Mustela nigripes (black-footed ferret): 132016195 Help Entry 132016195         CDS       T09425                                  Symbol RYR2 Name (RefSeq) ryanodine receptor 2 isoform X1   KO K04962   ryanodine receptor 2 Organism mnp  Mustela nigripes (black-footed ferret) Pathway mnp04020   Calcium signaling pathway mnp04024   cAMP signaling pathway mnp04260   Cardiac muscle contraction mnp04261   Adrenergic signaling in cardiomyocytes mnp04371   Apelin signaling pathway mnp04713   Circadian entrainment mnp04911   Insulin secretion mnp04921   Oxytocin signaling pathway mnp04972   Pancreatic secretion mnp05020   Prion disease mnp05022   Pathways of neurodegeneration - multiple diseases mnp05410   Hypertrophic cardiomyopathy mnp05412   Arrhythmogenic right ventricular cardiomyopathy mnp05414   Dilated cardiomyopathy mnp05415   Diabetic cardiomyopathy Brite KEGG Orthology (KO) [BR:mnp00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     132016195 (RYR2)    04020 Calcium signaling pathway     132016195 (RYR2)    04024 cAMP signaling pathway     132016195 (RYR2)  09150 Organismal Systems   09152 Endocrine system    04911 Insulin secretion     132016195 (RYR2)    04921 Oxytocin signaling pathway     132016195 (RYR2)   09153 Circulatory system    04260 Cardiac muscle contraction     132016195 (RYR2)    04261 Adrenergic signaling in cardiomyocytes     132016195 (RYR2)   09154 Digestive system    04972 Pancreatic secretion     132016195 (RYR2)   09159 Environmental adaptation    04713 Circadian entrainment     132016195 (RYR2)  09160 Human Diseases   09164 Neurodegenerative disease    05020 Prion disease     132016195 (RYR2)    05022 Pathways of neurodegeneration - multiple diseases     132016195 (RYR2)   09166 Cardiovascular disease    05410 Hypertrophic cardiomyopathy     132016195 (RYR2)    05412 Arrhythmogenic right ventricular cardiomyopathy     132016195 (RYR2)    05414 Dilated cardiomyopathy     132016195 (RYR2)    05415 Diabetic cardiomyopathy     132016195 (RYR2)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:mnp04040]     132016195 (RYR2)    04990 Domain-containing proteins not elsewhere classified [BR:mnp04990]     132016195 (RYR2) Ion channels [BR:mnp04040]  Voltage-gated cation channels   Ryanodine receptor    132016195 (RYR2) Domain-containing proteins not elsewhere classified [BR:mnp04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    132016195 (RYR2) SSDB OrthologParalogGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY MIR Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_8 Motif Other DBs NCBI-GeneID:  132016195 NCBI-ProteinID:  XP_059253344 LinkDB All DBs Position 4:complement(115293791..116033499) Genome browser AA seq 4893 aa AA seqDB search MMKTAQGGGHRTLLYGHAILLRHSYSGMYLCCLSTSRSSTDKLAFDVGLQEDTTGEACWW TIHPASKQRSEGEKVRVGDDLILVSVSSERYLHLSYGNGSLHVDAAFQQTLWSVAPISSG