KEGG   Miniopterus natalensis (Natal long-fingered bat): 107541106
Entry
107541106         CDS       T05883                                 
Symbol
PIK3CA
Name
(RefSeq) phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
  KO
K00922  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
Organism
mna  Miniopterus natalensis (Natal long-fingered bat)
Pathway
mna00562  Inositol phosphate metabolism
mna01100  Metabolic pathways
mna01521  EGFR tyrosine kinase inhibitor resistance
mna01522  Endocrine resistance
mna01524  Platinum drug resistance
mna04012  ErbB signaling pathway
mna04014  Ras signaling pathway
mna04015  Rap1 signaling pathway
mna04024  cAMP signaling pathway
mna04062  Chemokine signaling pathway
mna04066  HIF-1 signaling pathway
mna04068  FoxO signaling pathway
mna04070  Phosphatidylinositol signaling system
mna04071  Sphingolipid signaling pathway
mna04072  Phospholipase D signaling pathway
mna04081  Hormone signaling
mna04140  Autophagy - animal
mna04150  mTOR signaling pathway
mna04151  PI3K-Akt signaling pathway
mna04152  AMPK signaling pathway
mna04210  Apoptosis
mna04211  Longevity regulating pathway
mna04213  Longevity regulating pathway - multiple species
mna04218  Cellular senescence
mna04360  Axon guidance
mna04370  VEGF signaling pathway
mna04380  Osteoclast differentiation
mna04510  Focal adhesion
mna04550  Signaling pathways regulating pluripotency of stem cells
mna04611  Platelet activation
mna04613  Neutrophil extracellular trap formation
mna04620  Toll-like receptor signaling pathway
mna04625  C-type lectin receptor signaling pathway
mna04630  JAK-STAT signaling pathway
mna04650  Natural killer cell mediated cytotoxicity
mna04660  T cell receptor signaling pathway
mna04662  B cell receptor signaling pathway
mna04664  Fc epsilon RI signaling pathway
mna04666  Fc gamma R-mediated phagocytosis
mna04668  TNF signaling pathway
mna04670  Leukocyte transendothelial migration
mna04722  Neurotrophin signaling pathway
mna04725  Cholinergic synapse
mna04750  Inflammatory mediator regulation of TRP channels
mna04810  Regulation of actin cytoskeleton
mna04910  Insulin signaling pathway
mna04914  Progesterone-mediated oocyte maturation
mna04915  Estrogen signaling pathway
mna04917  Prolactin signaling pathway
mna04919  Thyroid hormone signaling pathway
mna04923  Regulation of lipolysis in adipocytes
mna04926  Relaxin signaling pathway
mna04929  GnRH secretion
mna04930  Type II diabetes mellitus
mna04931  Insulin resistance
mna04932  Non-alcoholic fatty liver disease
mna04933  AGE-RAGE signaling pathway in diabetic complications
mna04935  Growth hormone synthesis, secretion and action
mna04960  Aldosterone-regulated sodium reabsorption
mna04973  Carbohydrate digestion and absorption
mna05010  Alzheimer disease
mna05017  Spinocerebellar ataxia
mna05020  Prion disease
mna05100  Bacterial invasion of epithelial cells
mna05132  Salmonella infection
mna05135  Yersinia infection
mna05142  Chagas disease
mna05146  Amoebiasis
mna05160  Hepatitis C
mna05161  Hepatitis B
mna05162  Measles
mna05163  Human cytomegalovirus infection
mna05164  Influenza A
mna05165  Human papillomavirus infection
mna05166  Human T-cell leukemia virus 1 infection
