KEGG   Myotis myotis (greater mouse-eared bat): 118654213
Entry
118654213         CDS       T07220                                 
Symbol
MAP2K1
Name
(RefSeq) dual specificity mitogen-activated protein kinase kinase 1 isoform X1
  KO
K04368  mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
Organism
mmyo  Myotis myotis (greater mouse-eared bat)
Pathway
mmyo01521  EGFR tyrosine kinase inhibitor resistance
mmyo01522  Endocrine resistance
mmyo04010  MAPK signaling pathway
mmyo04012  ErbB signaling pathway
mmyo04014  Ras signaling pathway
mmyo04015  Rap1 signaling pathway
mmyo04022  cGMP-PKG signaling pathway
mmyo04024  cAMP signaling pathway
mmyo04062  Chemokine signaling pathway
mmyo04066  HIF-1 signaling pathway
mmyo04068  FoxO signaling pathway
mmyo04071  Sphingolipid signaling pathway
mmyo04072  Phospholipase D signaling pathway
mmyo04114  Oocyte meiosis
mmyo04140  Autophagy - animal
mmyo04148  Efferocytosis
mmyo04150  mTOR signaling pathway
mmyo04151  PI3K-Akt signaling pathway
mmyo04210  Apoptosis
mmyo04218  Cellular senescence
mmyo04270  Vascular smooth muscle contraction
mmyo04370  VEGF signaling pathway
mmyo04371  Apelin signaling pathway
mmyo04380  Osteoclast differentiation
mmyo04510  Focal adhesion
mmyo04517  IgSF CAM signaling
mmyo04540  Gap junction
mmyo04550  Signaling pathways regulating pluripotency of stem cells
mmyo04613  Neutrophil extracellular trap formation
mmyo04620  Toll-like receptor signaling pathway
mmyo04650  Natural killer cell mediated cytotoxicity
mmyo04660  T cell receptor signaling pathway
mmyo04662  B cell receptor signaling pathway
mmyo04664  Fc epsilon RI signaling pathway
mmyo04666  Fc gamma R-mediated phagocytosis
mmyo04668  TNF signaling pathway
mmyo04720  Long-term potentiation
mmyo04722  Neurotrophin signaling pathway
mmyo04725  Cholinergic synapse
mmyo04726  Serotonergic synapse
mmyo04730  Long-term depression
mmyo04810  Regulation of actin cytoskeleton
mmyo04910  Insulin signaling pathway
mmyo04912  GnRH signaling pathway
mmyo04914  Progesterone-mediated oocyte maturation
mmyo04915  Estrogen signaling pathway
mmyo04916  Melanogenesis
mmyo04917  Prolactin signaling pathway
mmyo04919  Thyroid hormone signaling pathway
mmyo04921  Oxytocin signaling pathway
mmyo04926  Relaxin signaling pathway
mmyo04928  Parathyroid hormone synthesis, secretion and action
mmyo04929  GnRH secretion
mmyo04934  Cushing syndrome
mmyo04935  Growth hormone synthesis, secretion and action
mmyo05010  Alzheimer disease
mmyo05022  Pathways of neurodegeneration - multiple diseases
mmyo05034  Alcoholism
mmyo05132  Salmonella infection
mmyo05135  Yersinia infection
mmyo05160  Hepatitis C
mmyo05161  Hepatitis B
mmyo05163  Human cytomegalovirus infection
mmyo05164  Influenza A
mmyo05165  Human papillomavirus infection
mmyo05166  Human T-cell leukemia virus 1 infection
mmyo05167  Kaposi sarcoma-associated herpesvirus infection
mmyo05170  Human immunodeficiency virus 1 infection
mmyo05200  Pathways in cancer
mmyo05205  Proteoglycans in cancer
mmyo05206  MicroRNAs in cancer
mmyo05207  Chemical carcinogenesis - receptor activation
mmyo05208  Chemical carcinogenesis - reactive oxygen species
mmyo05210  Colorectal cancer
mmyo05211  Renal cell carcinoma
mmyo05212  Pancreatic cancer
mmyo05213  Endometrial cancer
mmyo05214  Glioma
mmyo05215  Prostate cancer
mmyo05216  Thyroid cancer
mmyo05218  Melanoma
mmyo05219  Bladder cancer
mmyo05220  Chronic myeloid leukemia
mmyo05221  Acute myeloid leukemia
mmyo05223  Non-small cell lung cancer
mmyo05224  Breast cancer
mmyo05225  Hepatocellular carcinoma
mmyo05226  Gastric cancer
mmyo05230  Central carbon metabolism in cancer
mmyo05231  Choline metabolism in cancer
mmyo05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:mmyo00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    118654213 (MAP2K1)
   04012 ErbB signaling pathway
    118654213 (MAP2K1)
