Mustela nigripes (black-footed ferret): 131999010
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Entry
131999010 CDS
T09425
Symbol
PDE8A
Name
(RefSeq) high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A
KO
K18437
high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8 [EC:
3.1.4.53
]
Organism
mnp
Mustela nigripes (black-footed ferret)
Pathway
mnp00230
Purine metabolism
mnp01100
Metabolic pathways
mnp04927
Cortisol synthesis and secretion
mnp04934
Cushing syndrome
mnp05032
Morphine addiction
Brite
KEGG Orthology (KO) [BR:
mnp00001
]
09100 Metabolism
09104 Nucleotide metabolism
00230 Purine metabolism
131999010 (PDE8A)
09150 Organismal Systems
09152 Endocrine system
04927 Cortisol synthesis and secretion
131999010 (PDE8A)
09160 Human Diseases
09165 Substance dependence
05032 Morphine addiction
131999010 (PDE8A)
09167 Endocrine and metabolic disease
04934 Cushing syndrome
131999010 (PDE8A)
Enzymes [BR:
mnp01000
]
3. Hydrolases
3.1 Acting on ester bonds
3.1.4 Phosphoric-diester hydrolases
3.1.4.53 3',5'-cyclic-AMP phosphodiesterase
131999010 (PDE8A)
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GFIT
Motif
Pfam:
PDEase_I
PDE8A_N
PAS
PAS_9
PDE8
PAS_4
PAS_3
DUF5894
PAS_8
Sina_ZnF
Response_reg
Motif
Other DBs
NCBI-GeneID:
131999010
NCBI-ProteinID:
XP_059227492
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Position
13:complement(4229300..4375281)
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AA seq
830 aa
AA seq
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MGCAPSIHISEGRAVYHGGKEAEDAPGAAAPLPPPAGPKTTASPAARGAGLAEPEPRDGS
GRKVAVADVQFGPMRFHPDQLQVLLVFTKEDNQCNGFCRACEKAGFKCTVTKEAQAVLAC
FLDKHHDIIIIDHRNPRQLDAEALCRSIRSSKLSENTIIIGVVRRTDREESSVMPLIAAG
FTRRYVENPSLMACYNELLQLEFGEVRSQLKLRACNSVFTALEKSQEAIEITSEDRVIQY
ANPAFETTMGYQSGELIGKELAEVPINEKKADLLDTINSCIRIGKEWQGIYHAKKKNGDN
VQQNVKIIPVVGQGGKIRHYVSIIRVCNGSNKAEKITECVQSDPHTDNQSGKHKDRRKSS
LDVRTLASRASEGGSQRRHSSMARIHSMTIEAPITKVINIINAAQESSPVPVTEALDRVL
EILRTTELYSPQFGAKDDDPHANDLVGGLVSDGLRRLSGNEYVLSTKSLQQLPSGVITPI
SLHDIPPRIARAMENEEYWDFDIFELEAATHKRPLIYLGLKMFARFGICEFLNCSETTLR
SWLQVIEANYHSSNPYHNSTHSADVLHATAYFLCKERIKQTLDPVDEVAALIAATIHDVD
HPGRTNSFLCNAGSELAILYNDTAVLESHHAALAFQLTTRDDKCNIFKNMERNDYRTLRQ
GIIDMVLATEMTKHFEHVNKFVNSINKPLAALEADGEVARDEEAVNTMLRTPENRTLVKR
MLIKCADVSNPCRPLEQCIEWAARISEEYFSQTDEEKRQDLPVVMPVFDRNTCSIPKSQI
SFIDYFITDMFDAWDAFVDLPELMQHLDNNFKYWKGLDEMKLRSLRPPPE
NT seq
2493 nt
NT seq
+upstream
nt +downstream
nt
atgggctgcgccccgagcatccacatttccgagggccgggcggtgtaccacggcggcaag
