Macaca nemestrina (pig-tailed macaque): 105489042 Help Entry 105489042         CDS       T08765                                  Symbol SYNE1 Name (RefSeq) nesprin-1 isoform X1   KO K19326   nesprin-1 Organism mni  Macaca nemestrina (pig-tailed macaque) Pathway mni04820   Cytoskeleton in muscle cells Brite KEGG Orthology (KO) [BR:mni00001]  09140 Cellular Processes   09142 Cell motility    04820 Cytoskeleton in muscle cells     105489042 (SYNE1)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    03036 Chromosome and associated proteins [BR:mni03036]     105489042 (SYNE1) Chromosome and associated proteins [BR:mni03036]  Eukaryotic type   Centrosome formation proteins    LINC complex     105489042 (SYNE1) SSDB OrthologParalogGFIT Motif Pfam:  Spectrin Spectrin_SYNE1 SYNE1 CH KASH Spectrin_SYNE1_2 SYNE3 SR_desmoplakin_3 Motif Other DBs NCBI-GeneID:  105489042 NCBI-ProteinID:  XP_011751937 Ensembl:  ENSMNEG00000030564 LinkDB All DBs Position Unknown AA seq 8832 aa AA seqDB search MATSRGASRCPRDIANVMQRLQDEQEIVQKRTFTKWINSHLAKRKPPMVVDDLFEDMKDG VKLLALLEVLSGQKLPCEQGRRMKRIHAVANIGTALKFLEGRKSMHRGSPIKLVNINSTD IADGRPSIVLGLMWTIILYFQIEELTSNLPQLQSLSSSASSVDSIVSSETPSPPSKRKVT TKIQGNAKKALLKWVQYTAGKQTGIEVKDFGKSWRSGVAFHSVIHAIRPELVDLEKVKGR SNRENLEDAFTIAETELGIPRLLDPEDVDVDKPDEKSIMTYVAQFLKHYPDIHNAGTDGQ EDDEILPGFPSFANSIQNFKREDRLILKEMKVWIEQFERDLTRAQMVESNLQDKYQSFKH FRVQYEMKRKQIEHLVQPLHRDGKLSLDQALVKQSWDRVTSRLFDWHIQLDKSLPAPLGT IGAWLYRAEVALREEITIQQVHEETANTIQRKLEQHKDLLQNTDAHKRAFHEIYRTRSVN GIPVPPDQLEDMAERFHFVSSTSELHLMKMEFLELKYRLLSLLVLAESKLKSWIIKYGRR ESVEQLLQNYVSFIENSKFFEQYEVTYQILKQTAEMYVKADGSVEEAENVMKFMNETTAQ WRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEKMLNQSEIAKKDFFRNLPHW IQQHTAMNDAGNFLIETCDEMVSRDLKQQLLLLNGRWRELFMEVKQYAQADEMDRMKKEY TDCVVTLSAFATEAHKKLCEPLEVSFMNVKLLIQDLEDIEQRVPVMDAQYKIITKTAHLI TKESPQEEGKEMFATMSKLKEQLTKVKECYSPLLYESQQLLIPLEELEKQMTSFYDSLGK INEIITVLEREAQSSALFKQKHQELLACQENCKKTLTLIEKGSQSVQKFVTLSNVLKHFD QTRLQRQIADVHVAFQSMVKKTGDWKKHVETNSRLMKKFEESRAELEKVLRIAQEGLEEK GDPEELLRRHTEFFSQLDQRVLNAFLKACDELTDILPEQEQQGLQEAVRKLHKQWKDLQG EAPYHLLHLKIDVEKNRFLASVEECRTELDRETKLMPQEGSEKIIKEHRVFFSDKGPHHL CEKRLQLIEELCVKLPVRDPVRDTPGTCHVTLKELRAAIDSTYRKLMEDPDKWKDYTNRF SEFSSWISTNETQLKGIKGEAIDTANHREVKRAVEEIRNGVTKRGETLSWLKSRLKVLTE VSSENQAQKQGDELAKLSSSFKALVTLLSEVEKMVSNFGDCVQYKEIVKNSLEELISGSK EVQEQAEKILDTENLFEAQQLLLHHQQKTKRISAKKRDVQQQIAQAQQEEGGLPDRGREE LRKLESTLDGLERSRERQERRIQVTLRKWERFETNKETVVRYLFQTGSSHERFLSFSSLE SLSSELEQTKEFSKRTENIAVQAENLVKEASEIPLGPQNKQLLQQQAKSIKEQVKKLEDT LEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKELNALETSSSAMDMQISQIKVTIQEI ESKLSSIVGLEEEAQSFAQFVTTGESARIKAKLTQIRRYWEELREHAQCLEGTILGHLSQ QQKFEENLRKIQQSVSEFEDKLAVPIKICSSATETYKVLQEHMDLCQALESLSSLITTFS ASARKVVNRDSCVQEAAALQHQYEDTLRRAKERQTALENLLAHWQRLEKELSSFLTWLER GEAIASSPEMDISADRVKVEGELQLIQALQNEVVSQASFYSKLLQLKESLFSIASKDDVK MVKLHLEQLDERWRDLPQIIDKRINFLQSVVAEHQQFDELLLSFSVWIKMFLSELQTTSE ISIMDHQVALTRHKDHAAEVESKKVELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQLF EEASQVVERRQLALSHLAEFLQSHASLSGILHQLRQTVEATNSMNKNESDLIEKDLNDAL QDAKALESAAVSLDGILSKAQYHLKSGSSEQRTSCRATADQLCGEVERIQNLLGTKQSEA DALAVLKKAFQDQKEELLKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEH ELCWLKDKAKQIAQKDVAFAPEVDREINRLAVTWDDTKRLIHENQGQCCGLIDLMREYQN LKSTVSKVLENASSVIVTRTTIKDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLL SELKKIHSSDFSLVKTDMESTVDKWLDVAEKLEENMDRLRVSLSIWDDVLSSRDEIEGWS NNSVPQMAKNISNLDNRLRAEELLKEFESEVKNKALRLEELHSKVNDLKELTKNLETPPD LQFIEADLRQKLEHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWLAKVEESLMNCAQT