Macaca nemestrina (pig-tailed macaque): 105475406 Help Entry 105475406         CDS       T08765                                  Symbol PCLO Name (RefSeq) protein piccolo isoform X1   KO K16882   protein piccolo Organism mni  Macaca nemestrina (pig-tailed macaque) Pathway mni04911   Insulin secretion Brite KEGG Orthology (KO) [BR:mni00001]  09150 Organismal Systems   09152 Endocrine system    04911 Insulin secretion     105475406 (PCLO)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    04131 Membrane trafficking [BR:mni04131]     105475406 (PCLO) Membrane trafficking [BR:mni04131]  Exocytosis   Calcium ion-dependent exocytosis    Others     105475406 (PCLO) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  zf-piccolo C2 PDZ FYVE_2 FYVE_CARP1-2 Motif Other DBs NCBI-GeneID:  105475406 NCBI-ProteinID:  XP_011728924 Ensembl:  ENSMNEG00000033239 UniProt:  A0A2K6C4Y9 LinkDB All DBs Position Unknown AA seq 5191 aa AA seqDB search MGNEASLEGEGLPEGLAAAAAAGGGASGAGSPSHTAIPAGMEADLSQLSEEERRQIAAVM SRAQGLPKGSVPPAAAESPSMHRKQELDSSHSPKQSGRPPDPGRPAQPGLSKSRTTDTFR SEQKLPGRSPSTISLKESKSRTDFKEEHKSSMMPGFLSEVNPLSAVSSVVNKFNPFDLIS DSEASQEETTKKQKVVPKEQEKPEGITKPPSQQQPPKPVPKQQGPGRDPLQQDGPPKSIS SQQPEKIKSQPPGTGKPIQGPAQTPQTDHAKLPLPRDASRPQTKQADIVKGESVKPSLQS PSKPPIQQPTPGKPPAQQPGPEKSQPGPAKPPAQPPGLTKPLAQQPGTVKTPVQPPGTAK PPAQPLGPAKSPAQQTGSEKPSLEQPGPKTLAQPPGVGKTPAQQPGPAKPPTQQVGTPKP LAQQSGLQSPAKAPGPTKTPAQQAGPGKIPAQQAGPAKPSAQQTGPTRLPSQLPGPAKPP SQQPGSAKPPPQQPGSAKPPPQQPGSAKPPPQQPGSAKPPSQQPGSAKPSAQQPSPAKPL AQQSTKPVSQTGSGKPLQPPTMSPSAKQPLSQGLPKTICPLCNTTELLLHVPEKANFNTC TECQTTVCSLCGFNPNPHLVEVKEWLCLNCQMKRALGGDLAPVPSSPQPKPKAAPVTATS AVSKSSPQPQQTSPKKDAAPKQDLSKVPEPKKPPLVKQPTLHGSPSAKAKQPPEADSSSK PAPPKEPSVPSEQDKAPVADDKPKQPKMVKPTTDFVSSSSATIPDIPSSKVQSQAEEKTT PPLKTDSAKPSQSFPPTGEKVTPFDSKAIPRPASDSKIISHPGPSSESKGQKQVDPVQKK EEPKKAQTKMSPKQDAKPMPKGSPTPPGPRPTAGQTIPTPQQPPKPQEQSRRFSLNLGSI TDAPKSQPTTPQETVTGKLFGFGASIFSQASNLISTAGQPGPHSQSGPGAPTKQAPAPSQ PPASQGPPKSTGQAPPAPAKIIPVKKETKAPAAEKLEPKAEQAPTVKRTETEKKPPLMKD SKSLTAEPQKAVLPTKLERSPKPQPTCPVCKTELNIGSKDAPNFNTCTECKNQVCNLCGF NPTPHLTEIQEWLCLNCQTQRAISGQLGDIGKMPPVPSGPKASPMPVPTESPSQKTAVPP QVKLVKKPEQEVKTEAEKVILEEVKETLSMEKIPPMVATDQKQEESKLEKDKASALEEKK PLHEEKKLISEEEKICSEEKKQLLEEKKPTPEDKKLLPEAKASAPEEQKHDLLKSQVQIA EEKLEGRVAPKTVQEEKQPQTKMEDLPSGTPQSLPKEDDKTTKTIKEQPQPLCTAKPDQV EPGKEKTEKEDDKSDTSSSQQPKSPQGLSDTGYSSDGISSSLGEIPSLIPTDEKDILKGL KKDSFSQESSPSSPSDLAKLESTVLSILEAQASTLVDEKSEKKTQPHEVSPEQPKDQQKT QSVSETLEIAISEEGIKESQEERKDTFKKDTQQDIPSSKDHKEKSEFVDDITTRREHYDS VEESSESENSPVPQRKRRTSVGSSSSDEYKQEDSQGSGEEEDFIRKQIIEMSADEDASGS EDDEFIRNQLKEISSSTESQKKEETKGKGKITAGKHRRLTRKSSTSIDDDVGRRHSWHDE DDEAFDESPELKYRETKSQESEELVVAGGGGLRRFKTIELNSTITDKYSAESSQKKTSLY FEEEPELEMESLTDSPEDRSRGEGSSSLHASSFTPGTSPTSVSSLDEDSDSSPSHKKGES KQQRKARHRSHGPLLPTIEDSSEEEELREEEELLKEQEKQREIEQQQRKSSSKKSKKDKD