KEGG   Mustela nigripes (black-footed ferret): 132006530
Entry
132006530         CDS       T09425                                 
Symbol
IKBKB
Name
(RefSeq) inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1
  KO
K07209  inhibitor of nuclear factor kappa-B kinase subunit beta [EC:2.7.11.10]
Organism
mnp  Mustela nigripes (black-footed ferret)
Pathway
mnp01523  Antifolate resistance
mnp04010  MAPK signaling pathway
mnp04014  Ras signaling pathway
mnp04062  Chemokine signaling pathway
mnp04064  NF-kappa B signaling pathway
mnp04068  FoxO signaling pathway
mnp04150  mTOR signaling pathway
mnp04151  PI3K-Akt signaling pathway
mnp04210  Apoptosis
mnp04380  Osteoclast differentiation
mnp04620  Toll-like receptor signaling pathway
mnp04621  NOD-like receptor signaling pathway
mnp04622  RIG-I-like receptor signaling pathway
mnp04623  Cytosolic DNA-sensing pathway
mnp04625  C-type lectin receptor signaling pathway
mnp04657  IL-17 signaling pathway
mnp04658  Th1 and Th2 cell differentiation
mnp04659  Th17 cell differentiation
mnp04660  T cell receptor signaling pathway
mnp04662  B cell receptor signaling pathway
mnp04668  TNF signaling pathway
mnp04722  Neurotrophin signaling pathway
mnp04910  Insulin signaling pathway
mnp04920  Adipocytokine signaling pathway
mnp04930  Type II diabetes mellitus
mnp04931  Insulin resistance
mnp04932  Non-alcoholic fatty liver disease
mnp04936  Alcoholic liver disease
mnp05010  Alzheimer disease
mnp05132  Salmonella infection
mnp05135  Yersinia infection
mnp05142  Chagas disease
mnp05145  Toxoplasmosis
mnp05160  Hepatitis C
mnp05161  Hepatitis B
mnp05162  Measles
mnp05163  Human cytomegalovirus infection
mnp05164  Influenza A
mnp05165  Human papillomavirus infection
mnp05166  Human T-cell leukemia virus 1 infection
mnp05167  Kaposi sarcoma-associated herpesvirus infection
mnp05168  Herpes simplex virus 1 infection
mnp05169  Epstein-Barr virus infection
mnp05170  Human immunodeficiency virus 1 infection
mnp05171  Coronavirus disease - COVID-19
mnp05200  Pathways in cancer
mnp05206  MicroRNAs in cancer
mnp05208  Chemical carcinogenesis - reactive oxygen species
mnp05212  Pancreatic cancer
mnp05215  Prostate cancer
mnp05220  Chronic myeloid leukemia
mnp05221  Acute myeloid leukemia
mnp05222  Small cell lung cancer
mnp05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
mnp05417  Lipid and atherosclerosis
mnp05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:mnp00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    132006530 (IKBKB)
   04014 Ras signaling pathway
    132006530 (IKBKB)
   04064 NF-kappa B signaling pathway
    132006530 (IKBKB)
   04668 TNF signaling pathway
    132006530 (IKBKB)
   04068 FoxO signaling pathway
    132006530 (IKBKB)
   04151 PI3K-Akt signaling pathway
    132006530 (IKBKB)
   04150 mTOR signaling pathway
    132006530 (IKBKB)
 09140 Cellular Processes
  09143 Cell growth and death
   04210 Apoptosis
    132006530 (IKBKB)
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    132006530 (IKBKB)
   04621 NOD-like receptor signaling pathway
    132006530 (IKBKB)
   04622 RIG-I-like receptor signaling pathway
    132006530 (IKBKB)
   04623 Cytosolic DNA-sensing pathway
    132006530 (IKBKB)
   04625 C-type lectin receptor signaling pathway
