KEGG   Microcebus murinus (gray mouse lemur): 105885017
Entry
105885017         CDS       T07238                                 
Symbol
MAPK12
Name
(RefSeq) mitogen-activated protein kinase 12
  KO
K04441  p38 MAP kinase [EC:2.7.11.24]
Organism
mmur  Microcebus murinus (gray mouse lemur)
Pathway
mmur01522  Endocrine resistance
mmur04010  MAPK signaling pathway
mmur04015  Rap1 signaling pathway
mmur04068  FoxO signaling pathway
mmur04071  Sphingolipid signaling pathway
mmur04114  Oocyte meiosis
mmur04148  Efferocytosis
mmur04218  Cellular senescence
mmur04261  Adrenergic signaling in cardiomyocytes
mmur04370  VEGF signaling pathway
mmur04380  Osteoclast differentiation
mmur04517  IgSF CAM signaling
mmur04550  Signaling pathways regulating pluripotency of stem cells
mmur04611  Platelet activation
mmur04613  Neutrophil extracellular trap formation
mmur04620  Toll-like receptor signaling pathway
mmur04621  NOD-like receptor signaling pathway
mmur04622  RIG-I-like receptor signaling pathway
mmur04625  C-type lectin receptor signaling pathway
mmur04657  IL-17 signaling pathway
mmur04658  Th1 and Th2 cell differentiation
mmur04659  Th17 cell differentiation
mmur04660  T cell receptor signaling pathway
mmur04664  Fc epsilon RI signaling pathway
mmur04668  TNF signaling pathway
mmur04670  Leukocyte transendothelial migration
mmur04714  Thermogenesis
mmur04722  Neurotrophin signaling pathway
mmur04723  Retrograde endocannabinoid signaling
mmur04728  Dopaminergic synapse
mmur04750  Inflammatory mediator regulation of TRP channels
mmur04912  GnRH signaling pathway
mmur04914  Progesterone-mediated oocyte maturation
mmur04917  Prolactin signaling pathway
mmur04926  Relaxin signaling pathway
mmur04932  Non-alcoholic fatty liver disease
mmur04933  AGE-RAGE signaling pathway in diabetic complications
mmur04935  Growth hormone synthesis, secretion and action
mmur04936  Alcoholic liver disease
mmur05014  Amyotrophic lateral sclerosis
mmur05020  Prion disease
mmur05022  Pathways of neurodegeneration - multiple diseases
mmur05132  Salmonella infection
mmur05133  Pertussis
mmur05135  Yersinia infection
mmur05140  Leishmaniasis
mmur05142  Chagas disease
mmur05145  Toxoplasmosis
mmur05152  Tuberculosis
mmur05161  Hepatitis B
mmur05163  Human cytomegalovirus infection
mmur05167  Kaposi sarcoma-associated herpesvirus infection
mmur05169  Epstein-Barr virus infection
mmur05170  Human immunodeficiency virus 1 infection
mmur05171  Coronavirus disease - COVID-19
mmur05205  Proteoglycans in cancer
mmur05208  Chemical carcinogenesis - reactive oxygen species
mmur05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
mmur05415  Diabetic cardiomyopathy
mmur05417  Lipid and atherosclerosis
mmur05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:mmur00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    105885017 (MAPK12)
   04015 Rap1 signaling pathway
    105885017 (MAPK12)
   04370 VEGF signaling pathway
    105885017 (MAPK12)
   04668 TNF signaling pathway
    105885017 (MAPK12)
   04068 FoxO signaling pathway
    105885017 (MAPK12)
   04071 Sphingolipid signaling pathway
    105885017 (MAPK12)
  09133 Signaling molecules and interaction
   04517 IgSF CAM signaling
    105885017 (MAPK12)
 09140 Cellular Processes
  09141 Transport and catabolism
   04148 Efferocytosis
    105885017 (MAPK12)
  09143 Cell growth and death
   04114 Oocyte meiosis
    105885017 (MAPK12)
   04218 Cellular senescence
    105885017 (MAPK12)
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    105885017 (MAPK12)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    105885017 (MAPK12)
   04613 Neutrophil extracellular trap formation
    105885017 (MAPK12)
   04620 Toll-like receptor signaling pathway
    105885017 (MAPK12)
   04621 NOD-like receptor signaling pathway
    105885017 (MAPK12)
   04622 RIG-I-like receptor signaling pathway
    105885017 (MAPK12)
   04625 C-type lectin receptor signaling pathway
    105885017 (MAPK12)
   04660 T cell receptor signaling pathway
    105885017 (MAPK12)
   04658 Th1 and Th2 cell differentiation
    105885017 (MAPK12)
   04659 Th17 cell differentiation
    105885017 (MAPK12)
   04657 IL-17 signaling pathway
    105885017 (MAPK12)
   04664 Fc epsilon RI signaling pathway
    105885017 (MAPK12)
   04670 Leukocyte transendothelial migration
    105885017 (MAPK12)
  09152 Endocrine system
   04912 GnRH signaling pathway
    105885017 (MAPK12)
   04914 Progesterone-mediated oocyte maturation
    105885017 (MAPK12)
   04917 Prolactin signaling pathway
    105885017 (MAPK12)
   04926 Relaxin signaling pathway