ELRAQRRRERPKTPPSNLSPIEDASPTEELRQAAEMEELHRSSCSEYSPSIESDPEGFEI SPEKIIEVQKVYKLPTAVSLYSPTDEQSIMQKEGSQKALKSAEEMYEEMMHKTHKYKAFP AANERDEVFEKEPLYGGMLIEDYIYESLVEDTYNGSVDGSLLTRQEEENGFMQQRGREQK IRLSEQIYEDPMQKITDLQKEFYELESLHSVVPQEDIVSSSFIIPESHEIVDLGTMVTST GEEKKLLDADAAYEELMKRQQMQLTPGSSPTQAPIGEDMTESTMDFDRMPDASLTSSVLS GASLTDSTSSATLSIPDVKITQHFSTEEIEDEYVTDYTREIQEIIAHESLILTYSEPSES ATSVPPSDTPSLTSSVSSVCTTDSSSPITTLDSITTVYTEPVDMITKFEDSEEISSSTYF PGSIIDYPEEISVSLDRTTISDGRASADHIISLSDMASSIIESVAPKPGGPVADTISTDL SIAEKDPVKSAKKETGNGIILEVLEAYRDKKELEAELTKSSFSETVFDHPPSSVIILPMK EQLSTTYFTSGETFGQEKPVSQLPTGSPSVSSLPTKPRPFFRSSSLDISAQPPPPPPPPP PPPPPPPPPPPPPLPPPTSPKPTILPKKKLTVTAPVTTATPLFDAVTTVETTAVLKSSGL PVTRICTTAPPPVPPKPSSIPSGLVFTHRPEPSKPPIAPKPVIPQIPATTQKPTDIHPKP IGLSLTSSMTLNLVTSADYKLPSPTSPLSPHSNKSSPRFSKSLTETYVVITLPSEPGTPT DASASQAITSWPLGSPSKDLVSVEPVFSVIPPMTAVEVPSSSEQTFYISGALQTFSPTPV TAPSSFQATPMSVTQFVTTEVSKTEVSATGSTAPSVGLSSISITIPPEPLALDNLHLEKP QYEEDGKLQLVGDVIDLRTVPKVEVETTDKCIDLSASTMDVKRQITTNEVYGKQISAVQP SIINLSVTSSIVTPVSLPTETVTFVTCTASASYTTGTESLVGVERAITTPLQLTTSKHAE PPYRIPSDQVFPIAREEAPINLSLGTPAHAMTLAVTKPVTAPPVGVTNGWTDSTISQGIT DGEVVDLSTTKSHRTVVTMDESTSSVMTKIIEDDEKPVDLTAGRRAVCCDVVYKLPFGRS CTAQQPATTLPEDRFGYRDDHYQYDRSGPYGYRGIGGMKPSMSDTNLAEAGHFFYKSKNA FDYSEGTDTAVDLTSGRVTTGEVMDYSSKTTGPYPETRQVISGVGISTPQYSTARMTPPP GPQYCVGSVLRSSNGVVYSSVATPTPSTFAITTQPGSIFSTTVRDLSGIHTTDAVTSLPA LHHSQPMPRSYFITTGASETDIAVTGIDISASLQTITMESLTAETIDSVPTLTTASEVFP EVVGDESALLIVPEEDKQQQQLDLERELLELEKIKQQRFAEELEWERQEIQRFREQEKIM VQKKLEELQSMKQHLLYQQEEERQAQFMMRQETLAQQQLQLEQIQQLQQQLHQQLEEQKI RQIYQYNYDPSGTASPQTTTEQAILEGQYAAPEGSQFWATEDATTTASAVVAIEIPQSQG WYTVQSDGVTQYIAPPGILSTVSEIPLTDVVVKEEKQPKKRSSGAKVRGQYDEMGENMAD DPRSFKKIVDSGVQTDDEDATDRSYVSRRRRTKKSVDTSVQTDDEDQDEWDVPTRSRRKA RVGKYGDSMAEADKTKPLSKVSSIAVQTVAEISVQTEPVGTIRTPSIRARVDAKVEIIKH ISAPEKTYKGGSLGCQTEADSDTQSPQYLSATSPPKDKKRPTPLEIGYSSHLRADSTVQL APSPPKSPKVLYSPISPLSPGKALESAFVPYEKPLPDDISPQKVLHPDMAKVPPASPKAA KMMQRSMSDPKPLSPTADESSRAPFQYTEGYTTKGSQTMTPSGAQKKVKRTLPNPPPEEI STGTQSTFSTMGTVSRRRICRTNTMARAKILQDIDRELDLVERESAKLRKKQAELDEEEK EIDAKLRYLEMGINRRKEALLKEREKRERAYLQGVAEDRDYMSDSEVSSTRPARIESQHG IERPRTAPQTEFSQFIPPQTQTESQLVPPTSPYTQYQYSSPALPTQAPTSYTQQSHFQQQ TLYHQQVSPYQTQPTFQAVATMSFTPQAQPTPTPQPSYQLPSQMMVIQQKPRQTTLYLEP KITSNYEVIRNQPLMIAPVSTDNTYAVSHLGSKYNSLDLRIGLEERSSMASSPISSISAD SFYADIDHHTPRNYVLIDDIGEITKGTAALSTAFSLHEKDLSKTDRLLRTTETRRSQEVT DFLAPLQSSSRLHSYVKAEEDPMEDPYELKLLKHQIKQEFRRGTESLDHLAGLSHYYHAD TSYRHFPKSEKYSISRLTLEKQAAKQLPAAILYQKQSKHKKSLIDPKMSKFSPIQESRDL EPDYSSYMTSSTSSIGGISSRARLLQDDITFGLRKNITDQQKFMGSSLGTGLGTLGNTIR SALQDEADKPYSSGSRSRPSSRPSSVYGLDLSIKRDSSSSSLRLKAQEAEALDVSFSHAS SSARTKPTSLPISQSRGRIPIVAQNSEEESPLSPVGQPMGMARAAAGPLPPISADTRDQF GSSHSLPEVQQHMREESRTRGYDRDIAFIMDDFQHAMSDSEAYHLRREETDWFDKPRESR LENGHCLDRKLPERLVHSRPLSQHQEQIIQMNGKTMHYIFPHARIKITRDSKDHTVSGNG