KEGG   Macaca nemestrina (pig-tailed macaque): 105489758
Entry
105489758         CDS       T08765                                 
Symbol
MAPK12
Name
(RefSeq) mitogen-activated protein kinase 12 isoform X1
  KO
K04441  p38 MAP kinase [EC:2.7.11.24]
Organism
mni  Macaca nemestrina (pig-tailed macaque)
Pathway
mni01522  Endocrine resistance
mni04010  MAPK signaling pathway
mni04015  Rap1 signaling pathway
mni04068  FoxO signaling pathway
mni04071  Sphingolipid signaling pathway
mni04114  Oocyte meiosis
mni04148  Efferocytosis
mni04218  Cellular senescence
mni04261  Adrenergic signaling in cardiomyocytes
mni04370  VEGF signaling pathway
mni04380  Osteoclast differentiation
mni04550  Signaling pathways regulating pluripotency of stem cells
mni04611  Platelet activation
mni04613  Neutrophil extracellular trap formation
mni04620  Toll-like receptor signaling pathway
mni04621  NOD-like receptor signaling pathway
mni04622  RIG-I-like receptor signaling pathway
mni04625  C-type lectin receptor signaling pathway
mni04657  IL-17 signaling pathway
mni04658  Th1 and Th2 cell differentiation
mni04659  Th17 cell differentiation
mni04660  T cell receptor signaling pathway
mni04664  Fc epsilon RI signaling pathway
mni04668  TNF signaling pathway
mni04670  Leukocyte transendothelial migration
mni04714  Thermogenesis
mni04722  Neurotrophin signaling pathway
mni04723  Retrograde endocannabinoid signaling
mni04728  Dopaminergic synapse
mni04750  Inflammatory mediator regulation of TRP channels
mni04912  GnRH signaling pathway
mni04914  Progesterone-mediated oocyte maturation
mni04917  Prolactin signaling pathway
mni04926  Relaxin signaling pathway
mni04932  Non-alcoholic fatty liver disease
mni04933  AGE-RAGE signaling pathway in diabetic complications
mni04935  Growth hormone synthesis, secretion and action
mni04936  Alcoholic liver disease
mni05014  Amyotrophic lateral sclerosis
mni05020  Prion disease
mni05022  Pathways of neurodegeneration - multiple diseases
mni05132  Salmonella infection
mni05133  Pertussis
mni05135  Yersinia infection
mni05140  Leishmaniasis
mni05142  Chagas disease
mni05145  Toxoplasmosis
mni05152  Tuberculosis
mni05161  Hepatitis B
mni05163  Human cytomegalovirus infection
mni05167  Kaposi sarcoma-associated herpesvirus infection
mni05169  Epstein-Barr virus infection
mni05170  Human immunodeficiency virus 1 infection
mni05171  Coronavirus disease - COVID-19
mni05205  Proteoglycans in cancer
mni05208  Chemical carcinogenesis - reactive oxygen species
mni05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
mni05415  Diabetic cardiomyopathy
mni05417  Lipid and atherosclerosis
mni05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:mni00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    105489758 (MAPK12)
   04015 Rap1 signaling pathway
    105489758 (MAPK12)
   04370 VEGF signaling pathway
    105489758 (MAPK12)
   04668 TNF signaling pathway
    105489758 (MAPK12)
   04068 FoxO signaling pathway
    105489758 (MAPK12)
   04071 Sphingolipid signaling pathway
    105489758 (MAPK12)
 09140 Cellular Processes
  09141 Transport and catabolism
   04148 Efferocytosis
    105489758 (MAPK12)
  09143 Cell growth and death
   04114 Oocyte meiosis
    105489758 (MAPK12)
   04218 Cellular senescence
    105489758 (MAPK12)
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    105489758 (MAPK12)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    105489758 (MAPK12)
   04613 Neutrophil extracellular trap formation
    105489758 (MAPK12)
   04620 Toll-like receptor signaling pathway
    105489758 (MAPK12)
   04621 NOD-like receptor signaling pathway
    105489758 (MAPK12)
   04622 RIG-I-like receptor signaling pathway
    105489758 (MAPK12)
   04625 C-type lectin receptor signaling pathway
    105489758 (MAPK12)
   04660 T cell receptor signaling pathway
    105489758 (MAPK12)
   04658 Th1 and Th2 cell differentiation
    105489758 (MAPK12)
   04659 Th17 cell differentiation
    105489758 (MAPK12)
   04657 IL-17 signaling pathway
    105489758 (MAPK12)
   04664 Fc epsilon RI signaling pathway
    105489758 (MAPK12)
   04670 Leukocyte transendothelial migration
    105489758 (MAPK12)
  09152 Endocrine system
   04912 GnRH signaling pathway
    105489758 (MAPK12)
   04914 Progesterone-mediated oocyte maturation
    105489758 (MAPK12)
   04917 Prolactin signaling pathway
    105489758 (MAPK12)
   04926 Relaxin signaling pathway
    105489758 (MAPK12)
   04935 Growth hormone synthesis, secretion and action