mna05167  Kaposi sarcoma-associated herpesvirus infection
mna05168  Herpes simplex virus 1 infection
mna05169  Epstein-Barr virus infection
mna05170  Human immunodeficiency virus 1 infection
mna05171  Coronavirus disease - COVID-19
mna05200  Pathways in cancer
mna05203  Viral carcinogenesis
mna05205  Proteoglycans in cancer
mna05206  MicroRNAs in cancer
mna05207  Chemical carcinogenesis - receptor activation
mna05208  Chemical carcinogenesis - reactive oxygen species
mna05210  Colorectal cancer
mna05211  Renal cell carcinoma
mna05212  Pancreatic cancer
mna05213  Endometrial cancer
mna05214  Glioma
mna05215  Prostate cancer
mna05218  Melanoma
mna05220  Chronic myeloid leukemia
mna05221  Acute myeloid leukemia
mna05222  Small cell lung cancer
mna05223  Non-small cell lung cancer
mna05224  Breast cancer
mna05225  Hepatocellular carcinoma
mna05226  Gastric cancer
mna05230  Central carbon metabolism in cancer
mna05231  Choline metabolism in cancer
mna05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
mna05415  Diabetic cardiomyopathy
mna05417  Lipid and atherosclerosis
mna05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:mna00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    107541106 (PIK3CA)
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    107541106 (PIK3CA)
   04014 Ras signaling pathway
    107541106 (PIK3CA)
   04015 Rap1 signaling pathway
    107541106 (PIK3CA)
   04370 VEGF signaling pathway
    107541106 (PIK3CA)
   04630 JAK-STAT signaling pathway
    107541106 (PIK3CA)
   04668 TNF signaling pathway
    107541106 (PIK3CA)
   04066 HIF-1 signaling pathway
    107541106 (PIK3CA)
   04068 FoxO signaling pathway
    107541106 (PIK3CA)
   04070 Phosphatidylinositol signaling system
    107541106 (PIK3CA)
   04072 Phospholipase D signaling pathway
    107541106 (PIK3CA)
   04071 Sphingolipid signaling pathway
    107541106 (PIK3CA)
   04024 cAMP signaling pathway
    107541106 (PIK3CA)
   04151 PI3K-Akt signaling pathway
    107541106 (PIK3CA)
   04152 AMPK signaling pathway
    107541106 (PIK3CA)
   04150 mTOR signaling pathway
    107541106 (PIK3CA)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    107541106 (PIK3CA)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    107541106 (PIK3CA)
  09143 Cell growth and death
   04210 Apoptosis
    107541106 (PIK3CA)
   04218 Cellular senescence
    107541106 (PIK3CA)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    107541106 (PIK3CA)
   04550 Signaling pathways regulating pluripotency of stem cells
    107541106 (PIK3CA)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    107541106 (PIK3CA)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    107541106 (PIK3CA)
   04613 Neutrophil extracellular trap formation
    107541106 (PIK3CA)
   04620 Toll-like receptor signaling pathway
    107541106 (PIK3CA)
   04625 C-type lectin receptor signaling pathway
    107541106 (PIK3CA)
   04650 Natural killer cell mediated cytotoxicity
    107541106 (PIK3CA)
   04660 T cell receptor signaling pathway
    107541106 (PIK3CA)
   04662 B cell receptor signaling pathway
    107541106 (PIK3CA)
   04664 Fc epsilon RI signaling pathway
    107541106 (PIK3CA)
