KEGG   Microcebus murinus (gray mouse lemur): 105860097
Entry
105860097         CDS       T07238                                 
Symbol
MAPK8
Name
(RefSeq) mitogen-activated protein kinase 8 isoform X1
  KO
K04440  mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase) [EC:2.7.11.24]
Organism
mmur  Microcebus murinus (gray mouse lemur)
Pathway
mmur01522  Endocrine resistance
mmur04010  MAPK signaling pathway
mmur04012  ErbB signaling pathway
mmur04014  Ras signaling pathway
mmur04024  cAMP signaling pathway
mmur04068  FoxO signaling pathway
mmur04071  Sphingolipid signaling pathway
mmur04137  Mitophagy - animal
mmur04140  Autophagy - animal
mmur04141  Protein processing in endoplasmic reticulum
mmur04210  Apoptosis
mmur04215  Apoptosis - multiple species
mmur04217  Necroptosis
mmur04310  Wnt signaling pathway
mmur04380  Osteoclast differentiation
mmur04510  Focal adhesion
mmur04517  IgSF CAM signaling
mmur04530  Tight junction
mmur04620  Toll-like receptor signaling pathway
mmur04621  NOD-like receptor signaling pathway
mmur04622  RIG-I-like receptor signaling pathway
mmur04625  C-type lectin receptor signaling pathway
mmur04657  IL-17 signaling pathway
mmur04658  Th1 and Th2 cell differentiation
mmur04659  Th17 cell differentiation
mmur04660  T cell receptor signaling pathway
mmur04664  Fc epsilon RI signaling pathway
mmur04668  TNF signaling pathway
mmur04722  Neurotrophin signaling pathway
mmur04723  Retrograde endocannabinoid signaling
mmur04728  Dopaminergic synapse
mmur04750  Inflammatory mediator regulation of TRP channels
mmur04910  Insulin signaling pathway
mmur04912  GnRH signaling pathway
mmur04914  Progesterone-mediated oocyte maturation
mmur04917  Prolactin signaling pathway
mmur04920  Adipocytokine signaling pathway
mmur04926  Relaxin signaling pathway
mmur04930  Type II diabetes mellitus
mmur04931  Insulin resistance
mmur04932  Non-alcoholic fatty liver disease
mmur04933  AGE-RAGE signaling pathway in diabetic complications
mmur04935  Growth hormone synthesis, secretion and action
mmur04936  Alcoholic liver disease
mmur05010  Alzheimer disease
mmur05012  Parkinson disease
mmur05016  Huntington disease
mmur05017  Spinocerebellar ataxia
mmur05020  Prion disease
mmur05022  Pathways of neurodegeneration - multiple diseases
mmur05132  Salmonella infection
mmur05133  Pertussis
mmur05135  Yersinia infection
mmur05142  Chagas disease
mmur05145  Toxoplasmosis
mmur05152  Tuberculosis
mmur05161  Hepatitis B
mmur05162  Measles
mmur05166  Human T-cell leukemia virus 1 infection
mmur05167  Kaposi sarcoma-associated herpesvirus infection
mmur05169  Epstein-Barr virus infection
mmur05170  Human immunodeficiency virus 1 infection
mmur05171  Coronavirus disease - COVID-19
mmur05200  Pathways in cancer
mmur05208  Chemical carcinogenesis - reactive oxygen species
mmur05210  Colorectal cancer
mmur05212  Pancreatic cancer
mmur05231  Choline metabolism in cancer
mmur05415  Diabetic cardiomyopathy
mmur05417  Lipid and atherosclerosis
mmur05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:mmur00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04141 Protein processing in endoplasmic reticulum
    105860097 (MAPK8)
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    105860097 (MAPK8)
   04012 ErbB signaling pathway
    105860097 (MAPK8)
   04014 Ras signaling pathway
    105860097 (MAPK8)
   04310 Wnt signaling pathway
    105860097 (MAPK8)
   04668 TNF signaling pathway
    105860097 (MAPK8)
   04068 FoxO signaling pathway
    105860097 (MAPK8)
   04071 Sphingolipid signaling pathway
    105860097 (MAPK8)
   04024 cAMP signaling pathway
    105860097 (MAPK8)
  09133 Signaling molecules and interaction
   04517 IgSF CAM signaling
    105860097 (MAPK8)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    105860097 (MAPK8)
   04137 Mitophagy - animal
    105860097 (MAPK8)
  09143 Cell growth and death
   04210 Apoptosis
    105860097 (MAPK8)
   04215 Apoptosis - multiple species
    105860097 (MAPK8)
   04217 Necroptosis
    105860097 (MAPK8)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    105860097 (MAPK8)
   04530 Tight junction
    105860097 (MAPK8)
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    105860097 (MAPK8)
   04621 NOD-like receptor signaling pathway
    105860097 (MAPK8)
   04622 RIG-I-like receptor signaling pathway
    105860097 (MAPK8)
   04625 C-type lectin receptor signaling pathway
    105860097 (MAPK8)
   04660 T cell receptor signaling pathway
    105860097 (MAPK8)
   04658 Th1 and Th2 cell differentiation
    105860097 (MAPK8)
   04659 Th17 cell differentiation
    105860097 (MAPK8)
   04657 IL-17 signaling pathway
    105860097 (MAPK8)
   04664 Fc epsilon RI signaling pathway
    105860097 (MAPK8)
  09152 Endocrine system
   04910 Insulin signaling pathway
    105860097 (MAPK8)
   04920 Adipocytokine signaling pathway
    105860097 (MAPK8)
   04912 GnRH signaling pathway
    105860097 (MAPK8)
   04914 Progesterone-mediated oocyte maturation
    105860097 (MAPK8)