    105489758 (MAPK12)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    105489758 (MAPK12)
  09156 Nervous system
   04728 Dopaminergic synapse
    105489758 (MAPK12)
   04723 Retrograde endocannabinoid signaling
    105489758 (MAPK12)
   04722 Neurotrophin signaling pathway
    105489758 (MAPK12)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    105489758 (MAPK12)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    105489758 (MAPK12)
  09159 Environmental adaptation
   04714 Thermogenesis
    105489758 (MAPK12)
 09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    105489758 (MAPK12)
   05208 Chemical carcinogenesis - reactive oxygen species
    105489758 (MAPK12)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    105489758 (MAPK12)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    105489758 (MAPK12)
   05161 Hepatitis B
    105489758 (MAPK12)
   05171 Coronavirus disease - COVID-19
    105489758 (MAPK12)
   05163 Human cytomegalovirus infection
    105489758 (MAPK12)
   05167 Kaposi sarcoma-associated herpesvirus infection
    105489758 (MAPK12)
   05169 Epstein-Barr virus infection
    105489758 (MAPK12)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    105489758 (MAPK12)
   05135 Yersinia infection
    105489758 (MAPK12)
   05133 Pertussis
    105489758 (MAPK12)
   05152 Tuberculosis
    105489758 (MAPK12)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    105489758 (MAPK12)
   05140 Leishmaniasis
    105489758 (MAPK12)
   05142 Chagas disease
    105489758 (MAPK12)
  09164 Neurodegenerative disease
   05014 Amyotrophic lateral sclerosis
    105489758 (MAPK12)
   05020 Prion disease
    105489758 (MAPK12)
   05022 Pathways of neurodegeneration - multiple diseases
    105489758 (MAPK12)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    105489758 (MAPK12)
   05418 Fluid shear stress and atherosclerosis
    105489758 (MAPK12)
   05415 Diabetic cardiomyopathy
    105489758 (MAPK12)
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    105489758 (MAPK12)
   04932 Non-alcoholic fatty liver disease
    105489758 (MAPK12)
   04933 AGE-RAGE signaling pathway in diabetic complications
    105489758 (MAPK12)
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    105489758 (MAPK12)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:mni01001]
    105489758 (MAPK12)
Enzymes [BR:mni01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.24  mitogen-activated protein kinase
     105489758 (MAPK12)
Protein kinases [BR:mni01001]
 Serine/threonine kinases: CMGC group
  MAPK family [OT]
   105489758 (MAPK12)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1
Other DBs
NCBI-GeneID: 105489758
NCBI-ProteinID: XP_011753109
Ensembl: ENSMNEG00000042652
LinkDB
Position
Unknown
AA seq 390 aa
MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDSRTGAKVAIKKLYR
PFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLM
KHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRVSPGGGATHQPSPSAIPRLHVLPDLKPG
NLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMA
EMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASIL
TNASPLAVNLLEKMLVLDAEQRVTAAEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTL
DEWKRVTYKEVLSFKPPRQLGARVSKETAL
NT seq 1173 nt   +upstreamnt  +downstreamnt
atgagctctccgccgcctgcccgcagtggcttttaccgccaggaggtgaccaagacggcc
tgggaggtgcgcgccgtgtaccgggacctgcagcccgtgggctcgggcgcctatggcgcg
gtgtgctcggccgtggacagccgcaccggcgctaaggtggccatcaagaagctgtaccgg
cccttccagtccgagctgttcgccaagcgcgcctaccgcgagctgcgcctgctcaagcac
atgcgccacgagaacgtgattgggctgctggatgtgttcactcctgatgagaccctggat
gacttcacagacttttacctggtgatgccattcatgggcaccgacctgggcaagctcatg
aaacatgagaagctgggcgaggaccggatccagttcctcgtgtaccagatgctgaagggg
ctgaggtatatccatgctgccggcatcatccacagagtgagtcctggtggaggagccacc
catcagccctcccccagcgcaatcccccgcctccacgtcctacctgacctgaagcctggc
aacctggctgtgaacgaagactgtgagctgaagatcctggactttggcctggccaggcag
gcagacagcgagatgactggctatgtggtgacccggtggtaccgggcacccgaggtcatc
ttgaattggatgcgctacacgcagacggtggacatctggtctgtggggtgcatcatggcg
gagatgatcacaggcaagacgctgttcaaaggcagcgaccacctggaccagctgaaggag
atcatgaaagtgacagggacgcctccagctgagtttgtgcagcggctgcagagtgatgag
gccaagaactacatgaagggcctccctgagttggagaagaaggattttgcctccatcctg
accaatgcaagccctctggctgtgaacctcctggagaagatgctggtgctggatgcggag
cagcgggtgacggcagccgaggcactggcccatccctacttcgagtccctgcacgacacg
gaagatgagccccaggtccagaagtatgacgactcctttgatgacgtggaccgcacgctg
gatgaatggaagcgtgttacttacaaagaggtgctcagcttcaagcctccccggcagctg
ggagccagggtctccaaggagacggctctgtga

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