KEGG   Microcebus murinus (gray mouse lemur): 105861219
Entry
105861219         CDS       T07238                                 
Symbol
PLCB1
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
  KO
K05858  phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
mmur  Microcebus murinus (gray mouse lemur)
Pathway
mmur00562  Inositol phosphate metabolism
mmur01100  Metabolic pathways
mmur04015  Rap1 signaling pathway
mmur04020  Calcium signaling pathway
mmur04022  cGMP-PKG signaling pathway
mmur04062  Chemokine signaling pathway
mmur04070  Phosphatidylinositol signaling system
mmur04071  Sphingolipid signaling pathway
mmur04072  Phospholipase D signaling pathway
mmur04081  Hormone signaling
mmur04082  Neuroactive ligand signaling
mmur04261  Adrenergic signaling in cardiomyocytes
mmur04270  Vascular smooth muscle contraction
mmur04310  Wnt signaling pathway
mmur04371  Apelin signaling pathway
mmur04540  Gap junction
mmur04611  Platelet activation
mmur04613  Neutrophil extracellular trap formation
mmur04621  NOD-like receptor signaling pathway
mmur04713  Circadian entrainment
mmur04720  Long-term potentiation
mmur04723  Retrograde endocannabinoid signaling
mmur04724  Glutamatergic synapse
mmur04725  Cholinergic synapse
mmur04726  Serotonergic synapse
mmur04728  Dopaminergic synapse
mmur04730  Long-term depression
mmur04742  Taste transduction
mmur04750  Inflammatory mediator regulation of TRP channels
mmur04911  Insulin secretion
mmur04912  GnRH signaling pathway
mmur04915  Estrogen signaling pathway
mmur04916  Melanogenesis
mmur04918  Thyroid hormone synthesis
mmur04919  Thyroid hormone signaling pathway
mmur04921  Oxytocin signaling pathway
mmur04922  Glucagon signaling pathway
mmur04924  Renin secretion
mmur04925  Aldosterone synthesis and secretion
mmur04926  Relaxin signaling pathway
mmur04927  Cortisol synthesis and secretion
mmur04928  Parathyroid hormone synthesis, secretion and action
mmur04929  GnRH secretion
mmur04933  AGE-RAGE signaling pathway in diabetic complications
mmur04934  Cushing syndrome
mmur04935  Growth hormone synthesis, secretion and action
mmur04961  Endocrine and other factor-regulated calcium reabsorption
mmur04970  Salivary secretion
mmur04971  Gastric acid secretion
mmur04972  Pancreatic secretion
mmur04973  Carbohydrate digestion and absorption
mmur05010  Alzheimer disease
mmur05016  Huntington disease
mmur05017  Spinocerebellar ataxia
mmur05022  Pathways of neurodegeneration - multiple diseases
mmur05142  Chagas disease
mmur05143  African trypanosomiasis
mmur05146  Amoebiasis
mmur05163  Human cytomegalovirus infection
mmur05200  Pathways in cancer
mmur05415  Diabetic cardiomyopathy
mmur05417  Lipid and atherosclerosis
Module
mmur_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:mmur00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    105861219 (PLCB1)
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    105861219 (PLCB1)
   04310 Wnt signaling pathway
    105861219 (PLCB1)
   04371 Apelin signaling pathway
    105861219 (PLCB1)
   04020 Calcium signaling pathway
    105861219 (PLCB1)
