Mustela nigripes (black-footed ferret): 132011570
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Entry
132011570 CDS
T09425
Symbol
RAF1
Name
(RefSeq) RAF proto-oncogene serine/threonine-protein kinase isoform X1
KO
K04366
RAF proto-oncogene serine/threonine-protein kinase [EC:
2.7.11.1
]
Organism
mnp
Mustela nigripes (black-footed ferret)
Pathway
mnp01521
EGFR tyrosine kinase inhibitor resistance
mnp01522
Endocrine resistance
mnp04010
MAPK signaling pathway
mnp04012
ErbB signaling pathway
mnp04014
Ras signaling pathway
mnp04015
Rap1 signaling pathway
mnp04022
cGMP-PKG signaling pathway
mnp04024
cAMP signaling pathway
mnp04062
Chemokine signaling pathway
mnp04068
FoxO signaling pathway
mnp04071
Sphingolipid signaling pathway
mnp04072
Phospholipase D signaling pathway
mnp04140
Autophagy - animal
mnp04150
mTOR signaling pathway
mnp04151
PI3K-Akt signaling pathway
mnp04210
Apoptosis
mnp04218
Cellular senescence
mnp04270
Vascular smooth muscle contraction
mnp04360
Axon guidance
mnp04370
VEGF signaling pathway
mnp04371
Apelin signaling pathway
mnp04510
Focal adhesion
mnp04540
Gap junction
mnp04550
Signaling pathways regulating pluripotency of stem cells
mnp04613
Neutrophil extracellular trap formation
mnp04625
C-type lectin receptor signaling pathway
mnp04630
JAK-STAT signaling pathway
mnp04650
Natural killer cell mediated cytotoxicity
mnp04660
T cell receptor signaling pathway
mnp04662
B cell receptor signaling pathway
mnp04664
Fc epsilon RI signaling pathway
mnp04666
Fc gamma R-mediated phagocytosis
mnp04720
Long-term potentiation
mnp04722
Neurotrophin signaling pathway
mnp04726
Serotonergic synapse
mnp04730
Long-term depression
mnp04810
Regulation of actin cytoskeleton
mnp04910
Insulin signaling pathway
mnp04912
GnRH signaling pathway
mnp04914
Progesterone-mediated oocyte maturation
mnp04915
Estrogen signaling pathway
mnp04916
Melanogenesis
mnp04917
Prolactin signaling pathway
mnp04919
Thyroid hormone signaling pathway
mnp04921
Oxytocin signaling pathway
mnp04926
Relaxin signaling pathway
mnp04928
Parathyroid hormone synthesis, secretion and action
mnp04929
GnRH secretion
mnp04935
Growth hormone synthesis, secretion and action
mnp05010
Alzheimer disease
mnp05022
Pathways of neurodegeneration - multiple diseases
mnp05034
Alcoholism
mnp05132
Salmonella infection
mnp05152
Tuberculosis
mnp05160
Hepatitis C
mnp05161
Hepatitis B
mnp05163
Human cytomegalovirus infection
mnp05164
Influenza A
mnp05165
Human papillomavirus infection
mnp05167
Kaposi sarcoma-associated herpesvirus infection
mnp05170
Human immunodeficiency virus 1 infection
mnp05200
Pathways in cancer
mnp05205
Proteoglycans in cancer
mnp05206
MicroRNAs in cancer
mnp05207
Chemical carcinogenesis - receptor activation
mnp05208
Chemical carcinogenesis - reactive oxygen species
mnp05210
Colorectal cancer
mnp05211
Renal cell carcinoma
mnp05212
Pancreatic cancer
mnp05213
Endometrial cancer
mnp05214
Glioma
mnp05215
Prostate cancer
mnp05218
Melanoma
mnp05219
Bladder cancer
mnp05220
Chronic myeloid leukemia
mnp05221
Acute myeloid leukemia
mnp05223
Non-small cell lung cancer
mnp05224
Breast cancer
mnp05225
Hepatocellular carcinoma
mnp05226
Gastric cancer
mnp05230
Central carbon metabolism in cancer
mnp05231
Choline metabolism in cancer
mnp05235
PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:
mnp00001
]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
132011570 (RAF1)
04012 ErbB signaling pathway
132011570 (RAF1)
04014 Ras signaling pathway
132011570 (RAF1)
04015 Rap1 signaling pathway
132011570 (RAF1)
04370 VEGF signaling pathway
132011570 (RAF1)
04371 Apelin signaling pathway
132011570 (RAF1)
04630 JAK-STAT signaling pathway
132011570 (RAF1)
04068 FoxO signaling pathway
132011570 (RAF1)
04072 Phospholipase D signaling pathway
132011570 (RAF1)
04071 Sphingolipid signaling pathway