DTCEGLKKVKDIQKELQSQQSNISSTQENLNSLCRKYHSAELENLGCAMTGLIKKHEVVS QLCSKTQASLQESLEKHFSESMQEFQEWFLGAKASAKESSDRTGDSKVLEAKLHDLQNLL DSVSDGQSKLDAVTQEGQTLYAHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQDC ASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAARES LDKLSQRGQLLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKEKLRSCQVALQEHEALEEAL QSMWSWVKAIQDRLACAESTLGSKDTLEKRLSQIQDILLMKGEGEVKLNMAIGKGEQALR SSNKEGQRVIQTQLETLKEVWADIMSSSIHAQSTLESVISQWNDYLERKNQLEQWMESVD QKVEHPLQPQPGLKEKFALLDRLQSILSEAEDHTRALHRLIAKSRELYEKTEDESFKDTA QEELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSDMSGDS SATQKKLSKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQW EDSVFQTQSCLENLVSQMALSEQEFSGQAAQLEQALQEFSALLKTWAQQLTLLEGKNTDE EIVECWHKGQEILDALQKAEPRTEDLKSQLNELCRFSRDLSTYSGKVSGLIKEYNCLCLQ ASKGCQNKEQILQQRFRKAFRDFQQWLVNAKITTAKCFDIPQNISEVSTSLQKIQEFLSE SENGQHKLNVMLSKGELLSTLLTKEKAKGIQAKVSGAKEDWKNFHSNLHQKESALENLKI QMKDFEVSAEPIQDWLSKTEKMVHESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRL KEKAQQLWEGQAASKSFRHRVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQFSLGIKELQ DWMTDAIHMLDSYCHPTSDKSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSP EGIPTIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDDVRQFSGWMDSMEANLN ESERQHAELRDKISMLGKAKLLNEEVLSYSSLLETIEVKGAGMTEHYVTQLELQDLQERY RAIQERAKEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLR DLQELQVHCAEGQALLNSVLHTREDVIPSGIPQAEDRALESLRQDWQVYQHKLSETRTQF NNVVNKLRLMEQKFQQVDEWLQTAEEKISPRTIRQSNRATKEIQLHQMKKWHEEVTAYRD EVEEVGARAQEILDESHVNSRMGCQATQLTSRYQALFLQVLEQIKFLEEEIQSLEESESS LSSYSDWYGSTHKNFKNVATKIDKVDTTMMGKKLKTLEVLLKDMEKGHSLLKSAREKGER AVKYLEEGEADRLRKEIHDHVEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIA EYQEILRVPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEALLELVQDVTLK DKIDQLQSDYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLLQMSGRLVAPDLLET SSLETITQQLAHHKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGT KDSYSAICSTAQRVYQSLEHELQKHVSRQDTLQQCQAWLSTVQPDLEPSPQPPLSRAEAV KQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQLTEQMIEQRLVQAQNLTQGWE EIKHLKAELWIYLQDADQQLQNMKRRHSELELSIAQNMVSQVKDFVKKLQSKEASVNTII EKVNKLTKKEESPEHKEINHLNDQWLDLCHQSNNLCLQREEDLQRTRDYHDCMNVVEVFL EKFTTEWDNLARSDAESTAVHLEALKKLALALQERKYAIEDLKDQKQKMIEHLNLDDKEL VKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELMDWAEEQQPNIAEALKQ SPPPDMAQNLLMDHLAICSELEAKQMLLKSLIKDADRVMADLGLNERQVIQKALSDAQSH VNCLSDLVGQRRKYLNKALSEKSQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQV KTCKSAQASLKTYQNEVTGLWAQGRELMKGVTEQEKSEVLGKLQELQSVYDSVLQKCSHR LQELEKNLVSRKHFKEDFDKACHWLKQADIVTFPEINLMNESTELHTQLAKYQHILEQSP EYENLLLMLQRTGQTILPSLNEVDHSYLSEKLNTLPQQFNVIVALAKDKFYKVQEAILAR KEYASLIELTTQSLSELEAQFSRMSKVPTDLAVEEAVALQDGCRAILDEVVGLGEAVDEL NQKKEGFRSTGQPWQPDKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQ LKSVKEEQSKVNEETLPAEEKLKMYHSLGGSLQDSAILLKRVTIHLEDLAPHLDPLAYEK ARHQIQSWQEELKLLTSAIGETVTECESRMVQSIDFQTEMSRSLDWLRRVKAELSGPVYL DLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAELSEL DGDIQEALRTRQATLTEMFSQCQRYYQVFQAANDWLEDAQEMLQLAGNGLDVESAEENLK NHMEFFSTEDQFHSNLEELRGLVATLDPLIKPTGKEDLEQKMASLELRSQRMSQDSCAQV DLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVN SFHEKIVALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEW TGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQ QALSMLQDGAAPTPGGEPPLMQEITAMQDRCLNMQEKVKTNGKLVKQELKDREMVETQIN SVKCWVQETKEYLGNPTIEIDAQLEELQILLTEATNHRQNIEKMAEEQKDKYLGLYTILP SELSLQLAEVALDLKIRDQIQDKIKEVEQSKAMSQELSRQIQKIAKDLTTILTKLKAKTD NLVQAKTDQKVLGEELDGCNSKLMELDAAVQKFSEQNGQLGKPLAKKIGKLTELHQQTIR QAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLREQYILHQTLL EESKEIHSDLEVMTEKLQYLTSVYCTEKMSQQVAELGRETEELQQMIKIRLQNLQDAAKD MKKFEAELKKLQTALQQAQATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQ SALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQEAVVQYEQYEQEMKHLQQL IEGAHREIEDKPVATSNIQELQAQISQHEELAQKIKGYQEQIASLNSKCKMLTMKAKHAT MLLTVTEVEGLAEGTEDLDGELLPAPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEI SSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTSASQELYEPGLEPSA TAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPG RSPESQMAEHQSFLQALMDEILMLQDEINELQSSLAEELVSKSCEADPAEQLALQSTLTV LAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTA LGTPKEPMDMEAQLVDCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGKL RRLKGSLLELQRALHDKQLNMQQGTAQEKEESDVDLTATQSPGVQEWLAQARTTWTHQRQ SSLQQQKELEQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGMEGEK SSAEDQMRMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPIQDK SAVTSLLDGLNQAFEEVSSQSGGTKRQSIHLEQKLYDGVSATSTWLDDVEERLFVATALL PEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLL DSVVNQRCHQMKERLQQILNFQNDLKVLFTSLADNKYIILQKLANVFEQPVAEQIEAIQQ AEDGLKELDAGIIELKRRGDKLQIEQPSMQELSKLQDMYDELMMTIGSRRSGLNQNLTLK SQYERALQDLADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETLF RKIISFAVQKETQFHTELMTQASAVLKQAHKRGVELEYILETWSHLDEDQQELSRQLEVV ENSIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLESQ LNQLGERWLSNTNKVSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTV PQELEMVRDHLNAFLDFSKEVDAKSSLKSSVLSTGNQLLRLKKVDTATLRSELSHIDSQW TDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHE YLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQG LVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQDLE DLIKAKEKEVEKIEQNGLALIQNKKEDVSGIVVSTLQELGQTWANLDHMVGQLKILLKSV LDQWSNHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQ KFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLHSSKALLQLWQRYKDYS KQCASSVQQQEDRTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFVLHELGE QLKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWI VEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRLPLNDKEIK RMQNLNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQ HLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVI RRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQ FKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAALQAELTEIQEKWKSASVRLEEQKKKL AFLLKDWEKCEKGIADSLEKLRTFKKKLSQCLPDHHEELHAEQMRCKELENAVGSWTDDL TQLTLLKDTLSAYISADDISILNERIELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEK NKELCEWLTQMESKVSQNGDILIEEMIEKLKKDYQEEIAVAQENKIQLQQMGERLAKASH ESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESEL AKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDS IQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKTSERTAAFPSSS GVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQR WDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQ LKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHK KLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNPSLSLAQPLRSE RSGRDTPASVDSIPLEWDHDYDLSRDLESAVSRALPSEDEESQDDKDFYLRGAVGLSDVM IPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPE LDTSYKGYMKLLGECSGSIDSVKRLEHKLKEEEESLTGFVNLHSTETQTAGVIDRWELLQ AQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKL KELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLL QDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDCNLDAEILQDHHKQLMQIKHELLES QLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLDVSSS QQDLSSWSSADELDTSGSVSPTSGRSTPNRQKTPRGKCSLSQPGPSVSSPHSRSTKGGSD SSLSEPGPDRSSRAFLFRVLRAALPLQLLLLLLIGLACLVPMSEEDYSCALSNNFARSFH