   04070 Phosphatidylinositol signaling system
    105861219 (PLCB1)
   04072 Phospholipase D signaling pathway
    105861219 (PLCB1)
   04071 Sphingolipid signaling pathway
    105861219 (PLCB1)
   04022 cGMP-PKG signaling pathway
    105861219 (PLCB1)
  09133 Signaling molecules and interaction
   04082 Neuroactive ligand signaling
    105861219 (PLCB1)
   04081 Hormone signaling
    105861219 (PLCB1)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    105861219 (PLCB1)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    105861219 (PLCB1)
   04613 Neutrophil extracellular trap formation
    105861219 (PLCB1)
   04621 NOD-like receptor signaling pathway
    105861219 (PLCB1)
   04062 Chemokine signaling pathway
    105861219 (PLCB1)
  09152 Endocrine system
   04911 Insulin secretion
    105861219 (PLCB1)
   04922 Glucagon signaling pathway
    105861219 (PLCB1)
   04929 GnRH secretion
    105861219 (PLCB1)
   04912 GnRH signaling pathway
    105861219 (PLCB1)
   04915 Estrogen signaling pathway
    105861219 (PLCB1)
   04921 Oxytocin signaling pathway
    105861219 (PLCB1)
   04926 Relaxin signaling pathway
    105861219 (PLCB1)
   04935 Growth hormone synthesis, secretion and action
    105861219 (PLCB1)
   04918 Thyroid hormone synthesis
    105861219 (PLCB1)
   04919 Thyroid hormone signaling pathway
    105861219 (PLCB1)
   04928 Parathyroid hormone synthesis, secretion and action
    105861219 (PLCB1)
   04916 Melanogenesis
    105861219 (PLCB1)
   04924 Renin secretion
    105861219 (PLCB1)
   04925 Aldosterone synthesis and secretion
    105861219 (PLCB1)
   04927 Cortisol synthesis and secretion
    105861219 (PLCB1)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    105861219 (PLCB1)
   04270 Vascular smooth muscle contraction
    105861219 (PLCB1)
  09154 Digestive system
   04970 Salivary secretion
    105861219 (PLCB1)
   04971 Gastric acid secretion
    105861219 (PLCB1)
   04972 Pancreatic secretion
    105861219 (PLCB1)
   04973 Carbohydrate digestion and absorption
    105861219 (PLCB1)
  09155 Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    105861219 (PLCB1)
  09156 Nervous system
   04724 Glutamatergic synapse
    105861219 (PLCB1)
   04725 Cholinergic synapse
    105861219 (PLCB1)
   04728 Dopaminergic synapse
    105861219 (PLCB1)
   04726 Serotonergic synapse
    105861219 (PLCB1)
   04720 Long-term potentiation
    105861219 (PLCB1)
   04730 Long-term depression
    105861219 (PLCB1)
   04723 Retrograde endocannabinoid signaling
    105861219 (PLCB1)
  09157 Sensory system
   04742 Taste transduction
    105861219 (PLCB1)
   04750 Inflammatory mediator regulation of TRP channels
    105861219 (PLCB1)
  09159 Environmental adaptation
   04713 Circadian entrainment
    105861219 (PLCB1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    105861219 (PLCB1)
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    105861219 (PLCB1)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    105861219 (PLCB1)
   05142 Chagas disease
    105861219 (PLCB1)
   05143 African trypanosomiasis