LGIRIVGGKEIPGHSGEIGAYIAKILPGGSAEQTGKLMEGMQVLEWNGIPLTSKTYEEVQ SIISQQSGEAEICVRLDLNMLSDSENSQHLELHEPPKAVDKAKSPGVDPKQLAAELQKVS LQQSPLVLSSVVEKGSHVHSGPTSAGSSSVPSPGQPGSPSVSKKKHSSSKPTDATKVVSH PITGEIQLQINYDLGNLIIHILQARNLVPRDNNGYSDPFVKVYLLPGRGQVMVVQNASAE YKRRTKYVQKSLNPEWNQTVIYKSISMEQLKKKTLEVTVWDYDRFSSNDFLGEVLIDLSS TSHLDNTPRWYPLKEQTESIDHGKSHSSQSSQQSPKPSVIKSRSHGIFPDPSKDMQVPTI EKSHSSPGSSKSSSEGHLRSHGPSRSQSKTSVTQTHLEDAGAAIAAAEAAVQQLRIQPTA HKSGQSNHARKQHRHSIAGVLPIQRTQSDNLPPPANGNQDQSQLALRKVMSDGPVKPEGA KPPNHRPAESSVSTGSSGSSFGSGYSVDSEGSSSTAGETNLFPIPRIGKMGQNGQEPVKQ PGVGVGLADTEAKTQVMGEIKIALKKEMKTDGEQLIVEILQCRNITYKFKSPDHLPDLYV KIYVMNISTQKKVIKKKTRVCRHDREPSFNETFRFSLSPAGHSLQILLFSNGGKFMKKTL IGEACIWLDKVDLRKRIVNWHKLLVSPTQTH NT seq 15576 nt NT seq  +upstreamnt  +downstreamnt atgggcaacgaggcgagcttggaaggggaagggctcccggaagggctggcggcggccgca gcagccggaggaggggctagcggggcggggagcccctcgcacaccgcgataccggccggc atggaagcggatttgagccagctgagcgaagaggagaggagacagatcgccgctgtcatg tcaagggcgcaggggctgcccaagggaagcgtccccccggccgctgcggagtcgccttcc atgcacaggaaacaagagttggatagtagtcattctccaaagcaatcaggaagacccccg gaccctgggcgtccagctcaacctggtctcagtaaaagtagaactacagacactttcagg tcagagcagaaattgcctgggaggagcccttccactattagcttgaaagaatcaaagtcc agaactgattttaaggaagaacacaaatctagtatgatgcctggcttcctctcagaggtt aaccctttaagtgctgtctcctctgttgtaaataaattcaacccttttgatttgatatca gactctgaggcatcccaggaagaaaccaccaagaaacaaaaagtggttccgaaggagcaa gaaaaacctgagggaatcacaaaacctccgtcacagcaacagccacccaagccggttcct aagcagcaaggacctggtagggatccacttcagcaggatggccctcccaaatcaatatct tctcagcaaccagaaaaaattaaatcacaacctccaggtacaggaaagccaattcagggt cctgcccagactcctcagacagaccatgcaaaattgccacttccacgagatgcatccagg cctcagactaaacaggcagacatagtaaagggagaatcagttaaaccctctctgcaaagc ccatccaaaccacctattcagcaaccaactcctggaaaacctccagcacagcagcctgga cctgaaaaatcacagcctgggcctgcaaagcccccagctcagcccccagggctaacaaag ccactggctcaacaaccagggacagtgaaaaccccagtccagccaccagggacagcaaag cctccagctcagcctcttggtcctgctaagtctccagctcagcagactgggtcagagaag ccttcattggagcagcctgggccaaaaactctagctcagcctcctggagttgggaagact ccagctcaacagccagggccagcaaagcctccaacccagcaggtggggacaccaaaaccc ctagctcaacaatctgggctacagtctccagctaaggcacctgggcctacaaagactcca gctcagcaggctgggccaggaaagattccagctcaacaggcaggacccgcaaagccttct gcccagcagactggcccaacaaggcttccttcacaactgcctggtccagcaaagccccca tctcaacagcctggctcagcaaagcccccaccccaacagcctggctcagcaaagccccca ccccaacagcctggctcagcaaagcccccaccccaacagcctggctcagcaaagccccca tcacaacagcctggctcagcaaaaccctcagctcaacagcctagcccagcaaagcccttg gctcagcaatctacaaaaccagtaagccaaacaggatcaggaaaacctctgcagccacca acaatgtctccatctgcaaaacagcctctttcacaaggcctccctaaaaccatctgtcct ctttgcaataccactgaacttctgttgcatgttccagaaaaggccaattttaacacatgc actgagtgtcaaaccactgtctgtagcctctgtggttttaatcccaatcctcatttagtg gaggtaaaagagtggctctgtttgaactgtcaaatgaaaagagctctaggtggggatctg gctccagttccatcatcaccccagcccaaaccgaaggctgcacctgttaccgctacatca