KEGG   Microcebus murinus (gray mouse lemur): 105861093
Entry
105861093         CDS       T07238                                 
Symbol
AKT1
Name
(RefSeq) RAC-alpha serine/threonine-protein kinase isoform X1
  KO
K04456  RAC serine/threonine-protein kinase [EC:2.7.11.1]
Organism
mmur  Microcebus murinus (gray mouse lemur)
Pathway
mmur01521  EGFR tyrosine kinase inhibitor resistance
mmur01522  Endocrine resistance
mmur01524  Platinum drug resistance
mmur04010  MAPK signaling pathway
mmur04012  ErbB signaling pathway
mmur04014  Ras signaling pathway
mmur04015  Rap1 signaling pathway
mmur04022  cGMP-PKG signaling pathway
mmur04024  cAMP signaling pathway
mmur04062  Chemokine signaling pathway
mmur04066  HIF-1 signaling pathway
mmur04068  FoxO signaling pathway
mmur04071  Sphingolipid signaling pathway
mmur04072  Phospholipase D signaling pathway
mmur04140  Autophagy - animal
mmur04150  mTOR signaling pathway
mmur04151  PI3K-Akt signaling pathway
mmur04152  AMPK signaling pathway
mmur04210  Apoptosis
mmur04211  Longevity regulating pathway
mmur04213  Longevity regulating pathway - multiple species
mmur04218  Cellular senescence
mmur04261  Adrenergic signaling in cardiomyocytes
mmur04370  VEGF signaling pathway
mmur04371  Apelin signaling pathway
mmur04380  Osteoclast differentiation
mmur04510  Focal adhesion
mmur04550  Signaling pathways regulating pluripotency of stem cells
mmur04611  Platelet activation
mmur04613  Neutrophil extracellular trap formation
mmur04620  Toll-like receptor signaling pathway
mmur04625  C-type lectin receptor signaling pathway
mmur04630  JAK-STAT signaling pathway
mmur04660  T cell receptor signaling pathway
mmur04662  B cell receptor signaling pathway
mmur04664  Fc epsilon RI signaling pathway
mmur04666  Fc gamma R-mediated phagocytosis
mmur04668  TNF signaling pathway
mmur04722  Neurotrophin signaling pathway
mmur04725  Cholinergic synapse
mmur04728  Dopaminergic synapse
mmur04810  Regulation of actin cytoskeleton
mmur04910  Insulin signaling pathway
mmur04914  Progesterone-mediated oocyte maturation
mmur04915  Estrogen signaling pathway
mmur04917  Prolactin signaling pathway
mmur04919  Thyroid hormone signaling pathway
mmur04920  Adipocytokine signaling pathway
mmur04922  Glucagon signaling pathway
mmur04923  Regulation of lipolysis in adipocytes
mmur04926  Relaxin signaling pathway
mmur04929  GnRH secretion
mmur04931  Insulin resistance
mmur04932  Non-alcoholic fatty liver disease
mmur04933  AGE-RAGE signaling pathway in diabetic complications
mmur04935  Growth hormone synthesis, secretion and action
mmur04936  Alcoholic liver disease
mmur04973  Carbohydrate digestion and absorption
mmur05010  Alzheimer disease
mmur05017  Spinocerebellar ataxia
mmur05132  Salmonella infection
mmur05135  Yersinia infection
mmur05142  Chagas disease
mmur05145  Toxoplasmosis
mmur05152  Tuberculosis
mmur05160  Hepatitis C
mmur05161  Hepatitis B
mmur05162  Measles
mmur05163  Human cytomegalovirus infection
mmur05164  Influenza A
mmur05165  Human papillomavirus infection
mmur05166  Human T-cell leukemia virus 1 infection
mmur05167  Kaposi sarcoma-associated herpesvirus infection
mmur05168  Herpes simplex virus 1 infection
mmur05169  Epstein-Barr virus infection
mmur05170  Human immunodeficiency virus 1 infection
mmur05200  Pathways in cancer
mmur05205  Proteoglycans in cancer
mmur05207  Chemical carcinogenesis - receptor activation
mmur05208  Chemical carcinogenesis - reactive oxygen species
mmur05210  Colorectal cancer
mmur05211  Renal cell carcinoma
mmur05212  Pancreatic cancer
mmur05213  Endometrial cancer
mmur05214  Glioma
mmur05215  Prostate cancer
mmur05218  Melanoma
mmur05220  Chronic myeloid leukemia
mmur05221  Acute myeloid leukemia
mmur05222  Small cell lung cancer
mmur05223  Non-small cell lung cancer
mmur05224  Breast cancer
mmur05225  Hepatocellular carcinoma
mmur05226  Gastric cancer
mmur05230  Central carbon metabolism in cancer
mmur05231  Choline metabolism in cancer
mmur05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
mmur05415  Diabetic cardiomyopathy
mmur05417  Lipid and atherosclerosis
mmur05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:mmur00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    105861093 (AKT1)
   04012 ErbB signaling pathway
    105861093 (AKT1)
