KEGG   Mustela nigripes (black-footed ferret): 132021307
Entry
132021307         CDS       T09425                                 
Symbol
SOS1
Name
(RefSeq) son of sevenless homolog 1 isoform X1
  KO
K03099  son of sevenless
Organism
mnp  Mustela nigripes (black-footed ferret)
Pathway
mnp01521  EGFR tyrosine kinase inhibitor resistance
mnp01522  Endocrine resistance
mnp04010  MAPK signaling pathway
mnp04012  ErbB signaling pathway
mnp04014  Ras signaling pathway
mnp04062  Chemokine signaling pathway
mnp04068  FoxO signaling pathway
mnp04072  Phospholipase D signaling pathway
mnp04150  mTOR signaling pathway
mnp04151  PI3K-Akt signaling pathway
mnp04510  Focal adhesion
mnp04540  Gap junction
mnp04630  JAK-STAT signaling pathway
mnp04650  Natural killer cell mediated cytotoxicity
mnp04660  T cell receptor signaling pathway
mnp04662  B cell receptor signaling pathway
mnp04664  Fc epsilon RI signaling pathway
mnp04714  Thermogenesis
mnp04722  Neurotrophin signaling pathway
mnp04810  Regulation of actin cytoskeleton
mnp04910  Insulin signaling pathway
mnp04912  GnRH signaling pathway
mnp04915  Estrogen signaling pathway
mnp04917  Prolactin signaling pathway
mnp04926  Relaxin signaling pathway
mnp04935  Growth hormone synthesis, secretion and action
mnp05034  Alcoholism
mnp05160  Hepatitis C
mnp05161  Hepatitis B
mnp05163  Human cytomegalovirus infection
mnp05165  Human papillomavirus infection
mnp05200  Pathways in cancer
mnp05205  Proteoglycans in cancer
mnp05206  MicroRNAs in cancer
mnp05207  Chemical carcinogenesis - receptor activation
mnp05208  Chemical carcinogenesis - reactive oxygen species
mnp05210  Colorectal cancer
mnp05211  Renal cell carcinoma
mnp05213  Endometrial cancer
mnp05214  Glioma
mnp05215  Prostate cancer
mnp05220  Chronic myeloid leukemia
mnp05221  Acute myeloid leukemia
mnp05223  Non-small cell lung cancer
mnp05224  Breast cancer
mnp05225  Hepatocellular carcinoma
mnp05226  Gastric cancer
mnp05231  Choline metabolism in cancer
Brite
KEGG Orthology (KO) [BR:mnp00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    132021307 (SOS1)
   04012 ErbB signaling pathway
    132021307 (SOS1)
   04014 Ras signaling pathway
    132021307 (SOS1)
   04630 JAK-STAT signaling pathway
    132021307 (SOS1)
   04068 FoxO signaling pathway
    132021307 (SOS1)
   04072 Phospholipase D signaling pathway
    132021307 (SOS1)
   04151 PI3K-Akt signaling pathway
    132021307 (SOS1)
   04150 mTOR signaling pathway
    132021307 (SOS1)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    132021307 (SOS1)
   04540 Gap junction
    132021307 (SOS1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    132021307 (SOS1)
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    132021307 (SOS1)
   04660 T cell receptor signaling pathway
    132021307 (SOS1)
   04662 B cell receptor signaling pathway
    132021307 (SOS1)
   04664 Fc epsilon RI signaling pathway
    132021307 (SOS1)
   04062 Chemokine signaling pathway
    132021307 (SOS1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    132021307 (SOS1)
   04912 GnRH signaling pathway
    132021307 (SOS1)
   04915 Estrogen signaling pathway
    132021307 (SOS1)
   04917 Prolactin signaling pathway
    132021307 (SOS1)
   04926 Relaxin signaling pathway
    132021307 (SOS1)
   04935 Growth hormone synthesis, secretion and action
    132021307 (SOS1)
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    132021307 (SOS1)
  09159 Environmental adaptation
   04714 Thermogenesis
    132021307 (SOS1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    132021307 (SOS1)
