KEGG   Miniopterus natalensis (Natal long-fingered bat): 107541381
Entry
107541381         CDS       T05883                                 
Symbol
ARAF
Name
(RefSeq) serine/threonine-protein kinase A-Raf
  KO
K08845  A-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
Organism
mna  Miniopterus natalensis (Natal long-fingered bat)
Pathway
mna01521  EGFR tyrosine kinase inhibitor resistance
mna01522  Endocrine resistance
mna04010  MAPK signaling pathway
mna04012  ErbB signaling pathway
mna04068  FoxO signaling pathway
mna04270  Vascular smooth muscle contraction
mna04650  Natural killer cell mediated cytotoxicity
mna04720  Long-term potentiation
mna04726  Serotonergic synapse
mna04730  Long-term depression
mna04810  Regulation of actin cytoskeleton
mna04910  Insulin signaling pathway
mna04914  Progesterone-mediated oocyte maturation
mna04928  Parathyroid hormone synthesis, secretion and action
mna05010  Alzheimer disease
mna05022  Pathways of neurodegeneration - multiple diseases
mna05034  Alcoholism
mna05160  Hepatitis C
mna05161  Hepatitis B
mna05200  Pathways in cancer
mna05205  Proteoglycans in cancer
mna05208  Chemical carcinogenesis - reactive oxygen species
mna05210  Colorectal cancer
mna05211  Renal cell carcinoma
mna05212  Pancreatic cancer
mna05213  Endometrial cancer
mna05214  Glioma
mna05215  Prostate cancer
mna05218  Melanoma
mna05219  Bladder cancer
mna05220  Chronic myeloid leukemia
mna05221  Acute myeloid leukemia
mna05223  Non-small cell lung cancer
mna05224  Breast cancer
mna05225  Hepatocellular carcinoma
mna05226  Gastric cancer
Brite
KEGG Orthology (KO) [BR:mna00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    107541381 (ARAF)
   04012 ErbB signaling pathway
    107541381 (ARAF)
   04068 FoxO signaling pathway
    107541381 (ARAF)
 09140 Cellular Processes
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    107541381 (ARAF)
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    107541381 (ARAF)
  09152 Endocrine system
   04910 Insulin signaling pathway
    107541381 (ARAF)
   04914 Progesterone-mediated oocyte maturation
    107541381 (ARAF)
   04928 Parathyroid hormone synthesis, secretion and action
    107541381 (ARAF)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    107541381 (ARAF)
  09156 Nervous system
   04726 Serotonergic synapse
    107541381 (ARAF)
   04720 Long-term potentiation
    107541381 (ARAF)
   04730 Long-term depression
    107541381 (ARAF)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    107541381 (ARAF)
   05205 Proteoglycans in cancer
    107541381 (ARAF)
   05208 Chemical carcinogenesis - reactive oxygen species
    107541381 (ARAF)
  09162 Cancer: specific types
   05210 Colorectal cancer
    107541381 (ARAF)
   05212 Pancreatic cancer
    107541381 (ARAF)
   05225 Hepatocellular carcinoma
    107541381 (ARAF)
   05226 Gastric cancer
    107541381 (ARAF)
   05214 Glioma
    107541381 (ARAF)
   05221 Acute myeloid leukemia
    107541381 (ARAF)
   05220 Chronic myeloid leukemia
    107541381 (ARAF)
   05218 Melanoma
    107541381 (ARAF)
   05211 Renal cell carcinoma
    107541381 (ARAF)
   05219 Bladder cancer
    107541381 (ARAF)
   05215 Prostate cancer
    107541381 (ARAF)
   05213 Endometrial cancer
    107541381 (ARAF)
   05224 Breast cancer
    107541381 (ARAF)
   05223 Non-small cell lung cancer
    107541381 (ARAF)
  09172 Infectious disease: viral
   05161 Hepatitis B
    107541381 (ARAF)
   05160 Hepatitis C