132011570 (RAF1)
04024 cAMP signaling pathway
132011570 (RAF1)
04022 cGMP-PKG signaling pathway
132011570 (RAF1)
04151 PI3K-Akt signaling pathway
132011570 (RAF1)
04150 mTOR signaling pathway
132011570 (RAF1)
09140 Cellular Processes
09141 Transport and catabolism
04140 Autophagy - animal
132011570 (RAF1)
09143 Cell growth and death
04210 Apoptosis
132011570 (RAF1)
04218 Cellular senescence
132011570 (RAF1)
09144 Cellular community - eukaryotes
04510 Focal adhesion
132011570 (RAF1)
04540 Gap junction
132011570 (RAF1)
04550 Signaling pathways regulating pluripotency of stem cells
132011570 (RAF1)
09142 Cell motility
04810 Regulation of actin cytoskeleton
132011570 (RAF1)
09150 Organismal Systems
09151 Immune system
04613 Neutrophil extracellular trap formation
132011570 (RAF1)
04625 C-type lectin receptor signaling pathway
132011570 (RAF1)
04650 Natural killer cell mediated cytotoxicity
132011570 (RAF1)
04660 T cell receptor signaling pathway
132011570 (RAF1)
04662 B cell receptor signaling pathway
132011570 (RAF1)
04664 Fc epsilon RI signaling pathway
132011570 (RAF1)
04666 Fc gamma R-mediated phagocytosis
132011570 (RAF1)
04062 Chemokine signaling pathway
132011570 (RAF1)
09152 Endocrine system
04910 Insulin signaling pathway
132011570 (RAF1)
04929 GnRH secretion
132011570 (RAF1)
04912 GnRH signaling pathway
132011570 (RAF1)
04915 Estrogen signaling pathway
132011570 (RAF1)
04914 Progesterone-mediated oocyte maturation
132011570 (RAF1)
04917 Prolactin signaling pathway
132011570 (RAF1)
04921 Oxytocin signaling pathway
132011570 (RAF1)
04926 Relaxin signaling pathway
132011570 (RAF1)
04935 Growth hormone synthesis, secretion and action
132011570 (RAF1)
04919 Thyroid hormone signaling pathway
132011570 (RAF1)
04928 Parathyroid hormone synthesis, secretion and action
132011570 (RAF1)
04916 Melanogenesis
132011570 (RAF1)
09153 Circulatory system
04270 Vascular smooth muscle contraction
132011570 (RAF1)
09156 Nervous system
04726 Serotonergic synapse
132011570 (RAF1)
04720 Long-term potentiation
132011570 (RAF1)
04730 Long-term depression
132011570 (RAF1)
04722 Neurotrophin signaling pathway
132011570 (RAF1)
09158 Development and regeneration
04360 Axon guidance
132011570 (RAF1)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
132011570 (RAF1)
05206 MicroRNAs in cancer
132011570 (RAF1)
05205 Proteoglycans in cancer
132011570 (RAF1)
05207 Chemical carcinogenesis - receptor activation
132011570 (RAF1)
05208 Chemical carcinogenesis - reactive oxygen species
132011570 (RAF1)
05230 Central carbon metabolism in cancer
132011570 (RAF1)
05231 Choline metabolism in cancer
132011570 (RAF1)
05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
132011570 (RAF1)
09162 Cancer: specific types
05210 Colorectal cancer
132011570 (RAF1)
05212 Pancreatic cancer
132011570 (RAF1)
05225 Hepatocellular carcinoma
132011570 (RAF1)
05226 Gastric cancer
132011570 (RAF1)
05214 Glioma
132011570 (RAF1)
05221 Acute myeloid leukemia
132011570 (RAF1)
05220 Chronic myeloid leukemia
132011570 (RAF1)
05218 Melanoma
132011570 (RAF1)
05211 Renal cell carcinoma
132011570 (RAF1)
05219 Bladder cancer
132011570 (RAF1)
05215 Prostate cancer
132011570 (RAF1)
05213 Endometrial cancer
132011570 (RAF1)
05224 Breast cancer
132011570 (RAF1)
05223 Non-small cell lung cancer
132011570 (RAF1)
09172 Infectious disease: viral
05170 Human immunodeficiency virus 1 infection
132011570 (RAF1)
05161 Hepatitis B
132011570 (RAF1)
05160 Hepatitis C
132011570 (RAF1)
05164 Influenza A
132011570 (RAF1)
05163 Human cytomegalovirus infection
132011570 (RAF1)
05167 Kaposi sarcoma-associated herpesvirus infection
132011570 (RAF1)
05165 Human papillomavirus infection
132011570 (RAF1)
09171 Infectious disease: bacterial
05132 Salmonella infection
132011570 (RAF1)
05152 Tuberculosis
132011570 (RAF1)
