Microtus oregoni (creeping vole): 121432610 Help Entry 121432610         CDS       T08307                                  Symbol Ryr2 Name (RefSeq) ryanodine receptor 2 isoform X1   KO K04962   ryanodine receptor 2 Organism morg  Microtus oregoni (creeping vole) Pathway morg04020   Calcium signaling pathway morg04024   cAMP signaling pathway morg04260   Cardiac muscle contraction morg04261   Adrenergic signaling in cardiomyocytes morg04371   Apelin signaling pathway morg04713   Circadian entrainment morg04911   Insulin secretion morg04921   Oxytocin signaling pathway morg04972   Pancreatic secretion morg05020   Prion disease morg05022   Pathways of neurodegeneration - multiple diseases morg05410   Hypertrophic cardiomyopathy morg05412   Arrhythmogenic right ventricular cardiomyopathy morg05414   Dilated cardiomyopathy morg05415   Diabetic cardiomyopathy Brite KEGG Orthology (KO) [BR:morg00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     121432610 (Ryr2)    04020 Calcium signaling pathway     121432610 (Ryr2)    04024 cAMP signaling pathway     121432610 (Ryr2)  09150 Organismal Systems   09152 Endocrine system    04911 Insulin secretion     121432610 (Ryr2)    04921 Oxytocin signaling pathway     121432610 (Ryr2)   09153 Circulatory system    04260 Cardiac muscle contraction     121432610 (Ryr2)    04261 Adrenergic signaling in cardiomyocytes     121432610 (Ryr2)   09154 Digestive system    04972 Pancreatic secretion     121432610 (Ryr2)   09159 Environmental adaptation    04713 Circadian entrainment     121432610 (Ryr2)  09160 Human Diseases   09164 Neurodegenerative disease    05020 Prion disease     121432610 (Ryr2)    05022 Pathways of neurodegeneration - multiple diseases     121432610 (Ryr2)   09166 Cardiovascular disease    05410 Hypertrophic cardiomyopathy     121432610 (Ryr2)    05412 Arrhythmogenic right ventricular cardiomyopathy     121432610 (Ryr2)    05414 Dilated cardiomyopathy     121432610 (Ryr2)    05415 Diabetic cardiomyopathy     121432610 (Ryr2)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:morg04040]     121432610 (Ryr2)    04990 Domain-containing proteins not elsewhere classified [BR:morg04990]     121432610 (Ryr2) Ion channels [BR:morg04040]  Voltage-gated cation channels   Ryanodine receptor    121432610 (Ryr2) Domain-containing proteins not elsewhere