    132006530 (IKBKB)
   04660 T cell receptor signaling pathway
    132006530 (IKBKB)
   04658 Th1 and Th2 cell differentiation
    132006530 (IKBKB)
   04659 Th17 cell differentiation
    132006530 (IKBKB)
   04657 IL-17 signaling pathway
    132006530 (IKBKB)
   04662 B cell receptor signaling pathway
    132006530 (IKBKB)
   04062 Chemokine signaling pathway
    132006530 (IKBKB)
  09152 Endocrine system
   04910 Insulin signaling pathway
    132006530 (IKBKB)
   04920 Adipocytokine signaling pathway
    132006530 (IKBKB)
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    132006530 (IKBKB)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    132006530 (IKBKB)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    132006530 (IKBKB)
   05206 MicroRNAs in cancer
    132006530 (IKBKB)
   05208 Chemical carcinogenesis - reactive oxygen species
    132006530 (IKBKB)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    132006530 (IKBKB)
  09162 Cancer: specific types
   05212 Pancreatic cancer
    132006530 (IKBKB)
   05221 Acute myeloid leukemia
    132006530 (IKBKB)
   05220 Chronic myeloid leukemia
    132006530 (IKBKB)
   05215 Prostate cancer
    132006530 (IKBKB)
   05222 Small cell lung cancer
    132006530 (IKBKB)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    132006530 (IKBKB)
   05170 Human immunodeficiency virus 1 infection
    132006530 (IKBKB)
   05161 Hepatitis B
    132006530 (IKBKB)
   05160 Hepatitis C
    132006530 (IKBKB)
   05171 Coronavirus disease - COVID-19
    132006530 (IKBKB)
   05164 Influenza A
    132006530 (IKBKB)
   05162 Measles
    132006530 (IKBKB)
   05168 Herpes simplex virus 1 infection
    132006530 (IKBKB)
   05163 Human cytomegalovirus infection
    132006530 (IKBKB)
   05167 Kaposi sarcoma-associated herpesvirus infection
    132006530 (IKBKB)
   05169 Epstein-Barr virus infection
    132006530 (IKBKB)
   05165 Human papillomavirus infection
    132006530 (IKBKB)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    132006530 (IKBKB)
   05135 Yersinia infection
    132006530 (IKBKB)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    132006530 (IKBKB)
   05142 Chagas disease
    132006530 (IKBKB)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    132006530 (IKBKB)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    132006530 (IKBKB)
   05418 Fluid shear stress and atherosclerosis
    132006530 (IKBKB)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    132006530 (IKBKB)
   04936 Alcoholic liver disease
    132006530 (IKBKB)
   04932 Non-alcoholic fatty liver disease
    132006530 (IKBKB)
   04931 Insulin resistance
    132006530 (IKBKB)
  09176 Drug resistance: antineoplastic
   01523 Antifolate resistance
    132006530 (IKBKB)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:mnp01001]
    132006530 (IKBKB)
Enzymes [BR:mnp01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.10  IkappaB kinase
     132006530 (IKBKB)
Protein kinases [BR:mnp01001]
 Serine/threonine kinases: Other
  IKK family [OT]
   132006530 (IKBKB)
SSDB
Motif
Pfam: IKBKB_SDD Pkinase PK_Tyr_Ser-Thr IKKbetaNEMObind Pkinase_fungal Kdo ubiquitin Med30 YrbL-PhoP_reg APH Glyco_hydro_65m
Other DBs
NCBI-GeneID: 132006530
NCBI-ProteinID: XP_059240352
LinkDB
Position