SEAAQGYLIGGDVLRLLHGHMDECLTVPSGEHGEEQRRTVHYEGGAVSVHARSLWRLETL RVAWSGSHIRWGQPFRLRHVTTGKYLSLMEDKSLLLMDKEKADVKSTAFTFRSSKEKLDV GVRKEVDGMGTSEIKYGDSVCYIQHINTGLWLTYQSVDVKSVRMGSIQRKAIMHHEGHMD DGLNLSRSQHEESRTARVIRSTVFLFNRFIRGLDALSKKVKSSTVDLPIESVSLSLQDLI GYFHPPDEHLEHEDKQNRLRALKNRQNLFQEEGMINLVLECIDRLHVYSSAAHFADVAGR EAGESWKSILNSLYELLAALIRGNRKNCAQFSGSLDWLISRLERLEASSGILEVLHCVLV ESPEALNIIKEGHIKSIISLLDKHGRNHKVLDVLCSLCVCHGVAVRSNQHLICDNLLPGR DLLLQTRLVNHVSSMRPNIFLGVSEGSAQYKKWYYELMVDHTEPFVTAEATHLRVGWAST EGYSPYPGGGEEWGGNGVGDDLFSYGFDGLHLWSGCIARTVSSPNQHLLRTDDVISCCLD LSAPSISFRINGQPVQGMFENFNIDGLFFPVVSFSAGIKVRFLLGGRHGEFKFLPPPGYA PCYEAVLPKEKLKVEHSREYKQERTYTRDLLGPTVSLTQAAFTPIPVDTSQIVLPPHLER IREKLAENIHELWVMNKIELGWQYGPVRDDNKRQHPCLVEFSKLPEQERNYNLQMSLETL KTLLALGCHVGISDEHAEEKVKKMKLPKNYQLTSGYKPAPMDLSFIKLTPSQEAMVDKLA ENAHNVWARDRIRQGWTYGIQQDVKNRRNPRLVPYALLDDRTKKSNKDSLREAVRTLLGY GYNLEAPDQDHAARAEVCSGTGERFRIFRAEKTYAVKAGRWYFEFEAVTAGDMRVGWSRP GCQPDQELGSDERAFAFDGFKAQRWHQGNEHYGRSWQAGDVVGCMVDMTEHTMMFTLNGE ILLDDSGSELAFKDFDVGDGFIPVCSLGVAQVGRMNFGKDVSTLKYFTICGLQEGYEPFA VNTNRDITMWLSKRLPQFLQVPSNHEHIEVTRIDGTIDSSPCLKVTQKSFGSQNSSTDIM FYRLSMPIECAEVFSKTVAGGLPGAGLFGPKNDLEDYDADSDFEVLMKTAHGHLVPDRVD KDKEATKPEFNNHKDYAQEKPSRLKQRFLLRRTKPDYSTSHSARLTEDVLADDRDDYDYL MQTSTYYYSVRIFPGQEPANVWVGWITSDFHQYDTGFDLDRVRTVTVTLGDEKGKVHESI KRSNCYMVCAGESMSPGQGRNNNGLEIGCVVDAASGLLTFTANGKELGTYYQVEPSTKLF PAVFAQATSPNVFQFELGRIKNVMPLSAGLFKSEHKNPVPQCPPRLHVQFLSHVLWSRMP NQFLKVDVSRISERQGWLVQCLDPLQFMSLHIPEENRSVDILELTEQEELLKFHYHTLRL YSAVCALGNHRVAHALCSHVDEPQLLYAIENKYMPGLLRAGYYDLLIDIHLSSYATARLM MNSEFIVPMTEETKSITLFPDENKKHGLPGIGLSTSLRPRIQFSSPSFVSINNECYQYSP EFPLDILKAKTIQMLTEAVKEGSLHARDPVGGTTEFLFVPLIKLFYTLLIMGIFHNEDLK HILRLIEPSVFKEATTPEEETDTLEKEPSLEDSKPDGAGEDEAKGGKRPKEGLLQMKLPE PVKLQMCLLLQYLCDCQVRHRIEAIVAFSDDFVAKLQDNQRFRYNEVMQALNMSAALTAR KTKEFRSPPQEQINMLLNFKDDKSECPCPEEIRDQLLDFHEDLMTHCGIELDEDGSLDGN SDLTIRGRLLSLVEKVTYLKKKQAEKPVESDSKKSSTLQQLISETMVRWAQESVIEDPEL VRAMFVLLHRQYDGIGGLVRALPKTYTINGVSVEDTINLLASLGQIRSLLSVRMGKEEEK LMIRGLGDIMNNKVFYQHPNLMRALGMHETVMEVMVNVLGGGESKEITFPKMVANCCRFL CYFCRISRQNQKAMFDHLSYLLENSSVGLASPAMRGSTPLDVAAASVMDNNELALALREP DLEKVVRYLAGCGLQSCQMLVSKGYPDIGWNPVEGERYLDFLRFAVFCNGESVEENANVV VRLLIRRPECFGPALRGEGGNGLLAAMEEAIKISEDPSRDGPSPTSGSSKTLDTEEEEDD TIHMGNAIMTFYAALIDLLGRCAPEMHLIHAGKGEAIRIRSILRSLIPLGDLVGVISIAF QMPTVAKDGNVVEPDMSAGFCPDHKAAMVLFLDRVYGIEVQDFLLHLLEVGFLPDLRAAA SLDTAALSATDMALALNRYLCTAVLPLLTRCAPLFAGTEHHASLIDSLLHTVYRLSKGCS LTKAQRDSIEVCLLSICGQLRPSMMQHLLRRLVFDVPLLNEHAKMPLKLLTNHYERCWKY YCLPGGWGNFGAASEEELHLSRKLFWGIFDALSQKKYEQELFKLALPCLSAVAGALPPDY MESNYVSMMEKQSSMDSEGNFNPQPVDTSNITIPEKLEYFINKYAEHSHDRWSMDKLANG WIYGEIYSDSSKVQPLMKPYKLLSEKEKEIYRWPIKESLKTMLAWGWRIERTREGDSMAL YNRTRRISQTSQVSVDAAHGYSPRAIDMSNVTLSRDLHAMAEMMAENYHNIWAKKKKMEL ESKGGGNHPLLVPYDTLTAKEKAKDREKAQDILKFLQINGYAVSRGFKDLELDTPSIEKR FAYSFLQQLIRYVDEAHQYILEFDGGSRSKGEHFPYEQEIKFFAKVVLPLIDQYFKNHRL YFLSAASRPLCSGGQASNKEKEMVTSLFCKLGVLVRHRISLFGNDATSIVNCLHILGQTL