   04014 Ras signaling pathway
    105861093 (AKT1)
   04015 Rap1 signaling pathway
    105861093 (AKT1)
   04370 VEGF signaling pathway
    105861093 (AKT1)
   04371 Apelin signaling pathway
    105861093 (AKT1)
   04630 JAK-STAT signaling pathway
    105861093 (AKT1)
   04668 TNF signaling pathway
    105861093 (AKT1)
   04066 HIF-1 signaling pathway
    105861093 (AKT1)
   04068 FoxO signaling pathway
    105861093 (AKT1)
   04072 Phospholipase D signaling pathway
    105861093 (AKT1)
   04071 Sphingolipid signaling pathway
    105861093 (AKT1)
   04024 cAMP signaling pathway
    105861093 (AKT1)
   04022 cGMP-PKG signaling pathway
    105861093 (AKT1)
   04151 PI3K-Akt signaling pathway
    105861093 (AKT1)
   04152 AMPK signaling pathway
    105861093 (AKT1)
   04150 mTOR signaling pathway
    105861093 (AKT1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    105861093 (AKT1)
  09143 Cell growth and death
   04210 Apoptosis
    105861093 (AKT1)
   04218 Cellular senescence
    105861093 (AKT1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    105861093 (AKT1)
   04550 Signaling pathways regulating pluripotency of stem cells
    105861093 (AKT1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    105861093 (AKT1)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    105861093 (AKT1)
   04613 Neutrophil extracellular trap formation
    105861093 (AKT1)
   04620 Toll-like receptor signaling pathway
    105861093 (AKT1)
   04625 C-type lectin receptor signaling pathway
    105861093 (AKT1)
   04660 T cell receptor signaling pathway
    105861093 (AKT1)
   04662 B cell receptor signaling pathway
    105861093 (AKT1)
   04664 Fc epsilon RI signaling pathway
    105861093 (AKT1)
   04666 Fc gamma R-mediated phagocytosis
    105861093 (AKT1)
   04062 Chemokine signaling pathway
    105861093 (AKT1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    105861093 (AKT1)
   04922 Glucagon signaling pathway
    105861093 (AKT1)
   04923 Regulation of lipolysis in adipocytes
    105861093 (AKT1)
   04920 Adipocytokine signaling pathway
    105861093 (AKT1)
   04929 GnRH secretion
    105861093 (AKT1)
   04915 Estrogen signaling pathway
    105861093 (AKT1)
   04914 Progesterone-mediated oocyte maturation
    105861093 (AKT1)
   04917 Prolactin signaling pathway
    105861093 (AKT1)
   04926 Relaxin signaling pathway
    105861093 (AKT1)
   04935 Growth hormone synthesis, secretion and action
    105861093 (AKT1)
   04919 Thyroid hormone signaling pathway
    105861093 (AKT1)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    105861093 (AKT1)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    105861093 (AKT1)
  09156 Nervous system
   04725 Cholinergic synapse
    105861093 (AKT1)
   04728 Dopaminergic synapse
    105861093 (AKT1)
   04722 Neurotrophin signaling pathway
    105861093 (AKT1)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    105861093 (AKT1)
  09149 Aging
   04211 Longevity regulating pathway
    105861093 (AKT1)
   04213 Longevity regulating pathway - multiple species
    105861093 (AKT1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    105861093 (AKT1)
   05205 Proteoglycans in cancer
    105861093 (AKT1)
   05207 Chemical carcinogenesis - receptor activation
    105861093 (AKT1)
   05208 Chemical carcinogenesis - reactive oxygen species
    105861093 (AKT1)
   05230 Central carbon metabolism in cancer
    105861093 (AKT1)
   05231 Choline metabolism in cancer
    105861093 (AKT1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    105861093 (AKT1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    105861093 (AKT1)
   05212 Pancreatic cancer
    105861093 (AKT1)
   05225 Hepatocellular carcinoma
    105861093 (AKT1)
   05226 Gastric cancer
    105861093 (AKT1)
   05214 Glioma
    105861093 (AKT1)
   05221 Acute myeloid leukemia
    105861093 (AKT1)
   05220 Chronic myeloid leukemia
    105861093 (AKT1)
   05218 Melanoma
    105861093 (AKT1)
   05211 Renal cell carcinoma
    105861093 (AKT1)
   05215 Prostate cancer
    105861093 (AKT1)
   05213 Endometrial cancer
    105861093 (AKT1)
   05224 Breast cancer
    105861093 (AKT1)
   05222 Small cell lung cancer
    105861093 (AKT1)
   05223 Non-small cell lung cancer
    105861093 (AKT1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    105861093 (AKT1)
