| Entry | 
 | 
| Symbol | 
PLCB1 
  | 
| Name | 
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 
  | 
|   KO | 
 | 
| Organism | 
mna  Miniopterus natalensis (Natal long-fingered bat)
   | 
| Pathway | 
| mna04070   | Phosphatidylinositol signaling system |  
 | mna04072   | Phospholipase D signaling pathway |  
 | mna04261   | Adrenergic signaling in cardiomyocytes |  
 | mna04270   | Vascular smooth muscle contraction |  
 | mna04613   | Neutrophil extracellular trap formation |  
 | mna04621   | NOD-like receptor signaling pathway |  
 | mna04723   | Retrograde endocannabinoid signaling |  
 | mna04750   | Inflammatory mediator regulation of TRP channels |  
 | mna04919   | Thyroid hormone signaling pathway |  
 | mna04925   | Aldosterone synthesis and secretion |  
 | mna04927   | Cortisol synthesis and secretion |  
 | mna04928   | Parathyroid hormone synthesis, secretion and action |  
 | mna04933   | AGE-RAGE signaling pathway in diabetic complications |  
 | mna04935   | Growth hormone synthesis, secretion and action |  
 | mna04961   | Endocrine and other factor-regulated calcium reabsorption |  
 | mna04973   | Carbohydrate digestion and absorption |  
 | mna05022   | Pathways of neurodegeneration - multiple diseases |  
 | mna05163   | Human cytomegalovirus infection |  
  | 
| Module | 
| mna_M00130   | Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4 |  
  | 
| Brite | 
KEGG Orthology (KO) [BR:mna00001] 
 09100 Metabolism 
  09101 Carbohydrate metabolism 
   00562 Inositol phosphate metabolism 
    107536369 (PLCB1) 
 09130 Environmental Information Processing 
  09132 Signal transduction 
   04015 Rap1 signaling pathway 
    107536369 (PLCB1) 
   04310 Wnt signaling pathway 
    107536369 (PLCB1) 
   04371 Apelin signaling pathway 
    107536369 (PLCB1) 
   04020 Calcium signaling pathway 
    107536369 (PLCB1) 
   04070 Phosphatidylinositol signaling system 
    107536369 (PLCB1) 
   04072 Phospholipase D signaling pathway 
    107536369 (PLCB1) 
   04071 Sphingolipid signaling pathway 
    107536369 (PLCB1) 
   04022 cGMP-PKG signaling pathway 
    107536369 (PLCB1) 
  09133 Signaling molecules and interaction 
   04082 Neuroactive ligand signaling 
    107536369 (PLCB1) 
   04081 Hormone signaling 
    107536369 (PLCB1) 
 09140 Cellular Processes 
  09144 Cellular community - eukaryotes 
   04540 Gap junction 
    107536369 (PLCB1) 
 09150 Organismal Systems 
  09151 Immune system 
   04611 Platelet activation 
    107536369 (PLCB1) 
   04613 Neutrophil extracellular trap formation 
    107536369 (PLCB1) 
   04621 NOD-like receptor signaling pathway 
    107536369 (PLCB1) 
   04062 Chemokine signaling pathway 
    107536369 (PLCB1) 
  09152 Endocrine system 
   04911 Insulin secretion 
    107536369 (PLCB1) 
   04922 Glucagon signaling pathway 
    107536369 (PLCB1) 
   04929 GnRH secretion 
    107536369 (PLCB1) 