DARTVMKTGLESVKSALRAFLDNAAEDLEKTMENLKQGQFTHTRNQPRGVTQIINYTTVA LLPMLSSLFEHIGQHQFGEDLILEDVQVSCYRILTSLYALGTSKSIYVERQRSALGECLA AFAGAFPVAFLETHLDKHNIYSIYNTKSSRERAALNLPTNVEDVCPNIPSLEKLMEEIVE LAESGIRYTQMPHVMEVILPMLCSYMSRWWEHGPENNPERAEMCCTALNSEHMNTLLGNI LKIIYNNLGIDEGAWMKRLAVFSQPIINKVKPQLLKTHFLPLMEKLKKKAAMVVSEEDHL KAEARGDMSEAELLILDEFTTLARDLYAFYPLLIRFVDYNRAKWLKEPNPEAEDLFRMVA EVFIYWSKSHNFKREEQNFVVQNEINNMSFLITDTKSKMSKAAVSDQERKKMKRKGDRYS MQTSLIVAALKRLLPIGLNICAPGDQELIALAKNRFSMKDTEDEVRDIIRSNIHLQGKLE DPAIRWQMALYKDLPNRTEDTSDPEKTVERVLDIANVLFHLEQVEHPQRSKKAVWHKLLS KQRKRAVVACFRMAPLYNLPRHRAVNLFLQGYEKSWIETEEHYFEDKLIEDLAKPGANPP EEEEGTKRVDPLHQLILLFSRTALTEKCKLEEDFLYMAYADIMAKSCHDEEDDDGEEEVK SFEATGSQRSKHDIIKDLRNKFASLGENSLEKEMEKQKLLYQQARLHDRGAAEMVLQTIS ASKGDTGPMVAATLKLGIAILNGGNSTVQQKMLDYLKEKKDVGFFQSLAGLMQSCSVLDL NAFERQNKAEGLGMVTEEGSASHFESHRLQTGEKVLQDDEFTCDLFRFLQLLCEGHNSDF QNYLRTQTGNNTTVNIIISTVDYLLRVQESISDFYWYYSGKDVIDEQGQRNFSKAIQVAK QVFNTLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMQMKLSQDSSQIELLKELMDL QKDMVVMLLSMLEGNVVNGTIGKQMVDMLVESSNNVEMILKFFDMFLKLKDLTSSDTFKE YDPDGKGVISKRDFHKAMESHKHYTQSETEFLLSCAETDENETLDYEEFVKRFHEPAKDI GFNVAVLLTNLSEHMPNDTRLQTFLELAESVLNYFQPFLGRIEIMGSAKRIERVYFEISE SSRTQWEKPQVKESKRQFIFDVVNEGGEKEKMELFVNFCEDTIFEMQLAAQISESDLNER SANKDESEKEKPEEQGPRMGFFSILTVTSALLALRHNVLTLMRMLSLKSLKKQMKKVKKM TVKDMVTAAFSSYWSVFMSLLHFVASVSRGFFRIVCSLLLGGSLVEGAKKIRVAELLANM PDPTQDEVRGDGEEGDRKPMEAALPSEDLTDLKELTEESDLLSDIFGLDLKREGGQYKLI PHNPNAGLSDLMSNPVPIPDVQEKFQEQKVKEEEKEEKEENKSEPEKAEGEDGEKEEKTK EEKGKQKLRQLHTHRYGEPEVPESAFWKKIIAYQQKLLNYFARNFYNMRMLALFVAFAIN FILLFYKVSTSSVVEGKELPTRSLSENAKVSTLDTGSPRIIAVHYVLEESSGYMEPTLRI LAVLHTVISFFCIIGYYCLKVPLVIFKREKEVARKLEFDGLYITEQPSEDDIKGQWDRLV INTQSFPNNYWDKFVKRKVMDKYGEFYGRDRISELLGMDKAALDFSDAREKKKPKKDSSL SAVLNSIDVKYQMWKLGVVFTDNSFLYLAWYMTMSVLGHYNNFFFAAHLLDIAMGFKTLR TILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSEDGDTPDMKCDDMLTCYM FHMYVGVRAGGGIGDEIEDPAGDEYEIYRIIFDITFFFFVIVILLAIIQGLIIDAFGELR DQQEQVKEDMETKCFICGIGNDYFDTVPHGFETHTLQEHNLANYLFFLMYLINKDETEHT GQESYVWKMYQERCWEFFPAGDCFRKQYEDQLN NT seq 14682 nt NT seq  +upstreamnt  +downstreamnt atgatgaagactgctcaaggtggtggtcatcggacactcctctatggacatgccatattg ctccgccattcctacagtggcatgtatctgtgctgcctgtccacctcccggtcttcaact gataaactggcctttgatgttggcttgcaagaggacacaacaggggaggcttgctggtgg accattcatcccgcctccaagcagcggtcggaaggagagaaggttcgggtcggagatgac ctcatcttggtcagtgtgtcctctgagcggtacctgcatttgtcttacggcaatggaagc ttacacgtggacgctgctttccagcagactctctggagcgtggcccctatcagctcagga agcgaagccgcccaagggtatctaattggtggtgacgtcctcaggttgctgcacggacac atggatgaatgcctcactgtcccttcaggagaacacggggaagagcagcggagaactgtt cactatgaaggtggtgctgtatccgttcatgcacgttccctgtggagactagagacacta agagttgcgtggagtggaagccacataagatggggacagcctttccgactacgccatgtc acaacaggaaaatacttgagtctcatggaagacaaaagccttctgctcatggacaaagaa aaggctgatgtaaaatcaacggcatttaccttccgatcttccaaggaaaaattggatgta