classified [BR:morg04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    121432610 (Ryr2) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY Ins145_P3_rec MIR RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_8 Motif Other DBs NCBI-GeneID:  121432610 NCBI-ProteinID:  XP_041486621 LinkDB All DBs Position Unknown AA seq 4979 aa AA seqDB search MADAGEGEDEIQFLRTDDEVVLQCTATVHKEQQKLCLAAEGFGNRLCFLESTSNSKNVPP DLSICTFVLEQSLSVRALQEMLANTMEKSEGQVDVEKWKFMMKTAQGGGHRTLLYGHAIL LRHSYSGMYLCCLSTSRSSTDKLAFDVGLQEDTTGEACWWTIHPASKQRSEGEKVRVGDD LILVSVSSERYLHLSYGNSSWHVDAAFQQTLWSVAPISSGSEAAQGYLIGGDVLRLLHGH MDECLTVPSGEHGEEQRRTVHYEGGAVSVHARSLWRLETLRVAWSGSHIRWGQPFRLRHV TTGKYLSLMEDKNLLLMDKEKADVKSTAFAFRSSKEKLDVGVRKEVDGMGTSEIKYGDSI CYIQHVDTGLWLTYQSVDVKSARMGSIQRKAIMHHEGHMDDGLNLSRSQHEESRTARVIR STVFLFNRFIRGLDALSKKAKAPTIDLPIESVSLSLQDLIGYFHPPDEHLEHEDKQNRLR ALKNRQNLFQEEGMINLVLECIDRLHVYSSAAHFADVAGREAGESWKSILNSLYELLAAL IRGNRKNCAQFSGSLDWLISRLERLEASSGILEVLHCVLVESPEALNIIKEGHIKSIISL LDKHGRNHKVLDVLCSLCVCHGVAVRSNQHLICDNLLPGRDLLLQTRLVNHVSSMRPNIF LGVSEGSAQYKKWYYELMVDHTEPFVTAEATHLRVGWASTEGYSPYPGGGEEWGGNGVGD DLFSYGFDGLHLWSGCIARTVSSPNQHLLRTDDVISCCLDLSAPSISFRINGQPVQGMFE NFNIDGLFFPVVSFSAGIKVRFLLGGRHGEFKFLPPPGYAACYEAVLPKEKLKVEHSREY KQERAYTRDLLGPTVSLTQAAFTPVPVDTSQIVLPPHLERIREKLAENIHELWVMNKIEL GWQYGPVRDDNKRQHPCLVEFSKLPEQERNYNLQMSLETLKTLLALGCHVGIADEHAEEK VKKMKLPKNYQLTSGYKPAPMDLSFIKLTPSQEAMVDKLAENAHNVWARDRIRQGWTYGI QQDVKNRRNPRLVPYTLLDDRTKKSNKDSLREAVRTLLGYGYHLEAPDQDHAARAEVSSG TGERFRIFRAEKTYAVKAGRWYFEFEAVTAGDMRVGWSRPGCQPDLELGSDERAFAFDGF KAQRWHQGNEHYGRSWQAGDVVGCMVDMNEHTMMFTLNGEILLDDSGSELAFKDFDVGDG FIPVCSLGVAQVGRMNFGKDVSTLKYFTICGLQEGYEPFAVNTNRDITMWLSKRLPQFLQ VPSNHEHIEVTRIDGTIDSSPCLKVTQKSFGSQNSNTDIMFYRLSMPIECAEVFSKTVAG GLPGAGLYGPKNDLEDYDVDSDFEVLMKTAHGHLVPDRLDKDKETPKPEFNNHKDYAQEK PSRLKQRFLLRRTKPDYSTSHSARLTEDVLADDRDDYEYLMQTSTYYYSVRIFPGQEPAN VWVGWITSDFHQYDTGFDLDRVRTVTVTLGDEKGKVHESIKRSNCYMVCAGESMSPGQGR NNSNGLEIGCVVDAASGLLTFIANGKELSTYYQVEPSTKLFPAVFAQATSPNVFQFELGR IKNVMPLSAGLFKSEHKNPVPQCPPRLHVQFLSHVLWSRMPNQFLKVDVSRISERQGWLV QCLDPLQFMSLHIPEENRSVDILELTEQEELLQFHYHTLRLYSAVCALGNHRVAHALCSH VDEPQLLYAIENKYMPGLLRAGYYDLLIDIHLSSYATARLMMNNEFIVPMTEETKSITLF PNENKKHGLPGIGLSTSLRPRMQFSSPSFVSISSECYQYSPEFPLDILKAKTIQMLTEAV KEGSLHARDPVGGTTEFLFVPLIKLFYTLLIMGVFHNEDLKHILQLIEPSVFKEAASPEE EGGAPEKEISAEDSKLEGMGEEESKGGKRPKEGLLQMKLPEPVKLQMCLLLQYLCDCQVR