gcagtgagcaaatcatccccacagccacagcagacttccccaaagaaggatgctgcacca aaacaggatctctccaaggtacctgagcctaaaaagccaccactagtgaaacaaccaacc ctccatggctctccttcagccaaggccaagcagcctcctgaggcagattcttcatccaag ccagcccctcccaaagaaccttctgtcccatctgagcaggacaaggcccctgttgctgat gataaaccaaagcagcccaagatggtaaagccaaccacagactttgtatcttcatcatca gcaacaatacctgatattccaagctccaaagtacagtcacaagctgaagagaaaacaacc cctcctctaaaaacagactctgccaaaccctcacagagttttccaccaacaggggaaaaa gtcaccccatttgattctaaagccatacctcgacctgcatcagattcaaaaattatttca catcctggtcctagttcagagagcaaaggtcaaaaacaagttgaccccgtacaaaagaag gaagagcccaagaaagcacaaaccaaaatgagtcctaaacaagatgccaagccaatgcca aaagggtcaccaacaccccctggcccacgacctactgctggccaaactatccccacacct caacagcccccaaagcctcaggagcagtcaagacgtttcagtctgaatctgggaagtatt actgatgcccccaaatcacagcctacaactcctcaagagaccgtgactgggaaactcttt gggtttggagcatcaatcttcagccaggcatcaaatttaatttccactgcaggtcaacct ggacctcattcacaaagtggaccaggggccccaacgaaacaagcccctgccccttcacag ccacctgcttcacaagggccacccaaatccacaggtcaagcaccaccagcacctgcaaaa attatacctgtgaaaaaggaaacaaaagccccagcagctgaaaaattagagcccaaagct gaacaagctccaacagtaaaaagaacagaaacagaaaaaaagccaccacttatgaaggat agcaaatctttaacagctgagcctcaaaaggctgtccttcccacaaaactggagagatct cccaaaccacaaccaacctgtcctgtctgcaaaactgaactcaatataggttctaaggat gctcctaacttcaatacttgcactgaatgcaagaatcaagtgtgtaatctctgtggattt aaccctacaccacatttgactgagattcaagaatggctctgtttaaattgccaaacccag agagcaatatcaggacagcttggagacataggcaaaatgccacctgtgccatcaggaccc aaagcatctcccatgcctgttcctacagaatcaccatctcagaaaacagcagtgcctccc caagtaaaattagtgaaaaagccagaacaagaagtaaaaacagaagctgaaaaagtaatt ctggaagaagtaaaggaaacactatcaatggaaaaaattcctcctatggtagccacagat caaaaacaagaagagagtaaactagagaaagacaaagcttcagctcttgaagaaaaaaag ccactccatgaagaaaaaaaactaatctctgaagaagaaaagatatgttctgaagaaaaa aagcaacttctagaagaaaaaaagccaacccctgaagacaaaaagctactcccagaggca aaagcatcagccccagaagaacaaaaacatgacttacttaaatctcaagtacaaattgct gaagaaaagcttgaaggcagagtggctccaaagacagtgcaagaagagaaacaaccgcag accaagatggaagatttaccatctggcacacctcagagtttacctaaagaagatgataag acaaccaaaacaataaaagaacagccacagccattgtgcacagcaaaacctgatcaggtg gaacctgggaaagaaaaaacagaaaaggaagatgacaaatcagacacctcaagttctcag cagcctaaaagcccccaaggtctgagcgacacgggatattcttctgatggaatatcaagc tcacttggtgaaattccaagtcttattccaactgatgaaaaggatattctcaagggactc aaaaaggactctttttcacaagaaagcagcccttccagcccctcagatttggctaaatta gaaagtacagtcctatctattttggaagctcaagcaagtacacttgttgatgaaaagtca gaaaagaaaacacaaccccatgaagtttctcctgagcagcctaaagaccaacagaaaact cagagtgtgtctgaaaccttggaaattgctatttcagaagaggggatcaaagaaagtcaa gaagaaaggaaagacacttttaaaaaagatacccagcaagatattccttccagcaaggac cataaagaaaagtctgagtttgttgatgacataactactagaagagagcattatgattca gttgaagagagtagtgaaagtgaaaactcacctgttccacaaagaaaacgaagaactagt gttggctcatcaagcagtgatgagtataaacaggaagacagccaaggatcaggggaagag gaggacttcattcgaaaacaaatcatagaaatgagtgctgatgaagatgcttcaggttct gaagatgatgagttcatcaggaaccagctcaaagagattagtagtagtactgagagccag