   04912 GnRH signaling pathway 
    107536369 (PLCB1) 
   04915 Estrogen signaling pathway 
    107536369 (PLCB1) 
   04921 Oxytocin signaling pathway 
    107536369 (PLCB1) 
   04926 Relaxin signaling pathway 
    107536369 (PLCB1) 
   04935 Growth hormone synthesis, secretion and action 
    107536369 (PLCB1) 
   04918 Thyroid hormone synthesis 
    107536369 (PLCB1) 
   04919 Thyroid hormone signaling pathway 
    107536369 (PLCB1) 
   04928 Parathyroid hormone synthesis, secretion and action 
    107536369 (PLCB1) 
   04916 Melanogenesis 
    107536369 (PLCB1) 
   04924 Renin secretion 
    107536369 (PLCB1) 
   04925 Aldosterone synthesis and secretion 
    107536369 (PLCB1) 
   04927 Cortisol synthesis and secretion 
    107536369 (PLCB1) 
  09153 Circulatory system 
   04261 Adrenergic signaling in cardiomyocytes 
    107536369 (PLCB1) 
   04270 Vascular smooth muscle contraction 
    107536369 (PLCB1) 
  09154 Digestive system 
   04970 Salivary secretion 
    107536369 (PLCB1) 
   04971 Gastric acid secretion 
    107536369 (PLCB1) 
   04972 Pancreatic secretion 
    107536369 (PLCB1) 
   04973 Carbohydrate digestion and absorption 
    107536369 (PLCB1) 
  09155 Excretory system 
   04961 Endocrine and other factor-regulated calcium reabsorption 
    107536369 (PLCB1) 
  09156 Nervous system 
   04724 Glutamatergic synapse 
    107536369 (PLCB1) 
   04725 Cholinergic synapse 
    107536369 (PLCB1) 
   04728 Dopaminergic synapse 
    107536369 (PLCB1) 
   04726 Serotonergic synapse 
    107536369 (PLCB1) 
   04720 Long-term potentiation 
    107536369 (PLCB1) 
   04730 Long-term depression 
    107536369 (PLCB1) 
   04723 Retrograde endocannabinoid signaling 
    107536369 (PLCB1) 
  09157 Sensory system 
   04742 Taste transduction 
    107536369 (PLCB1) 
   04750 Inflammatory mediator regulation of TRP channels 
    107536369 (PLCB1) 
  09159 Environmental adaptation 
   04713 Circadian entrainment 
    107536369 (PLCB1) 
 09160 Human Diseases 
  09161 Cancer: overview 
   05200 Pathways in cancer 
    107536369 (PLCB1) 
  09172 Infectious disease: viral 
   05163 Human cytomegalovirus infection 
    107536369 (PLCB1) 
  09174 Infectious disease: parasitic 
   05146 Amoebiasis 
    107536369 (PLCB1) 
   05142 Chagas disease 
    107536369 (PLCB1) 
   05143 African trypanosomiasis 
    107536369 (PLCB1) 
  09164 Neurodegenerative disease 
   05010 Alzheimer disease 
    107536369 (PLCB1) 
   05016 Huntington disease 
    107536369 (PLCB1) 
   05017 Spinocerebellar ataxia 
    107536369 (PLCB1) 
   05022 Pathways of neurodegeneration - multiple diseases 
    107536369 (PLCB1) 
  09166 Cardiovascular disease 
   05417 Lipid and atherosclerosis 
    107536369 (PLCB1) 
   05415 Diabetic cardiomyopathy 
    107536369 (PLCB1) 
  09167 Endocrine and metabolic disease 
   04933 AGE-RAGE signaling pathway in diabetic complications 
    107536369 (PLCB1) 