ggcgtgagaaaagaagttgatggcatggggacatctgaaataaaatatggagactcagta tgctacatacaacatataaatacgggcctgtggctgacttaccagtctgtggatgtgaaa tcagtgaggatgggatccatacaacgtaaagctattatgcatcacgaaggtcacatggac gatggcttgaatttatctagatctcagcatgaagaatcgcggactgcacgagtcatccgg agtacagttttccttttcaatagatttataaggggccttgatgcactcagcaagaaagtg aagtcttccacggtggacctccctatagaatctgtgagtctaagtctgcaggacctgatt ggttactttcaccccccagatgagcatttagagcatgaagacaagcagaacagattgcga gctctgaagaaccggcagaatctcttccaggaagagggaatgatcaacctcgtgctcgag tgtatagacaggctgcacgtgtacagcagcgcggcccactttgctgatgtcgccgggaga gaagccggcgagtcctggaagtcgattctgaattctctctatgagttgctagcggctcta attagaggaaatcgtaaaaactgtgctcaattttctggctcccttgactggttgatcagc cgattggaaagactagaagcttcttctggtattcttgaagttttacactgtgtgttagta gaaagtccagaagctctaaatattattaaggaaggacacattaaatccataatctctctt ttagacaagcatgggagaaaccacaaggttctggacgtcttgtgttctctctgtgtctgc catggagtagcagtccgttccaaccagcatctcatctgtgacaatctgctgccaggaaga gatctactgttgcagacacgtcttgtgaaccatgtcagcagcatgagacccaacattttt ctgggcgtcagtgaagggtccgctcagtataagaagtggtactatgagctgatggtggac cacacggagccgtttgtgaccgccgaagccacgcacctgcgggtgggctgggcgtccacc gaagggtactcgccctacccaggaggcggtgaggagtggggtggaaacggcgtcggagat gacctcttctcctacggattcgatggccttcatctctggtcaggctgcattgctcgtact gtaagctcaccaaaccagcatctgctgagaacggatgatgtcatcagttgctgtctagat ctgagtgccccgagcatctcattccgaatcaacggacaacctgttcaaggaatgtttgag aatttcaacattgatggcctcttctttccggttgttagtttctctgcaggaataaaggta cgctttctgcttggggggagacacggagaatttaaattcctcccgccacctgggtacgct ccttgttatgaagccgttctgccgaaagaaaagttgaaagtggagcacagtcgagagtac aagcaagaaaggacatacacacgggacctcctggggcccacggtctccctgacgcaggct gccttcacgcccatccctgtggataccagccagatcgtgttgcctcctcacctagagaga ataagagaaaaactggcagagaatatccatgaactttgggttatgaataaaattgaactt ggctggcagtatggtccggttagagatgacaataagagacagcacccctgtctggtggag ttctccaagctgcctgagcaggaacgcaattacaacttgcagatgtcgctggagaccctg aagactttgctggcgttaggatgtcatgtgggtatatcagacgaacatgctgaagaaaag gtgaaaaaaatgaagctgcctaagaattaccagctgacaagtgggtacaagcctgcccca atggacctgagctttatcaaactcaccccatctcaggaagcgatggtggacaagttggca gaaaatgcccataatgtgtgggcccgggatcgaatccggcagggctggacttatggcatc caacaggatgtaaagaacagaagaaaccctcgtctggttccctatgcccttctagatgac cgcaccaagaaatccaataaggacagcctccgtgaggccgtgcgcacgctgctggggtat ggctacaacctggaagcgccagatcaagatcatgctgccagagcggaggtgtgtagcggc accggggagcggttccgaatcttccgcgccgagaagacctacgctgtcaaggcaggaagg tggtattttgagttcgaggcagtcactgccggcgacatgagggttggctggagcaggcca ggttgtcaacctgaccaagagcttggctccgacgaacgtgcctttgcttttgatggcttc aaggcccagcggtggcaccagggtaatgagcactatgggcgctcttggcaagccggcgat gttgtgggatgtatggtggacatgacggagcacaccatgatgttcacactgaatggcgaa atccttctggatgattcgggctcagaactggcgttcaaggactttgatgttggcgatgga ttcattcctgtctgtagccttggagtggctcaagtgggccgcatgaactttggaaaggat gtcagcaccttgaaatatttcaccatctgtggcttacaagagggctatgaaccattcgca gttaacacgaacagggatattacgatgtggctgagcaagaggcttcctcagtttctccag gtcccatccaatcacgagcatatcgaggtgaccagaatagacggcaccatagacagttct