KEGG   Mustela nigripes (black-footed ferret): 131999543
Entry
131999543         CDS       T09425                                 
Symbol
MAP2K1
Name
(RefSeq) dual specificity mitogen-activated protein kinase kinase 1
  KO
K04368  mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
Organism
mnp  Mustela nigripes (black-footed ferret)
Pathway
mnp01521  EGFR tyrosine kinase inhibitor resistance
mnp01522  Endocrine resistance
mnp04010  MAPK signaling pathway
mnp04012  ErbB signaling pathway
mnp04014  Ras signaling pathway
mnp04015  Rap1 signaling pathway
mnp04022  cGMP-PKG signaling pathway
mnp04024  cAMP signaling pathway
mnp04062  Chemokine signaling pathway
mnp04066  HIF-1 signaling pathway
mnp04068  FoxO signaling pathway
mnp04071  Sphingolipid signaling pathway
mnp04072  Phospholipase D signaling pathway
mnp04114  Oocyte meiosis
mnp04140  Autophagy - animal
mnp04148  Efferocytosis
mnp04150  mTOR signaling pathway
mnp04151  PI3K-Akt signaling pathway
mnp04210  Apoptosis
mnp04218  Cellular senescence
mnp04270  Vascular smooth muscle contraction
mnp04370  VEGF signaling pathway
mnp04371  Apelin signaling pathway
mnp04380  Osteoclast differentiation
mnp04510  Focal adhesion
mnp04540  Gap junction
mnp04550  Signaling pathways regulating pluripotency of stem cells
mnp04613  Neutrophil extracellular trap formation
mnp04620  Toll-like receptor signaling pathway
mnp04650  Natural killer cell mediated cytotoxicity
mnp04660  T cell receptor signaling pathway
mnp04662  B cell receptor signaling pathway
mnp04664  Fc epsilon RI signaling pathway
mnp04666  Fc gamma R-mediated phagocytosis
mnp04668  TNF signaling pathway
mnp04720  Long-term potentiation
mnp04722  Neurotrophin signaling pathway
mnp04725  Cholinergic synapse
mnp04726  Serotonergic synapse
mnp04730  Long-term depression
mnp04810  Regulation of actin cytoskeleton
mnp04910  Insulin signaling pathway
mnp04912  GnRH signaling pathway
mnp04914  Progesterone-mediated oocyte maturation
mnp04915  Estrogen signaling pathway
mnp04916  Melanogenesis
mnp04917  Prolactin signaling pathway
mnp04919  Thyroid hormone signaling pathway
mnp04921  Oxytocin signaling pathway
mnp04926  Relaxin signaling pathway
mnp04928  Parathyroid hormone synthesis, secretion and action
mnp04929  GnRH secretion
mnp04934  Cushing syndrome
mnp04935  Growth hormone synthesis, secretion and action
mnp05010  Alzheimer disease
mnp05022  Pathways of neurodegeneration - multiple diseases
mnp05034  Alcoholism
mnp05132  Salmonella infection
mnp05135  Yersinia infection
mnp05160  Hepatitis C
mnp05161  Hepatitis B
mnp05163  Human cytomegalovirus infection
mnp05164  Influenza A
mnp05165  Human papillomavirus infection
mnp05166  Human T-cell leukemia virus 1 infection
mnp05167  Kaposi sarcoma-associated herpesvirus infection
mnp05170  Human immunodeficiency virus 1 infection
mnp05200  Pathways in cancer
mnp05205  Proteoglycans in cancer
mnp05206  MicroRNAs in cancer
mnp05207  Chemical carcinogenesis - receptor activation
mnp05208  Chemical carcinogenesis - reactive oxygen species
mnp05210  Colorectal cancer
mnp05211  Renal cell carcinoma
mnp05212  Pancreatic cancer
mnp05213  Endometrial cancer
mnp05214  Glioma
mnp05215  Prostate cancer
mnp05216  Thyroid cancer
mnp05218  Melanoma
mnp05219  Bladder cancer
mnp05220  Chronic myeloid leukemia
mnp05221  Acute myeloid leukemia
mnp05223  Non-small cell lung cancer
mnp05224  Breast cancer
mnp05225  Hepatocellular carcinoma
mnp05226  Gastric cancer
mnp05230  Central carbon metabolism in cancer
mnp05231  Choline metabolism in cancer
mnp05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:mnp00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    131999543 (MAP2K1)
   04012 ErbB signaling pathway
    131999543 (MAP2K1)
   04014 Ras signaling pathway
    131999543 (MAP2K1)
