KEGG   Macaca nemestrina (pig-tailed macaque): 105481533
Entry
105481533         CDS       T08765                                 
Symbol
PLCB1
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1
  KO
K05858  phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
mni  Macaca nemestrina (pig-tailed macaque)
Pathway
mni00562  Inositol phosphate metabolism
mni01100  Metabolic pathways
mni04015  Rap1 signaling pathway
mni04020  Calcium signaling pathway
mni04022  cGMP-PKG signaling pathway
mni04062  Chemokine signaling pathway
mni04070  Phosphatidylinositol signaling system
mni04071  Sphingolipid signaling pathway
mni04072  Phospholipase D signaling pathway
mni04081  Hormone signaling
mni04082  Neuroactive ligand signaling
mni04261  Adrenergic signaling in cardiomyocytes
mni04270  Vascular smooth muscle contraction
mni04310  Wnt signaling pathway
mni04371  Apelin signaling pathway
mni04540  Gap junction
mni04611  Platelet activation
mni04613  Neutrophil extracellular trap formation
mni04621  NOD-like receptor signaling pathway
mni04713  Circadian entrainment
mni04720  Long-term potentiation
mni04723  Retrograde endocannabinoid signaling
mni04724  Glutamatergic synapse
mni04725  Cholinergic synapse
mni04726  Serotonergic synapse
mni04728  Dopaminergic synapse
mni04730  Long-term depression
mni04742  Taste transduction
mni04750  Inflammatory mediator regulation of TRP channels
mni04911  Insulin secretion
mni04912  GnRH signaling pathway
mni04915  Estrogen signaling pathway
mni04916  Melanogenesis
mni04918  Thyroid hormone synthesis
mni04919  Thyroid hormone signaling pathway
mni04921  Oxytocin signaling pathway
mni04922  Glucagon signaling pathway
mni04924  Renin secretion
mni04925  Aldosterone synthesis and secretion
mni04926  Relaxin signaling pathway
mni04927  Cortisol synthesis and secretion
mni04928  Parathyroid hormone synthesis, secretion and action
mni04929  GnRH secretion
mni04933  AGE-RAGE signaling pathway in diabetic complications
mni04934  Cushing syndrome
mni04935  Growth hormone synthesis, secretion and action
mni04961  Endocrine and other factor-regulated calcium reabsorption
mni04970  Salivary secretion
mni04971  Gastric acid secretion
mni04972  Pancreatic secretion
mni04973  Carbohydrate digestion and absorption
mni05010  Alzheimer disease
mni05016  Huntington disease
mni05017  Spinocerebellar ataxia
mni05022  Pathways of neurodegeneration - multiple diseases
mni05142  Chagas disease
mni05143  African trypanosomiasis
mni05146  Amoebiasis
mni05163  Human cytomegalovirus infection
mni05200  Pathways in cancer
mni05415  Diabetic cardiomyopathy
mni05417  Lipid and atherosclerosis
Module
mni_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:mni00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    105481533 (PLCB1)
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    105481533 (PLCB1)
   04310 Wnt signaling pathway
    105481533 (PLCB1)
   04371 Apelin signaling pathway
    105481533 (PLCB1)
   04020 Calcium signaling pathway
    105481533 (PLCB1)
   04070 Phosphatidylinositol signaling system