18:37662149..37723656
AA seq 756 aa
MSWSPSLPTQTCGAWEMKERLGTGGFGNVIRWHNQETGEQIAIKQCRQELSPRNRERWCL
EIQIMRRLNHPNVVAARDVPEGMQSLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREG
PILTLLSDIASALRYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGSLCT
SFVGTLQYLAPELLEQQKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHSKVRQKSE
MDIVVSEDLNGAVKFSSSLPYPNNLNSILAQRLEKWLQLMLMWHPRQRGTDPVYGPNGCF
KALDDILNLKLVHILNMVTGIIHTYPVTEDESLQSLQARIQQDTGIPEKDQELLQEAGLA
LIPDKPAAQCISDGKLNEGRTLDMDLVFLFDNSKIAYETQISPRPQPESVSCILQEPKRN
LSFFQLRKVWGQVWHSIQTLKEDCNRLQQGQRAAMMNLLRNNSCLSKMKNSMASMSQQLK
AKLDFFKTSIQIDLEKYSEQTEFGITSDKLLLAWREMEQAVELCGRENEVRLLVERMMAL
QTDIVDLQRSPMGRKQGGTLDDLEEQARELYRRLREKPRDQRTDGDSQEMVRLLLQAIQG
FEKKVRVIYTQLSKTVVCKQKALELLPKVEEVVSLMNEDEKTVVRLQEKRQKELWNLLKI
ACSKVRGPVSGSPDSMNASRLSHSGQLLSQPSAAPNSLPEAIKKSGELVTEAHTLCSQLE
HAMQDTIKEQDQSLRSLDWSWLQTEEEEQNSLEQAS
NT seq 2271 nt   +upstreamnt  +downstreamnt
atgagctggtcaccttctctgccaacccagacgtgtggggcctgggagatgaaagaacga
ctcgggacggggggatttggaaatgtcatccgatggcacaatcaggaaacaggtgagcag
attgctatcaagcagtgccggcaggagctcagcccccggaatcgagagcggtggtgcctg
gagatccagatcatgagaaggctgaaccaccccaatgtggtggctgcccgggacgtcccc
gaggggatgcagagtttggctcccaatgacttgcccctgctggccatggagtactgccag
ggaggagatctccgcaagtacctgaaccagtttgagaactgctgtggcctgcgggaagga
cccatcctcaccttgctgagtgacattgcctctgcactcagatatcttcatgaaaacaga
atcatccatcgggatctaaagccagaaaacatcgtcctgcagcaaggagagcaaagatta
atacacaaaattattgacctaggatatgccaaggaactggatcagggcagtctttgtact
tcctttgtgggcaccctgcagtacttggccccagagctcctggagcagcagaagtacacg
gtgaccgtggactactggagcttcggcaccttggctttcgagtgcatcaccggcttccgc
ccttttctccctaactggcagcctgtgcagtggcactccaaagtccggcagaagagtgag
atggacatcgttgtcagtgaggacctgaacggagccgtgaagttttcaagctccttaccc
taccccaataatctcaacagcatcctggcacagcgactggagaagtggctgcagctgatg
ctcatgtggcacccacgacagaggggcactgatcctgtgtacgggcccaacggctgcttc
aaggccctggatgacatcttaaacctgaagctggttcatatcttgaacatggtcacaggc
atcattcacacctatccagtgacagaagacgagagtctgcagagcttgcaggccagaatc
cagcaggacacaggaatccccgagaaggaccaggagctgctacaggaagctgggctggcg
ctgatccctgacaagcctgctgctcagtgtatttcagacggcaagctgaatgagggccgc
acgctggacatggatctcgtctttctctttgacaacagtaaaatcgcctatgagactcag
atctccccccggccccaacctgaaagtgtcagctgtatccttcaagagcccaagaggaac
ctgtctttcttccagctgaggaaggtgtggggccaggtctggcacagcatccaaaccctg
aaggaggactgtaaccggctgcagcagggacagcgagctgccatgatgaatctccttcgg
aataatagctgcctctccaagatgaagaattctatggcttccatgtctcagcagctcaaa
gccaagttggacttctttaaaaccagcatccagattgacctggagaagtacagtgagcaa
acggagtttgggatcacgtcagataagctgctgctggcctggagggaaatggaacaggct
gtggagctctgtgggcgggagaacgaggtgaggctcctggtggagcggatgatggcgctc
cagaccgacatcgtggacctgcagaggagccccatggggcggaagcagggcggcacgctg
gacgacctagaagagcaggcaagggagctttataggaggcttcgggagaaacccagagac
cagcgaacggatggcgacagtcaggagatggtccggctgctcctccaggccatccaaggc
tttgagaagaaagtgagagtgatttatacgcagctcagtaaaactgtggtatgcaagcag
aaggctctggaattgttgcccaaggtggaagaggtggtgagtttaatgaacgaagatgag
aagaccgttgtccggcttcaggagaagcggcagaaggaactctggaatcttctgaagatc
gcttgtagcaaagtccgtggtcctgtcagtggaagcccagacagcatgaatgcttctcgc
ctcagtcactcgggtcagctgctgtctcagccttctgctgcccccaacagcttacccgag
gccatcaagaaaagtggagagctggtgactgaagcgcacaccctgtgttcgcagctagaa
catgcaatgcaagacaccatcaaagaacaggaccagagtttgaggtctctagactggagc
tggctacagacagaggaagaagaacagaacagcctggaacaggcctcttga

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