Entry |
|
Symbol |
PLCB4
|
Name |
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1
|
KO |
|
Organism |
mni Macaca nemestrina (pig-tailed macaque)
|
Pathway |
mni04070 | Phosphatidylinositol signaling system |
mni04072 | Phospholipase D signaling pathway |
mni04261 | Adrenergic signaling in cardiomyocytes |
mni04270 | Vascular smooth muscle contraction |
mni04613 | Neutrophil extracellular trap formation |
mni04621 | NOD-like receptor signaling pathway |
mni04723 | Retrograde endocannabinoid signaling |
mni04750 | Inflammatory mediator regulation of TRP channels |
mni04919 | Thyroid hormone signaling pathway |
mni04925 | Aldosterone synthesis and secretion |
mni04927 | Cortisol synthesis and secretion |
mni04928 | Parathyroid hormone synthesis, secretion and action |
mni04933 | AGE-RAGE signaling pathway in diabetic complications |
mni04935 | Growth hormone synthesis, secretion and action |
mni04961 | Endocrine and other factor-regulated calcium reabsorption |
mni04973 | Carbohydrate digestion and absorption |
mni05022 | Pathways of neurodegeneration - multiple diseases |
mni05163 | Human cytomegalovirus infection |
|
Module |
mni_M00130 | Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4 |
|
Brite |
KEGG Orthology (KO) [BR:mni00001]
09100 Metabolism
09101 Carbohydrate metabolism
00562 Inositol phosphate metabolism
105481530 (PLCB4)
09130 Environmental Information Processing
09132 Signal transduction
04015 Rap1 signaling pathway
105481530 (PLCB4)
04310 Wnt signaling pathway
105481530 (PLCB4)
04371 Apelin signaling pathway
105481530 (PLCB4)
04020 Calcium signaling pathway
105481530 (PLCB4)
04070 Phosphatidylinositol signaling system
105481530 (PLCB4)
04072 Phospholipase D signaling pathway
105481530 (PLCB4)
04071 Sphingolipid signaling pathway
105481530 (PLCB4)
04022 cGMP-PKG signaling pathway
105481530 (PLCB4)
09133 Signaling molecules and interaction
04082 Neuroactive ligand signaling
105481530 (PLCB4)
04081 Hormone signaling
105481530 (PLCB4)
09140 Cellular Processes
09144 Cellular community - eukaryotes
04540 Gap junction
105481530 (PLCB4)
09150 Organismal Systems
09151 Immune system
04611 Platelet activation
105481530 (PLCB4)
04613 Neutrophil extracellular trap formation
105481530 (PLCB4)
04621 NOD-like receptor signaling pathway
105481530 (PLCB4)
04062 Chemokine signaling pathway
105481530 (PLCB4)
09152 Endocrine system
04911 Insulin secretion
105481530 (PLCB4)
04922 Glucagon signaling pathway
105481530 (PLCB4)
04929 GnRH secretion
105481530 (PLCB4)
04912 GnRH signaling pathway
105481530 (PLCB4)
04915 Estrogen signaling pathway
105481530 (PLCB4)
04921 Oxytocin signaling pathway