    105481533 (PLCB1)
   04072 Phospholipase D signaling pathway
    105481533 (PLCB1)
   04071 Sphingolipid signaling pathway
    105481533 (PLCB1)
   04022 cGMP-PKG signaling pathway
    105481533 (PLCB1)
  09133 Signaling molecules and interaction
   04082 Neuroactive ligand signaling
    105481533 (PLCB1)
   04081 Hormone signaling
    105481533 (PLCB1)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    105481533 (PLCB1)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    105481533 (PLCB1)
   04613 Neutrophil extracellular trap formation
    105481533 (PLCB1)
   04621 NOD-like receptor signaling pathway
    105481533 (PLCB1)
   04062 Chemokine signaling pathway
    105481533 (PLCB1)
  09152 Endocrine system
   04911 Insulin secretion
    105481533 (PLCB1)
   04922 Glucagon signaling pathway
    105481533 (PLCB1)
   04929 GnRH secretion
    105481533 (PLCB1)
   04912 GnRH signaling pathway
    105481533 (PLCB1)
   04915 Estrogen signaling pathway
    105481533 (PLCB1)
   04921 Oxytocin signaling pathway
    105481533 (PLCB1)
   04926 Relaxin signaling pathway
    105481533 (PLCB1)
   04935 Growth hormone synthesis, secretion and action
    105481533 (PLCB1)
   04918 Thyroid hormone synthesis
    105481533 (PLCB1)
   04919 Thyroid hormone signaling pathway
    105481533 (PLCB1)
   04928 Parathyroid hormone synthesis, secretion and action
    105481533 (PLCB1)
   04916 Melanogenesis
    105481533 (PLCB1)
   04924 Renin secretion
    105481533 (PLCB1)
   04925 Aldosterone synthesis and secretion
    105481533 (PLCB1)
   04927 Cortisol synthesis and secretion
    105481533 (PLCB1)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    105481533 (PLCB1)
   04270 Vascular smooth muscle contraction
    105481533 (PLCB1)
  09154 Digestive system
   04970 Salivary secretion
    105481533 (PLCB1)
   04971 Gastric acid secretion
    105481533 (PLCB1)
   04972 Pancreatic secretion
    105481533 (PLCB1)
   04973 Carbohydrate digestion and absorption
    105481533 (PLCB1)
  09155 Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    105481533 (PLCB1)
  09156 Nervous system
   04724 Glutamatergic synapse
    105481533 (PLCB1)
   04725 Cholinergic synapse
    105481533 (PLCB1)
   04728 Dopaminergic synapse
    105481533 (PLCB1)
   04726 Serotonergic synapse
    105481533 (PLCB1)
   04720 Long-term potentiation
    105481533 (PLCB1)
   04730 Long-term depression
    105481533 (PLCB1)
   04723 Retrograde endocannabinoid signaling
    105481533 (PLCB1)
  09157 Sensory system
   04742 Taste transduction
    105481533 (PLCB1)
   04750 Inflammatory mediator regulation of TRP channels
    105481533 (PLCB1)
  09159 Environmental adaptation
   04713 Circadian entrainment
    105481533 (PLCB1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    105481533 (PLCB1)
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    105481533 (PLCB1)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    105481533 (PLCB1)
   05142 Chagas disease
    105481533 (PLCB1)
   05143 African trypanosomiasis