   04666 Fc gamma R-mediated phagocytosis
    107541106 (PIK3CA)
   04670 Leukocyte transendothelial migration
    107541106 (PIK3CA)
   04062 Chemokine signaling pathway
    107541106 (PIK3CA)
  09152 Endocrine system
   04910 Insulin signaling pathway
    107541106 (PIK3CA)
   04923 Regulation of lipolysis in adipocytes
    107541106 (PIK3CA)
   04929 GnRH secretion
    107541106 (PIK3CA)
   04915 Estrogen signaling pathway
    107541106 (PIK3CA)
   04914 Progesterone-mediated oocyte maturation
    107541106 (PIK3CA)
   04917 Prolactin signaling pathway
    107541106 (PIK3CA)
   04926 Relaxin signaling pathway
    107541106 (PIK3CA)
   04935 Growth hormone synthesis, secretion and action
    107541106 (PIK3CA)
   04919 Thyroid hormone signaling pathway
    107541106 (PIK3CA)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    107541106 (PIK3CA)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    107541106 (PIK3CA)
  09156 Nervous system
   04725 Cholinergic synapse
    107541106 (PIK3CA)
   04722 Neurotrophin signaling pathway
    107541106 (PIK3CA)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    107541106 (PIK3CA)
  09158 Development and regeneration
   04360 Axon guidance
    107541106 (PIK3CA)
   04380 Osteoclast differentiation
    107541106 (PIK3CA)
  09149 Aging
   04211 Longevity regulating pathway
    107541106 (PIK3CA)
   04213 Longevity regulating pathway - multiple species
    107541106 (PIK3CA)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    107541106 (PIK3CA)
   05206 MicroRNAs in cancer
    107541106 (PIK3CA)
   05205 Proteoglycans in cancer
    107541106 (PIK3CA)
   05207 Chemical carcinogenesis - receptor activation
    107541106 (PIK3CA)
   05208 Chemical carcinogenesis - reactive oxygen species
    107541106 (PIK3CA)
   05203 Viral carcinogenesis
    107541106 (PIK3CA)
   05230 Central carbon metabolism in cancer
    107541106 (PIK3CA)
   05231 Choline metabolism in cancer
    107541106 (PIK3CA)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    107541106 (PIK3CA)
  09162 Cancer: specific types
   05210 Colorectal cancer
    107541106 (PIK3CA)
   05212 Pancreatic cancer
    107541106 (PIK3CA)
   05225 Hepatocellular carcinoma
    107541106 (PIK3CA)
   05226 Gastric cancer
    107541106 (PIK3CA)
   05214 Glioma
    107541106 (PIK3CA)
   05221 Acute myeloid leukemia
    107541106 (PIK3CA)
   05220 Chronic myeloid leukemia
    107541106 (PIK3CA)
   05218 Melanoma
    107541106 (PIK3CA)
   05211 Renal cell carcinoma
    107541106 (PIK3CA)
   05215 Prostate cancer
    107541106 (PIK3CA)
   05213 Endometrial cancer
    107541106 (PIK3CA)
   05224 Breast cancer
    107541106 (PIK3CA)
   05222 Small cell lung cancer
    107541106 (PIK3CA)
   05223 Non-small cell lung cancer
    107541106 (PIK3CA)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    107541106 (PIK3CA)
   05170 Human immunodeficiency virus 1 infection
    107541106 (PIK3CA)
   05161 Hepatitis B
    107541106 (PIK3CA)
   05160 Hepatitis C
    107541106 (PIK3CA)
   05171 Coronavirus disease - COVID-19
    107541106 (PIK3CA)
   05164 Influenza A
    107541106 (PIK3CA)
   05162 Measles
    107541106 (PIK3CA)
   05168 Herpes simplex virus 1 infection
