Mustela nigripes (black-footed ferret): 132012366
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Entry
132012366 CDS
T09425
Symbol
GART
Name
(RefSeq) trifunctional purine biosynthetic protein adenosine-3
KO
K11787
phosphoribosylamine--glycine ligase / phosphoribosylglycinamide formyltransferase / phosphoribosylformylglycinamidine cyclo-ligase [EC:
6.3.4.13
2.1.2.2
6.3.3.1
]
Organism
mnp
Mustela nigripes (black-footed ferret)
Pathway
mnp00230
Purine metabolism
mnp00670
One carbon pool by folate
mnp01100
Metabolic pathways
mnp01523
Antifolate resistance
Module
mnp_M00048
De novo purine biosynthesis, PRPP + glutamine => IMP
Brite
KEGG Orthology (KO) [BR:
mnp00001
]
09100 Metabolism
09104 Nucleotide metabolism
00230 Purine metabolism
132012366 (GART)
09108 Metabolism of cofactors and vitamins
00670 One carbon pool by folate
132012366 (GART)
09160 Human Diseases
09176 Drug resistance: antineoplastic
01523 Antifolate resistance
132012366 (GART)
Enzymes [BR:
mnp01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.2 Hydroxymethyl-, formyl- and related transferases
2.1.2.2 phosphoribosylglycinamide formyltransferase 1
132012366 (GART)
6. Ligases
6.3 Forming carbon-nitrogen bonds
6.3.3 Cyclo-ligases
6.3.3.1 phosphoribosylformylglycinamidine cyclo-ligase
132012366 (GART)
6.3.4 Other carbon-nitrogen ligases
6.3.4.13 phosphoribosylamine---glycine ligase
132012366 (GART)
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Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
GARS_A
Formyl_trans_N
AIRS_C
GARS_N
GARS_C
AIRS
ATP-grasp
CPSase_L_D2
ATP-grasp_3
ATP-grasp_2
ATP-grasp_4
Dala_Dala_lig_C
RimK
Sacchrp_dh_NADP
ATP-grasp_5
Motif
Other DBs
NCBI-GeneID:
132012366
NCBI-ProteinID:
XP_059248267
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All DBs
Position
2:complement(208170575..208204806)
Genome browser
AA seq
1009 aa
AA seq
DB search
MAAQVLVIGSGGREHTLAWKLAQSNHVKHVLVAPGNAGTSSLEKISNTAISINDHTALAQ
FCKDEKIEFVVVGPEAPLAAGIVGNLTSAGVRCFGPTAEAAQLESSKRFAKEFMDRHGIP
TARWRAFTKPEEACSFIMSADFPALVVKASGLAAGKGVIVAKSKEEACRAVQEIMQDKAY
GAAGETIVIEEFLEGEEVSCLCFTDGRTVAPMPPAQDHKRLLEGDHGPNTGGMGAYCPAP
QVSKDLFLKIKNTILQRTVDGMQQEGTPYTGVLYAGIMLTKDGPKVLEFNCRFGDPECQV
ILPLLKSDLYEVIQSTLDGLLCTSLPVWFDNCAAVTVVMASKGYPGDYTKGVEITGFPAA
QALGLEVFHAGTALKDGRVVTNGGRVLTVTAIRENLILALEEAKKGLAAIKFEGAIYRKD
IGYRAIAFLQQPRGLTYKESGVDIAAGNMLVKKIKPLAKATSRPGCDVDLGGFAGLFDLK
AAGFKDPLLASGTDGVGTKLKIAQQCNKHDTIGQDLVAMCVNDILAQGAEPLFFLDYFSC
GKLDLNTTEAVVAGIARACGKAGCALLGGETAEMPDMYPPGEYDLAGFAVGAMERDQKLP
HLERITEGDIVIGVASSGLHSNGFSLVRKIVAKSSLQYSSPAPEGCGDQTLGDLLLTPTR
IYSHSLLPVLRSGHVKAFAHITGGGLLENIPRVLPQKFGVDLDAQTWRVPRIFSWLQQEG
HLSEEEMARTFNCGIGAALVVSKDLAEQILRDIKQHKEEAWVIGKVVACPEGSPRVKVKN
LIETMQINGSLLENGTTKNHFSVQSKKARVAVLISGTGSNLQALIDSTREPSSCAHIVVV
ISNKAAVAGLDKAERAGIPSRVINHKLYKSRVEFDTAVDQVLEEYSTDIVCLAGFMRILS
GPFVRKWDGKMLNIHPSLLPSFKGSNAHEQALEAGVTVTGCTVHFVAEDVDAGQIILQES
VPVKRGDTVATLSERVKLAEHKIFPAALQLVASGAVRLGENGKICWVTE
NT seq
3030 nt
NT seq
+upstream
nt +downstream
nt
atggcagcccaagtacttgtaattggcagcggtggaagggaacacacactggcctggaaa
cttgcacagtctaatcatgtcaaacatgtgttggttgccccaggaaatgcaggcacttcc