ccgtgtttaaaggtcactcagaagtccttcggttctcagaacagcagcaccgatatcatg ttctatcggctgagcatgcccatcgaatgtgcagaggttttctccaagacggtggcagga ggactcccaggcgctgggctctttgggcccaagaatgatctggaggattatgatgcagat tctgactttgaggttctaatgaagaccgctcacggccatctggtgccagatcgagtggac aaagacaaggaagccacaaaaccagagtttaataaccacaaagattatgctcaggaaaag ccctctcgtctgaaacaaagatttttgcttagaagaacaaagccagattacagcacgagc cattctgcaagactcacggaagatgtccttgcagatgatcgagatgattacgattacttg atgcaaacatccacgtactattactcagtgagaatctttcctggccaagaacctgctaac gtctgggtaggctggattacatcagattttcatcaatatgatacaggctttgacttggac agagttcgtacagtaaccgttactctaggagacgagaagggaaaagtgcatgagagcatc aaacgcagtaactgctatatggtgtgtgcgggcgagagcatgagccccgggcaagggcgc aacaacaatggcctggagattgggtgtgtcgtggacgctgccagcgggctgctcacgttc actgccaacggcaaggagctgggcacgtactaccaggtggagccaagtacaaaattattt cctgcagtgtttgcacaagcaacaagtcccaatgttttccagtttgagttgggaagaata aagaatgtgatgcctctgtcggcgggattattcaagagcgagcacaaaaaccccgtgccg cagtgtccgccgcgtctccacgtgcagtttctgtcccacgtcctgtggagcaggatgccc aaccagttcttgaaggtagatgtctctcgaatcagtgagcgccaaggctggctggtgcag tgtttggatcctctgcagttcatgtctcttcatatcccggaggagaacaggtctgtggac atactggagctgacggagcaggaggagctgctgaaattccactatcacactctccggctt tactccgctgtctgcgctcttgggaaccaccgggtggcacacgccttgtgcagccatgtc gatgagcctcagcttctctacgccatcgagaacaagtacatgccgggcttgctgcgcgct ggctactatgacctgctgattgacatccacctgagctcctacgccacggccaggctcatg atgaacagtgagttcatcgtgcccatgacggaggagaccaagagcatcacccttttccct gacgagaacaaaaaacatggcctcccggggattggcctgagcacctccctcaggccacgg atacagttttcctcccccagttttgtaagcattaataatgaatgttaccagtacagtcca gagttcccgctggacatcctcaaggccaaaaccattcagatgttgacagaagctgttaag gagggcagccttcatgcccgggaccccgttggggggacaactgagttcctctttgtacct ctcatcaagcttttctacactctgctaatcatggggatcttccacaatgaggacttgaaa cacatcttgcggttgatagagcccagtgtgttcaaggaagccaccactccggaagaggag acggacacgctggagaaagagcccagcctagaagactccaagccagacggagctggtgaa gatgaagccaaagggggtaagaggcccaaggaaggcctgctccaaatgaaactgcctgag ccagttaaattgcagatgtgcctgctgcttcagtacctctgtgactgccaagtccggcac cggatagaagccattgtggccttttccgatgacttcgtagcaaagctccaagacaaccag cgttttcgatacaacgaagtaatgcaagccttaaacatgtcagctgccctcacagcccgg aaaacaaaggaatttagatcgccccctcaagagcagatcaatatgcttctcaattttaag gatgacaaaagtgaatgtccatgtcctgaagaaatccgtgaccagcttttagattttcat gaagatttgatgacacattgtggaattgagctggatgaagatgggtctttggatggaaac agtgacttaacaattagaggacgcctgctgtccctggtagaaaaggtgacatacctgaag aagaaacaagctgaaaaaccagttgagagtgactccaagaagtcctccactcttcaacag ttgatttctgaaaccatggtccgatgggcacaagagtctgtcattgaagaccccgagttg gtgagggccatgtttgtgttgctccatcgacagtacgatggcattgggggtctggtccgg gctctgccaaagacctacactataaatggtgtctccgtggaggataccatcaacctgctg gcgtctcttggtcagatccgttctctgctgagcgtaagaatgggcaaagaagaagagaag cttatgattcgtggattaggggatatcatgaataataaagtattttaccagcaccctaat ctcatgagggcacttgggatgcatgagacagtgatggaggtcatggtgaatgtccttgga ggtggagagtccaaggaaatcacttttcccaagatggtggccaactgttgccgtttcctt tgttacttctgtcgtataagtaggcagaatcaaaaagctatgtttgatcatctcagctat