HRIEAIVAFSDDFVAKLQDNQRFRYNEVMQALNMSAALTARKTKEFRSPPQEQINMLLNF KDDKSECPCPEEIRDQLLDFHEDLMTHCGIELDEDGSLDGSNDLTIRGRLLSLVEKVTYL KKKQAEKPVASDSRKPSSLQQLISETMVRWAQESVIEDPELVRAMFVLLHRQYDGIGGLV RALPKTYTINGVSVEDTINLLASLGQIRSLLSVRMGKEEEKLMIRGLGDIMNNKVFYQHP NLMRALGMHETVMEVMVNVLGGGESKEITFPKMVANCCRFLCYFCRISRQNQKAMFDHLS YLLENSSVGLASPAMRGSTPLDVAAASVMDNNELALALREPDLEKVVRYLAGCGLQSCQM LVSKGYPDIGWNPVEGERYLDFLRFAVFCNGESVEENANVVVRLLIRRPECFGPALRGEG GNGLLSAMEEAIKIAEDPSRDGPSPTSGSSKTLDTEEEEDDTIHMGNAIMTFYAALIDLL GRCAPEMHLIHAGKGEAIRIRSILRSLIPLGDLVGVISIAFQMPTIAKDGKVVEPDMSAG FCPDHKAAMVLFLDRVYGIEVQDFLLHLLEVGFLPDLRAAASLDTAALSATDMALALNRY LCTAVLPLLTRCAPLFAGTEHHASLIDSLLHTVYRLSKGCSLTKAQRDSIEVCLLSICGQ LRPSMMQHLLRRLVFDVPLLNEHAKMPLKLLTNHYERCWKYYCLPGGWGNFGAASEEELH LSRKLFWGIFDALSQKKYEQELFKLALPCLSAVAGALPPDYMESNYVSMMEKQSSMDSEG NFNPQPVDTSNITIPEKLEYFINKYAEHSHDKWSMDKLANGWIYGEIYSDSSKVQPLMKP YKLLSEKEKEIYRWPIKESLKTMLAWGWRIERTREGDSMALYNRTRRISQTSQVSIDAAH GYSPRAIDMSNVTLSRDLHAMAEMMAENYHNIWAKKKKMELESKGGGNHPLLVPYDTLTA KEKAKDREKAQDIFKFLQISGYAVSRGFKDLDLDTPSIEKRFAYSFLQQLIRYVDEAHQY ILEFDGGSRSKGEHFPYEQEIKFFAKVVLPLIDQYFKNHRLYFLSAASRPLCTGGHASNK EKEMVTSLFCKLGVLVRHRISLFGNDATSIVNCLHILGQTLDARTVMKTGLDSVKSALRA FLDNAAEDLEKTMENLKQGQFTHTRSQPKGVTQIINYTTVALLPMLSSLFEHIGQHQFGE DLILEDVQVSCYRILTSLYALGTSKSIYVERQRSALGECLAAFAAAFPIAFLETHLDKHN VYSIYNTRSSRERAALSLPANVEDVCPNIPSLEKLMAEIIELAESGIRYTQMPHMMEVVL PMLCSYMSRWWEHGPENHPERAEMCCTALNSEHMNTLLGNILKIIYNNLGIDEGAWMKRL AVFSQPIINKVKPQLLKTHFLPLMEKLKKKAAMVVSEEDHLKAEARGDMSEAELLILDEF TTLARDLYAFYPLLIRFVDYNRAKWLKEPNPEAEELFRMVAEVFIFWSKSHNFKREEQNF VVQNEINNMSFLITDTKSKMSKAAVSDQERKKMKRKGDRYSMQTSLIVAALKRLLPIGLN ICAPGDQELIALAKNRFSLKDTEEEVQDIIRSNIHLQGKLEDPAIRWQMALYKDLPNRTE DTSDPEKTVERVLDIANVLFHLEQKSKYTEYTGRRYFSLVEHPQRSKKAVWHKLLSKQRK RAVVACFRMAPLYNLPRHRAVNLFLQGYEKSWIETEEHYFEDKLIEDLAKPGAEPAEEDE ATKRVDPLHQLILLFSRTALTEKCKLEEDFLYMAYADIMAKSCHDEEDDDGEEEVKSFEV TGSQRSKEKEMEKQKLLYQQARLHDRGAAEMVLQTISASKGDTGPMVAATLKLGIAILNG GNSTVQQKMLDYLKEKKDVGFFQSLAGLMQSCSVLDLNAFERQNKAEGLGMVTEEGSGEK VLQDDEFTCDLFRFLQLLCEGHNSDFQNYLRTQTGNNTTVNIIISTVDYLLRVQESISDF YWYYSGKDIIDEQGQRNFSKAIQVAKQVFNTLTEYIQGPCTGNQQSLAHSRLWDAVVGFL HVFAHMQMKLSQDSSQIELLKELMDLQKDMVVMLLSMLEGNVVNGTIGKQMVDMLVESSN NVEMILKFFDMFLKLKDLTSSDTFKEYDPDGKGVISKRDFHKAMESHKHYTQSETEFLLS CAETDENETLDYEEFVKRFHEPAKDIGFNVAVLLTNLSEHMPNDTRLQTFLELAESVLNY FQPFLGRIEIMGSAKRIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGEKEKMEL FVNFCEDTIFEMQLAAQISESDLNERSANKEESEKERPEEQGPRMGFFSLLTIQSALFAL RYNILTLVRTLSLKNLKKQMKRMKKMTVKDMVTAFFSSYWSVFVTLLHFVASVCRGFFRI VSSLLLGGSLVEGAKKIKVAELLANMPDPTQDEVRGDEEEGERKSLESALPSEDLTDLKE LTEESDLLSDIFGLDLKREGGQYKLIPHNPNAGLSDLMTNPMPVPEVQEKFQEQKAKEEK EEKEETKSEPEKAEGEDGEKEDKAKDDKGKQKLRQLHTHRYGEPEVPESAFWKKIIAYQQ KLLNYFARNFYNMRMLALFVAFAINFILLFYKVSTSSVVEGKELPARSSGDTAKVPTSLD SSPHRIIAVHYVLEESSGYMEPTLRILAILHTVISFFCIIGYYCLKVPLVIFKREKEVAR KLEFDGLYITEQPSEDDIKGQWDRLVINTQSFPNNYWDKFVKRKVMDKYGEFYGRDRISE LLGMDKAALDFSDAREKKKPKKDSSLSAVLNSIDVKYQMWKLGVVFTDNSFLYLAWYMTM SVLGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNF FRKFYNKSEDGDTPDMKCDDMLTCYMFHMYVGVRAGGGIGDEIEDPAGDEYEIYRIIFDI TFFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGNDYFDTVPHGFETH TLQEHNLANYLFFLMYLINKDETEHTGQESYVWKMYQERCWEFFPAGDCFRKQYEDQLN NT seq 14940 nt NT seq  +upstreamnt  +downstreamnt atggctgatgcgggcgaaggcgaggacgagatccagttcttgagaactgacgatgaggtg gttctgcagtgcactgcgaccgtccacaaggagcagcagaagctatgcttggcagcagaa gggtttggcaacagactttgttttttggagtctacatccaattccaagaatgtccccccg gacctgtccatctgcacctttgtgctggagcagtccctgtcagtgcgtgccctgcaggag atgctggccaacacaatggagaagtcagaagggcaggttgatgtggaaaaatggaagttc atgatgaagactgctcaaggtggaggtcaccgcacactcctctatggacacgccatattg ctacggcattcctacagtggtatgtatttgtgctgtctctccacctcccggtcttccact gacaaactggcctttgatgttggccttcaagaggacaccacaggggaggcttgctggtgg accatacatcctgcctctaagcagagatcagaaggagaaaaggtgcgggttggagatgac ctcatcttggtcagtgtgtcctctgaaaggtacttgcacttgtcctatggcaacagcagc tggcatgtggatgctgccttccagcagaccctctggagcgtggcccccatcagctccgga agtgaagcagcccaagggtatcttattggtggcgatgttctccggctgctacatggacac atggatgagtgtctcactgtcccttcaggagaacatggtgaagaacagcggagaacagtt cattacgaaggtggtgctgtatcagttcatgcgcgctccctctggagactagagacccta agagtcgcgtggagtggaagtcacataagatggggccagccgttccgactacggcatgtc acaacaggaaaatacttaagccttatggaagacaagaacctcctactcatggacaaagaa aaggctgatgtaaaatcaactgcatttgccttccggtcttccaaggaaaaattggatgta ggggtgagaaaagaagttgatggcatgggaacctcagaaatcaaatacggagactccatt tgctatattcaacatgtggatacaggcctgtggctcacataccagtctgtagatgtgaaa tcagcacgaatgggatccatacagcgtaaggccattatgcaccatgaaggccacatggat gacggcttgaacttatccagatcgcagcatgaagagtcccgcacggcccgtgttatccgg agcacagtgttcctcttcaacagattcataaggggcctggatgctctcagcaagaaagcg aaggcacccaccattgacttgcccattgagtctgtgagcctgagtttgcaggacctcatc ggctacttccatccccctgatgagcacttggaacacgaggacaagcagaacaggctgcga