    105481533 (PLCB1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    105481533 (PLCB1)
   05016 Huntington disease
    105481533 (PLCB1)
   05017 Spinocerebellar ataxia
    105481533 (PLCB1)
   05022 Pathways of neurodegeneration - multiple diseases
    105481533 (PLCB1)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    105481533 (PLCB1)
   05415 Diabetic cardiomyopathy
    105481533 (PLCB1)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    105481533 (PLCB1)
   04934 Cushing syndrome
    105481533 (PLCB1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:mni04131]
    105481533 (PLCB1)
Enzymes [BR:mni01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     105481533 (PLCB1)
Membrane trafficking [BR:mni04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    105481533 (PLCB1)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    105481533 (PLCB1)
SSDB
Motif
Pfam: PI-PLC-X PLC-beta_C PH_14 PI-PLC-Y PLCB1-4-like_EFh EF-hand_like
Other DBs
NCBI-GeneID: 105481533
NCBI-ProteinID: XP_011739484
Ensembl: ENSMNEG00000044638
UniProt: A0A2K6E7S8
LinkDB
Position
Unknown
AA seq 1216 aa
MAGAQPGVHALQLKPVCVSDSLKKGIKFVKWDDDSTIVTPIILRTDPQGFFFYWTDQNKE
TELLDLSLVKDARCGRHAKAPKDPKLRELLDVGNIGRLEQRMITVVYGPDLVNISHLNLV
AFQEEVAKEWTNEVFSLATNLLAQNMSRDAFLEKAYTKLKLQVTPEGRIPLKNIYRLFSA
DRKRVETALEACSLPSSRNDSIPQEDFTPEVYRVFLNNLCPRPEIDNIFSEFGAKSKPYL
TVDQMMDFINLKQRDPRLNEILYPPLKQEQVQVLIEKYEPNSSFAKKGQISVDGFMRYLS
GEENGVVSPEKLDLNEDMSQPLSHYFINSSHNTYLTAGQLAGNSSVEMYRQVLLSGCRCV
ELDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPFPILLSFENHVDSPKQ
QAKMAEYCRLIFGDALLMEPLEKYPLESGVPLPSPMELMYKILVKNKKKSHKSSEGSGKK
KLSEQASNTCSDSSSMFEPSSPGAGEADTESDDDDDDDDCKKSSMDEGTAGSEAMATEEM
SNLVNYIQPVKFESFEISKKRNKSFEMSSFVETKGLEQLTKSPVEFVEYNKMQLSRIYPK
GTRVDSSNYMPQLFWNAGCQMVALNFQTMDLAMQINMGMYEYNGKSGYRLKPEFMRRPDK
HFDPFTEGIVDGIVANTLSVKIISGQFLSDKKVGTYVEVDMFGLPVDTRRKAFKTKTSQG
NAVNPVWEEEPIVFKKVVLPTLACLRIAVYEEGGKFIGHRILPVQAIRPGYHYICLRNER
NQPLMLPAVFVYIEVKDYVPDTYADVIEALSNPIRYVNLMEQRAKQLAALTLEDEEEVKK
EADPGETPSETPSEVRTTPAENGVNHTTSLTPKPPSQALHSQPAPGSVKAPAKTEDLIQS
VLTEVEAQTIEELKQQKSFVKLQKKHYKEMKDLVKRHHKKTTDLIKEHTTKYNEIQNDYL
RRRAALEKSAKKDSKKKSEPSSPDHGSSTIEQDLAALDAEMTQKLIDLKDKQQQQLLNLR
QEQYYSEKYQKREHIKLLIQKLTDVAEECQNNQLKKLKEICEKEKKELKKKMDKKRQEKI
TEAKSKDKSQMEEEKTEMIRSYIQEVVQYIKRLEEAQSKRQEKLVEKHKEIRQQILDEKP
KLQVELEQEYQDKFKRLPLEILEFVQEAMKGKISEDSNHGSAPLSLSSDPGKVNHKTPSS
EELGGDIPGKEFDTPL
NT seq 3651 nt   +upstreamnt  +downstreamnt
atggccggggctcaacccggagtgcacgccttgcaactcaagcccgtgtgcgtgtccgac
agcctcaagaagggcatcaaattcgtcaagtgggatgatgactcaactattgttactcca
attattttgaggactgaccctcagggatttttcttttactggacagatcaaaacaaggag
acggagctactggatctcagccttgtcaaagatgccagatgtgggagacacgccaaagct
cccaaggaccccaaattacgtgaacttttggatgtggggaacatcgggcgcctggagcag
cgcatgatcacggtggtgtatgggcctgacctcgtgaacatctcccatttgaatctcgtg
gctttccaagaagaagtggccaaggaatggacaaatgaggttttcagtttggcaacaaac
ctgctggcccaaaacatgtccagggatgcatttctggaaaaagcctatactaaacttaag
ctgcaagtcactccagaagggcgtattcctctcaaaaacatatatcgcttgttttcagca
gaccggaagcgagttgaaactgctttagaggcttgtagtcttccatcttcaaggaatgat
tcaatacctcaagaagatttcactccagaagtgtacagagttttcctcaacaacctttgc
