Macaca nemestrina (pig-tailed macaque): 105472697
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Entry
105472697 CDS
T08765
Symbol
GART
Name
(RefSeq) trifunctional purine biosynthetic protein adenosine-3
KO
K11787
phosphoribosylamine--glycine ligase / phosphoribosylglycinamide formyltransferase / phosphoribosylformylglycinamidine cyclo-ligase [EC:
6.3.4.13
2.1.2.2
6.3.3.1
]
Organism
mni
Macaca nemestrina (pig-tailed macaque)
Pathway
mni00230
Purine metabolism
mni00670
One carbon pool by folate
mni01100
Metabolic pathways
mni01523
Antifolate resistance
Module
mni_M00048
De novo purine biosynthesis, PRPP + glutamine => IMP
Brite
KEGG Orthology (KO) [BR:
mni00001
]
09100 Metabolism
09104 Nucleotide metabolism
00230 Purine metabolism
105472697 (GART)
09108 Metabolism of cofactors and vitamins
00670 One carbon pool by folate
105472697 (GART)
09160 Human Diseases
09176 Drug resistance: antineoplastic
01523 Antifolate resistance
105472697 (GART)
Enzymes [BR:
mni01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.2 Hydroxymethyl-, formyl- and related transferases
2.1.2.2 phosphoribosylglycinamide formyltransferase 1
105472697 (GART)
6. Ligases
6.3 Forming carbon-nitrogen bonds
6.3.3 Cyclo-ligases
6.3.3.1 phosphoribosylformylglycinamidine cyclo-ligase
105472697 (GART)
6.3.4 Other carbon-nitrogen ligases
6.3.4.13 phosphoribosylamine---glycine ligase
105472697 (GART)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
GARS_A
Formyl_trans_N
AIRS_C
GARS_N
GARS_C
AIRS
ATP-grasp
CPSase_L_D2
ATP-grasp_2
Dala_Dala_lig_C
ATP-grasp_4
ATP-grasp_3
Sacchrp_dh_NADP
RimK
ATP-grasp_5
LUD_dom
GAE_BBS1
Motif
Other DBs
NCBI-GeneID:
105472697
NCBI-ProteinID:
XP_011724492
Ensembl:
ENSMNEG00000037254
UniProt:
A0A2K6CVU3
LinkDB
All DBs
Position
Unknown
AA seq
1010 aa
AA seq
DB search
MAARVLIIGSGGREHTLAWKLAQSHHVKQVLVAPGNAGTACSEKISNNAISISDHTALAQ
FCKEEKIEFVVVGPEAPLAAGIVGNLTSAGVRCFGPTAEAAQLESSKRFAKEFMDRHGIP
TAQWKAFTKPEEACSFIMSADFPALVVKASGLAAGKGVIVAKSKEEACKAVQEIMQEKAF
GAAGETIVIEELLDGEEVSCLCFTDGKTVAPMPPAQDHKRLLEGDGGPNTGGMGAYCPAP
QVSNDLLLKIKDTVLQRTVDGMQQEGTPYTGILYAGIMLTEDGPKVLEFNCRFGDPECQV
ILPLLKSDLYEVIQSTLDGLLCTSLPVWLENHTALTVVMASKGYPGDYTKGVEITGFSEA
QALGLEVFHAGTALKNGKVVTHGGRVLAVTAIRENLVSALEEAKKGLAAIKFEGAIYRKD
IGFRAIAFLQQPRGLTYKESGVDIAAGNTLVKKIQPLAEATSRSGCKVDLGGFAGLFDLK
AAGFKDPLLASGTDGVGTKLKIAQLCNKHDTIGQDLVAMCVNDILAQGAEPLFFLDYFSC
GKLDLSVTEAVVAGIAKACGKAGCALLGGETAEMPDMYPPGEYDLAGFAVGAMERDQKLP
HLERITEGDVVVGIASSGLHSNGFSLVRKIVAKSFLQYSSPAPDGCGDQTLGDLLLTPTR
IYSHSLLPILRSGHVKAFAHITGGGLLENIPRVLPEKLGVDLDAQTWRIPKVFSWLQQEG
QLSEEEMARTFNCGVGAALVVSKEQTEQILRDIQQHKEEAWVIGSVVARAEGSPRVKVKN
LIESMQINGSVLKNGSLKNHFSFEKKKARVAVLISGTGSNLQALIDSTREPNSSAEIDVV
ISNKAAVAGLDKAERAGIPTRVINHKLYKNRVEFDNAIDLVLEEFSIDIVCLAGFMRILS
GPFVQKWNGKMLNIHPSLLPSFKGSNAHEQALETGVTVTGCTVHFVAEDVDAGQIILQEA
VPVKRGDTVATLSERVKLAEHKIFPAALQLVASGTVQLGENGKICWVKEE
NT seq
3033 nt
NT seq
+upstream
nt +downstream
nt
atggcagcccgagtacttataattggcagtggaggaagggaacatacgctggcctggaaa
cttgcacagtctcatcatgtcaaacaagtgttggttgccccaggaaacgcaggcactgcc