   04917 Prolactin signaling pathway
    105860097 (MAPK8)
   04926 Relaxin signaling pathway
    105860097 (MAPK8)
   04935 Growth hormone synthesis, secretion and action
    105860097 (MAPK8)
  09156 Nervous system
   04728 Dopaminergic synapse
    105860097 (MAPK8)
   04723 Retrograde endocannabinoid signaling
    105860097 (MAPK8)
   04722 Neurotrophin signaling pathway
    105860097 (MAPK8)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    105860097 (MAPK8)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    105860097 (MAPK8)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    105860097 (MAPK8)
   05208 Chemical carcinogenesis - reactive oxygen species
    105860097 (MAPK8)
   05231 Choline metabolism in cancer
    105860097 (MAPK8)
  09162 Cancer: specific types
   05210 Colorectal cancer
    105860097 (MAPK8)
   05212 Pancreatic cancer
    105860097 (MAPK8)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    105860097 (MAPK8)
   05170 Human immunodeficiency virus 1 infection
    105860097 (MAPK8)
   05161 Hepatitis B
    105860097 (MAPK8)
   05171 Coronavirus disease - COVID-19
    105860097 (MAPK8)
   05162 Measles
    105860097 (MAPK8)
   05167 Kaposi sarcoma-associated herpesvirus infection
    105860097 (MAPK8)
   05169 Epstein-Barr virus infection
    105860097 (MAPK8)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    105860097 (MAPK8)
   05135 Yersinia infection
    105860097 (MAPK8)
   05133 Pertussis
    105860097 (MAPK8)
   05152 Tuberculosis
    105860097 (MAPK8)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    105860097 (MAPK8)
   05142 Chagas disease
    105860097 (MAPK8)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    105860097 (MAPK8)
   05012 Parkinson disease
    105860097 (MAPK8)
   05016 Huntington disease
    105860097 (MAPK8)
   05017 Spinocerebellar ataxia
    105860097 (MAPK8)
   05020 Prion disease
    105860097 (MAPK8)
   05022 Pathways of neurodegeneration - multiple diseases
    105860097 (MAPK8)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    105860097 (MAPK8)
   05418 Fluid shear stress and atherosclerosis
    105860097 (MAPK8)
   05415 Diabetic cardiomyopathy
    105860097 (MAPK8)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    105860097 (MAPK8)
   04936 Alcoholic liver disease
    105860097 (MAPK8)
   04932 Non-alcoholic fatty liver disease
    105860097 (MAPK8)
   04931 Insulin resistance
    105860097 (MAPK8)
   04933 AGE-RAGE signaling pathway in diabetic complications
    105860097 (MAPK8)
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    105860097 (MAPK8)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:mmur01001]
    105860097 (MAPK8)
Enzymes [BR:mmur01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.24  mitogen-activated protein kinase
     105860097 (MAPK8)
Protein kinases [BR:mmur01001]
 Serine/threonine kinases: CMGC group
  MAPK family [OT]
   105860097 (MAPK8)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr Kdo ABC1 RIO1 Kinase-like FTA2 APH
Other DBs
NCBI-GeneID: 105860097
NCBI-ProteinID: XP_012600009
Ensembl: ENSMICG00000006997
UniProt: A0A8B7EXB0
LinkDB
Position
15:22950808..23078086
AA seq 427 aa
MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP
FQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ
MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF
MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQ
LGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSK
MLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEV
MDLEERTKNGVIRGQPSPLGAAVINGSQHPSSSSSVNDVSSMSTDPTLASDTDSSLEASA
GPLGCCR
NT seq 1284 nt   +upstreamnt  +downstreamnt
atgagcagaagcaagcgtgacaacaatttttatagtgtagagattggagattctacattc
acagtcctgaaacgatatcagaatttaaaaccgataggctcaggagcccaaggaatagta
tgtgctgcttatgatgccattcttgagagaaatgttgcaatcaagaaactaagccggcca
tttcagaatcaaacccatgctaagcgggcctacagagagctagtacttatgaaatgtgtt
aatcacaaaaatataattggccttttgaatgttttcacaccacagaaatccctagaagaa
tttcaagatgtttacatagtcatggagctcatggatgcaaatctttgccaagtgattcag
atggagctggatcatgagagaatgtcctaccttctctatcagatgctatgtggaatcaag
caccttcactctgctgggattattcatcgggacttaaagcccagtaatatagtagtaaaa
tcagactgcactttgaagattcttgactttggtctggccaggactgcaggaacaagcttt
atgatgacgccttacgtagtgactcgctactacagagcgcccgaggtcatcctaggcatg
ggctacaaggaaaacgttgacatttggtcagttgggtgcatcatgggagaaatgatcaaa
ggtggtgttttgttcccaggtacagatcatattgatcagtggaataaagttattgaacag
ctcggaacaccatgtcctgaattcatgaagaaactgcaaccaacagtaaggacttatgtt
gaaaacagacctaaatatgctggatatagctttgagaaactcttccccgatgtacttttc
ccagctgactcggaacacaacaaacttaaagccagccaggcaagggatttgttatccaaa
atgctggtaatagatgcatctaaaaggatctctgtagatgaagctctccagcacccatat
atcaatgtctggtatgacccttctgaagcagaagctccaccaccaaagatacctgacaag
caattagatgaaagggagcacacaatagaagaatggaaagaattgatatataaggaagtt
atggacttggaagagagaaccaagaatggagttatacgggggcagccttctcctttaggt
gcagcagtgatcaatggctctcagcatccatcgtcatcgtcgtctgtcaatgatgtgtct
tcaatgtcaacagatccgactttggcctcagatacagacagcagtctagaagcatcagct
ggacctctgggctgctgtagatga

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