFADSLCPSTSLLYLGRTEYTITMYDTKTRELRWNAT
YFDYAASLPEDDVDYKMSHFVSNGDGLVVTVDSESGDVLWIQNYASPVVAFYVWQGEVLR
KVVHINVAVETLRYLTFMSGEVGRITKWKYPFPKETEAKSKLTPTLYVGKYSTSLYASPS
MVHEGVAVVPRGSTLPLLEGPQTDGVTIGDKGECVITPSTDLKFDPGLKGKSKLNYLRNY
WLLIGHHETPLSASTKMLERFPNNLPKHRENVIPADSEKRSFEEVINIVGQTSDNTPTTV
SQDVEEKLARAPAKPEAPVDSMLKDMATIILSTFLLVGWVAFIITYPLSVHQQRQLQHQQ
FQKELEKIQLLQQQQLPFHPHGDLTQDPEFLDSSGPFSESSGTSSPSPSPRASNHSLHPS
SSASRAGTSPSLEQDDEDEETRMVIVGKISFCPKDVLGHGAEGTIVYKGMFDNRDVAVKR
ILPECFSFADREVQLLRESDEHPNVIRYFCTEKDRQFQYIAIELCAATLQEYVEQKDFAH
LGLEPITLLHQTTSGLAHLHSLNIVHRDLKPHNILLSMPNAHGRIKAMISDFGLCKKLAV
GRHSFSRRSGVPGTEGWIAPEMLSEDCKDNPTYTVDIFSAGCVFYYVISEGNHPFGKSLQ
RQANILLGACNLDCFHSDKHEDVIARELIEKMIAMDPQQRPSAKHVLKHPFFWSLEKQLQ
FFQDVSDRIEKEALDGPIVRQLERGGRAVVKMDWRENITVPLQTDLRKFRTYKGGSVRDL
LRAMRNKKHHYRELPVEVQETLGSIPDDFVRYFTSRFPHLLSHTYQAMELCRHERLFQTY
YWHEPTEPQPPVIPYAL
NT seq
2934 nt
NT seq
+upstream
nt +downstream
nt
atgccggcccggtggctgttgctcctgctggcgctgctgctaccgccgcccggccccggg
agttttggaagaaccagcacagttacactgcctgagaccttgttgtttgtctcgaccctg
gatggaagcttgcatgctgttagcaagaggacgggctccatcaagtggactttaaaagaa
gatccagtcctgcaggtcccaacacacgtggaagagccggctttcctcccagatcccaat
gatggcagtctgtacacacttggaggcaagaacaacgaaggcctgacgaaacttcccttt
accatcccagaattggttcaggcctccccatgccgaagttcagatggaatcctctacatg
ggtaaaaagcaagatatttggtatgttatcgacctcctgactggcgagaagcagcagact
ttgtcatcggcctttgctgatagtctctgcccatcaacttcccttctatatcttggacgg
acagaatacaccatcaccatgtatgacaccaagacccgggagctccgctggaatgccacc
tattttgactatgcagcctcactgccggaagacgacgtggactacaagatgtcccacttt
gtgtccaatggcgatggactggtggtaactgtggacagtgaatctggggatgtcctgtgg
atccaaaactatgcctctcctgtggtggccttctacgtctggcagggggaggtcctgaga
aaggtggtgcacatcaacgttgctgtggagactctacgctacttgaccttcatgtctggg
gaagtggggcgcatcaccaagtggaagtatccattccccaaggagacagaggccaagagc
aagctaacgcctactctgtatgttgggaagtattccaccagcctctatgcctctccctca
atggtgcatgagggggttgctgtcgtgcctcgaggcagcactcttcctttgctggaaggc
ccccagacagatggcgtcaccattggagacaaaggagagtgtgtgatcactcccagcaca
gacctcaagtttgaccctggactcaaagggaagagcaagctgaactacttgaggaattac
tggcttctcataggacaccatgaaactcctctgtctgcatccaccaagatgctggagaga
tttcctaacaacctgcccaaacatcgagaaaatgtgattcctgctgattcagaaaaaagg
agctttgaggaagttatcaacatagttggccagacttcagacaacacaccgaccaccgta
tctcaggatgtggaggagaagctcgctcgcgcccctgccaagcctgaggcccccgtggac
tccatgctcaaggacatggctaccattatcctgagcaccttcctgctggttggatgggtg
gcgttcatcatcacttaccccctgagcgtgcatcagcagcgtcagctccagcaccaacag
ttccagaaggagctggagaagattcagctcctgcagcagcagcagctgcccttccaccca
cacggagaccttacccaggaccctgagttcctggattcatctggccccttctcagagagc
tctggcaccagcagccccagcccatcccccagagcctccaaccactccctccaccccagc
agctctgcctccagggccggcaccagcccctctctggagcaggatgatgaggatgaggaa
accagaatggtgattgttgggaaaatttcattctgccccaaggatgtcctgggtcatgga
gctgagggcacaattgtatacaaaggtatgtttgacaaccgagatgtggccgtgaagagg
atcctccctgagtgttttagctttgccgaccgtgaggtccagctgcttcgagaatcagac
gagcacccaaatgtgatccgctacttttgcacagagaaggaccggcagttccagtacatt
gctatcgagctgtgtgcagccaccctacaagagtatgtggagcagaaggactttgcccac
cttggcctcgagcccatcaccctgcttcatcagaccacctcaggcctggcacacctgcat
tctctcaacattgttcacagagacctgaagccccacaacattctcctctccatgcccaac
gcacatggcaggatcaaggcgatgatctctgactttggcctctgcaagaagctggcagtg
ggcaggcacagtttcagccgccgttcaggggtacctggcactgaagggtggatcgcccca
gagatgctgagtgaagactgtaaggacaaccctacctacacggtggacatcttttctgca
ggctgtgtcttttactatgtcatctctgagggcaaccatccttttggcaaatccttgcag
cggcaggccaacatcctcctgggcgcctgcaaccttgactgtttccactcagacaagcat
gaggacgtcattgctcgtgaattgatagagaaaatgattgctatggatccccagcagcgt
ccctctgcaaagcacgtgctgaaacaccccttcttctggagcctggagaagcagctccag
tttttccaggatgtaagtgaccgaatagaaaaggaggccttggacggtccaatcgtacgg
cagttggagagaggcgggagagctgtggtcaagatggactggcgggagaacatcactgtc
cccctgcagacagatctgcgcaaattcagaacctacaaaggtggctctgtgagagacctc
ctccgagccatgagaaacaagaaacaccactaccgggagctccccgtggaggttcaggag
acgctgggctccatcccggatgactttgtgcgctacttcacttcccgcttcccccacctc
ctctctcacacctaccaagccatggagctgtgcagacatgagagactctttcagacctac
tactggcacgagcccacagaaccccagcctccagtgattccatatgccctctga
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