aagaaggaagaaaccaagggaaaaggcaaaataacagcagggaaacacagacgactgact cgaaaaagtagcacaagcattgatgatgatgtaggaagacgtcactcatggcatgatgaa gacgatgaagcatttgatgaaagtcctgaacttaaatacagagaaactaaaagtcaggaa agtgaagaacttgtagttgctggaggaggagggctacgccgatttaaaacaattgagctc aacagtacaataacagataaatattctgcagagtcatcacagaaaaaaacaagtttgtat tttgaggaagagccagaattagaaatggaaagcctgacagactcacctgaagataggtca aggggagaggggtcttcgagtctgcatgcttccagcttcactcctggtacatcccctaca tcagtatcatcacttgatgaggacagtgacagtagcccgagtcacaaaaaaggagagagc aaacagcaacgcaaagctcggcacagatcacatggccctcttttgcctactattgaagat tcttcagaggaagaagaattgagagaagaagaagaattattaaaggagcaagaaaagcag agggaaatagaacagcaacaaagaaagagttctagtaaaaaatcaaagaaagacaaagac gaacttcgagctcagagaagaagggaaaggccaaagacaccacctagtaatctctctccc attgaagatgcatctccaacagaagagttacgtcaggctgcagaaatggaggagctccat agatcttcttgttctgaatattcacctagcatagaatcagacccagaaggttttgaaata agcccggaaaaaataatagaagtacaaaaagtttataaattgcccacagctgtgtcatta tactcaccaacagatgagcaatctattatgcagaaagaaggtagccaaaaggcgttaaaa agtgctgaggagatgtatgaagaaatgatgcataaaacacacaaatacaaagcttttcca gctgcaaatgaacgagatgaagtgtttgaaaaagagcctttgtatggtggaatgctaata gaggattatatttatgaatctttagtagaagacacgtacaatggatctgtagatggcagc ctgctaacaaggcaagaagaagaaaatggatttatgcagcagagaggaagagagcaaaag ataagactttcagaacaaatttatgaagatcctatgcagaaaattacagacctccagaaa gagttttatgagttagaaagcttacattctgttgtgcctcaggaagatattgtttcaagc tcttttatcatcccagaaagccatgagatagtggacctgggtactatggtaacttctaca ggagaagaaaagaaactactagatgctgatgctgcctatgaggaacttatgaagaggcaa cagatgcagttaacacctggatctagcccaacccaggcccccatcggtgaggatatgaca gagtccaccatggactttgacagaatgcctgatgcatctttgacatcaagtgttctctca ggagcatctcttacagattcgaccagcagtgcaacactgtctatcccagatgttaaaata acccaacatttttcaacagaagaaattgaggatgaatatgtaaccgattatacaagagaa attcaagagataattgcccatgaatcgctgattttgacctactcggagccttcagaaagt gctacatctgtcccaccctctgacacaccttctctcacatcatctgtttcctcggtctgt accacagatagctcttcacccattactaccctggatagcataaccacagtttatacagaa ccagtggacatgataactaaatttgaggattctgaggaaatttcttcatcaacttatttt ccaggcagcattatagactacccggaagaaataagtgtatctttagatcggactaccata tcagatggtagagctagtgctgatcatattatttccttatccgatatggcatcttctatc atagaatctgtagcacctaaacctggagggccagttgctgacactatttctactgactta tctatagctgaaaaggacccagtgaagagcgccaagaaggaaactgggaatggaatcatt ctggaggttttggaagcttacagagataaaaaggagttggaggccgaactaacaaaaagt agcttctctgaaactgtgtttgatcacccaccttcttctgtaataatccttccaatgaaa gagcagctttcaactacgtactttacatctggagagacctttggtcaggaaaaacctgtg tctcagttaccaactggcagtccttctgtttcctctcttccaactaaacctcgcccattc tttagaagttcttctttggacatatcagctcaacctcctccccctcctccccctccccct cctcctcctcctccaccaccgccacctcctcccccaccacttcctccaccaacttcacct aaaccaactattcttcctaaaaaaaagttaacagttacagctccagtgactacagctaca cctctgtttgatgctgttactactgtagagaccacagctgttctgaaaagtagtggatta cctgttacaagaatatgtaccaccgcacctcctcctgttcctcctaagccatcttcaatt