   04014 Ras signaling pathway
    118654213 (MAP2K1)
   04015 Rap1 signaling pathway
    118654213 (MAP2K1)
   04370 VEGF signaling pathway
    118654213 (MAP2K1)
   04371 Apelin signaling pathway
    118654213 (MAP2K1)
   04668 TNF signaling pathway
    118654213 (MAP2K1)
   04066 HIF-1 signaling pathway
    118654213 (MAP2K1)
   04068 FoxO signaling pathway
    118654213 (MAP2K1)
   04072 Phospholipase D signaling pathway
    118654213 (MAP2K1)
   04071 Sphingolipid signaling pathway
    118654213 (MAP2K1)
   04024 cAMP signaling pathway
    118654213 (MAP2K1)
   04022 cGMP-PKG signaling pathway
    118654213 (MAP2K1)
   04151 PI3K-Akt signaling pathway
    118654213 (MAP2K1)
   04150 mTOR signaling pathway
    118654213 (MAP2K1)
  09133 Signaling molecules and interaction
   04517 IgSF CAM signaling
    118654213 (MAP2K1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    118654213 (MAP2K1)
   04148 Efferocytosis
    118654213 (MAP2K1)
  09143 Cell growth and death
   04114 Oocyte meiosis
    118654213 (MAP2K1)
   04210 Apoptosis
    118654213 (MAP2K1)
   04218 Cellular senescence
    118654213 (MAP2K1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    118654213 (MAP2K1)
   04540 Gap junction
    118654213 (MAP2K1)
   04550 Signaling pathways regulating pluripotency of stem cells
    118654213 (MAP2K1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    118654213 (MAP2K1)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    118654213 (MAP2K1)
   04620 Toll-like receptor signaling pathway
    118654213 (MAP2K1)
   04650 Natural killer cell mediated cytotoxicity
    118654213 (MAP2K1)
   04660 T cell receptor signaling pathway
    118654213 (MAP2K1)
   04662 B cell receptor signaling pathway
    118654213 (MAP2K1)
   04664 Fc epsilon RI signaling pathway
    118654213 (MAP2K1)
   04666 Fc gamma R-mediated phagocytosis
    118654213 (MAP2K1)
   04062 Chemokine signaling pathway
    118654213 (MAP2K1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    118654213 (MAP2K1)
   04929 GnRH secretion
    118654213 (MAP2K1)
   04912 GnRH signaling pathway
    118654213 (MAP2K1)
   04915 Estrogen signaling pathway
    118654213 (MAP2K1)
   04914 Progesterone-mediated oocyte maturation
    118654213 (MAP2K1)
   04917 Prolactin signaling pathway
    118654213 (MAP2K1)
   04921 Oxytocin signaling pathway
    118654213 (MAP2K1)
   04926 Relaxin signaling pathway
    118654213 (MAP2K1)
   04935 Growth hormone synthesis, secretion and action
    118654213 (MAP2K1)
   04919 Thyroid hormone signaling pathway
    118654213 (MAP2K1)
   04928 Parathyroid hormone synthesis, secretion and action
    118654213 (MAP2K1)
   04916 Melanogenesis
    118654213 (MAP2K1)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    118654213 (MAP2K1)
  09156 Nervous system
   04725 Cholinergic synapse
    118654213 (MAP2K1)
   04726 Serotonergic synapse
    118654213 (MAP2K1)
   04720 Long-term potentiation
    118654213 (MAP2K1)
   04730 Long-term depression
    118654213 (MAP2K1)
   04722 Neurotrophin signaling pathway
    118654213 (MAP2K1)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    118654213 (MAP2K1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    118654213 (MAP2K1)
   05206 MicroRNAs in cancer
    118654213 (MAP2K1)
   05205 Proteoglycans in cancer
    118654213 (MAP2K1)
   05207 Chemical carcinogenesis - receptor activation
    118654213 (MAP2K1)
   05208 Chemical carcinogenesis - reactive oxygen species
    118654213 (MAP2K1)
   05230 Central carbon metabolism in cancer
    118654213 (MAP2K1)
   05231 Choline metabolism in cancer
    118654213 (MAP2K1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    118654213 (MAP2K1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    118654213 (MAP2K1)
   05212 Pancreatic cancer
    118654213 (MAP2K1)
   05225 Hepatocellular carcinoma