    105885017 (MAPK12)
   04935 Growth hormone synthesis, secretion and action
    105885017 (MAPK12)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    105885017 (MAPK12)
  09156 Nervous system
   04728 Dopaminergic synapse
    105885017 (MAPK12)
   04723 Retrograde endocannabinoid signaling
    105885017 (MAPK12)
   04722 Neurotrophin signaling pathway
    105885017 (MAPK12)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    105885017 (MAPK12)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    105885017 (MAPK12)
  09159 Environmental adaptation
   04714 Thermogenesis
    105885017 (MAPK12)
 09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    105885017 (MAPK12)
   05208 Chemical carcinogenesis - reactive oxygen species
    105885017 (MAPK12)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    105885017 (MAPK12)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    105885017 (MAPK12)
   05161 Hepatitis B
    105885017 (MAPK12)
   05171 Coronavirus disease - COVID-19
    105885017 (MAPK12)
   05163 Human cytomegalovirus infection
    105885017 (MAPK12)
   05167 Kaposi sarcoma-associated herpesvirus infection
    105885017 (MAPK12)
   05169 Epstein-Barr virus infection
    105885017 (MAPK12)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    105885017 (MAPK12)
   05135 Yersinia infection
    105885017 (MAPK12)
   05133 Pertussis
    105885017 (MAPK12)
   05152 Tuberculosis
    105885017 (MAPK12)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    105885017 (MAPK12)
   05140 Leishmaniasis
    105885017 (MAPK12)
   05142 Chagas disease
    105885017 (MAPK12)
  09164 Neurodegenerative disease
   05014 Amyotrophic lateral sclerosis
    105885017 (MAPK12)
   05020 Prion disease
    105885017 (MAPK12)
   05022 Pathways of neurodegeneration - multiple diseases
    105885017 (MAPK12)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    105885017 (MAPK12)
   05418 Fluid shear stress and atherosclerosis
    105885017 (MAPK12)
   05415 Diabetic cardiomyopathy
    105885017 (MAPK12)
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    105885017 (MAPK12)
   04932 Non-alcoholic fatty liver disease
    105885017 (MAPK12)
   04933 AGE-RAGE signaling pathway in diabetic complications
    105885017 (MAPK12)
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    105885017 (MAPK12)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:mmur01001]
    105885017 (MAPK12)
Enzymes [BR:mmur01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.24  mitogen-activated protein kinase
     105885017 (MAPK12)
Protein kinases [BR:mmur01001]
 Serine/threonine kinases: CMGC group
  MAPK family [OT]
   105885017 (MAPK12)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1 APH Kdo Haspin_kinase Kinase-like
Other DBs
NCBI-GeneID: 105885017
NCBI-ProteinID: XP_012645006
Ensembl: ENSMICG00000027958
UniProt: A0A8C5VHI3
LinkDB
Position
7:complement(12704017..12713582)
AA seq 367 aa
MSSPPPARSGFYRQEVTKTAWEVRAVYQDLQPVGSGAYGAVCSAVDSRTGAKVAIKKLYR
PFQSELFAKRAYRELRLLKHMHHENVIGLLDVFTPDESLDDFTDFYLVMPFMGTDLGKLM
KHEKLSEDRIQFLVYQMLKGLKYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADS
EMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGNDHLDQLKEIMK
VTGTPSPEFVQRLQSADAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRV
TAAGALAHPYFESLHDTEDTPVAQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGTR
VSKETAL
NT seq 1104 nt   +upstreamnt  +downstreamnt
atgagctctccgccacctgcccgcagtggcttttaccgccaggaggtgaccaagaccgcc
tgggaggtgcgcgccgtgtaccaggacctgcagcccgtgggctcgggcgcttacggcgcg
gtgtgctcggccgtggacagccggacgggcgccaaggtggccatcaagaagctgtaccgg
cccttccagtcagagctgttcgccaagcgcgcctaccgcgagctgcggctcctcaaacac
atgcaccacgagaacgtgatcgggctgctggatgtgttcactcctgacgagagcctggat
gacttcacagacttttacctggtgatgccgttcatggggactgacctgggcaaactcatg
aagcacgagaagctgagtgaggaccggatccagttcctggtgtaccagatgctgaagggg
ctcaagtatatccacgccgctggcatcatccacagggacctgaagccaggcaatctagca
gtgaacgaggactgtgagcttaagatcctggactttggcctggccaggcaggcagacagt
gagatgaccggctacgtggtgacgcggtggtaccgggcgcctgaggtcatcttgaactgg
atgcgctacacacagacggtggacatctggtccgtgggctgcatcatggcagagatgatc
actgggaagacgctgttcaagggcaacgaccacctggaccagctgaaggagatcatgaag
gtgaccggcacgccgtcgcccgagtttgtgcagaggctgcagagcgcggatgcgaagaac
tacatgaagggcctccccgagctggagaagaaggacttcgcctccatcctgaccaacgcc
agccccctggcggtgaacctcctggagaagatgctggtgctggacgcggagcagcgggtg
acggcagccggggcgctggcgcacccctacttcgagtcgctgcacgacacggaggacacg
cccgtggcccagaagtacgacgactccttcgacgacgtggaccgcacgctggacgagtgg
aagcgtgtcacctacaaagaggtgctcagcttcaagccgcccaggcagctggggaccagg
gtttccaaggagacggctctgtga

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