ccatctggacttgtatttacccacaggcctgagccaagcaaacctccaatcgcccccaaa ccagtgattcctcagattccagcaactacacaaaaaccaacagatatacaccccaaacca ataggcctgtctttaacttcaagtatgaccttaaatttagtgacttcagcagattataaa ttgccttcccctacctccccactttccccacactccaacaagtcctcaccaagattttcc aaatccctcacggaaacttatgtagttattacattgccatctgaacctgggactccgaca gatgcttctgctagtcaagcaattaccagttggcccttgggatcaccctccaaagatctg gtttctgttgaacctgtgttttctgtaattcctcctatgacagctgtagaagttccaagt tcatcagaacagaccttctatatctctggagctttacagacattttctcctacccctgtc acagcaccctcttcatttcaagcaactcccatgtcagttacacagtttgtcactactgaa gtttccaagactgaggtttcagcaaccggaagtacagctcctagtgttggtctcagcagc atttccataacaattcctccagaacctcttgctctagataacctacatttagagaagcct cagtatgaagaagatggaaaattgcaacttgttggtgatgtaattgatttgcgtacagta ccaaaggtagaagttgaaacaactgataaatgtattgatctttctgcttctacaatggat gtgaaaaggcagatcacaacaaatgaagtttatgggaaacaaattagtgctgtccaaccc tctattataaatcttagtgtaacatcatcaatagtgactcctgtatctctgcccactgag acagtgacctttgtcacatgcacagctagtgcaagttatactacaggcacagaaagccta gtgggtgtagaacgtgcaataacaacaccactccagcttacaacatcaaagcatgctgag cccccatacaggataccaagtgaccaggtctttcctatagctagggaagaagcgccgata aacttatctctaggtactccagcacatgcaatgacattggctgttacaaaacctgtcact gcgcctcctgttggtgtcacaaatggatggactgatagcaccatatctcaggggatcact gatggggaagtagtggatctcagtacaaccaagtctcatagaacagtcgtaacaatggat gagtctacttcaagtgtgatgaccaaaataatagaagatgatgaaaaacccgttgactta acagcagggagaagagctgtgtgctgtgatgtggtttataaattaccgtttggaaggagc tgcacagcacagcagcctgcaactactcttcctgaggatcgttttggttatagggatgac cactatcagtatgatcgatcagggccatatggttatagagggattgggggaatgaagcct tccatgtctgacacaaatttagcagaagctggacattttttctataaaagtaagaatgct tttgattattctgaaggaactgacacagcagtagatctgacttcagggagagttactaca ggtgaggtaatggattattcaagcaagactacaggtccatatccagaaacacgacaagtc atttcaggagttgggattagtaccccacagtattccacagcaagaatgacaccaccgcca ggaccccagtattgtgtggggagtgttttgaggtcatctaatggtgttgtctattcttca gtagcaactccgacaccctctacctttgctatcaccacacaacccggctccattttcagc accacagtgagggatttgtctggtattcatacaactgatgcagtgacttcattacctgcc ctgcaccatagccagccaatgcctagatcgtattttataacaacaggtgcatctgaaacg gacattgcagtaactggtattgatatcagtgccagcttgcaaactattactatggagtct cttactgctgagacaatagactctgttcccactttaaccacagcatctgaagtgtttcct gaagtggtgggagatgaaagtgctcttttgattgtccctgaagaagataaacaacagcag cagctagacttggagcgtgagctcctggagctggagaaaattaagcaacagcgctttgct gaggaattggagtgggaacgtcaggaaattcaaagattccgagaacaagaaaagatcatg gttcagaaaaagttggaggagctgcaatctatgaagcaacaccttctctatcagcaagaa gaagagcggcaagcccagttcatgatgaggcaggagacgttagctcagcaacagttacag cttgagcagatccaacagctgcaacaacagcttcaccagcagctggaggagcaaaagatt cggcagatctaccagtataactatgacccttctggaactgcttctccacaaaccactaca gagcaggcaattttggaaggtcagtatgctgccccagaaggcagtcagttttgggcaact gaagatgcaaccactacagcttcagctgttgtggcaattgaaataccacaaagccaagga tggtacaccgttcagtctgatggtgttactcagtacattgccccacctggtatcctgagc actgtttcagaaatacctctaacagatgttgttgtaaaagaggaaaaacagcccaaaaag