Microcebus murinus (gray mouse lemur): 105875228
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Entry
105875228 CDS
T07238
Symbol
FPGS
Name
(RefSeq) folylpolyglutamate synthase, mitochondrial isoform X1
KO
K01930
folylpolyglutamate synthase [EC:
6.3.2.17
]
Organism
mmur
Microcebus murinus (gray mouse lemur)
Pathway
mmur00790
Folate biosynthesis
mmur01100
Metabolic pathways
mmur01240
Biosynthesis of cofactors
mmur01523
Antifolate resistance
mmur04981
Folate transport and metabolism
Brite
KEGG Orthology (KO) [BR:
mmur00001
]
09100 Metabolism
09108 Metabolism of cofactors and vitamins
00790 Folate biosynthesis
105875228 (FPGS)
09150 Organismal Systems
09154 Digestive system
04981 Folate transport and metabolism
105875228 (FPGS)
09160 Human Diseases
09176 Drug resistance: antineoplastic
01523 Antifolate resistance
105875228 (FPGS)
Enzymes [BR:
mmur01000
]
6. Ligases
6.3 Forming carbon-nitrogen bonds
6.3.2 Acid-D-amino-acid ligases (peptide synthases)
6.3.2.17 tetrahydrofolate synthase
105875228 (FPGS)
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Paralog
Gene cluster
GFIT
Motif
Pfam:
Mur_ligase_M
Mur_ligase_C
Motif
Other DBs
NCBI-GeneID:
105875228
NCBI-ProteinID:
XP_012627472
Ensembl:
ENSMICG00000005654
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Position
10:89872880..89900736
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AA seq
624 aa
AA seq
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MKGARSLATSWPVAEKFCWEVAMEQQGPCGRPFSATAGSFKAASHLRAALSLAAVSARGA
TSRGAARRRLSAWPVPQEPSMEYQDAVRMLNTLQTNAGYLEQVKRQRGDPQTQLEAMEQY
LARSGLQVEDLDGLNIIHVTGTKGKGSTCAFTECILRSYGLKTGFFSSPHLVQVRERIRI
NGQPISPELFTKHFWRLYHRLEETKDSSCVSMPPYFRFLTLMAFHVFLQEKVDLAVVEVG
IGGAYDCTNIIRKPVVCGVSSLGIDHTSLLGDTLEKIAWQKGGIFKQGVPAFTVLQPEGP
LAVLRDRAQQISCPLYLCPPLEALEEGGPPLTLGLEGEHQRSNAALALQLARCWLQQQDH
QGAGELKASRPSLLWQLPLAPTFQPTSHMQLGLRNTEWPGRTQVLRRGPLTWYLDGAHTS
NSVQACVRWFRQALQGSQRLSAGPEVRVLLFNSTGDRDSAALLKLLQPCQFDYAVFCPNL
TEVASTGSADQQNFTVTLDHVLLRCLEHQQHWNRLDEEQASPDLWSSPSLEPGGPASLLL
APRPPHSCASSLVFSCISHALQWISQGRDPVFQPPRPPRGLFAHPVAASGASVLQEAVAI
HVLVTGSLHLVGGVLKLLEPSLSQ
NT seq
1875 nt
NT seq
+upstream
nt +downstream
nt
atgaaaggtgccaggtccctggctacctcctggccagtggctgagaagttctgctgggaa
gtggccatggagcagcagggcccgtgcgggcgacctttctccgctacagctggctccttc
aaggcggcgagtcacctgcgcgcagctctgtccctggcagcggtttccgcgcgcggcgca
acgagccggggcgcggcgaggcggaggttgagcgcgtggccggtgccgcaggagcctagc
atggagtatcaggatgcagtgcgcatgctcaacaccctgcagaccaatgccggctacctg
gaacaggtgaagcgccaacggggcgacccccagacacagcttgaagccatggagcagtac
ctggcacggagtgggttgcaggtggaggacttggacgggctgaacatcatccatgtcact
gggaccaaggggaagggctccacgtgtgccttcacggaatgtatcctccgaagctatggc
ctgaagacgggattctttagctctccccacctggtgcaggtgcgtgagcggatccgcatc
aacgggcagcccatcagccctgagctattcaccaagcacttctggcgcctctaccaccgg
ctggaggagaccaaggacagcagctgtgtctccatgcccccctacttccgcttcctcacg
ctcatggccttccacgtcttcctccaagagaaggtggacctggcggtggtggaagtgggc
atcggcggggcttatgactgcaccaacatcatcaggaagcctgtggtgtgtggagtctcc
tctcttggcatcgaccacaccagccttctgggggacacgttggagaagatcgcatggcag
aaagggggcatctttaagcaaggtgtccctgcctttactgtgctccagcccgaaggtccc
ctggcagtgctgcgggatcgagcgcagcagatctcatgtcctctctacctgtgcccaccg
ctggaagccctggaggaaggggggccaccgctgacgctgggcctggagggagagcaccag
cggtccaatgctgccttggccttgcagctggcccgctgctggctgcagcagcaggaccac
cagggcgctggggagctgaaggcgtccaggccgagcctcctgtggcagctgcccctggca
ccgacgttccagcccacgtcccacatgcagctcggccttcggaacacggagtggccgggc
cggacgcaggtgctgcggcgcgggcccctcacctggtacctggacggcgcgcacacctcc
aacagcgtgcaggcctgcgtgcgctggttccggcaggcgctgcagggcagccagaggctg
agcgctgggcctgaggtgcgtgtcttgctcttcaactccaccggggaccgggactccgcc
gccctgctgaagctgctgcagccctgccagtttgactatgctgtcttctgccccaacctg
acagaggtggcatccacaggcagtgcagaccagcagaacttcacagtgacactggaccac
gtgctgctccgctgcctcgaacaccaacagcactggaaccgcctggatgaggagcaggcc
agcccggacctctggagcagccccagcctggagcctggagggccggcgtctctgctgctg
gcgcctcgcccaccccacagctgcgccagctccctcgtcttcagctgcatctcccacgcc
ttgcagtggatcagccaaggccgggaccctgtcttccagccaccccgtcccccaaggggc
ctctttgcccaccctgtggcagctagcggggccagtgtactccaagaggctgttgccatc
cacgtgctggtcaccggcagcctgcacctggtgggtggtgtcttgaagcttctggaaccc
tccttgtcccagtag
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