    118654213 (MAP2K1)
   05226 Gastric cancer
    118654213 (MAP2K1)
   05214 Glioma
    118654213 (MAP2K1)
   05216 Thyroid cancer
    118654213 (MAP2K1)
   05221 Acute myeloid leukemia
    118654213 (MAP2K1)
   05220 Chronic myeloid leukemia
    118654213 (MAP2K1)
   05218 Melanoma
    118654213 (MAP2K1)
   05211 Renal cell carcinoma
    118654213 (MAP2K1)
   05219 Bladder cancer
    118654213 (MAP2K1)
   05215 Prostate cancer
    118654213 (MAP2K1)
   05213 Endometrial cancer
    118654213 (MAP2K1)
   05224 Breast cancer
    118654213 (MAP2K1)
   05223 Non-small cell lung cancer
    118654213 (MAP2K1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    118654213 (MAP2K1)
   05170 Human immunodeficiency virus 1 infection
    118654213 (MAP2K1)
   05161 Hepatitis B
    118654213 (MAP2K1)
   05160 Hepatitis C
    118654213 (MAP2K1)
   05164 Influenza A
    118654213 (MAP2K1)
   05163 Human cytomegalovirus infection
    118654213 (MAP2K1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    118654213 (MAP2K1)
   05165 Human papillomavirus infection
    118654213 (MAP2K1)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    118654213 (MAP2K1)
   05135 Yersinia infection
    118654213 (MAP2K1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    118654213 (MAP2K1)
   05022 Pathways of neurodegeneration - multiple diseases
    118654213 (MAP2K1)
  09165 Substance dependence
   05034 Alcoholism
    118654213 (MAP2K1)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    118654213 (MAP2K1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    118654213 (MAP2K1)
   01522 Endocrine resistance
    118654213 (MAP2K1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:mmyo01001]
    118654213 (MAP2K1)
Enzymes [BR:mmyo01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     118654213 (MAP2K1)
Protein kinases [BR:mmyo01001]
 Serine/threonine kinases: STE group
  STE7 family
   118654213 (MAP2K1)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1 Pkinase_fungal Kinase-like Haspin_kinase Seadorna_VP7
Other DBs
NCBI-GeneID: 118654213
NCBI-ProteinID: XP_036161443
LinkDB
Position
Unknown
AA seq 393 aa
MPKKKPTPIQLNPAPDGSAVNGTSAAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKV
GELKDDDFEKISELGAGNGGVVFKVSHQPSGLVMARKLIHLEIKPAIRNQIIRELQVLHE
CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYL
REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHY
SVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSY
GMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAF
IKRSDAEEVDFAGWLCSTIGLNQPSTPTHAAGV
NT seq 1182 nt   +upstreamnt  +downstreamnt
atgcccaagaagaagccgacgcccatccagctgaacccggccccggacggctccgcggtt
aacgggaccagcgcggcggagaccaacctggaggctttgcagaagaagttggaggagctg
gagctcgatgagcagcagcggaagcgccttgaggcctttcttacccagaagcagaaggtg
ggggaactgaaggatgatgactttgagaagatcagtgagctgggtgccggcaatggtggt
gtggtgttcaaggtctcccaccagccgtccggcctggttatggccagaaagctaattcac
ctggagatcaaacctgcgatccggaaccagataataagggagctgcaggttctacatgag
tgtaactccccatacattgtgggcttctatggtgcattctacagcgatggagagatcagc
atctgcatggagcatatggatgggggttccttggatcaagtcctgaagaaagctggaaga
attcctgaacaaattttaggaaaagttagcattgctgtaataaaaggtctgacatatctg
agggagaaacacaagattatgcatagagatgtcaagccttctaacatcctagtcaactcc
cgtggggagatcaagctctgtgactttggagtcagcgggcagctcatcgactccatggcc
aactccttcgtgggcacaaggtcctacatgtcgccagagagactccaggggactcattac
tcggtgcagtcggacatctggagcatggggctctctctggttgagatggcggttgggagg
tatcccatccctcctccggatgccaaggagctggagctgatgtttgggtgccaggtggag
ggagatgcggctgagacaccaccccggccaaggacccctgggaggccccttagctcttat
ggaatggacagccgaccgcccatggcaatttttgagttattggattacatagtcaacgag
cctcctccaaaactgcccagtggagtattcagtctggaatttcaagattttgtgaataaa
tgcttaataaaaaaccctgcagagagagcagatttgaagcaactcatggttcatgctttt
atcaagagatctgatgctgaggaagtggattttgcaggttggctctgctccaccatcggc
cttaaccagcccagcacaccaacccatgcggctggtgtctaa

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