   04015 Rap1 signaling pathway
    131999543 (MAP2K1)
   04370 VEGF signaling pathway
    131999543 (MAP2K1)
   04371 Apelin signaling pathway
    131999543 (MAP2K1)
   04668 TNF signaling pathway
    131999543 (MAP2K1)
   04066 HIF-1 signaling pathway
    131999543 (MAP2K1)
   04068 FoxO signaling pathway
    131999543 (MAP2K1)
   04072 Phospholipase D signaling pathway
    131999543 (MAP2K1)
   04071 Sphingolipid signaling pathway
    131999543 (MAP2K1)
   04024 cAMP signaling pathway
    131999543 (MAP2K1)
   04022 cGMP-PKG signaling pathway
    131999543 (MAP2K1)
   04151 PI3K-Akt signaling pathway
    131999543 (MAP2K1)
   04150 mTOR signaling pathway
    131999543 (MAP2K1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    131999543 (MAP2K1)
   04148 Efferocytosis
    131999543 (MAP2K1)
  09143 Cell growth and death
   04114 Oocyte meiosis
    131999543 (MAP2K1)
   04210 Apoptosis
    131999543 (MAP2K1)
   04218 Cellular senescence
    131999543 (MAP2K1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    131999543 (MAP2K1)
   04540 Gap junction
    131999543 (MAP2K1)
   04550 Signaling pathways regulating pluripotency of stem cells
    131999543 (MAP2K1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    131999543 (MAP2K1)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    131999543 (MAP2K1)
   04620 Toll-like receptor signaling pathway
    131999543 (MAP2K1)
   04650 Natural killer cell mediated cytotoxicity
    131999543 (MAP2K1)
   04660 T cell receptor signaling pathway
    131999543 (MAP2K1)
   04662 B cell receptor signaling pathway
    131999543 (MAP2K1)
   04664 Fc epsilon RI signaling pathway
    131999543 (MAP2K1)
   04666 Fc gamma R-mediated phagocytosis
    131999543 (MAP2K1)
   04062 Chemokine signaling pathway
    131999543 (MAP2K1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    131999543 (MAP2K1)
   04929 GnRH secretion
    131999543 (MAP2K1)
   04912 GnRH signaling pathway
    131999543 (MAP2K1)
   04915 Estrogen signaling pathway
    131999543 (MAP2K1)
   04914 Progesterone-mediated oocyte maturation
    131999543 (MAP2K1)
   04917 Prolactin signaling pathway
    131999543 (MAP2K1)
   04921 Oxytocin signaling pathway
    131999543 (MAP2K1)
   04926 Relaxin signaling pathway
    131999543 (MAP2K1)
   04935 Growth hormone synthesis, secretion and action
    131999543 (MAP2K1)
   04919 Thyroid hormone signaling pathway
    131999543 (MAP2K1)
   04928 Parathyroid hormone synthesis, secretion and action
    131999543 (MAP2K1)
   04916 Melanogenesis
    131999543 (MAP2K1)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    131999543 (MAP2K1)
  09156 Nervous system
   04725 Cholinergic synapse
    131999543 (MAP2K1)
   04726 Serotonergic synapse
    131999543 (MAP2K1)
   04720 Long-term potentiation
    131999543 (MAP2K1)
   04730 Long-term depression
    131999543 (MAP2K1)
   04722 Neurotrophin signaling pathway
    131999543 (MAP2K1)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    131999543 (MAP2K1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    131999543 (MAP2K1)
   05206 MicroRNAs in cancer
    131999543 (MAP2K1)
   05205 Proteoglycans in cancer
    131999543 (MAP2K1)
   05207 Chemical carcinogenesis - receptor activation
    131999543 (MAP2K1)
   05208 Chemical carcinogenesis - reactive oxygen species
    131999543 (MAP2K1)
   05230 Central carbon metabolism in cancer
    131999543 (MAP2K1)
   05231 Choline metabolism in cancer
    131999543 (MAP2K1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    131999543 (MAP2K1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    131999543 (MAP2K1)
   05212 Pancreatic cancer
    131999543 (MAP2K1)
   05225 Hepatocellular carcinoma
    131999543 (MAP2K1)
   05226 Gastric cancer
    131999543 (MAP2K1)
   05214 Glioma
