KEGG   Mustela nigripes (black-footed ferret): 132015377
Entry
132015377         CDS       T09425                                 
Name
(RefSeq) steroid 17-alpha-hydroxylase/17,20 lyase
  KO
K00512  steroid 17alpha-monooxygenase / 17alpha-hydroxyprogesterone deacetylase [EC:1.14.14.19 1.14.14.32]
Organism
mnp  Mustela nigripes (black-footed ferret)
Pathway
mnp00140  Steroid hormone biosynthesis
mnp01100  Metabolic pathways
mnp04913  Ovarian steroidogenesis
mnp04917  Prolactin signaling pathway
mnp04927  Cortisol synthesis and secretion
mnp04934  Cushing syndrome
Module
mnp_M00109  C21-Steroid hormone biosynthesis, progesterone => cortisol/cortisone
mnp_M00110  C19/C18-Steroid hormone biosynthesis, pregnenolone => androstenedione => estrone
mnp_M00976  C19-Steroid hormone biosynthesis, pregnenolone => testosterone => dihydrotestosterone
mnp_M00977  C19-Steroid hormone biosynthesis (androgen backdoor pathway), pregnenolone => androsterone => dihydrotestosterone
Brite
KEGG Orthology (KO) [BR:mnp00001]
 09150 Organismal Systems
  09152 Endocrine system
   04913 Ovarian steroidogenesis
    132015377
   04917 Prolactin signaling pathway
    132015377
   04927 Cortisol synthesis and secretion
    132015377
 09160 Human Diseases
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    132015377
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450 [BR:mnp00199]
    132015377
Enzymes [BR:mnp01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.19  steroid 17alpha-monooxygenase
     132015377
    1.14.14.32  17alpha-hydroxyprogesterone deacetylase
     132015377
Cytochrome P450 [BR:mnp00199]
 Cytochrome P450, animal type
  CYP17 family
   132015377
SSDB
Motif
Pfam: p450
Other DBs
NCBI-GeneID: 132015377
NCBI-ProteinID: XP_059251906
LinkDB
Position
4:complement(166363616..166369606)
AA seq 508 aa
MWELLAFVLFALAYFLWPKAKRSSAKYPRSLPSLPLVGSLPFLPRGGHPHVNFFKLQKKY
GPIYSFRMGTKTTVMVGHHQLAKEVLVKKGKEFSGRPQVVTLDILSNNRKGIAFADHGAN
WQLHRKLVLTTFALFKDGDQRLEKIICQENSLLCDFLATQNGQSIDLSLPLFLAVTNIIC
LICFNSSYKNGDPALRIIKNYNDGILDSLGVDNMVDIFPGLKIFPNKTVEKMKNCVKMRD
ELLKDILRKCKENFSSDSITNLLDILIQAKMNLDNNNTTSDRDPKLLSDEYILTTVGDIF
GAGVETTTSVVKWTVAFLLHNPQLQKKIQEEIDQNVGFGRTPTMSDRNQLLLLEATIREV
LRIRPVAPMLIPHKAIVDSSIGEFAIDKGTSVIINLWALHHSEKEWHRPDQFLPERFLDP
TKSQLISPSLSYLPFGAGPRSCLGETLARQELFLVMSWLLQRFDLEVPDGGQLPSLEGNP
KMVFLIDAFKVKIKVRQAWRDAQAESSP
NT seq 1527 nt   +upstreamnt  +downstreamnt
atgtgggagctcctggctttcgtgctgttcgcccttgcctatttcttatggcccaaggca
aagcgctccagtgccaaatatcctcggagcctcccgtccctgcccttggtgggcagcctg
ccgttcctccccagaggtggccatccgcacgtgaacttcttcaagctgcagaaaaaatac
ggccccatctattcctttcgtatgggtaccaagactacggtgatggtgggccaccaccag
ctggccaaggaggtgcttgtcaagaaaggcaaggaattctctgggcggccccaagtggtg
actctggacatcctgtctaacaaccgaaagggcatcgccttcgcagaccatggtgccaac
tggcagctgcacaggaagctggtactgaccacatttgcactgttcaaggatggcgaccag
aggctagagaagatcatttgtcaggaaaacagtttactgtgtgatttcctggccacccag
aatgggcagtccatagacttgtccttgcctctcttcctggcggtgaccaacataatctgc
ttgatctgcttcaactcctcctacaagaatggagatcccgctctgaggatcataaagaat
tacaacgacggcatcttggattctttgggagtggataatatggtagacatattccccggg
ttgaagattttccccaacaaaaccgtggaaaaaatgaagaactgtgttaaaatgcgagat
gagttgctgaaagacatccttagaaaatgtaaggagaacttcagcagcgactccatcacc
aacctgctggacatactgatccaagccaagatgaacttggacaataacaacactacctca
gaccgggacccaaaactgctttcagatgaatacattctcaccactgtaggggacatcttt
ggggccggcgtagagaccaccacgtctgtggtgaaatggactgtggccttcttgctacac
aatcctcagttgcagaagaagatccaggaggaaattgaccagaatgtaggtttcggccgc
acaccaactatgagtgaccggaaccagctcctcttgctggaggccaccatccgagaggtg
ctccgcatccggcctgtggcccccatgctcatcccccacaaggctatcgttgattccagc
attggcgagtttgccattgacaagggcacaagtgtcatcatcaatctgtgggcactgcat
cacagtgagaaggagtggcaccggccagaccagttcctgccggagcgcttcttggacccc
acaaagagtcagctcatctctccatcgctaagttacttacccttcggagcaggaccccgc
tcttgcctaggcgagaccctggcccgccaggagctcttcctcgtcatgtcctggttgctg
caaaggtttgacctggaggtcccagatggcgggcagctgccttccctggagggcaacccc
aagatggtctttctgatcgacgctttcaaagtgaagatcaaggtgcgccaggcctggagg
gacgcccaggctgagagtagcccctag

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