PMLRYTNGPPPL NT seq 26499 nt NT seq  +upstreamnt  +downstreamnt atggcaacctccagaggggcctcccggtgtcctcgggatatcgccaatgtgatgcagagg ctgcaagatgagcaagagatagtacaaaaacgaactttcacaaaatggatcaactctcat ctggccaagcggaaacctccaatggtggtggatgatctttttgaagacatgaaagatggt gttaaactgcttgcccttctggaggtcctgtctgggcagaagctgccttgtgaacaagga cgccggatgaagcgaatccatgctgtggctaacattggcacggcactcaagttcctcgaa ggaagaaagtccatgcacagaggatcaccgattaaattagtcaacattaactccaccgat atagctgacggccgaccctcaatagttcttggattgatgtggaccattattctgtatttc cagatcgaagagttgaccagcaacttgccccagctccagtctttgtccagcagcgcatcc tccgtggacagcatagttagctctgagactcccagcccaccaagtaaacggaaggtgacc accaagatccaaggaaatgctaagaaggctttattaaagtgggttcagtacacggctggc aagcagactggaatagaagtaaaagattttgggaagagttggagaagcggggttgccttt cattcagttattcatgccattcgacccgaactggtggacttggagaaagtgaaaggcaga tccaaccgagaaaatctggaggatgctttcactatcgccgaaacggaactggggatccca agactgctagatcctgaagatgttgatgtggataaaccagatgagaagtctattatgacc tatgtagcccagtttctgaaacattatcctgacatccacaatgcaggcactgatgggcaa gaggatgatgaaatacttccaggtttcccatcttttgcaaattctatacaaaattttaag agagaagacaggctaattttgaaggaaatgaaagtttggatagaacaatttgagagagat ttgacaagagcacagatggtggaatcaaatttacaggataaatatcagtcatttaagcac ttcagagttcaatacgaaatgaagaggaaacagattgaacatttagtacaaccattacat agagatggtaaattgtcacttgaccaagcattggtaaaacaatcttgggatagagtgact tccaggctctttgactggcatatacagcttgataaatctcttcctgcacctctgggcacc ataggtgcctggctgtacagagcggaggtggccctgagagaggaaataaccattcagcag gtccacgaggaaacagcaaacacgatacaacggaaacttgagcaacataaggatctgctt caaaacacagatgcccacaaaagagcattccatgaaatctaccggaccaggtctgttaac gggattccagtgccacctgatcaattagaggacatggccgagaggtttcattttgtttcc tccacatcggagctacacctaatgaaaatggaatttttagaattaaagtaccgtctgctt tcactgctggttcttgcagagtcaaagctgaagtcttggatcattaagtacgggaggaga gagtcagtggagcagcttctacaaaactacgtgtctttcatagaaaatagcaagttcttt gaacaatatgaagtgacataccagatcttgaaacagacagctgagatgtatgtcaaagca gatggttcagtggaagaagctgagaatgtgatgaaattcatgaatgaaaccactgctcag tggaggaatctctcagtagaagttaggagtgtgaggagcatgctggaagaagtgatctct aactgggatcgctatggcaatacagtggctagtctgcaagcctggctagaggatgctgaa aaaatgctcaatcaatcagaaattgccaaaaaggatttttttcgaaatttacctcattgg attcagcagcatactgccatgaatgatgctggcaattttctaattgaaacctgtgatgag atggtttcccgtgacctgaagcagcaattactgttgctaaatgggcggtggagggagttg tttatggaagtcaagcaatatgctcaagctgatgagatggacagaatgaagaaggaatac acagactgtgttgttaccctgtctgcttttgcaacggaagcccataagaaactttgtgaa cccttagaagtctcttttatgaatgtcaagttattaattcaagacttggaggatattgag cagagggtgcctgtgatggatgcccaatacaagataattacaaagacagcacacctcatt accaaagaaagcccccaagaagaaggaaaagaaatgtttgcaacaatgtcaaagctcaaa gagcagctaaccaaggtcaaagaatgttactccccactcctttatgagtctcagcagctg ttgattccgttggaggaattagaaaagcagatgacgtccttttatgactcacttgggaaa atcaatgaaattatcacagttcttgagcgtgaagcacaatcgagtgctctttttaaacaa aaacatcaggaactgttagcttgtcaagaaaactgtaagaaaaccttgacacttattgag aaaggcagtcaaagtgttcaaaagtttgtgaccttgagcaacgtgttaaagcattttgat cagacgaggctacaaagacagattgcagatgttcatgttgcttttcagagtatggtaaag aaaactggagattggaagaagcatgtggaaaccaacagtcgcttgatgaagaagtttgag gagtctcgagcagagttggagaaggtactgcggattgctcaggagggcttggaggaaaag ggggatccggaggagctcctgcggagacacactgagtttttcagtcagctggatcagagg gtgctcaatgcgttcctgaaagcttgtgatgaactcaccgacatccttccagagcaggag cagcaggggcttcaggaagctgttcgaaagctccacaaacaatggaaggatcttcaagga gaagccccttatcatttgcttcatctgaagattgacgtggagaagaataggttcttagcc tctgtagaagaatgcagaactgagctggatcgagagaccaagctgatgccccaggaaggc agtgaaaagataattaaagagcacagggttttcttcagtgacaaaggtcctcatcatctc tgtgagaaaaggttacagctcatcgaggaactctgtgtgaaactcccagtccgggatcca gtaagggacacacctggaacctgtcacgtgactctcaaagagctccgagctgccattgac