agaagttctggagctaaagtccgaggacagtatgatgaaatgggagaaaatatggcagat gatccccgaagttttaaaaagatagtggacagtggtgtacaaacggatgacgaagatgcc acagatcggagctatgtgagtaggagaaggagaactaaaaagagtgtggatacaagcgtc caaactgatgatgaagatcaggatgagtgggatgtgcctactagatcaaggaggaaagct cgtgtagggaaatatggtgacagcatggcagaggctgacaagaccaaacccctttccaaa gtctccagcatagcagttcaaacggtagcagagatatctgtgcaaactgaaccagttgga accataagaacaccctccatacgggcacgagtggatgccaaggtagaaataattaaacac atttcagcacctgaaaagacttacaaagggggcagtttaggatgtcaaacagaagcagat tcagacacacaaagtcctcaatacctgagtgccacatctccacccaaagacaagaaacgc ccaacacctttagagattggttattcatctcacctccgggcagattccacagtacagctg gctccttccccacccaaatcccccaaagtcctttattcacccatctcaccactttcacca ggcaaagccttagaatcagcctttgtaccttatgaaaaacccctccctgatgatataagt ccacagaaagtactgcatccagatatggctaaagttcccccagcaagtcctaaggcagcc aagatgatgcagcgttctatgtctgaccccaagcctctgagtccaacagcagacgaaagt tccagggctccttttcagtataccgagggctatacgactaaaggttctcaaaccatgaca ccctctggagcccagaaaaaagttaaaagaactctgccaaatccacctcctgaggagatt tccacaggaactcaatccacattcagcacaatgggcacagtttccaggagaaggatctgc agaaccaacacaatggcacgagccaagattctccaggacatagacagagagcttgatctt gtggaaagggaatctgcaaagcttagaaagaaacaagcagagcttgatgaagaagaaaag gagattgatgccaagctacgatacctggaaatgggaattaacaggaggaaagaggcatta ttaaaggagagagaaaagagagaacgagcttacctccagggagtagctgaggatcgtgat tacatgtctgacagtgaagtaagtagcacaagaccagcccgaatagaaagtcagcatggc attgagcgaccaagaactgctccccaaactgaattcagccagtttataccaccacaaacc caaacagaatctcaactagttcctccgacaagtccttacacacaataccaatactcttcc cctgctcttcctacccaagcacccacctcatacacccaacaatctcattttcagcaacaa actttgtaccatcagcaagtttcaccttatcagactcagccaacattccaagctgtggca acaatgtccttcacacctcaagctcaacctacgccaaccccacagccttcttatcagtta ccttcacagatgatggtgatacaacagaagccacggcaaactacattatatttggagccc aagataacctcaaactatgaagtgattcgcaaccaaccccttatgatagcacctgtttct actgataacacatacgctgtttcccatcttggtagtaagtacaatagtttagacttgaga ataggtttagaggaaagaagtagcatggcaagcagtccaatatcaagcatatccgcagat tctttctatgcagatattgatcaccatactccacgaaattatgtcctaattgacgacatt ggagagatcaccaaaggaacagcggcgttaagcaccgcatttagccttcatgaaaaggat ctgtcaaaaacagaccgtctccttcgaaccactgagacacgccggtctcaagaagtgaca gatttcctagcacctttacagtcttcctctagattgcatagttatgtgaaggcagaggaa gacccaatggaggatccttatgagttaaagcttctgaaacatcagattaaacaggaattt cgtcgagggacagagagcttagatcacctcgctggtctttctcattattaccatgctgat actagctatagacattttccaaaatctgagaagtatagcatcagtagactcacacttgaa aagcaagcagcaaaacaactgccagcagccatactttatcaaaagcagtcaaagcataag aaatcactaattgaccctaaaatgtcaaaattttcacctattcaagaaagtagagacctt gaacctgactattcaagctatatgacttctagcacttcatctattggtggcatttcctct agggcaaggcttcttcaagatgacatcacttttggcctcagaaaaaatattacagaccaa cagaaatttatgggatcctctcttggcacaggactaggcacattaggaaataccatacgc tcagctttgcaggatgaagcagataagccatacagtagtggcagcaggtccagaccctcc tccagaccttcctctgtctatgggcttgatttatcaattaaaagggattcttctagctct