    107541381 (ARAF)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    107541381 (ARAF)
   05022 Pathways of neurodegeneration - multiple diseases
    107541381 (ARAF)
  09165 Substance dependence
   05034 Alcoholism
    107541381 (ARAF)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    107541381 (ARAF)
   01522 Endocrine resistance
    107541381 (ARAF)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:mna01001]
    107541381 (ARAF)
Enzymes [BR:mna01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     107541381 (ARAF)
Protein kinases [BR:mna01001]
 Serine/threonine kinases: TKL group
  RAF family [OT]
   107541381 (ARAF)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase RBD C1_1 Kinase-like ABC1 Pkinase_fungal zf-RING-like TUG-UBL1 Kdo
Other DBs
NCBI-GeneID: 107541381
NCBI-ProteinID: XP_016073888
LinkDB
Position
Unknown
AA seq 606 aa
MEPPRGPPANGAEPSRAVGTVKVYLPNKQRTVVTVRDGMSVYDSLDKALKVRGLNQDCCV
VYRLIRGRKTVTAWDTAIAPLDGEELIVEVLEDVPLTMHNFVRKTFFSLAFCDFCLKFLF
HGFRCQTCGYKFHQHCSSKVPTVCVDMSTNCRQYYHSIQDLSGGSRQHEAPSNRLLNEPL
TPQGSSSCTQHRDPEHFPFPAPANAPLQRIRSTSTPNVHMVSTTTPMDSSLIQLAAQNFS
TDAAGSRGGGDGAPRGSPSPASVSSGRKSPHSKSPSEQRERKSLADDKKKVKNLGYRDSG
YYWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVAQPTAEQAQAFKNEMQVLRK
TRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYL
HAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRM
QDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGSRDQIIFMVGRGYLSPDLSKISSNCPK
AMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLS
AARLVP
NT seq 1821 nt   +upstreamnt  +downstreamnt
atggagccgccacggggcccccctgccaatggggctgagccatcccgggcagtgggcact
gtcaaagtgtacctgcccaacaagcaacgcacagtggtgactgtccgggatggcatgagt
gtctatgactctctagataaggctctcaaggtgcggggtctcaatcaggattgctgcgtg
gtctatcgactcatcagagggcgaaagacagtcactgcctgggacacagccattgccccc
ctggatggcgaggagctcattgttgaggtccttgaagacgtcccactgaccatgcacaat
tttgtacggaagacattcttcagcctggcgttctgtgacttctgccttaagtttctgttc
catggcttccgctgccaaacctgtggctacaagttccaccagcattgttcctctaaggtc
cccacagtctgtgttgacatgagtaccaactgccgacagtactaccacagtatccaggat
ttgtccggaggctccagacagcatgaggctccctcgaaccgtcttctgaatgagccgcta
acccctcagggttccagctcctgcacccagcaccgagaccctgagcactttccctttcct
gccccggccaacgcccccctccagcgcatacgctccacatctacccccaacgtccatatg
gtcagcaccacaacccccatggactccagcctcatccagctcgctgcccagaatttcagc
actgatgctgctggtagtagaggtggtggtgatggagccccccgggggagccccagcccg
gccagtgtgtcctcggggaggaagtccccacattccaagtctccatcagaacaacgggag
aggaagtccttggctgatgacaagaagaaagtgaagaatctggggtaccgggactcgggc
tattactgggaggtgccacccagtgaggtgcagctgctgaagaggatcgggacgggctcg
tttggcaccgtgtttcgcgggcggtggcatggcgatgtggctgtgaaggtgctcaaggtg
gcccaacccacagctgagcaggcccaggccttcaagaacgagatgcaggtgctcaggaag
acacgtcacgtcaacatcttgctgttcatgggcttcatgacccggccgggattcgccatc
atcacacagtggtgcgagggctccagcctctaccaccacctgcatgtggctgacacacgc
ttcgacatggtccagctcattgacgtggcccggcagactgctcagggcatggactacctc
catgccaagaacatcatccaccgggatctcaagtctaacaacatcttcctacacgagggg
ctcacagtgaagatcggtgacttcggcctggccacagtgaagacgcggtggagcggggct
cagcccttggagcagccctcaggctctgtgctgtggatggcggctgaggtgatccgtatg
caggacccgaacccctacagcttccagtcagatgtctacgcctatggggttgtgctctac
gagctcatgactggctccttgccttatagccacattggcagccgtgaccagattatcttt
atggtgggtcgtggctatctgtccccggacctcagcaaaatctccagcaactgccccaag
gccatgcggcgcctgctgtcagactgcctcaagttccagcgagaagagcggcccctcttc
ccccagatcctggccacgattgagctgctgcagcggtcactccccaagattgagcggagt
gcctccgaaccctccttgcaccgcacccaggctgatgagttgcctgcctgcctactcagc
gcagcccgccttgtgccttag

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