tgctctgaaaagatttcaaataacgccatctcaatcagtgaccacactgcccttgctcaa
ttctgcaaagaggagaaaattgaattcgtagttgttggaccagaagcacctctggctgct
gggattgttgggaacctgacgtctgcaggagtgcgatgctttggcccaacagcagaagcg
gctcagttagagtccagcaaaagatttgccaaagagtttatggacagacatggaatccca
actgcgcaatggaaggctttcaccaaacctgaagaggcctgcagcttcattatgagtgca
gacttccctgctttggttgtgaaggccagtggtcttgcggctggaaaaggggtgattgtt
gcaaagagcaaagaagaggcctgcaaagctgtacaagagatcatgcaggagaaagccttt
ggggcagccggagaaacaattgtcattgaagaacttcttgacggagaagaggtgtcttgt
ctgtgcttcactgatggcaagactgtggcccccatgccaccggcacaggaccataagcga
ttactggagggagatggcggccctaacacagggggaatgggagcctattgtccggcccct
caggtttctaatgatctattactaaaaattaaagatactgttcttcagaggacagtggat
ggcatgcagcaagagggtactccatatacaggtattctctatgctggaataatgctgacc
gaggatggcccaaaagttctagagtttaattgccgttttggtgatccagagtgccaagta
atcctcccacttcttaaaagtgatctttatgaagtgattcagtccaccttagatggactg
ctctgcacatctctgcctgtttggctagaaaaccacaccgccctaactgttgtcatggca
agtaaaggttatcctggagactacaccaagggtgtagagataacagggttttccgaggct
caagctctaggactggaggtgttccacgcaggcactgcccttaaaaatggcaaagtagta
actcatgggggtagagttcttgcagtcacagccatccgggaaaatctcgtatcagctctc
gaggaagccaagaaaggactagcagctataaagtttgagggagcaatttataggaaagac
attggctttcgtgccatagctttcctccagcagcccaggggtttgacttacaaggaatct
ggagtagacattgcagctggaaatacgctggtcaagaaaattcagcctttagcagaagcc
acttccagatcaggctgtaaagttgatcttggaggttttgctggtctttttgatttaaaa
gcagctggtttcaaagatccccttctggcctctggaacagatggcgttggaactaagcta
aagattgcccagctgtgcaacaaacatgataccattggtcaagatttggtagcaatgtgt
gttaatgatattctggcacaaggagcagagcccctcttcttccttgattacttttcctgt
ggaaaacttgacctcagtgtaactgaagccgttgttgctggaattgctaaagcttgtgga
aaagctggatgtgctcttcttggaggtgaaacagcagaaatgcctgacatgtatccccct
ggagagtatgacctagctgggtttgccgttggtgccatggagcgagatcagaaactccct
cacctggaaagaatcaccgagggtgatgttgttgttggaatagcttcatctggtcttcat
agcaatggatttagccttgtgaggaagatcgtggcaaaatctttcctccagtactcctct
ccagcacctgatggttgtggtgaccagactttaggggacttacttctcacgccaaccaga
atctacagccattcactgttacctatcctacgttcaggacatgtcaaagcgtttgcccat
attactggtggaggattactagagaacatccccagagtcctccctgagaaacttggggta
gatttagatgcccagacctggaggatccccaaagtcttctcatggttacagcaggaagga
caactctctgaggaagagatggccagaacatttaactgtggggttggcgctgcccttgtg
gtatcaaaggagcagacagagcagattctgagggatatccagcagcacaaggaagaagcc
tgggtgattggcagtgtggttgcacgagctgaaggttctccacgtgtgaaagtcaagaat
ctaattgaaagcatgcaaataaatgggtcagtgttgaagaatggctccctgaaaaatcat
ttctcttttgaaaaaaaaaaggccagagtggctgtcttaatatctggaacaggatcgaac
ctgcaagcacttatagacagtactcgggaaccaaatagctctgcagaaattgatgttgtt
atctccaacaaagccgcagtagctgggttagataaagcggaaagagctggtattcccact
agagtaattaatcataaactgtataaaaatcgtgtagaatttgacaatgcaattgaccta
gtccttgaagagttctccatagacatagtctgtcttgcaggattcatgagaattctttct
ggcccctttgtccaaaagtggaatggaaaaatgctcaatatccacccatccttgctccct
tcttttaagggttcgaatgcccatgagcaagccctggaaaccggagtcacagttactggg
tgtactgtacactttgtagctgaagatgtagatgctggacaaattattttgcaagaagct
gttcccgtgaagaggggtgatactgttgcaactctttctgaaagagtaaaattagcagaa
cataaaatatttcctgcagccctccagttggtggccagtggaactgtacagcttggagaa
aatggcaagatctgttgggttaaagaggaatga
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