   04934 Cushing syndrome 
    107536369 (PLCB1) 
 09180 Brite Hierarchies 
  09182 Protein families: genetic information processing 
   04131 Membrane trafficking [BR:mna04131] 
    107536369 (PLCB1) 
Enzymes [BR:mna01000] 
 3. Hydrolases 
  3.1  Acting on ester bonds 
   3.1.4  Phosphoric-diester hydrolases 
    3.1.4.11  phosphoinositide phospholipase C 
     107536369 (PLCB1) 
Membrane trafficking [BR:mna04131] 
 Exocytosis 
  Calcium ion-dependent exocytosis 
   Phospholipases 
    107536369 (PLCB1) 
 Endocytosis 
  Macropinocytosis 
   Phospholipase C 
    107536369 (PLCB1) 
  | 
| SSDB | 
 | 
| Motif | 
 | 
| Other DBs | 
 | 
| LinkDB | 
 | 
| Position | 
Unknown 
  | 
| AA seq | 
1216 aa  
MAGAQPGVHALQLKPVCVSDSLKKGTKFVKWDDDSTIVTPIILRSDPQGFFFYWTDQNKE 
TELLDLSLVKDARCGRHAKAPKDPKLRELLDVGNIGRLEHRMITVVYGPDLVNISYLNLV 
AFQEEVAKEWTNEVFSLATNLLAHNMSRDAFLEKAYTKLKLQVTPEGRIPLKNIYRLFSA 
DRKRVETALEACSLPSSRNDSIPQEDFTPEVYRVFLNNLCPRPEIDNIFSEFGAKSKPYL 
TVDQMMDFINLKQRDPRLNEILYPPLKQEQVQVLIEKYEPNTSLAKKGQISVDGFMRYLS 
GEENGVVSPEKLDLNEDMSQPLSHYFINSSHNTYLTAGQLAGNSSVEMYRQVLLSGCRCV 
ELDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPFPILLSFENHVDSPKQ 
QAKMAEYCRLIFGDALLMEPLEKYPLESGVPLPSPMDLMYKILVKNKKKSHKSSEGSGKK 
KLSEQASNTCSDSSSVFEPSSPGAGEADTESDDDDDDDDCKKSSMDEGTAGSEAMATEEM 
SNLVNYIQPVKFESFEISKKRNRSFEMSSFVETKGLEQLTKSPVEFVEYNKMQLSRIYPK 
GTRVDSSNYMPQLFWNAGCQMVALNFQTVDLAMQINMGMYEYNGKSGYRLKPEFMRRPDK 
HFDPFTEGIVDGIVANTLSVKIISGQFLSDKKVGTYVEVDMFGLPVDTRRKAFKTKTSQG 
NAVNPVWEEEPIVFKKVVLPSLACLRIAAYEEGSKFIGHRILPVQAVRPGYHYISLRNER 
NQPLMLPAVFVYIEVKDYVPDTYADVIEALSNPIRYVNLMEQRAKQLAALTLDDEEEARR 
EADPGETPSEAPSEARTTPAENGVNHTTSLAPKPPSQALHSQPAPGSVKAPAKTEDLIQS 
VLTEVEAQTIEELKQQKAFVKLQKKHYKEMKDLVKRHHKKTTDLIKEHTTKYNEIQNDYL 
RRRVALEKTAKKDSKKRSEPSSPDHGSSTIEQDLAALDAEMTQKLIDLKDKQQQQLLNLR 
QEQYYSEKYQKREHIKLLIQKLTDVAEECQSSQLKKLKELCEKEKKELKKKMDKKRQEKI 
TEAKSKDKSQMEEEKTEMIRSYIQEVVQYIKRLEEAQSKRQEKLVEKHKEIRQQILDEKP 
KLQVELEQEYQDKFKRLPLEILEFVQEAMKGKISEDSNHSSAPSSLASDPGKLNHRPPSS 
EELEGDHPGKEFDTPL | 
| NT seq | 
3651 nt   +upstreamnt  +downstreamnt 
atggccggggctcagcccggagtgcacgctctgcaactcaagccggtgtgtgtgtccgac 
agcctcaagaagggcaccaaattcgtcaagtgggatgatgactccactatcgtcactcca 
attattttgaggtctgaccctcagggatttttcttttactggacagatcaaaacaaggag 
acggagctgctagatctcagcctcgtcaaggatgccagatgtgggagacatgcaaaggct 
cccaaggaccccaaactacgtgaacttctggatgtggggaacatcggacgtctggaacat 
cgcatgataacggtggtgtatgggcccgacttagttaacatctcctatttgaacctcgtg 
gctttccaagaagaagtggccaaggaatggacaaatgaggttttcagtttggcaacaaac 
ctgctggcccataacatgtccagggacgcatttctggaaaaagcctatactaaacttaag 
ctgcaagtcactccagaagggcgtattcctctcaaaaacatctaccgcttgttttcagct 
gaccggaaacgagttgaaaccgctttagaggcttgtagtcttccatcttcaaggaatgat 
tcgatacctcaagaagatttcactccagaagtgtaccgagttttcctgaacaacctttgc 
cctcggcctgaaattgataacatcttttctgaatttggtgccaaaagcaagccatatctt 
accgttgatcagatgatggatttcatcaacctcaagcagcgagatccccggctaaatgaa 
atactttaccctcctttaaagcaagagcaagtccaagtattgattgagaagtatgaaccc 