cctcgacctgaaattgataacatcttttcagaatttggtgccaaaagcaaaccatatctt
accgttgaccagatgatggattttatcaaccttaagcagcgagatcctcggcttaatgaa
atactttatccacctctaaaacaagagcaagtccaagtattgattgagaagtatgaaccc
aacagcagcttcgccaaaaaaggacaaatatcagtggatgggttcatgcgctatctgagt
ggagaagaaaacggagtcgtttcacctgagaaactggatttgaatgaagacatgtctcag
cccctttctcactatttcattaattcctcgcacaacacctacctcacagctggccaactg
gctggaaactcctctgttgagatgtatcgccaagtgcttctgtctggttgtcgctgtgtg
gagttggactgctggaagggacgaactgcagaagaggaacctgtcatcacccatggcttc
accatgacaactgaaatatctttcaaggaagtgatagaagcaattgcggagtgtgcattt
aagacttcaccttttccaattctcctttcatttgagaaccatgtggattccccgaagcag
caagccaagatggcggagtactgccgactgatctttggggatgcccttctcatggagccc
ctggaaaaatatccactggaatctggagttcctcttccaagccctatggagttaatgtat
aaaattttggtgaaaaataagaagaaatcacacaagtcatcagaaggaagcggcaaaaag
aagctctcagaacaagcctccaacacctgcagcgactcctccagcatgttcgagccctca
tccccaggagccggagaagctgatacggaaagtgacgacgatgatgatgatgatgactgt
aaaaaatcttcaatggatgaggggaccgctggaagtgaggctatggccacagaggaaatg
tctaacctggtgaactacattcagccggtcaagtttgagtcatttgaaatttcaaaaaaa
agaaataaaagttttgaaatgtcttccttcgtggaaaccaaaggacttgaacaactcacc
aagtctccggtggaatttgtagaatataacaaaatgcagcttagcaggatatatccaaaa
ggaacacgtgtggattcatccaactatatgcctcagctcttctggaatgcgggttgtcag
atggtggcacttaatttccagacaatggacctggctatgcaaataaatatggggatgtat
gaatacaacggaaagagtggctatcgattgaagccagagttcatgaggaggcctgacaag
cattttgatccatttactgaaggcatcgtagatgggatagtggcaaacactttgtctgtt
aagattatatcaggtcagtttctttctgataagaaagtggggacttacgtggaagtggat
atgtttggtttgcctgtggatacaaggaggaaggcatttaagaccaagacatcccaagga
aatgctgtgaatcctgtctgggaagaagaacctattgtgttcaaaaaggtggttcttcct
actctggcctgtttgagaatagcagtttatgaagaaggaggtaaattcattggccaccgt
atcttgccagtgcaagccattcggccaggctatcactatatatgtctaaggaatgaaagg
aaccagcctctgatgctgcctgctgtctttgtctacatagaagtgaaagactatgtgcca
gacacatatgcagatgtcattgaagctttatcaaacccaatccggtatgtgaacctgatg
gagcagagagctaagcaattggctgctttgacactggaagatgaagaagaagtaaagaaa
gaggctgatcctggagaaacaccatcagagactccaagtgaagtgagaacaactccagca
gaaaacggggtgaatcacactacatccctgacacccaagccaccctcccaggctctccac
agccagccagctccaggttctgtaaaggcacctgccaaaacagaagatcttattcagagt
gtcttaacagaagtggaagcacagaccatcgaagagctaaagcaacagaaatcgtttgtg
aaacttcaaaagaagcactacaaagaaatgaaagacctggttaagagacaccacaagaaa
accactgaccttatcaaagaacacactaccaagtataatgaaattcagaatgactacttg
agaaggagagcagctttggaaaagtccgccaaaaaggacagtaagaaaaaatcggaaccc
agcagccctgatcatggttcatcaacgattgagcaagacctcgctgccctggatgctgaa
atgacccaaaaattgatagacttgaaggacaaacaacagcagcagctgcttaatcttcgg
caagaacagtattatagtgaaaaataccagaagcgagaacatattaaactgcttattcaa
aagttgacggatgtcgcagaagagtgtcagaacaatcagttaaagaagctcaaagaaatc
tgtgagaaagaaaagaaagaattaaagaagaaaatggataaaaagaggcaggagaagata
acagaagctaaatctaaagacaaaagtcagatggaagaggagaagacagagatgatccgg
tcatatatccaggaagtggtgcagtacatcaagaggctagaagaggcgcaaagtaaacgg
caagaaaaactcgtagagaaacacaaggaaatacgtcagcagatcctggatgaaaagccc
aagctgcaggtggagctggagcaagaataccaagacaaattcaaaagactgcccctcgag
attttggaattcgtgcaggaagccatgaaaggaaagatcagtgaagacagcaatcacggt
tctgcccctctctccctgtcctcagaccctggaaaagtgaaccacaagactccctccagt
gaggagctgggaggagacatcccaggaaaagaatttgatactcctctgtga

DBGET integrated database retrieval system