tccctaagactgaaagctcaagaggctgaagctctagatgtttcatttagtcacgcatca tcctctgccagaactaagccgaccagtttgccaattagtcaaagtagaggaagaatacca attgtggcccagaattctgaagaagaaagcccactcagtcctgttggccagccaatggga atggccagggctgcagctggacccctgccaccaatatctgcagacaccagggatcagttt ggatcaagccactcattgcctgaagttcagcaacacatgagggaagaatcacggactcga ggctatgaccgtgacatagccttcatcatggatgacttccaacatgccatgtcagacagt gaagcctatcatctgcgtcgtgaggaaacagattggtttgataaacccagggagtctcgt ctggaaaatggacattgtctggaccgaaaactgccagaaagattggtccactctagacca ctcagccagcatcaagaacaaatcatacagatgaacgggaaaactatgcactacatcttt cctcacgcaaggataaaaataacaagagactcaaaggatcacacagtttcaggtaatgga ttaggaattagaattgtgggtggtaaagaaatccctggacatagtggagaaattggagcc tacattgccaagattcttcctgggggaagtgcagaacagacagggaaacttatggaaggg atgcaagtattggaatggaatggaattcccttgacttctaaaacatatgaagaagttcag agtatcattagtcagcaaagtggggaagcagaaatatgtgtaagactggacctcaatatg ctatcagattctgaaaattcccagcatctggaacttcatgagccaccaaaagctgtggat aaggcgaaatccccaggggtcgatcctaagcagttggcagcagaactccagaaggtttca ctacagcagtcaccgctggttctgtcatcggttgttgaaaaaggatctcatgttcattca ggtcctacatcagcaggatccagttccgttcccagccctgggcaaccagggtccccttca gtgagcaaaaagaagcacagcagcagcaagcctaccgatgcaacaaaggttgtctctcat ccaattacgggagaaattcagcttcaaattaactatgatcttggaaatctcataatacat attctccaagcaagaaatcttgttcctcgagacaacaatggttattctgacccttttgtg aaagtgtaccttcttccagggagaggtcaagtcatggttgtccagaatgcaagtgctgag tacaagagaaggactaaatatgtccagaaaagtcttaatcctgagtggaatcaaacagta atttataaaagtatttccatggaacagctcaagaagaaaacactggaggtgacagtttgg gattatgatagattttcatccaacgacttccttggggaggtattgattgatttatctagc acatctcacctcgataacactccaaggtggtatcctctcaaagaacagactgaaagcatt gatcatggcaagtcgcattccagtcagagcagccagcagtccccaaagccatctgttatc aaaagcagaagccatggtatcttccctgacccatcaaaggacatgcaggttcccaccatt gagaaatcccatagtagtcctggtagctcaaaatcatcatcagaaggccatctccgttct catggaccatctcgcagtcaaagcaaaaccagcgtcactcagacccacctggaagatgca ggggctgccatagctgctgccgaagctgccgtgcaacaactccgcattcaaccaacagca cataaaagcggtcagtctaatcatgccaggaagcagcacagacacagcatagcaggagtc ctccccattcaaagaactcagtctgataatctgcctccaccagccaatggcaaccaagac caaagccagctagccctcaggaaggtgatgtctgatggaccagtcaagccagaaggagca aagcctcccaatcaccggcctgcagaaagctctgtgtccaccggctcctcgggcagcagc tttggcagtgggtatagcgtggacagtgaaggaagcagcagcactgcaggggagactaat ctatttcctattccgaggatagggaagatgggacagaatggacaagagcctgtaaaacag ccaggggtaggagtaggactagcagacactgaagctaaaactcaggtaatgggagaaata aagattgcactgaagaaggaaatgaagacagatggtgaacaactaatagttgaaattctc caatgcagaaatattacatacaaatttaagtctcctgatcatctaccagatttatatgtg aaaatatatgtgatgaatatttctacccaaaaaaaggtgatcaagaaaaaaacaagagta tgcagacatgatcgagagccttcattcaatgaaacttttcgattcagtctaagtcctgca ggacattctcttcagattttacttttctccaatggagggaagtttatgaaaaagacctta attggtgaagcctgtatctggcttgacaaagtggatctcagaaaaagaatagtcaattgg cacaaacttttggtcagtcctactcaaacgcattga

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