ttactggagaatagcagtgtcggtcttgcctcaccagctatgagaggttcaacgccgttg gatgtggcagccgcgtcggtgatggataataatgaactggccttagctctgcgtgaacca gatctggaaaaggtagttcgatatttggctggttgtggactgcagagctgccagatgttg gtgtctaagggttatccagacattggttggaatccagttgaaggagagagatatcttgac tttctcagatttgctgtcttctgtaatggggagagcgtggaagagaacgcgaacgttgtg gtgaggttgctcatccggaggcctgagtgtttcggtcctgctctgagaggggaaggtggg aatggtctgctcgcagccatggaagaagccataaaaatatctgaggatccctcacgagat ggtccgtccccaactagtggatccagtaaaacacttgatacagaagaggaggaagatgac actatccacatggggaatgccatcatgaccttttatgcagccttgattgacctcttagga cgctgtgctcctgaaatgcatttgattcatgctggtaagggggaagccatccgaattcgg tccattttgagatccctaattccgctgggagatttggtgggagtaatcagcattgctttt cagatgccaacagtagccaaagatgggaatgtggtggagcctgacatgtctgcagggttt tgcccagatcacaaggcagccatggttttgttccttgacagggtctatggaattgaggtt caagatttcctcctccatcttctcgaggttggctttctgccagatctccgggctgctgct tctttagatacggctgctctgagtgctacagacatggccttggccctcaatcgatacctt tgcacagccgtgctgcctctgttaacaagatgtgcccccctttttgcgggcacagagcac catgcttctctcattgactccttacttcacactgtgtacagactctctaagggctgctct ctcaccaaagctcagcgggattccatagaagtttgtttactctctatttgtggccaactg agaccttctatgatgcagcacttgctccgaagattagtatttgacgtcccgttattaaat gaacatgcaaagatgcctcttaagctgctgacaaatcattatgaaagatgctggaagtat tactgtttgcctggagggtgggggaactttggagctgcctctgaagaagagcttcattta tcaagaaagctgttttggggcatctttgacgccctgtctcaaaagaaatatgaacaagaa cttttcaaactggcactgccttgcctgagtgcagttgcgggagctttgcccccagactac atggagtcaaattatgtcagtatgatggaaaaacagtcatcaatggattctgaagggaac tttaacccacaacctgttgatacctcaaatattacaatccccgagaagctggaatacttc attaacaagtacgcagaacattctcatgacagatggtcaatggacaagttggcaaatgga tggatttatggagaaatatattcagactcgtctaaagttcaaccattaatgaagccatat aaactattatccgaaaaggaaaaagaaatttatcgctggccgatcaaagagtctttaaaa accatgctggcgtggggttggaggattgagagaacgagggagggagacagcatggccctc tacaatcggacgcgtcgcatttctcagacaagtcaggtttctgtggatgctgcacacggg tatagtcctcgagccattgatatgagcaacgtcacactgtcccgagacctgcacgctatg gcagaaatgatggctgaaaactaccacaatatatgggcaaagaaaaagaaaatggagctg gaatccaaaggaggtggaaaccatcccctgctggtaccctatgatacgctgacagccaaa gagaaggccaaggatagggaaaaagcacaggacatcctcaagttcttgcagatcaatggc tacgccgtatccaggggattcaaagacctggaattggacacaccgtccattgagaaacga tttgcttatagcttccttcagcaactcattcgctacgtcgatgaagcccatcagtatatc ctggagtttgatggtggcagcagaagcaaaggagaacatttcccttatgaacaagaaatc aagttcttcgctaaagttgttcttcccttaattgatcagtatttcaaaaaccatcgttta tacttcttgtctgccgcaagtcgacctctttgttctggaggacaagcatcaaacaaggag aaagaaatggtgactagcctattctgcaaacttggagttcttgtcaggcataggatttca ctatttggaaatgatgccacatcaattgtcaactgccttcatattttgggtcagaccttg gatgccaggactgtgatgaagactggcctagagagtgttaaaagcgcactccgagctttt ctggacaacgctgcagaggacctggagaagaccatggagaacctcaagcagggccagttc acccacacccgaaaccaacccagaggtgtcactcagatcatcaattacaccacggtggct ctgttgccgatgctgtcgtcattatttgagcatattggccagcatcagtttggagaagat ctaatattggaagatgtacaggtatcatgttacagaattctgactagcttgtatgctcta