agcacctacaggaagctcatggaagacccagacaagtggaaggactacactaacagattc tctgagttctcatcttggatatctacaaatgagacacaattaaaggggatcaagggtgag gccatcgatactgccaaccacagagaggttaaacgtgccgttgaagagatcagaaatggt gttaccaaaaggggcgagaccctcagctggctgaaatccaggctgaaagttttgacagaa gtttcttctgagaaccaagcccaaaagcagggagatgaattggcaaaattatccagctct ttcaaggctctggtgacgctgctgtcagaggttgaaaagatggtaagcaattttggggac tgtgtacagtacaaagaaatagtcaaaaattctcttgaagaattaatttctggctctaaa gaagtccaggaacaagctgagaagatcttggatactgaaaatctgtttgaagcacagcag ttacttcttcatcaccagcaaaagacaaagcggatctcagcaaagaagagagatgtgcag cagcagatcgcgcaggcgcagcaggaagaaggagggttgcctgaccgaggccgcgaggag ctgcggaagctggagagcaccctggacggcctggagcgaagccgggagaggcaggagcgc cgcatccaggtcacattaagaaaatgggagcgatttgaaacaaacaaagaaacagtagta agatacctttttcaaacaggttccagtcatgaacgcttcttaagttttagcagtttggaa agtttatcttcagaattggaacaaacaaaggagttctctaaacggacagaaaatattgca gtccaggctgagaaccttgtaaaggaagcttcagagataccacttgggccccaaaataag cagctgcttcaacagcaggccaagtcaatcaaagaacaagtcaaaaaattagaagacacg cttgaagaagatattaaaaccatggaaatggtgaaaaccaagtgggatcattttggcagt aattttgagactctgtccgtctggataactgagaaagaaaaagagctcaatgccttggaa acttcgtcatctgccatggacatgcaaatcagccaaattaaggtcacaattcaggaaata 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gagagcaaaaaggttgaattgcagagtctgcagggtcacttagcaaagttgggttctctg ggccgtgctgaggacctccacctcctgcagggcaaggctgaggactgcttccagctgttt gaggaggccagccaggttgtggagaggcggcagcttgccctgtcccatttggcagaattc ctccagagccatgcctctctgtccggcattctccaccagctgaggcaaacggtggaagca accaacagtatgaataagaacgagtctgatttgatagaaaaggacctcaatgatgctctt caagatgctaaagcattagaatctgctgctgtcagtctcgatggcattctttccaaagcc caataccatctgaaaagtgggagctctgagcaaaggacttcctgcagagccacggctgat cagctctgtggagaggtagaaaggatccagaaccttctgggaaccaagcagagtgaggca gatgccctggcagtgttgaaaaaagcattccaagaccagaaagaggagcttctgaaaagc attgaggacattgaagaaaggactgacaaagagcgactgaaagaacctacccgccaagct cttcagcagaggttaagagtgtttaatcagctagaagatgaattgaattctcacgagcat gaactatgttggttgaaagacaaagccaagcaaattgcccagaaagatgtagcttttgca cctgaagttgacagggagataaaccgcttagcagtcacctgggatgataccaaaagacta attcatgaaaatcagggtcaatgctgtggacttattgacttaatgagagaatatcagaac ctgaagtcaactgtatctaaagtcttagaaaatgccagcagtgtgattgtaaccagaact accattaaagatcaagaagatcttaaatgggctttttccaagcatgaaactgccaagaac 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aagattgacaaagtagatacaacaatgatggggaagaaattgaagacgttggaggttttg ctcaaagacatggagaaaggtcacagtttgctgaaatcagcccgggagaaaggagagagg gctgttaaatacttggaggaaggcgaggcagacaggttaagaaaggagattcatgatcac gtggagcagttgaaggaactgaccagcactgtccggaaagaacacatgacactggaaaaa ggtcttcatttagcaaaggaattctcagataaatgcaaagccctgacacagtggatagca gaataccaggagatcctacgtgttcctgaagaacccaaaatggaattatatgagaaaaaa gctcagttatctaaatacaagtcacttcaacaaacagtgctgtcccatgaaccatcagta aagtcagtgagagagaagggtgaagctcttctggaactagtgcaggatgtcactttaaag gacaaaatagatcaacttcaaagtgattaccaggacctgtgcagcataggaaaggagcat gtgttcagtctggaggcgaaagtcaaagaccatgaagactacaacagtgagctccaagag gttgaaaagtggctgctgcagatgtccggcagactggtggcccctgacctcctggagacg agcagcctggagacaatcacccagcaactggcccaccacaaggcaatgatggaagaaatt gctggttttgaagaccgtttgaacaatcttcaaatgaaaggtgatactttgattggccaa tgtgcagaccacctgcaagcgaaacttaaacaaaacgtccatgctcatctgcagggtaca aaggacagctactcagcgatctgcagcacagctcagagggtgtaccagagtttggaacat gaacttcagaagcacgtcagccgacaagacaccctgcagcagtgccaggcctggctttct 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gaaatgttgcagctggcaggcaatggcctagatgtggagagcgcagaggaaaatctcaaa aaccacatggaatttttcagtacagaggatcagttccacagtaacctggaggagctccgc ggcctggtagccaccctggacccactcatcaagccaacaggcaaagaagacctagaacag aaaatggcttctctggaactcaggagccagaggatgagccaggactcttgtgcccaagtg