    105861219 (PLCB1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    105861219 (PLCB1)
   05016 Huntington disease
    105861219 (PLCB1)
   05017 Spinocerebellar ataxia
    105861219 (PLCB1)
   05022 Pathways of neurodegeneration - multiple diseases
    105861219 (PLCB1)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    105861219 (PLCB1)
   05415 Diabetic cardiomyopathy
    105861219 (PLCB1)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    105861219 (PLCB1)
   04934 Cushing syndrome
    105861219 (PLCB1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:mmur04131]
    105861219 (PLCB1)
Enzymes [BR:mmur01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     105861219 (PLCB1)
Membrane trafficking [BR:mmur04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    105861219 (PLCB1)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    105861219 (PLCB1)
SSDB
Motif
Pfam: PI-PLC-X PLC-beta_C PH_14 PI-PLC-Y PLCB1-4-like_EFh EF-hand_like
Other DBs
NCBI-GeneID: 105861219
NCBI-ProteinID: XP_020137503
Ensembl: ENSMICG00000006563
UniProt: A0A8B7WQF6
LinkDB
Position
18:26973077..27734023
AA seq 1216 aa
MAGAQPGVHALQLKPVCVSDSLKKGTKFVKWDDDSTIVTPIILRTDPQGFFFYWTDQNKE
TELLDLSLVKDARCGRHAKAPKDPKLRELLDVGNIGRLEHRMITVVYGPDLVNISHLNLV
AFQEEVAKEWTNEVFSLATNLLAQNMSRDAFLEKAYTKLKLQVTPEGRIPLKNIYRLFSA
DRKRVETALEACSLPSSRNDSIPQEDFTPDVYRVFLNNLCPRPEIDNIFSEFGAKSKPYL
TVDQMMDFINLKQRDPRLNEILYPPLKQEQVQVLIEKYEPNDSLAKKGQISVDGFMRYLS
GEENGVVSPEKLDLNEDMSQPLSHYFINSSHNTYLTAGQLAGNSSVEMYRQVLLSGCRCV
ELDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPFPILLSFENHVDSPKQ
QAKMAEYCRLIFGDALLMEPLEKYPLESGVPLPSPMDLMYKILVKNKKKSHKSSEGSGKK
KLSEQASNTYSDSSSVFEPSSPGAGEADTESDDDDDDDDCKKSSMDEGTAGSEAMATEEM
SNLVNYIQPVKFESFEISKKRNKSFEMSSFVETKGLEQLTKSPVEFVEYNKMQLSRIYPK
GTRVDSSNYMPQLFWNAGCQMVALNFQTMDLAMQINMGMYEYNGKSGYRLKPEFMRRPDK
HFDPFTEGIVDGIVANTLSVKIISGQFLSDKKVGTYVEVDMFGLPVDTRRKAFKTKTSQG
NAVNPIWEEEPIVFKKVVLPSLACLRIAVYEEGGKFIGHRILPVQAIRPGYHYICLRNER
NQPLTLPAVFVYIEVKDYVPDTYADVIEALSNPIRYVNLMEQRAKQLAALTLEDEEEIKK
EADPGETPSEAPSEARTTPAENGVNHTTSLAPKPPSQALHSQPAPGSVKAPAKTEDLIQS
VLTEVEAQTIEELKQQKSFVKLQKKHYKEMKDLVKRHHKKTTDLIKEHTTKYNEIQNDYL
RRRAALEKTAKKDSKKKSEPSSPDHGSSTIEQDLAALDAEMTQKLIDLKDKQQQQLLNLR
QEQYYSEKYQKREHIKLLIQKLTDVAEECQNNQLKKLKEICEKEKKELKKKMDKKRQEKI
TEAKSKDKSQMEEEKTEMIRSYIQEVVQYIKRLEEAQSKRQEKLVEKHKEIRQQILDENP
KLQVELEQEYQDKFKRLPLEILEFVQEAMKGKISEDSNHGSAPLSLSSDPGKVNHKPPSS
EELGGDIPGKEFDTPL
NT seq 3651 nt   +upstreamnt  +downstreamnt
atggccggggctcaacccggagtgcacgccttgcaactcaagcccgtgtgcgtgtccgac
agcctcaagaagggcaccaaattcgtcaagtgggatgatgactcaactattgttactcca
attattttgaggactgaccctcagggatttttcttttactggacagatcaaaataaggag
acagagctgttggatctcagccttgtcaaggatgccagatgtgggagacacgccaaagct
cccaaggaccccaaattgcgtgaacttttggatgtggggaacatcgggaggctagagcac
cgcatgatcaccgtggtgtacgggcctgacctcgtcaacatctcccatctaaatctcgtg
gctttccaggaagaagtggccaaggaatggacaaatgaggttttcagtctggcaacaaac
ctgttggcccaaaacatgtccagggatgcatttctggaaaaagcctacactaaactcaag
ctgcaagtcactccagaagggcgtattcctctcaaaaacatatatcgcttgttttcagca
gaccgaaagcgagttgaaactgctttggaggcttgtagtcttccatcttcaaggaatgat
tcgatacctcaagaagatttcactccagatgtgtacagagttttcctgaacaacctttgc