ggaaccagcaaaagtatttatgtggaaaggcaacgatctgcgttaggagaatgtcttgct gcttttgctggtgcctttcctgtagcatttttggaaactcatctcgacaaacataacatt tattccatctacaatactaagtcctcacgagaaagagcagctctcaatttgccaactaat gtggaagatgtttgcccaaatataccgtctttggagaaactcatggaagaaattgtggaa ttagccgagtctggcattcgctacacacaaatgccccatgtgatggaagtcatactgccc atgctttgcagctacatgtcccgttggtgggagcacggacccgaaaacaacccggaaagg gctgaaatgtgctgcacagcgctgaactccgagcacatgaacacgctcctggggaatata ttgaaaatcatatataataacttgggaattgatgagggcgcgtggatgaagaggttagca gttttttcgcagcccattataaataaagtgaaacctcagctcctaaaaactcatttcttg ccattaatggagaaactcaagaaaaaagcggcgatggtggtgtctgaggaggaccatctg aaggcggaggccaggggggatatgtccgaggcagaacttctcattctcgatgagttcacc acgctggccagagatctctatgccttctacccgctactgattagatttgtagactacaac agggcaaagtggttaaaagagcctaaccctgaagcagaggaccttttccgcatggtggcc gaagtgtttatctactggtctaaatcccataatttcaaaagagaagagcagaacttcgtg gtacagaatgaaatcaacaatatgtctttcctcattactgacaccaaatcaaagatgtca aaggcagctgtctctgatcaggagaggaagaaaatgaagcgcaaaggagatcgatactcg atgcagacgtcccttattgtggcagctctgaagcgactgctgcccattgggttgaacatc tgtgcgcctggggaccaggagctcattgctctggccaaaaaccgatttagtatgaaagac actgaagatgaagtacgagatataatccgcagtaatattcatttacaaggcaagttggag gatcctgctattcgatggcaaatggctctttacaaagacttaccgaacaggaccgaagat acgtcggatccagagaagactgtggaaagagtattagatatagcgaatgtgcttttccat cttgagcaggtggagcatccacagagatcgaagaaggctgtatggcacaaactgttatcc aagcagaggaaaagggcagtggtagcctgcttccggatggctcctttatacaatctgcca aggcaccgggctgtcaatctctttcttcagggatatgagaagtcttggattgaaacggaa gaacactattttgaagataaactgatagaagatttagcaaaacctggagccaaccctcca gaagaagaagaaggcacgaagcgagttgatcccctccatcagctcatacttctgtttagt cgaacagctttaacagagaaatgcaaactggaggaagattttttatatatggcgtatgca gatattatggcaaagagttgtcatgatgaggaagatgatgatggggaagaagaagtgaag agttttgaagccacaggatcccaacgcagcaagcacgatattatcaaagatttaagaaac aaatttgccagcctcggcgagaactctctggaaaaagaaatggaaaagcaaaagctactc taccaacaagccaggctccacgaccgcggggcagctgagatggtgctacagaccatcagt gccagcaaaggggatacaggaccaatggtagctgcgactttgaaacttggaattgctatc ttaaatgggggcaactccacagtgcagcagaaaatgcttgactacctcaaggagaaaaag gatgtgggcttctttcagagtctggctggcctgatgcagtcctgtagtgtcctcgaccta aatgcatttgagagacaaaacaaagctgaaggacttggaatggtgaccgaagaaggatca gcctctcactttgaaagtcacagactacagactggagaaaaggttctccaggacgacgaa ttcacttgcgacctctttcgcttcctacaactgctctgtgagggacacaactcagatttt caaaattatctgagaactcagactggcaataatacgactgtgaacataatcatctcgacc gtagactacctcctgagagtccaggaatccattagcgatttctactggtattactctggg aaagatgttattgatgaacaaggacaacggaatttctccaaagcaattcaagtagcaaag caagtctttaacactctcacagagtatattcagggtccttgcaccgggaatcagcagagc ttggcccacagcaggctgtgggatgcagttgtgggctttcttcacgtatttgcccacatg cagatgaagctgtctcaggattccagtcaaattgagctcttaaaagaattaatggatctt cagaaggatatggtggtcatgttgctgtccatgttagaaggaaatgttgtcaatggaacc atcggcaagcagatggtcgacatgctcgtggaatcttccaacaacgtggagatgattcta aagttttttgacatgttcttaaaactaaaggatttgacatcttctgacacatttaaggaa tatgatcccgacggcaagggagtcatttccaagagggacttccataaagcgatggagagc