gatctcttgcagagatgcacagctcaatggcacgattaccagaaagcaagggaagaagtt attgaattgatgaatgatacagaaaagaaattgtctgagttttctttgttgaagacttct tctagtcatgaagcagaagaaaaattgtcagagcacaaggctttagtgtcagtggttaac tctttccatgagaaaatcgtggcccttgaggaaaaagcttcacaactggagaaaaccgga aatgatgctagcaaagccaccctgagcaggtcaatgaccactgtctggcagcgctggaca cgccttcgagctgtggcccaagaccaggagaagatcctggaagatgcagtggatgagtgg acgggctttaacaacaaggttaaaaaggccactgaaatgattgatcagctgcaagataag ttacctggcagttcagcagagaaggcgtcgaaagcggaactcttaactcttcttgaatac cacgacacgttcgttctggagctggagcagcagcagtcggccttgggcatgctccggcag caagccctcagcatgctccaggatggagccgccccgacccccgggggagagccaccgctc atgcaggaaatcaccgcgatgcaagatcggtgcctgaacatgcaggagaaagtgaagact aatggaaagttggtgaagcaagagctgaaggaccgagaaatggtggagactcagatcaat 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accctgacctctccagaagttggacgtctcagtctcaaggagcagctctctcatcggcag catctgttgtctgagatggagtcactgaagccgaaggtgcaagcagtgcagctctgccag agtgccctccggatccccgaggacgtggtcgccagcttacctctgtgtcatgctgctctg cggctgcaggaagaggccagccggctgcagcacaccgccatccagcagtgcaacatcatg caggaggctgtggtgcagtatgaacaatatgagcaagaaatgaaacatctccagcaactg atagaaggagcccacagagagattgaggataaacctgttgccaccagtaacatacaggag ctgcaggctcagatttctcagcatgaggagctggcgcagaaaattaagggctaccaggag cagatcgcttctttgaattccaagtgcaagatgctgacgatgaaagccaagcacgccacc atgctgctgacggtgaccgaggtcgaggggctggcggaagggacagaggacctggacggg gagctcctccccgcgccttcggcccacccctctgtggtcatgatgactgcaggtcgctgt cacactttgctgtcaccggtcactgaggagtctggggaggagggaaccaacagtgagatt tcctctccacctgcctgtcgctccccttcacctgtggctaatacagatgcttctgttaac caggacattgcatattaccaagccttgtctgctgagaggttgcagacagatgccgcaaag attcaccccagcacatcagcgtcccaggagttgtatgaaccaggattggagccatccgct actgccaaactgggtgatttgcagcgttcttgggaaaccttaaagaatgtgatcagtgag aagcagcgcacactctatgaagctttggaacgccagcagaagtaccaggactccctccag tccatctctacgaagatggaggccattgagctgaaactcagtgagagcccagagcccggc aggagtccagaaagccagatggctgaacatcagtctttcctccaggcattgatggatgag attctcatgctccaggatgaaatcaatgagctccagtcctctctcgcagaggagctggta tccaagtcttgtgaggccgaccccgcggagcagctggccttgcagtccacgctcactgtc ttagccgagcgaatgtccaccatcaggatgaaagcctcagggaaacggcagcttttggag gagaagttgaatgatcagctggaggaacaaaggcaggaacaggccctgcagaggtatcgc tgtgaagccgatgagctggacagctggctcttgagtaccaaggccactctggatactgcg ctgggtacacccaaggagcccatggacatggaggcccagcttgtggactgccagaacatg ctggtggaaatagagcagaaggtggtggctttatcagagctgtcagtccacaatgagaac ctgctgctggagggcaaagctcacaccaaggacgaggccgagcagctggctggaaagctg agaaggctcaaggggagcctgctggagctgcagagagccctgcatgataagcagctcaac atgcagcagggaacagcacaggagaaggaggagagcgatgttgacctaacagccacgcag agccccggcgtccaggaatggctggcccaagctcgcaccacatggacccaccagcggcag agcagtctccagcaacaaaaagagttagaacaggaattagctgagcagaagagtctcctt cgctcagtagccagtcgtggagaggagattctaattcaacattcggccgcagagacctct ggtgacgctggcgaaaaacctgatgtgttatcccaggagttggggatggaaggggagaaa tcatccgctgaagaccagatgagaatgaaatgggaaagcttacatcaagaatttagtacc aagcagaaactactacagaatgttctggaacaggaacaagagcaagtgctttatagcagg ccaaatcgactcttgtctggtgtgccgctgtacaaaggggacgtgccgatccaagataaa tctgcagttacgtctttgctggatggactgaaccaggccttcgaggaggtttcatcccag agtggagggacaaagaggcagagtatacacttggagcagaagttatatgatggggtctca gccacctctacttggttggatgatgttgaagaacgtttatttgttgccacagcactttta ccagaagaaacagaaacttgtctcttcaaccaagagattcttgccaaagacattaaggaa atgtctgaagaaatggataagaacaaaaacttgttttcgcaagcttttccagagaatggt gataatcgagatgttattgaagatactttgggttgtcttttgggcaggttatccttgcta gactcagtagtgaatcaacgatgtcatcagatgaaagaaagacttcagcaaatactaaat ttccagaatgatctgaaagtgctgtttacatcactggctgacaacaaatacatcattctg cagaaactggcaaatgtatttgaacaacccgtagcagaacaaatagaggcaatacaacag gctgaagatggactcaaagaattggatgcaggaatcattgaattaaagagacgtggtgac