gaggccgaggacgcgccgggagccgccgcgccgctgccgccgcccgccggcccgaagacc
accgcctcgcccgcggcccgcggcgccggcctcgcggagcccgagcctcgcgacggcagc
ggcaggaaggtagcagtagctgacgtgcagttcggcccaatgagatttcatccagatcag
ctccaggtacttttagtgtttaccaaagaagataaccagtgtaatggattctgcagggca
tgtgaaaaagcagggtttaagtgcacagttaccaaggaggctcaggctgttcttgcctgt
ttcctggacaagcaccatgacatcatcatcatcgaccacagaaacccccggcagctggac
gcagaggcgctgtgcaggtctattagatcatcaaaactctctgaaaacacaattattatt
ggtgtagtacgcaggacggatagagaagaatcatctgtgatgcccctcattgctgctggc
tttacgaggaggtatgtggagaaccccagcctcatggcctgctacaacgagctgctccag
ctggagttcggagaggtgcggtcccagctcaaactcagggcttgtaactcagtattcact
gcattagagaaaagtcaagaagcaattgaaattacaagtgaagaccgcgttatacagtat
gcaaatcctgcatttgaaacaaccatgggctatcagtcaggtgaattaataggaaaggag
ttagcagaagtgcctataaatgaaaaaaaggctgatttgctcgatactataaactcgtgc
atcaggataggcaaggaatggcaagggatctaccacgccaagaagaaaaatggagataac
gtgcaacaaaatgtgaagatcatacctgtcgtcggacagggaggaaaaattagacactat
gtgtccattatcagagtgtgcaatggcagcaataaggctgagaaaataactgaatgtgtt
cagtctgaccctcatacagataatcagtcaggcaaacacaaagacagaaggaagagctcg
ctagatgtcagaactcttgcttctcgagcaagtgaaggtggcagccagagacgacactcc
tccatggcccggatacattccatgacgatcgaggcgcccatcaccaaggtcatcaacatt
atcaatgctgcccaggagagcagtcccgtgcctgtgacggaagccttggaccgtgtgctg
gaaattctgagaaccactgagttatactcaccgcagtttggtgctaaggatgacgatccc
catgccaacgacctcgttgggggcttggtgtctgatggtttgcgaagactgtccgggaat
gagtatgttctctcaacaaaaagccttcagcagctgcctagcggtgtgataacccccatc
tcccttcacgacatccccccgcggatcgcacgggccatggagaacgaggagtactgggac
ttcgatatttttgaactggaggccgccacacataagaggcctttgatttatcttggtctc
aaaatgtttgctcgcttcggaatctgtgaattcttgaactgctccgagacgacgctgcga
tcgtggttgcaggttattgaagccaattaccactcttccaacccctaccacaactcgaca
cactctgctgacgtgcttcacgccactgcctacttcctgtgcaaagagaggataaagcaa
actctagatccagtggacgaggtcgcggccctcatcgcagccaccatccacgacgtggac
caccccgggagaaccaactcgttcctgtgcaatgctggaagcgagctggccattttgtat
aatgacactgctgtgctggagagccaccacgcggccttggccttccagctgaccacccga
gatgacaaatgcaatatcttcaagaacatggagaggaacgactaccggacgctgcgccag
gggatcattgacatggtcttagccacagaaatgacaaagcacttcgagcacgtcaacaaa
tttgtcaacagcatcaacaagcccctggcagcgctcgaagcagatggggaagtggctaga
gacgaagaagccgtgaacaccatgctcaggaccccagagaaccggactcttgttaagcgg
atgctgatcaagtgcgcggatgtgtccaatccctgccggcccctggagcagtgcattgag
tgggccgcacgcatctccgaagaatacttttctcagacggatgaggagaagcggcaagac
ttgcccgtggtgatgccggtttttgacagaaacacctgcagcatccccaagtcccagatc
tccttcatcgactacttcatcacggacatgtttgatgcttgggacgcctttgtagacctg
cctgagttaatgcagcatcttgacaacaactttaaatactggaaaggactggatgaaatg
aagctgcggagcctccggccgccccctgaatag
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