cataagcactacacacagtccgaaaccgagtttcttttgtcctgcgcggagaccgacgaa aacgagaccctcgactatgaagagttcgtcaaacggttccacgagcctgcgaaggacatc ggcttcaacgtcgccgttctcctgaccaacctgtctgaacacatgcccaacgacacccgg ctgcagaccttcctggagctggccgagagcgtgctgaactacttccagcccttcctgggc cgcatcgagatcatgggaagcgccaagcgcatcgagcgggtctatttcgaaatcagcgag tccagccgcacgcagtgggagaagccccaggtcaaggagtccaaacggcagttcatattc gatgtggtcaacgaagggggagagaaggagaagatggagctcttcgtcaacttctgcgag gacaccatcttcgagatgcagctggcggcgcagatctcagagtcggatctgaatgagagg tcggcgaacaaggacgagagtgagaaggagaagccggaagaacaggggcccaggatgggc ttcttttccatcctgacggtcacgtcggccctgctggctcttaggcacaatgtcttgact ctcatgcgaatgctcagcctgaagagcctgaagaaacagatgaagaaggtgaagaagatg accgtgaaggacatggtcacagccgccttttcgtcctactggagcgtcttcatgagcctc ctgcatttcgtggccagcgtttccagaggcttcttccgcatcgtctgcagcctgctgctg gggggcagcctggtagaaggagcgaagaagatcagggtggcggagctcttagctaacatg ccggaccccacccaggacgaggtgaggggggacggcgaggagggggacaggaagcccatg gaggccgccctgccctcggaagacctcacagacctgaaggaactgacggaggaaagcgac ctcctttcggacatattcggcttggatctgaagagagaaggaggacagtacaaactcatt cctcataacccgaacgctggcctcagtgacctcatgagcaacccggtccccatccccgac gtgcaagaaaaattccaggaacagaaggtgaaagaggaagaaaaggaggaaaaagaagaa aacaaatctgaacccgaaaaggccgagggagaagatggagaaaaagaagaaaaaaccaaa gaagagaagggtaaacagaagttgaggcagctccacacacacagatatggagagccagaa gttcctgagtcagcgttctggaagaaaatcatagcatatcaacagaaacttctaaactat tttgctcgcaacttttacaacatgagaatgttagccttatttgtcgcatttgcaatcaat ttcatcttgctcttttataaggtctccacttcttctgtggttgaaggaaaggagctcccc acacgcagtttgagtgaaaatgccaaagtcagcaccctagacactggctcgccccgaatc atcgcggttcactatgtcctggaggagagcagtggctatatggagcccacgctgaggatc ctagctgttctccacacagtcatttctttcttctgcatcatcggatactactgcttgaaa gtcccattggttatttttaagcgagaaaaggaagtagctcgaaaactggaatttgatggg ctttatattacagaacaaccttcagaagatgatattaaaggccagtgggatagacttgta atcaacacacagtcatttcccaacaactactgggacaaatttgttaaaagaaaggttatg gataagtacggagagttctacggccgggacagaatcagcgagctcctaggcatggacaaa gccgctctggacttcagcgatgcccgggagaagaagaagccgaagaaagacagctccctg tcagctgtattgaactctatcgatgtgaagtatcagatgtggaaactcggagtcgtcttc actgacaactccttcctctacttggcctggtatatgactatgtccgttcttggacactat aataacttcttttttgctgctcatcttctcgatattgctatgggatttaagacgctaaga accattttgtcatcggtaactcacaatggcaagcagcttgtattaactgttggcttatta gctgttgttgtatacctatatactgttgtggcattcaattttttccgaaaattctacaat aaaagtgaagacggtgatacccccgatatgaaatgcgatgatatgctaacgtgctatatg ttccacatgtatgtcggggtacgtgctggaggagggatcggtgatgaaatcgaagaccca gcaggcgatgaatatgagatctatcgaatcatctttgacatcaccttcttcttcttcgtg attgtcattctcttggccataatacaaggtttaattattgatgcttttggagaactaaga gaccaacaggagcaagtcaaagaagacatggagaccaaatgctttatctgtgggataggc aacgattacttcgacacagtaccacatggctttgaaactcacactttacaggaacacaat ctggccaattacctgttttttctgatgtatctcataaacaaagatgaaacagagcacaca ggacaggaatcttatgtctggaagatgtatcaagaaaggtgctgggaatttttcccagca ggggactgtttccggaaacagtatgaggaccagctaaattaa

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