aagttacagattgagcagccgtccatgcaagaactctccaagctccaggacatgtatgat gagctgatgatgaccattggctctcggaggagtggcctgaaccagaaccttacactcaag agtcagtatgagagggccctacaagatctggctgacttgctagaaactggtcaggagaag atggcaggagaccagaaaatcatcgtgtcttccaaagaggaaatccagcaactacttgac aaacataaggaatactttcagggcctggaatctcatatgatcttgactgaaacactcttc agaaagataatcagctttgcagtccagaaggaaacccagttccatacagagctgatgact caggcttctgctgtactgaaacaggctcacaagaggggtgtggagctggagtacattcta gagacgtggtcgcatctagatgaggaccagcaggagcttagcagacagctggaggtggtg gaaaacagcatcccaagcgtgggtctggtggaggagaacgaggacaggcttattgaccgc ataacactctaccagcatttaaaatctagccttaatgaataccagcccaaattatatcaa gtattagatgatggcaaacgacttctgatatccatcagctgctcagatctagaaagtcaa ctaaatcaacttggagagcgctggctaagtaacaccaacaaagtgtctaaggaacttcac agactggaaacaatattgaaacactggaccagatatcaaagtgaatctgcagatctaatt cactggttacagtctgcaaaagacaggctagaattttggactcagcaatctgtgacagtc ccacaagagctggaaatggtccgggatcatctaaatgctttcctggacttttctaaagaa gtggatgccaaatcttccctgaaatcatctgttctgagtactggaaatcagctccttcga ctgaaaaaggtggacacagccacgctgcgctctgagctgtcgcacattgatagccagtgg actgacctgctaaccaatatcccagccgtccaggagaagctccaccagctccaaatggat aaactgccttcccgccatgccatttctgaagtcatgagttggatttctctaatggaaaat gttattcagaaggatgaagataatattaaaaattccataggttacaaggcaattcatgaa taccttcagaaatataagggttttaagatagacattaactgtaaacagctgacggtggat tttgtgaaccagtctgtgctacaaatcagcagtcaggatgtggaaagtaaacgtagtgat aagactgattttgctgagcaacttggagcaatgaataaaagttggcaaattctgcaaggt ctagtaactgagaagatccagctgttggaagggttattggaatcttggtcagaatatgaa aataatgtacaatgtctgaaaacatggtttgaaactcaggaaaagagactaaaacaacag catcgaattggagatcaggcttctgttcaaaatgcgctgaaagactgtcaggatctggaa gatttgattaaagcaaaagaaaaagaagtagagaaaattgagcagaatggacttgctttg attcagaacaagaaagaagacgtctctggcattgtcgtgagcacactgcaagagctcggc caaacctgggcaaatttagatcacatggttggacaattaaagatactgttgaaatcagtg cttgaccaatggagcaatcacaaagtggcctttgacaagataaacagttacctcatggag gccagatactctctttcccgattccgtctgctgactggctccttagaagctgtgcaagtt caggtggacaatcttcagaatctccaagatgatctagaaaaacaggaaaggagcttacag aaatttggctctatcaccaaccaattattaaaagagtgccacccgcctgtgacagaaact cttaccaatacactgaaagaagtcaacatgagatggaataacttgctggaagagattgct gagcagctacactccagcaaggccctacttcagctttggcaaagatacaaggactactcg aaacagtgtgcttcgtcggttcagcagcaggaggatcgaaccaatgagctgttgaaggca gccacaaacaaggacatcgccgatgatgaggttgctacatggattcaagattgcaacgac ctcctcaaaggactgggtacagttaaagactccctctttgttctccatgagctgggagag caactgaagcaacaagtggatgcttcagcagcatcagctattcaatcggatcaactctct ttgagtcaacacttgtgtgccctagagcaggctctctgcaaacagcagacttcgttacag gctggagttcttgattacgaaacctttgccaagagtttagaagctctggaggcctggata gtggaagctgaagaaatactacaagggcaggaccctagccattcatctgacctctccaca atccaggaaaggatggaagaacttaagggacagatgttaaaattcagcagcatggctcca gatttagaccgtctaaatgagcttggatatagattacccttgaatgataaggaaatcaaa aggatgcagaatctgaaccgccattggtctctgatctcctctcagactacagaaagattc agcaagttgcagtcatttttgctacaacatcagactttcttggaaaaatgtgaaacatgg atggagttcctagttcagacagaacaaaagttagcagtagagatttcaggaaattatcag catcttttggaacagcagagagcacatgagttgtttcaagccgagatgttcagtcgtcag cagattttgcactcaatcattattgatgggcaacgtcttctagaacaaggtcaagttgat gacagggatgaattcaacctgaaattgacactcctcagtaatcagtggcagggagtgatt cgcagggcccagcagaggcgggggatcattgacagccagattcgccagtggcaacgctat agggagatggcagaaaagcttcgtaaatggttggttgaagtgtcctacctccccatgagt ggtctcggaagtgttcctataccactgcaacaagcaaggaccctctttgatgaagtgcag ttcaaagaaaaggtgttcctgcggcaacaaggcagctacatcctgactgtggaggctggc aagcaactccttctgtctgcggatagtggcgctgaggccgctttgcaggccgaactcact gaaatccaagagaaatggaaatcagccagcgtgcggctggaagaacagaagaaaaaacta gccttcttgttgaaagactgggaaaaatgtgagaaaggaatagcagattccctggagaaa