aacactagcctcgccaagaaaggacagatatccgtggacggctttatgcgctacctgagt 
ggggaagaaaacggagtggtgtcacccgagaagctggatctgaatgaagatatgtcgcag 
cccctttctcactatttcatcaattcctcgcacaacacctacctcacagctggacagctg 
gctggaaactcctccgtcgagatgtatcgtcaagtgcttctttctggttgtcgctgtgtg 
gagttggactgctggaaaggacggaccgcagaggaggaaccagtcatcactcatgggttc 
accatgacgaccgaaatatccttcaaggaagtgatagaagcaatcgctgagtgtgcattt 
aagacttcacctttcccaatcctcctttcatttgagaatcacgtggattccccgaagcag 
caggctaagatggccgagtattgccgactgatctttggggacgcccttctcatggagcca 
ctggagaaatacccactggaatctggagttcctcttccaagccctatggatttaatgtac 
aaaattttggtgaaaaataagaagaaatcgcacaagtcgtcagaaggaagtggcaaaaag 
aagctctcagaacaagcctccaacacgtgcagcgactcctccagcgtgttcgagccctcg 
tctcccggagccggggaggctgatacggagagcgacgatgacgatgatgatgatgactgt 
aaaaagtcttcaatggatgagggtactgctgggagtgaggccatggccacagaagagatg 
tctaacctggtgaactatattcagcccgtcaagtttgagtcatttgaaatttccaaaaaa 
agaaatagaagttttgaaatgtcttccttcgtggaaaccaaaggacttgagcaactgacg 
aagtctccggtggaattcgtagaatataacaaaatgcagcttagcaggatatatccgaaa 
ggaacacgtgtagattcgtccaactatatgcctcagctcttctggaatgcaggctgtcag 
atggttgcccttaatttccaaaccgtggacctggctatgcagatcaatatggggatgtat 
gagtacaatgggaagagcggctacaggctgaagccagagtttatgcggaggcctgacaag 
cactttgacccgttcactgagggcatcgtggatgggatcgtggccaacacgttatccgtt 
aagattatttcgggccagttcctttctgataagaaagtcgggacgtatgtggaagtggat 
atgtttggcttgcctgtggacacaaggaggaaagcgtttaagaccaagacatcccaggga 
aatgctgtaaaccccgtctgggaggaagagcccattgtgttcaaaaaggtggttcttccg 
tcgctggcctgcctgaggatcgccgcttacgaagaggggagcaagtttatcggccaccgg 
atcttgccggtgcaagcagttcggccaggctatcactacatctctctgaggaatgagagg 
aaccagcccctgatgctcccggctgtcttcgtctacatagaggtgaaagactatgtccca 
gatacctatgcagatgtgattgaagctctgtccaacccgatccgctacgtgaatctgatg 
gagcagagagctaagcagctggccgctttgacgctggacgatgaagaggaggcaaggaga 
gaggctgatcctggagaaacaccgtcagaggctccgagtgaagccaggacgaccccagca 
gaaaatggagtgaatcacactacatccctggcacccaaacctccctctcaggctctccac 
agccaacccgcgccaggctctgtgaaggcacctgccaaaacagaagatcttatacagagc 
gttttaacagaagtggaagcgcagactattgaagagctaaagcaacagaaggcgtttgta 
aaacttcaaaagaagcactacaaagaaatgaaagacctggtgaagagacaccacaagaaa 
accacggaccttatcaaggaacacactaccaagtacaatgagattcagaatgactaccta 
agaaggagggtggctttggaaaagacagccaagaaggacagtaagaaaagatcggaaccc 
agcagccctgaccacggctcatccaccattgagcaagatcttgctgccctggatgccgaa 
atgacccaaaagttaatagacttgaaggacaaacaacaacagcaactgctcaatcttcga 
caagagcagtactacagtgaaaaataccagaagcgagaacatattaaactgcttatccag 
aagctgacggacgtcgccgaggaatgccagagcagccagctgaagaagctcaaagagctg 
tgtgagaaagagaagaaggagttaaagaagaaaatggataaaaagaggcaggagaagata 
acagaagcgaagtccaaagacaaaagccagatggaagaggagaagacagagatgatccgg 
tcctacatccaggaggtggtgcagtacatcaagaggttagaagaggcacaaagtaaacgg 
caagaaaaactggtagagaaacacaaggagatacgtcagcagatcctggatgaaaagccc 
aagctgcaggtggaactggagcaagagtaccaagacaagttcaaaagactgcccctggag 
attctggagttcgtacaggaagccatgaaagggaagatcagtgaggacagcaatcacagt 
tctgccccttcctccctggcctcagaccctggaaaactgaaccacaggcctccctccagt 
gaggagctggaaggagatcacccaggaaaagagttcgatactcctctgtga |