   05170 Human immunodeficiency virus 1 infection
    105861093 (AKT1)
   05161 Hepatitis B
    105861093 (AKT1)
   05160 Hepatitis C
    105861093 (AKT1)
   05164 Influenza A
    105861093 (AKT1)
   05162 Measles
    105861093 (AKT1)
   05168 Herpes simplex virus 1 infection
    105861093 (AKT1)
   05163 Human cytomegalovirus infection
    105861093 (AKT1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    105861093 (AKT1)
   05169 Epstein-Barr virus infection
    105861093 (AKT1)
   05165 Human papillomavirus infection
    105861093 (AKT1)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    105861093 (AKT1)
   05135 Yersinia infection
    105861093 (AKT1)
   05152 Tuberculosis
    105861093 (AKT1)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    105861093 (AKT1)
   05142 Chagas disease
    105861093 (AKT1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    105861093 (AKT1)
   05017 Spinocerebellar ataxia
    105861093 (AKT1)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    105861093 (AKT1)
   05418 Fluid shear stress and atherosclerosis
    105861093 (AKT1)
   05415 Diabetic cardiomyopathy
    105861093 (AKT1)
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    105861093 (AKT1)
   04932 Non-alcoholic fatty liver disease
    105861093 (AKT1)
   04931 Insulin resistance
    105861093 (AKT1)
   04933 AGE-RAGE signaling pathway in diabetic complications
    105861093 (AKT1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    105861093 (AKT1)
   01524 Platinum drug resistance
    105861093 (AKT1)
   01522 Endocrine resistance
    105861093 (AKT1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:mmur01001]
    105861093 (AKT1)
Enzymes [BR:mmur01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     105861093 (AKT1)
Protein kinases [BR:mmur01001]
 Serine/threonine kinases: AGC group
  AKT/PKB family
   105861093 (AKT1)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr PH Pkinase_C Kinase-like PH_11 PH_20 Seadorna_VP7
Other DBs
NCBI-GeneID: 105861093
NCBI-ProteinID: XP_012601844
Ensembl: ENSMICG00000013771
UniProt: A0A8C5VV71
LinkDB
Position
3:complement(15983271..16004494)
AA seq 480 aa
MNDVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQRESPLNNFSVAQC
QLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKKQEEEMMDF
RSGSPSDNSGAEEMEVALAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKI
LKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLS
RERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGI
KDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFEL
ILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQDVYEKK
LSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSYSASGTA
NT seq 1443 nt   +upstreamnt  +downstreamnt
atgaacgacgtggccatcgtgaaggagggctggctgcacaaacgaggggaatacatcaag
acgtggcggccccgctacttcctcctcaagaacgacggcaccttcatcggctacaaggag
cggccgcaggacgtggaccagcgcgagtctcccctgaacaacttctccgtggcacaatgc
cagctgatgaagacggagcggcccaggcccaacaccttcatcatccgctgcctgcagtgg
accacggtcatcgagcgcaccttccacgtggagacgccggaggagcgggaggagtggacg
accgccatccagacagtggccgacggactgaagaagcaggaggaggagatgatggacttc
cggtcgggctcacccagcgacaactctggggctgaagagatggaggtggccctggccaag
cccaagcaccgcgtgaccatgaacgagttcgagtacctgaagctgctgggcaagggcacc
ttcgggaaggtgatcctggtgaaggagaaggccaccggccgctactacgccatgaagatc
ctgaagaaggaggtcatcgtggccaaggacgaggtggcccacacgctcaccgagaaccgc
gtcctccagaactccaggcaccccttcctcacggccctgaagtactccttccagacccac
gaccgcctctgctttgtcatggagtacgccaacgggggcgagctcttcttccacctgtcc
cgcgagcgcgtgttctcggaggaccgggcccgcttctacggcgccgagatcgtgtcggcc
ctggactacctgcactcggagaagaacgtggtgtaccgggacctcaagctggagaacctc
atgctggacaaggacgggcacatcaagatcacagacttcgggctgtgcaaggagggcatc
aaggatggcgccaccatgaagaccttctgcggcacgcccgagtacctggcccccgaggtg
ctggaggacaacgactacggccgggccgtggactggtgggggctgggcgtggtcatgtac
gagatgatgtgcggccgcctgcccttctacaaccaggaccacgagaagctcttcgagctc
atcctcatggaggagatccgcttcccacgcacgcttggccccgaggccaagtccctgctc
tcggggctgctcaagaaagaccctaagcagaggctcggcgggggctccgaggacgccaag
gagatcatgcagcaccgcttcttcgccggcatcgtgtggcaggacgtgtacgagaagaag
ctcagcccgcccttcaagccccaggtcacatcagagaccgacaccaggtattttgacgag
gagttcacggcccagatgatcaccatcacgccgcccgaccaagacgacagcatggagtgc
gtggacagcgagcggaggccgcacttcccccagttctcctactcggccagcggcacggcc
tga

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