    107541106 (PIK3CA)
   05163 Human cytomegalovirus infection
    107541106 (PIK3CA)
   05167 Kaposi sarcoma-associated herpesvirus infection
    107541106 (PIK3CA)
   05169 Epstein-Barr virus infection
    107541106 (PIK3CA)
   05165 Human papillomavirus infection
    107541106 (PIK3CA)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    107541106 (PIK3CA)
   05135 Yersinia infection
    107541106 (PIK3CA)
   05100 Bacterial invasion of epithelial cells
    107541106 (PIK3CA)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    107541106 (PIK3CA)
   05142 Chagas disease
    107541106 (PIK3CA)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    107541106 (PIK3CA)
   05017 Spinocerebellar ataxia
    107541106 (PIK3CA)
   05020 Prion disease
    107541106 (PIK3CA)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    107541106 (PIK3CA)
   05418 Fluid shear stress and atherosclerosis
    107541106 (PIK3CA)
   05415 Diabetic cardiomyopathy
    107541106 (PIK3CA)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    107541106 (PIK3CA)
   04932 Non-alcoholic fatty liver disease
    107541106 (PIK3CA)
   04931 Insulin resistance
    107541106 (PIK3CA)
   04933 AGE-RAGE signaling pathway in diabetic complications
    107541106 (PIK3CA)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    107541106 (PIK3CA)
   01524 Platinum drug resistance
    107541106 (PIK3CA)
   01522 Endocrine resistance
    107541106 (PIK3CA)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:mna04131]
    107541106 (PIK3CA)
Enzymes [BR:mna01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     107541106 (PIK3CA)
Membrane trafficking [BR:mna04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    107541106 (PIK3CA)
SSDB
Motif
Pfam: PI3Ka PI3_PI4_kinase PI3K_C2 PI3K_rbd PI3K_p85B DUF2321 ABC1 Ribosomal_S15
Other DBs
NCBI-GeneID: 107541106
NCBI-ProteinID: XP_016073555
LinkDB
Position
Unknown
AA seq 1068 aa
MPPRPSSGELWGIHLMPPRILVECLLPNGMIVTLECLREATLVTIKHELFKEARKYPLHQ
LLQDESSYIFVSVTQEAEREEFFDETRRLCDLRLFQPFLKVIEPVGNREEKILNREIGFA
IGMPVCEFDMVKDPEVQDFRRNILNVCKEAVDLRDLNSPHSRAMYVYPPNVESSPELPKH
IYNKLDKGQIIVVIWVIVSPNNDKQKYTLKINHDCVPEQVIAEAIRKKTRSMLLSSEQLK
LCVLEYQGKYILKVCGCDEYFLEKYPLSQYKYIRSCIMLGRMPNLMLMAKESLYSQLPMD
CFTMPSYSRRISTATPYMNGETSTKSLWVVNSSLRIKILCATYVNVNIRDIDKIYVRTGI
YHGGEPLCDNVNTQRVPCSNPRWNEWLNYDIYIPDLPRAARLCLSICSVKGRKGAKEEHC
PLAWGNINLFDYTDTLVSGKMALNLWPVPHGLEDLLNPIGVTGSNPNKETPCLELEFDWF
NSVVKFPDMSVIEEHANWSVSREAGFSYSHAGLSNRLARDNELRENDKEQLRAICTRDPL
SEITEQEKDFLWSHRHYCVTIPEILPKLLLSVKWNSRDEVAQMYCLVKEWPPIKPEQAME
LLDCNYPDPMVRGFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALTN
QRIGHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGMYLKHLNRQVEAMEKLINLTDILK
QEKKDETQKVQMKFLVEQMRRPDFMDALQGFLSPLNPAHQLGNLRLEECRIMSSAKRPLW
LNWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLS
IGDCVGLIEVVRNSHTIMQIQCKGGLKGALQFNSHTLHQWLKDKNKGEIYDAAIDLFTRS
CAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDF
LIVISKGAQECTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSFDDIA
YIRKTLALDKTEQEALEYFMKQMNDAHHGGWTTKMDWIFHTIKQHALN
NT seq 3207 nt   +upstreamnt  +downstreamnt
atgcctccaagaccatcatcaggtgaactgtggggcatccacttgatgcccccaagaatc
ctagtagaatgtttactaccaaatggaatgatagtgactttagaatgcctccgtgaggct