tccttggaaaagatttcaaatactgccatctcaatcaatgaccacacagcccttgctcag
ttctgcaaagatgagaaaattgaattcgtagttgttggaccagaggcacctctggctgct
ggaattgttggtaacctgacgtctgcaggagtccgatgctttggtcccactgcagaagca
gctcagttagagtccagcaagagattcgccaaagagtttatggaccgacatggaatccca
actgcacggtggagagctttcaccaaacctgaagaagcctgcagctttataatgagtgca
gacttccctgctttggttgtgaaggccagtggtcttgcagctggaaaaggagtgattgtt
gccaagagcaaggaagaggcctgcagagctgtacaggagatcatgcaggataaagcttat
ggagcagctggagaaacaattgtcattgaagaatttcttgaaggagaagaggtgtcttgt
ctgtgcttcactgatggaaggaccgtggcccccatgcccccagcacaagaccataagcga
ttgctggaaggagatcatggccccaacacagggggaatgggagcctattgtccagcacct
caggtttctaaggatttgttcctgaaaataaaaaataccattcttcagaggacagtggac
ggcatgcaacaggagggtacgccatacacaggtgttctctatgctggtataatgctgacc
aaggatggcccaaaagttctggagttcaattgccgttttggtgatccagagtgccaagtg
atcctcccacttcttaaaagtgatctttatgaagtgattcagtctaccttggatggcctg
ctctgtacatctctgcctgtttggtttgataactgcgctgcagtaactgtcgtgatggca
agtaaaggctatccgggagattacaccaagggtgtggagataacagggtttcctgcggct
caagctttaggactggaggtgttccacgcaggcactgccctgaaagatggcagagtggtg
actaacgggggtagagtccttacggtaacagcgatccgggaaaatctcatcttggccctt
gaagaagccaaaaaaggactagctgctataaaatttgagggagccatttacaggaaggac
ataggctatcgcgccatagcttttctccagcagcccaggggcctgacttacaaggaatct
ggggtagacattgcagctggaaatatgctggtcaagaaaattaaacctttagcaaaagct
acctccagaccaggctgtgatgttgatcttggaggttttgctggtctttttgatttgaaa
gcagctggtttcaaagatcctcttctggcaagtggaacagatggtgttggaactaaactg
aagattgcccagcagtgtaacaaacatgataccattggtcaagatctggttgcaatgtgt
gtcaatgacattctggcccaaggggcagagccccttttcttcctcgattacttttcctgt
ggaaaacttgaccttaatacaactgaagctgttgtcgctggaatcgccagagcctgtgga
aaagctggatgtgctctccttggaggtgaaactgcagaaatgcccgacatgtatcctccg
ggagaatatgacctagctggttttgccgttggtgccatggagcgggatcagaaactccct
cacctggaaagaatcactgaaggggatattgttattggagtagcttcatctggtcttcac
agcaatggatttagccttgtaaggaaaattgtagcaaaatcttccctccagtactcatct
ccagcacctgaaggctgtggtgatcagaccttaggggacttacttcttactccaaccaga
atctacagccattcactgctacctgtcctacgttcaggacacgtcaaggcctttgcccat
attactggtggaggattgctagaaaacatcccccgagtccttcctcagaagtttggggtg
gatttagatgcccagacctggagggtccccaggatcttctcatggttacagcaggaagga
cacctctctgaggaagaaatggccagaacatttaactgtgggattggggctgccctcgtg
gtgtcaaaggatctggcagagcagattctgagagatattaagcagcacaaggaggaagcc
tgggtgattggcaaggtggtggcatgtcctgaaggttctcctcgtgtgaaagtcaagaat
ttgatagaaaccatgcaaataaatggatcactattggaaaatggcaccacgaaaaatcat
ttctctgtccaatcaaaaaaggcaagagtggctgtcttaatatctggaacaggatcaaac
ctgcaagctctcatagacagcactagggagccaagtagctgtgcgcacatagtcgtcgtt
atctccaacaaagccgcagtggctggcttagataaagcggagagagctggaattcccagc
agagtaattaatcataaattatataaaagtcgggtagaatttgacactgcagttgaccaa
gtccttgaggagtactccacagacatagtctgtcttgcaggattcatgagaattttatct
ggcccctttgtcaggaaatgggatgggaagatgctcaacatccacccatccttgctcccg
tcttttaagggttcaaatgcccacgagcaagccctagaagctggtgtcacagtcaccggc
tgtaccgtgcactttgtagctgaagatgtagatgctggacagattattttacaagaatct
gttccagtgaagagaggggacactgttgcaactctgtctgaaagagtgaaattagcagag
cacaaaatattccctgcagccctccagctggtagccagtggagctgtacggcttggagaa
aatggcaagatttgttgggtcacagagtga
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