105481530 (PLCB4)
04926 Relaxin signaling pathway
105481530 (PLCB4)
04935 Growth hormone synthesis, secretion and action
105481530 (PLCB4)
04918 Thyroid hormone synthesis
105481530 (PLCB4)
04919 Thyroid hormone signaling pathway
105481530 (PLCB4)
04928 Parathyroid hormone synthesis, secretion and action
105481530 (PLCB4)
04916 Melanogenesis
105481530 (PLCB4)
04924 Renin secretion
105481530 (PLCB4)
04925 Aldosterone synthesis and secretion
105481530 (PLCB4)
04927 Cortisol synthesis and secretion
105481530 (PLCB4)
09153 Circulatory system
04261 Adrenergic signaling in cardiomyocytes
105481530 (PLCB4)
04270 Vascular smooth muscle contraction
105481530 (PLCB4)
09154 Digestive system
04970 Salivary secretion
105481530 (PLCB4)
04971 Gastric acid secretion
105481530 (PLCB4)
04972 Pancreatic secretion
105481530 (PLCB4)
04973 Carbohydrate digestion and absorption
105481530 (PLCB4)
09155 Excretory system
04961 Endocrine and other factor-regulated calcium reabsorption
105481530 (PLCB4)
09156 Nervous system
04724 Glutamatergic synapse
105481530 (PLCB4)
04725 Cholinergic synapse
105481530 (PLCB4)
04728 Dopaminergic synapse
105481530 (PLCB4)
04726 Serotonergic synapse
105481530 (PLCB4)
04720 Long-term potentiation
105481530 (PLCB4)
04730 Long-term depression
105481530 (PLCB4)
04723 Retrograde endocannabinoid signaling
105481530 (PLCB4)
09157 Sensory system
04742 Taste transduction
105481530 (PLCB4)
04750 Inflammatory mediator regulation of TRP channels
105481530 (PLCB4)
09159 Environmental adaptation
04713 Circadian entrainment
105481530 (PLCB4)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
105481530 (PLCB4)
09172 Infectious disease: viral
05163 Human cytomegalovirus infection
105481530 (PLCB4)
09174 Infectious disease: parasitic
05146 Amoebiasis
105481530 (PLCB4)
05142 Chagas disease
105481530 (PLCB4)
05143 African trypanosomiasis
105481530 (PLCB4)
09164 Neurodegenerative disease
05010 Alzheimer disease
105481530 (PLCB4)
05016 Huntington disease
105481530 (PLCB4)
05017 Spinocerebellar ataxia
105481530 (PLCB4)
05022 Pathways of neurodegeneration - multiple diseases
105481530 (PLCB4)
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
105481530 (PLCB4)
05415 Diabetic cardiomyopathy
105481530 (PLCB4)
09167 Endocrine and metabolic disease
04933 AGE-RAGE signaling pathway in diabetic complications
105481530 (PLCB4)
04934 Cushing syndrome
105481530 (PLCB4)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:mni04131]
105481530 (PLCB4)
Enzymes [BR:mni01000]
3. Hydrolases
3.1 Acting on ester bonds
3.1.4 Phosphoric-diester hydrolases
3.1.4.11 phosphoinositide phospholipase C