acattagttactataaagcatgaactgtttaaagaagcaagaaagtaccctctccatcaa
cttcttcaagatgaatcttcttacatttttgtaagtgttacccaagaagcagaaagggaa
gaattttttgatgaaacaagacgactttgtgaccttcgactctttcaaccctttttgaaa
gtaattgagccagtaggcaatcgtgaagaaaagatcctcaatcgagaaattggctttgct
atcggcatgccagtgtgtgaatttgacatggttaaagatccagaagtacaggacttccga
agaaatattctgaatgtttgtaaagaagctgtggatcttagggatcttaattctcctcac
agtagagcaatgtatgtctatcctccaaatgtagaatcttcaccagaactgccaaagcac
atatataataaattagataaagggcaaataatagtggtgatttgggtaatagtttctcca
aataatgacaagcagaagtatactttgaaaatcaaccatgactgtgtgccagaacaagta
attgctgaagcaatcaggaaaaaaacgcgaagtatgttgctatcatctgaacaattaaaa
ctctgtgttttagaatatcagggcaaatatattttaaaagtgtgtggatgtgatgaatac
ttcttagaaaaatatcctctgagtcaatataagtatataagaagctgtataatgcttggg
aggatgcccaatttgatgctgatggctaaagaaagcctttattcgcaactgccaatggac
tgttttacgatgccatcttattccagacgcatctccacagcgacaccatatatgaatgga
gagacttctacaaaatccctttgggttgtaaatagttcactcagaataaaaattctttgt
gcaacctatgtaaatgtaaatattcgagacattgacaagatctatgttcgaacaggtatc
taccatggtggagagcccttatgtgataatgtgaacactcaaagagtaccttgttccaat
cccaggtggaatgaatggctgaattacgatatatacattcctgatcttcctcgtgctgct
cggctttgcctttccatttgttctgttaaaggtcgaaaaggtgctaaagaggaacactgt
ccattggcgtggggaaatataaacttgtttgattacacagatactctagtatctggaaaa
atggctttgaatctttggccagtacctcatggattagaagatttgctgaatcctattggt
gttactggatcaaatccaaataaagaaactccatgcttagagctggagtttgactggttc
aacagtgtggtcaagtttccagatatgtcagtgattgaagagcatgccaactggtctgtg
tcccgagaagcaggatttagttattcccatgcgggactgagtaacagactagctagagac
aatgaattaagggaaaatgataaagaacagctccgagccatttgtacccgagatcctctc
tctgaaatcactgagcaagagaaagattttctgtggagccacagacactattgtgtaact
atccctgaaatcctacccaaattgcttctgtctgttaaatggaattctagagatgaagta
gctcagatgtactgcttggtaaaagagtggcctccaatcaaacctgaacaggctatggag
cttctggactgcaactacccagaccctatggttcgaggttttgctgttcgatgcttggag
aaatatttaacagatgacaaactttctcaatacctaattcaactagtacaggtcctaaaa
tatgaacagtatttggataacctgcttgtgagatttttactcaaaaaagcattgactaat
caaaggattgggcactttttcttttggcatttaaaatctgagatgcacaataaaacagtg
agccagaggttcgggctgcttttggagtcctactgccgtgcgtgtggcatgtacctgaag
cacctgaacaggcaggtggaggccatggagaagctcatcaacctgacggacatcctgaag
caggagaagaaggatgagacgcagaaggtacagatgaagtttttagttgagcaaatgcgg
cgaccagatttcatggatgctctacagggttttctgtctcctctaaatcctgctcatcag
ttaggaaatctcaggcttgaagagtgtcgaattatgtcctctgcaaaaaggccactgtgg
ttgaattgggagaacccagacatcatgtcagagttactctttcagaacaatgagatcatc
tttaaaaatggggatgatttacgacaagatatgctaacacttcaaattattcgcattatg
gaaaatatctggcaaaatcaaggccttgatcttcgaatgttaccttatggttgtctgtcc
attggggactgtgtgggactcattgaggtggtgagaaattctcacacgattatgcagatt
cagtgcaaaggtggcctgaaaggtgcactgcagttcaacagccacactctgcatcagtgg
ctcaaagacaagaacaagggagaaatatatgatgcagccattgatctgtttactcgttca
tgtgctggatattgtgtcgctactttcattttgggaattggagaccgtcacaatagcaac
atcatggttaaagatgatggacaactgttccacatagattttggacactttttggatcac
aagaagaaaaaatttggttataaacgagaacgtgtaccatttgttttgacacaagatttc
ttaatagtgattagtaaaggagcccaagaatgcaccaagacaagagaatttgagaggttt
caggagatgtgttacaaagcttatctagctattcggcagcatgccaatctcttcataaat
cttttctcaatgatgcttggctctggaatgccagaactacagtcttttgatgatattgca
tacattcgaaagaccctagctttagataaaactgagcaagaggctttggaatatttcatg
aaacaaatgaacgatgcacatcatggtggctggacaacaaaaatggattggatcttccac
acaattaagcagcatgctttgaactga

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