cctcgacctgaaatcgataacatcttttcggaatttggtgccaaaagcaaaccatacctt
accgttgatcagatgatggattttatcaaccttaagcagcgtgatccccggctaaatgaa
atactttacccacctctaaaacaagagcaagtccaagtattgattgagaagtatgaaccc
aatgatagcctcgccaaaaaaggacagatatccgtggatggatttatgcgctatctgagt
ggagaagaaaacggagttgtttcacctgagaaactggatttgaatgaagacatgtctcag
cccctttctcactatttcattaattcctcgcacaacacctacctcacagctggccagctg
gctggaaactcctctgttgagatgtatcgccaagtgctcctgtctgggtgtcgctgtgtg
gagctagactgctggaagggacggactgcagaagaggaacctgttatcacccatggattc
accatgacgactgaaatatccttcaaggaagtgatagaagcgatcgcggagtgtgcattt
aagacttcaccttttccgattctcctttcatttgagaaccatgtggattccccaaagcag
caggccaagatggcggagtactgccgactgatctttggggatgctcttctcatggagcca
ctggaaaaatacccactggaatctggagttccccttccaagccctatggatttaatgtat
aagattttggtgaaaaataagaagaaatcacacaagtcttcagaaggaagtggcaaaaag
aagctctcggaacaagcttccaacacgtacagcgactcttccagcgtgttcgagccttcg
tccccaggagctggggaagcggatacagagagtgatgatgatgacgatgatgatgactgt
aaaaaatcttcaatggatgaggggaccgctgggagtgaggccatggccacagaagagatg
tccaacctggtgaactatattcagccggtcaagttcgagtcatttgaaatttcaaaaaaa
agaaataaaagttttgaaatgtcttccttcgtggaaaccaaaggacttgaacagcttacg
aaatctccggtggaatttgtagaatataacaaaatgcagctcagcaggatatatccaaaa
ggaactcgtgtggattcatccaactatatgcctcagctcttctggaatgcaggctgtcag
atggtggcccttaatttccagacaatggacctggctatgcaaataaacatggggatgtat
gaatacaacgggaaaagtggctacagattaaagccagagtttatgcggaggcctgacaag
cattttgatccatttactgaaggcattgtagacgggatagtggccaacactttgtctgtt
aagattatttcaggtcagtttctttctgataagaaagtggggacttatgtggaggtggat
atgtttggtttgcccgtggacacaaggaggaaggcatttaagaccaaaacatcccaagga
aatgctgtaaatcctatctgggaagaagaacctattgtgttcaaaaaggtggttcttcct
tcgctggcctgcttgaggatagcagtttatgaagaaggaggtaaatttatcggccaccgg
atcttgccagtgcaagccattcggccaggctatcactatatctgtctgaggaatgaaaga
aaccagcctctaacgctgccagctgtgtttgtctacatagaagtgaaggactacgtgcca
gatacatatgcagatgtgattgaagctttgtcaaacccaatccgatatgtgaatctgatg
gagcagagagctaagcaactggctgctttgaccctggaagatgaagaagaaataaagaaa
gaggctgatcctggggaaacaccatctgaggctccaagtgaagccaggacgactccagca
gaaaacggggtgaatcacactacatccctggcacccaaaccaccctcccaggctctccac
agccagccagctccaggttctgtaaaggcacctgccaaaacagaagaccttattcagagt
gtcttaacagaagtggaggcgcagaccatcgaagagctgaagcaacagaaatcatttgtg
aaacttcaaaagaagcactacaaagaaatgaaagacttggttaagagacaccacaagaaa
accactgaccttatcaaagaacacactacaaaatacaatgaaattcagaacgactacctg
agaaggagagcggctttggaaaagactgccaaaaaagacagtaagaaaaaatcagagccc
agtagccctgaccatggctcatcaacgattgaacaagaccttgctgctctggatgcggaa
atgacccaaaagctaatagacctgaaggacaaacaacagcagcagctgcttaatcttcgt
caagaacagtattatagtgaaaaataccagaagcgggaacatattaaactgcttattcaa
aagttgacagacgttgctgaagagtgtcagaacaatcagctaaagaagctcaaagaaatc
tgtgagaaagagaagaaggaattaaagaagaaaatggataaaaagaggcaggagaagatt
acagaagctaaatccaaagacaaaagtcagatggaagaggagaagacagaaatgattcgg
tcatatatccaggaggtggtgcagtacatcaagaggttagaagaggcgcaaagtaaacgg
caagaaaaactcgtagagaaacacaaggagatacgtcagcagatcctggatgaaaatccc
aagctgcaggtggagctggagcaagaataccaagacaagttcaaaagactgcccctagag
attttggagtttgtgcaggaagccatgaaagggaagatcagtgaagacagcaatcacggt
tctgcccctctctctctgtcctcagaccctggaaaagtgaaccacaagcctccttccagt
gaggagttgggaggagacatcccaggaaaagagtttgatactcctctgtga

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