ctacgaactttcaaaaagaagctttcccagtgtctaccggatcaccacgaagagctccat gcagaacaaatgcgttgcaaggaattagaaaatgcagttgggagctggacagatgacttg acccagttgacgctgctgaaggacaccctctctgcctacatcagtgctgatgatatctcc attcttaatgaacgcatagagcttctgcaaaggcagtgggaagaactatgccaccagctc tccttaaggcggcagcaaataggtgaaagattgaacgaatgggcagtcttcagtgaaaag aacaaggaactctgtgagtggttgactcaaatggaaagcaaggtttctcagaatggagac attctcattgaagaaatgatagagaagctcaagaaggattatcaagaggaaattgctgtt gctcaagagaacaaaatacagctccaacaaatgggagaacgacttgctaaagccagccac gaaagcaaagcatctgagattgaatacaaactgggaaaggttaacgaccggtggcagcat ctcctggacctcattgcagccagggtgaagaagctgaaggagaccctggtggccgtgcag cagctcgataagaacatgagcagcctgaggacctggctcgctcacattgagtcagagctg gccaagccaatagtctacgattcctgtaactcggaagaaatacagagaaagcttaatgag cagcaggaacttcagagagacatagagaagcacagtacaggtgttgcatctgtcctcaac ctgtgtgaagtcctgctgcacgactgtgatgcctgtgccactgatgccgagtgtgactct atccagcaggctacaagaaacctggaccggcggtggagaaacatttgtgctatgtccatg gaaaggagactcaaaatcgaagagacgtggcgattgtggcagaaatttctggatgactat tcacgttttgaagattggctgaagacttcagaaaggacagctgcatttcccagctcttct ggggtaatctatacagttgccaaggaagaactaaagaaatttgaggctttccagcgacag gtccacgagtgcctgacgcagctggaactgatcaacaagcagtaccgccgcctggccaga gagaaccgcactgattcagcctgtagcctcaaacagatggttcacgaaggcaaccagaga tgggacaacctgcaaaagcgcgtcacctccatcttgcgcagactcaagcattttattggc cagcgtgaggagtttgagactgcgcgggacagcattctggtctggctcacggagatggat ctgcagctcactaatattgaacatttttctgagtgtgatgttcaagctaaaataaagcaa ctcaaggccttccagcaggaaatttccctgaaccacaataagattgagcagataattgcc caaggagaacagctgatagaaaagagtgagcccttggatgcggcgatcatcgaggaggaa ctagacgagctccgacggtactgccaggaggtcttcgggcgtgtggaaagataccataag aaactgatccgcctgcctctcccagatgatgagcacgacctctcagacagagagctggag ctggaagactctgcggctctgtcagacctgcactggcatgaccgctctgcagacagcctg ctttctccacagccttcctccaacccctccctgtcgctcgctcagcccctccggagcgag cggtcgggacgagacaccccggctagtgtggactccatccccctggagtgggatcacgac tatgacctcagtcgggacctggagtctgcagtgtccagagctctgccctctgaggatgaa gagagtcaggacgacaaagatttctacctccggggagctgttggcttatcagatgtaatg atccctgaaagccctgaggcctatgtaaaactcacagaaaatgcaatcaaaaatacctct ggggaccacagcgccctagagtcacagatccgacaactgggcaaagccctggatgatagc cgctttcagatacagcaaaccgaaaatatcattcgcagcaaaactcccacggggccagag ctagacaccagctacaaaggctacatgaaactgctgggcgaatgcagtggcagtatagac tccgtgaagagactggagcacaaactgaaggaggaagaggagagccttactggctttgtt aacctgcatagtaccgaaacccaaacggctggtgtgattgaccgatgggagcttctccag gcccaggcgttgagcaaggagctgaggatgaagcagaaccttcagaagtggcagcagttt aactcggacttgaacagcatctgggcctggctgggggacacggaggaggagctggaacag ctccagcgtctggaactcagcactgacatccagacaatcgagctccagatcaaaaagctc aaggagctccagaaagccgtggaccaccgcaaagccatcatcctctccatcaatctctgc agccctgagttcacccaggctgacagcaaggagagtcgggacctgcaggatcgcttgtca cagatgaatgggcgctgggaccgagtgtgttctctgctggaggagtggcggggcctactg caagatgccctgatgcagtgccagggtttccatgaaatgagccatggtttgcttcttatg ctggagaacattgacagaaggaaaaatgaaattgtccctattgattgtaaccttgatgca gagatacttcaggaccatcacaaacagcttatgcaaataaagcatgagctgttggaatcc caactcagagtagcctctttgcaagacatgtcttgccaactactggtgaatgctgaagga acagactgtttagaagccaaagaaaaagtccatgttattggaaatcggctcaaacttctc ttgaaggaggtcagtcgtcatatcaaggaactggagaagttattagacgtgtcaagtagt cagcaggatttgtcttcctggtcttctgctgatgaactggacacctcagggtctgtgagt cccacatcaggaaggagcaccccaaacagacagaaaacgccacgaggcaaatgtagtctc tcacagcctggaccctctgtcagcagtccacatagcaggtccacaaaaggtggctccgat tcctccctttctgagcctgggccagatcggtccagccgcgccttcctgttcagagtcctc cgagcagctcttccccttcagcttctcctgctgctcctcatcgggctcgcctgccttgta ccaatgtcagaggaagactacagctgtgccctctccaacaactttgcccggtcattccac cccatgctcagatacacgaatggccctcctccactctga

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