   05206 MicroRNAs in cancer
    132021307 (SOS1)
   05205 Proteoglycans in cancer
    132021307 (SOS1)
   05207 Chemical carcinogenesis - receptor activation
    132021307 (SOS1)
   05208 Chemical carcinogenesis - reactive oxygen species
    132021307 (SOS1)
   05231 Choline metabolism in cancer
    132021307 (SOS1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    132021307 (SOS1)
   05225 Hepatocellular carcinoma
    132021307 (SOS1)
   05226 Gastric cancer
    132021307 (SOS1)
   05214 Glioma
    132021307 (SOS1)
   05221 Acute myeloid leukemia
    132021307 (SOS1)
   05220 Chronic myeloid leukemia
    132021307 (SOS1)
   05211 Renal cell carcinoma
    132021307 (SOS1)
   05215 Prostate cancer
    132021307 (SOS1)
   05213 Endometrial cancer
    132021307 (SOS1)
   05224 Breast cancer
    132021307 (SOS1)
   05223 Non-small cell lung cancer
    132021307 (SOS1)
  09172 Infectious disease: viral
   05161 Hepatitis B
    132021307 (SOS1)
   05160 Hepatitis C
    132021307 (SOS1)
   05163 Human cytomegalovirus infection
    132021307 (SOS1)
   05165 Human papillomavirus infection
    132021307 (SOS1)
  09165 Substance dependence
   05034 Alcoholism
    132021307 (SOS1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    132021307 (SOS1)
   01522 Endocrine resistance
    132021307 (SOS1)
SSDB
Motif
Pfam: RasGEF RasGEF_N RhoGEF SOS1_NGEF_PH PH PH_10 PH_19 IQ_SEC7_PH RHG20_PH Takusan
Other DBs
NCBI-GeneID: 132021307
NCBI-ProteinID: XP_059261475
LinkDB
Position
7:complement(31665890..31812319)
AA seq 1333 aa
MQAQQLPYEFFSEENAPKWRGLLVPALKKVQGQVHPTLESSDDALQYVEELILQLLNMLC
QAQPRSASDVEERVQKSFPHPIDKWAIADAQSAIEKRKRRNPLSLPVEKIHPLLKEVLGY
KIDHQVSVYIVAVLEYISADILKLVGNYVRNIRHYEITKQDIKVAMCADKVLMDMFHQDV
EDINILSLTDEEPSTSGEQTYYDLVKAFMAEIRQYIRELNLIIKVFREPFVSNSKLFSAN
DVENIFSRIVDIHELSVKLLGHIEDTVEMTDEGSPHPLVGSCFEDLAEELAFDPYESYAR
DILRPGFHDRFLSQLSKPGAALYLQSIGEGFKEAVQYVLPRLLLAPVYHCLHYFELLKQL
EEKSEDQEDKECLKQAITALLNVQSGMEKICSKSLAKRRLSESACRFYSQQMKGKQLAIK
KMNEIQKNIDGWEGKDIGQCCNEFIMEGTLTRVGAKHERHIFLFDGLMICCKSNHGQPRL
PGASNAEYRLKEKFFMRKVQINDKDDTSEYKHAFEIILKDENSVIFSAKSAEEKNNWMAA
LISLQYRSTLERMLDVTMLQEEKEEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPI
IKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADR
IAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDADLLQRMEEFIGT
VRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLH
PIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIV
ETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKI
LEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSK
RRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRN
PKPLPRFPKKYSYPLKSPGVRPSNPRPGTMRHPTPLQQEPRKISYSRIPESETESTASAP
NSPRTPLTPPPASGASSTTDVCSVFDSDHSSPFHSSSDTVFIQVSLPHGPRSASVSSISL
TKGTDEVPVPPPVPPRRRPESAPAESSPSKIMSKHLDSPPAIPPRQPTSKAYSPRYSISD
RTSISDPPESPPLLPPREPVRTPDVFSSSPLHLQPPPLGKKSDHGNAFFPNSPSPFTPPP
PQTPSPHGTRRHLPSPPLTQEVDLPSITGPPVPPRQSTSQHIPKLPPKTYKREHTHPSMH
RDGPPLLENAHSS
NT seq 4002 nt   +upstreamnt  +downstreamnt
atgcaggcgcagcagctgccgtacgagtttttcagcgaggagaacgcacccaagtggcgg
gggctgctggtgccggcgctgaaaaaggtccaggggcaagttcatccaactcttgagtct
agtgatgatgctcttcaatatgttgaagaattaattttgcagttattaaatatgctatgc
caagctcagccccgaagtgcttcagatgtagaggaacgtgttcaaaaaagtttccctcat
ccaattgataagtgggcaatagctgatgcccagtcggctattgaaaagaggaagcgaaga
aaccctttatctctcccagtagaaaaaattcatcctttactaaaggaggtcctaggttat
aaaattgaccaccaggtctctgtttacatagtagcagtattagaatacatttctgcagac
attttaaagctggtggggaattatgtacgaaatatacggcattatgaaattacaaagcag
gatattaaagtggcaatgtgtgctgataaggtattaatggacatgtttcatcaagatgta