105481530 (PLCB4)
Membrane trafficking [BR:mni04131]
Exocytosis
Calcium ion-dependent exocytosis
Phospholipases
105481530 (PLCB4)
Endocytosis
Macropinocytosis
Phospholipase C
105481530 (PLCB4)
|
SSDB |
|
Motif |
|
Other DBs |
|
LinkDB |
|
Position |
Unknown
|
AA seq |
1206 aa
MAKPYEFNWQKEVPSFLQEGAVFDRYEEESFVFEPNCLFKVDEFGFFLTWKSEGKEGQVL
ECSLINSIRSGAIPKDPKILAALEAVGKSENDLEGRIVCVCSGTDLVNISFTYMVAENPE
VTKQWVEGLRSIIHNFRANNVSPMTCLKKHWMKLAFMTNTNGKIPVRSITRTFASGKTEK
VIFQALKELGLPSGKNDEIEPTAFTYEKFYELTQKICPRTDIEDLFKKINGDKTDYLTVD
QLVSFLNEHQRDPRLNEILFPFYDAKRAMQIIEMYEPDEDLKKKGLISSDGFCRYLMSDE
NAPVFLDRLELYQEMDHPLAHYFISSSHNTYLTGRQFGGKSSVEMYRQVLLAGCRCVELD
CWDGKGEDQEPIITHGKAMCTDILFKDVIQAIKETAFVTSEYPVILSFENHCSKYQQYKM
SKYCEDLFGDLLLKQALESHPLEPGRPLPSPNDLKRKILIKNKRLKPEVEKKQLEALRSM
MEAGESASPANILEDDNEEEIESADQEEEAHPEFKFGNELSADDLGHKEAVANSVKKASD
DLEHENNKKGLVTVEDEQAWMASYKYVGATTNIHPYLSTMINYAQPVKFQGFHVAEERNI
HYNMSSFNESVGLGYLKTHAIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQMVS
LNYQTPDLAMQLNQGKFEYNGSCGYLLKPDFMRRPDRTFDPFSETPVDGVIAATCSVQVI
SGQFLSDKKIGTYVEVDMYGLPTDTIRKEFRTRMVMNNGLNPVYNEESFVFRKVILPDLA
VLRIAVYDDNNKLIGQRILPLDGLQAGYRHISLRNEGNKPLSLPTIFCNIVLKTYVPDGF
GDIVDALSDPKKFLSITEKRADQMRAMGIETSDIADVPSDTSKNDKKGKANTTKANVTPQ
SSSELRPTTTAALASGVEAKKGIELIPQVRIEDLKQMKAYLKHLKKQQKELNSLKKKHAK
EHSTMQKLHCTQVDKIVAQYDKEKSTHEKILEKAMKKKGGSNCLEMKKETEIKIQTLTSD
HKSKVKEIVAQHTKEWSEMINTHSAEEQEIRDLHLSQQCELLKKLLISAHEQQTQQLKLS
HDRESKEMRAHQAKISMENSKAISQDKSIKNKAERERRVRELNSSNTKKFLEERKRLAMK
QSKEMDQLKKVQLEHLEFLEKQNEQLLKSCHAVSQSQGEGDAADGEIGSRDGPQTSNSSM
KLQNAN |
NT seq |
3621 nt +upstreamnt +downstreamnt
atggccaaaccttatgaatttaactggcagaaggaagttccttcctttttgcaagaagga
gcagtttttgacagatacgaagaggaatcctttgtgtttgaacccaactgcctcttcaaa
gtggatgagtttggcttctttctgacatggaaaagtgaaggcaaggaaggacaggtgcta
gaatgctccctcatcaacagtattcggtcgggagccataccaaaggatcccaaaatcttg
gctgctcttgaagctgttggaaaatcagagaatgatctggaaggtcggatagtttgtgtc
tgcagtggcacagatctagtgaacattagttttacctacatggtggctgaaaatccagaa
gtaactaagcaatgggtagaaggcctgagatcaatcatacacaacttcagggccaacaat
gtcagtccaatgacgtgcctcaagaaacactggatgaaattggcatttatgaccaacaca
aatggtaaaattccagttaggagtattactagaacctttgcatcggggaaaacagaaaag
gtgatctttcaagcactcaaggagttaggtcttcccagtggaaagaatgatgaaattgag
cccacggcatttacttatgaaaagttctatgaactgacacaaaagatttgtcctcggaca
gatatagaagatcttttcaaaaaaatcaatggagacaaaactgattatttaacggtagac
caattagtgagctttctaaatgaacatcaacgagatcctcgattgaatgaaattttattt
ccattttatgatgccaaaagggcaatgcagatcattgagatgtatgaacctgatgaagat
ttgaagaaaaaaggccttatatcaagtgatgggttttgcagatatctgatgtcagatgaa
aacgccccagtcttcctagatcgtttagaactttaccaagaaatggaccatcctctggct
cactacttcatcagttcttcccataacacttacctgactggcagacagttcggcgggaag