    131999543 (MAP2K1)
   05216 Thyroid cancer
    131999543 (MAP2K1)
   05221 Acute myeloid leukemia
    131999543 (MAP2K1)
   05220 Chronic myeloid leukemia
    131999543 (MAP2K1)
   05218 Melanoma
    131999543 (MAP2K1)
   05211 Renal cell carcinoma
    131999543 (MAP2K1)
   05219 Bladder cancer
    131999543 (MAP2K1)
   05215 Prostate cancer
    131999543 (MAP2K1)
   05213 Endometrial cancer
    131999543 (MAP2K1)
   05224 Breast cancer
    131999543 (MAP2K1)
   05223 Non-small cell lung cancer
    131999543 (MAP2K1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    131999543 (MAP2K1)
   05170 Human immunodeficiency virus 1 infection
    131999543 (MAP2K1)
   05161 Hepatitis B
    131999543 (MAP2K1)
   05160 Hepatitis C
    131999543 (MAP2K1)
   05164 Influenza A
    131999543 (MAP2K1)
   05163 Human cytomegalovirus infection
    131999543 (MAP2K1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    131999543 (MAP2K1)
   05165 Human papillomavirus infection
    131999543 (MAP2K1)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    131999543 (MAP2K1)
   05135 Yersinia infection
    131999543 (MAP2K1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    131999543 (MAP2K1)
   05022 Pathways of neurodegeneration - multiple diseases
    131999543 (MAP2K1)
  09165 Substance dependence
   05034 Alcoholism
    131999543 (MAP2K1)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    131999543 (MAP2K1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    131999543 (MAP2K1)
   01522 Endocrine resistance
    131999543 (MAP2K1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:mnp01001]
    131999543 (MAP2K1)
Enzymes [BR:mnp01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     131999543 (MAP2K1)
Protein kinases [BR:mnp01001]
 Serine/threonine kinases: STE group
  STE7 family
   131999543 (MAP2K1)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1 Pkinase_fungal Kinase-like Haspin_kinase Seadorna_VP7 Arabinose_bd
Other DBs
NCBI-GeneID: 131999543
NCBI-ProteinID: XP_059228310
LinkDB
Position
13:45905015..45985298
AA seq 393 aa
MPKKKPTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKV
GELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHE
CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYL
REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHY
SVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELVFGCPVEGDAAETPPRPRTPGRPLSSY
GMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAF
IKRSDGEEVDFAGWLCSTIGLNQPSTPTHAAGV
NT seq 1182 nt   +upstreamnt  +downstreamnt
atgcccaagaagaagccgacgcccatccagctgaacccggcccccgacggctccgcggtt
aacgggaccagctcggcggagaccaacctggaggccttgcagaagaagcttgaggagctg
gagcttgatgagcagcagcggaagcgccttgaggcctttctcacccagaagcagaaggtc
ggggaattgaaggatgatgactttgagaaaatcagtgagcttggcgcaggcaacggtggt
gtggtgttcaaggtctcccacaagccatcaggcctggtcatggccagaaagctcattcac
ctggagatcaaacctgcaatccggaaccagatcataagggagcttcaggtcctacacgag
tgcaactccccctacatcgtgggcttctacggtgcattctacagcgatggcgagatcagc
atctgcatggagcacatggatgggggttccttggatcaagtcctgaagaaagctggaaga
attcctgagcaaattttaggaaaagttagcattgctgtaataaaaggtctgacatacctg
agggagaagcacaagattatgcacagagatgtcaagccttccaacatcctcgtgaactcc
cgtggggagatcaagctctgtgactttggggtcagtgggcaactcatcgactccatggcc
aactcctttgtgggcacaaggtcctacatgtcgccggaaagactccaggggacccactac
tcagtgcagtcggacatctggagcatggggctgtctctggttgagatggcggtggggagg
tatcccatccctcccccagacgccaaggagctggagctggtgtttgggtgcccagtggag
ggagatgcggcggagacaccacccagacccaggactcctggaaggcccctcagctcttat
ggaatggatagccgacctcccatggcaatttttgagctgctggattacatagtcaatgag
cctcctccaaaactgcccagtggagtgttcagtctggaatttcaagattttgtgaataaa
tgcttaataaaaaacccagcagagagagcagatctgaagcaactcatggttcatgccttt
atcaagagatctgatggggaggaagtggattttgcaggttggctctgctccaccattggc
cttaaccagcccagcacaccgacccacgcagctggcgtctaa

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