gaagatataaatatattatctttaactgatgaagagccttccacctcaggagagcaaact
tactatgatttggtaaaagcatttatggcagaaattcgacagtacataagggaactaaat
ttaattataaaagtttttagagagccctttgtctccaattcaaaattgttttcagctaat
gatgtagaaaatatatttagtcgtatagtagatatacatgaacttagtgtaaagttactg
ggccatatagaagatactgtggaaatgactgatgaaggtagcccccatcccttagtagga
agctgctttgaagacttagcagaggaactggcctttgatccatacgaatcatacgctcgc
gatatcttacggcctggttttcacgatcgtttccttagtcagttatcaaagcctggagca
gcactctatttacagtcaataggcgaaggcttcaaagaagctgttcagtatgttctgccc
aggctacttctagcccctgtttaccactgtctgcattactttgaacttttgaagcagtta
gaagaaaagagtgaagatcaagaagacaaggaatgtttgaaacaagcaataacagctttg
cttaatgttcagagtggtatggaaaaaatatgttctaaaagtcttgcaaaacgaagattg
agtgaatctgcatgtcggttttatagtcagcaaatgaaggggaaacaactagcaatcaag
aaaatgaacgagattcaaaagaatattgatggttgggagggaaaagacattggacagtgt
tgcaatgaatttataatggaaggaactcttacacgtgtaggagccaaacatgagagacac
atatttctctttgatggcttaatgatttgctgtaaatcaaatcatgggcagccaagactt
cctggtgctagcaatgcagaataccgtcttaaagaaaagtttttcatgagaaaggtacaa
attaatgacaaagatgacaccagtgagtacaagcatgcttttgaaataattttaaaagat
gaaaatagtgttatattttctgccaagtcagctgaagagaaaaacaattggatggcagcc
ttgatatctttacaataccggagtacgctggagaggatgcttgatgtgacgatgctgcag
gaagagaaggaggagcagatgaggctccctagtgccgatgtttatagatttgcagagcct
gactctgaagagaatataatatttgaagaaaacatgcagcccaaggctggaattccaatt
atcaaagcaggaactgttattaagctaatagagaggctcacataccatatgtatgcagat
cccaattttgttcggacatttcttacaacatacagatccttttgtaaacctcaagaacta
ctgagtcttataatagaaaggtttgaaattccagagcctgagcccacagaagctgatcgc
atagctatagagaatggagatcagcccttgagtgcagaactaaaaaggtttagaaaagaa
tacatacagcctgtacagctgcgagtattaaatgtatgtcggcattgggtagagcaccac
ttctatgattttgaaagggatgcagatcttttgcagcgaatggaagaatttattggaaca
gtgagaggtaaagctatgaaaaaatgggttgaatccatcactaaaataatccaaaggaaa
aaaattgcaagagacaatggaccaggtcataatattacatttcagagttcacctcccacg
gttgagtggcatataagcaggcctgggcacatagagacttttgacctgctcaccttacac
ccaatagaaattgctcgacaactcactttacttgaatcagatctatatagagctgtacaa
ccatcagaattagttggaagtgtgtggactaaagaagacaaagaaattaattctcctaat
ctcctaaaaatgatccggcataccacgaatctcactctgtggtttgagaaatgtattgta
gaaactgaaaacttagaagaaagagtagctgtggtgagtcgaatcattgagattctacaa
gtctttcaagagctgaacaacttcaatggtgtccttgaggttgtcagtgctatgaactcc
tcacctgtttacagactagatcacacatttgagcaaataccaagtcgccaaaagaaaatc
ttagaagaagctcatgaattaagtgaagatcactataagaaatatttggcaaaactcagg
tctattaatccaccatgtgtgcctttctttggaatttacctaactaatatcttgaaaaca
gaagaaggcaaccctgaggtcctaaaaaggcatggaaaagagcttataaactttagcaaa
aggaggaaagtagcagaaataacaggagagatccagcagtaccaaaatcagccttattgt
ttacgagtagaatcagatatcaaaaggttctttgaaaatttgaatccaatgggaaatagc
atggaaaaagaatttacagattatcttttcaacaaatccctagaaatagaaccacgaaac
cctaagcctcttccaagatttccaaaaaaatatagctatcccctaaaatctcctggcgtt
cgtccatcaaacccaagaccaggtaccatgagacatcccacacctctgcagcaggagcca
aggaaaattagttacagtaggatccctgaaagtgaaacagaaagtacagcatctgcacca
aattctccaagaacaccgttaacacctcctcctgcgtctggtgcttctagtaccaccgat
gtttgcagcgtttttgattccgatcattcgagcccttttcattcaagcagcgataccgtc
tttatccaagtttcactgccccatggcccaagatctgcttcagtatcatctataagttta
accaagggcactgatgaggtgcccgtcccccctcctgttcctccacgaagacggccggaa
tctgcccccgccgaatcttcgccatctaagattatgtctaagcatttggacagcccccca
gcaattcctcctaggcagcccacatcaaaagcctattcgccacgatactccatatcagac
cggacctctatatcagaccctcctgagagccctcccttattaccaccacgagaacctgtg
aggacacctgatgttttctccagctcaccactacatctccagcctccccctttgggcaaa
aaaagcgatcatggcaatgccttcttcccaaatagcccttccccttttacaccacctcct
cctcaaacaccctctcctcatggcacaagaaggcacttgccgtcgccaccactgacacaa
gaagtggaccttccttccatcaccgggccgcctgttcctccacgacaaagcacttctcag
catatccctaaactccctccaaaaacttataaaagggagcacacgcacccatccatgcac
agagatggacccccactgttggagaatgcccattcctcctga

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