09164 Neurodegenerative disease
05010 Alzheimer disease
132011570 (RAF1)
05022 Pathways of neurodegeneration - multiple diseases
132011570 (RAF1)
09165 Substance dependence
05034 Alcoholism
132011570 (RAF1)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
132011570 (RAF1)
01522 Endocrine resistance
132011570 (RAF1)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
mnp01001
]
132011570 (RAF1)
Enzymes [BR:
mnp01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.1 non-specific serine/threonine protein kinase
132011570 (RAF1)
Protein kinases [BR:
mnp01001
]
Serine/threonine kinases: TKL group
RAF family [OT]
132011570 (RAF1)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Pkinase
PK_Tyr_Ser-Thr
RBD
C1_1
Kinase-like
ABC1
zf-RING-like
Pkinase_fungal
C1_2
Motif
Other DBs
NCBI-GeneID:
132011570
NCBI-ProteinID:
XP_059246341
LinkDB
All DBs
Position
2:complement(53976179..54062799)
Genome browser
AA seq
668 aa
AA seq
DB search
MEHIQGAWKTISNGFGFKDTVFDGPSCISPTIVQPFGFQRRASDDGKLTDSSKTSNTIRV
FLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAAS
LIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKV
PTMCVDWSNIRQLLLFPNSTIGDSGVPALPSLTMRRMRESVSRMPVSSQHRYSTPHAFTF
NSSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIENNSLNASPRAWSRRFCLRGRDA
IRSHSESASPSALSSSPNNLSPTGWSQPKTPVPAQRERAPGSGTQEKNKIRPRGQRDSSY
YWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKT
RHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLH
AKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQ
DNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKA
MKRLVADCVKKVKEERPLFPQILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLT
TSPRLPVF
NT seq
2007 nt
NT seq
+upstream
nt +downstream
nt
atggagcacatacagggggcctggaagacgatcagcaatggttttggattcaaagacaca
gtgtttgacggccccagctgcatctcgcctacaatagttcagccatttggctttcagcgt
cgggcgtcagatgatggcaaacttacggactcgtctaagacaagcaacactattcgtgtt
ttcttgccaaacaagcaaagaacggtggtcaatgtgcgaaatggaatgagcttgcacgat
tgccttatgaaagcactcaaggtgaggggcctacagccggagtgctgtgctgtgttcaga
cttctccatgaacataaaggtaaaaaggcacgtttagattggaatactgatgctgcctcg
ttgattggagaagaacttcaagtagatttcctggatcacgttcccctcacaacacacaac
tttgcacggaagacctttctgaagcttgcgttctgtgacatctgtcagaagttcctgcta
aatggatttcgttgtcagacttgtggctacaaatttcatgagcactgtagcaccaaagtt
cctactatgtgtgtggattggagtaatatcagacagctcttattgtttccaaattctact
attggtgatagtggggtcccagcactgccttctttgacgatgcgtcggatgcgagagtct
gtttcccggatgcctgttagttcccagcacagatattccacaccccatgccttcacattc
aactcctccagcccttcctctgaaggttctctttcccagaggcagaggtccacgtccaca
cctaatgtccacatggtcagcaccaccctgcctgtggacagcaggatgattgagaataac
agcctgaatgcttctcccagggcgtggtccagacgattttgtttgaggggaagagatgca
attcgaagccacagtgaatcagcctcaccttcagccttgtccagcagccctaacaatctg
agcccaacaggctggtcacagcccaaaacccctgtgccagcacagagagagcgggcacca
ggatctgggacccaggagaaaaacaaaattaggcctcgtggacagagagattcaagctat
tactgggaaatagaagccagcgaagtgatgctctccactcggattgggtcaggctccttt
ggaacggtgtataagggcaagtggcacggagatgttgcagtaaaaatcctaaaggttgtc
gaccccacaccagagcagttccaggccttcaggaacgaggtggctgtgctccgcaaaaca
cggcacgtgaacatcctgctcttcatggggtacatgacaaaggacaacctggcgattgtg
acccagtggtgtgaaggcagcagcctctacaaacacctgcatgtccaggagactaaattc
cagatgttccagttgattgacatcgcccgccagactgctcagggaatggactatttgcat
gcaaagaacatcatccacagagacatgaaatccaacaatatatttctccacgaaggcctg
acggtgaaaattggagattttggtttggcaacagtaaagtcgcgctggagtggttctcag
caagttgaacaacccactggctctgtcctgtggatggcccctgaggtgatccgaatgcag
gataacaacccgttcagcttccagtctgatgtctactcctacggcattgtgctctatgag
ctcatgacaggggagcttccttactcccacatcaataaccgtgatcagatcatcttcatg
gtgggccgagggtatgcctccccagacctcagtaagctatataagaactgccccaaagca
atgaagaggcttgtagccgactgtgtgaagaaggttaaggaagagaggcctctttttccc
cagatcctgtcttccattgagctgctccaacattctctgccgaaaatcaaccggagcgct
tctgagccatccctgcaccgggcggcccacactgaggatatcaacgcctgcacactgact
acgtcccctagactgcctgtcttctag
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integrated database retrieval system