tcttcggtagagatgtacagacaggttctcctggctggttgcagatgtgttgaacttgac
tgctgggatggaaaaggtgaagaccaagaaccaataataactcatggaaaagcaatgtgt
acagatatcctttttaaggatgtaattcaagccatcaaggaaactgcatttgtcacatca
gaatatcctgtaattctctcctttgaaaatcactgcagcaaatatcaacagtacaagatg
tccaaatattgcgaagatctatttggagatctcctgttgaaacaagcgcttgaatcacat
ccacttgaaccaggcagacctttgccatcccccaatgacctcaaaagaaaaatactcata
aaaaacaagaggctgaaacctgaagttgaaaaaaaacagctggaagctttgagaagcatg
atggaagctggagaatctgcctccccagcaaacatcttagaggatgataatgaagaggag
atcgaaagtgctgaccaagaggaggaagctcaccccgaattcaaatttggaaatgaactt
tctgctgatgacttgggtcacaaggaagctgttgcaaatagcgtcaagaaggcctcagat
gaccttgaacatgaaaacaacaaaaagggcctggtaactgtagaagatgagcaggcgtgg
atggcatcttataaatatgtaggtgctaccactaatatccatccatatttgtccacaatg
atcaactacgcccagcctgtaaagtttcaaggtttccatgtggcagaagaacgcaatatt
cattataacatgtcttcttttaatgaatcagtcggtcttggctacttgaagacacatgca
attgaatttgtcaattataacaaacggcaaatgagtcgcatttaccccaagggaggccga
gtcgattccagtaattacatgcctcagattttctggaacgctggctgccagatggtttcc
ctgaactatcaaaccccagatttagcgatgcaattgaatcagggaaaatttgagtataat
ggatcgtgcgggtaccttctcaaaccagatttcatgaggcggcctgatcgaacatttgac
cccttctctgaaactcctgttgatggcgttattgcagccacttgctcagtgcaggttata
tcaggtcaattcttatcagataagaaaattggcacctatgtagaagtggatatgtatggg
ttgcccactgacactatacgtaaggaattccgaactcgtatggttatgaataatggacta
aatccagtttacaatgaagagtctttcgtatttcggaaggtgatcctgccagacctggct
gtcttgagaatagcagtgtatgatgataacaacaagctgattggccagaggatcctcccg
cttgatggcctccaagcaggataccgacacatttcccttcgaaatgagggaaataaacca
ttatcactgccaacaattttctgcaatattgttcttaaaacatacgtgcctgatggattt
ggagatattgtggatgctttatcagatccaaagaaatttctctcaattacagaaaagaga
gcagaccaaatgagagctatgggcattgaaactagtgacatagctgatgtgcccagtgac
acttccaaaaatgacaagaaaggaaaggccaataccaccaaagcaaacgtgacccctcag
agtagctctgagctcagaccaaccaccacagctgccctggcctctggtgtggaagccaaa
aaaggtattgaacttatccctcaagtaaggatagaagatttaaagcagatgaaggcttac
ttgaagcatttaaagaaacagcagaaagagctaaattctttaaagaagaaacatgcaaag
gagcacagtaccatgcagaagttacactgcacgcaagttgacaaaattgtggcacagtat
gacaaagagaagtcgactcatgagaaaatcctagagaaggcaatgaagaagaagggggga
agtaattgtctcgaaatgaaaaaagaaacagaaattaaaattcagacgctgacatcagat
cacaaatctaaggtcaaagagattgtagcacagcacacaaaggaatggtcagaaatgatc
aatacccacagtgctgaggagcaagaaatccgagacctgcacctcagccagcagtgtgag
ctgctgaaaaagctactcatcagtgcccacgagcagcaaacccagcagctgaaactgtcc
catgacagggaaagcaaggaaatgcgagcacaccaggctaagatttctatggaaaatagc
aaagccatcagccaagataaatctatcaagaataaggcagaacgggaaaggcgagtcagg
gagttaaacagcagcaacactaaaaagtttctggaagaaagaaagagactcgcaatgaag
cagtccaaagaaatggatcagttgaaaaaagtccagcttgaacatctagaattcctagag
aaacagaatgagcagcttttgaaatcctgtcatgcagtgtcccaatcgcaaggcgaagga
gatgcagcagatggtgaaattggaagccgagatggaccgcagaccagcaacagtagtatg
aaactccaaaatgcgaactga |