gccctgaagaataggcagaatctcttccaggaagagggaatgatcaacttggttctggag tgcatagaccgcctgcatgtctacagcagtgcagcccactttgcagacgtcgcagggaga gaagcgggggagtcttggaaatccatcctaaattctctgtacgagttgctggcggctcta attagaggaaatcgtaaaaactgtgctcaattttctggctccctcgactggctgatcagc agactggaaagactggaagcgtcctctggcattctggaggtcctccactgtgtgttagtg gaaagcccagaagctctgaatatcatcaaagaaggacatatcaaatccatcatctcactt ttagacaagcatggaagaaaccacaaggtcctggacgtgttgtgctctctttgtgtttgc catggggttgctgtccgttccaaccagcatctcatctgtgacaatctgctgccaggacga gatctgttactgcagacccgtcttgtgaatcatgtcagcagcatgaggcctaatatcttc ctgggcgtcagcgaagggtctgcgcagtataagaagtggtactatgagctcatggtggac cacactgagcccttcgtgacagcagaagctactcacctgcgagtgggctgggcttccact gaagggtattccccgtaccccggcgggggtgaagagtggggtggtaatggcgttggtgat gacctcttctcctacgggttcgatggccttcacctctggtcaggttgtatagctcgaact gtgagctcacccaatcagcacttgttgagaactgacgatgtcatcagttgctgtttagat ctaagtgccccgagcatctcattccgcattaatggacagcctgttcaaggaatgtttgag aacttcaatatcgatggcctgttctttccggttgttagtttctctgcaggaataaaggtt cgctttttgcttgggggaagacatggagaattcaagttcctccctccacctggctatgca gcttgctatgaagctgttctgccgaaagagaaattgaaagtagaacacagccgagaatat aagcaagaaagggcatacacacgagatttgctggggcccacagtgtccctgacccaagct gctttcacccccgttcctgtggacaccagccagattgtgttgcctcctcacctggagagg ataagagaaaagctggcagagaatatccatgagctctgggttatgaataaaattgagctt ggctggcagtatggtccggttagagatgacaacaagagacagcatccatgtctggtggag ttcagcaaactgccggaacaggagcgcaactacaatttgcagatgtcacttgaaactctc aagactttgctggcattaggatgtcatgttggcatagcagatgaacacgctgaggagaag gtgaagaagatgaagctgcccaagaattaccagctgaccagtggatacaagcctgccccc atggatctgagctttataaaactcaccccctctcaggaagcaatggtggacaagttggcc gaaaatgctcacaacgtgtgggcccgggatcgaatccggcagggctggacttatggcatc cagcaggatgtcaagaacagaagaaaccctcgtcttgttccctataccctcttggatgac cgaaccaagaagtcaaacaaagacagtctccgagaggcggttcgcacactgctgggctat ggctaccacctggaagctcccgatcaggaccacgccgcgagagccgaggtgagcagcggc actggggagaggttccgcatcttcagggctgagaagacctatgccgtgaaggcgggacgc tggtactttgaattcgaggcagtcacggctggagacatgcgggtgggctggagcaggcca ggctgccagccggatctagagctgggttctgatgaacgtgcctttgcttttgatggcttt aaggcccagcggtggcaccagggcaatgaacactacgggcgctcttggcaagcaggtgat gttgtgggctgtatggttgatatgaacgaacataccatgatgttcactctgaatggcgag atcctgctggatgactcaggctccgagctggctttcaaggactttgacgttggtgatggc ttcatccctgtgtgtagcctgggggtggcacaagtaggcaggatgaacttcgggaaggac gtcagcactttgaaatatttcaccatctgtggcttacaagaaggctatgagccatttgcc gttaacacaaacagggacatcaccatgtggctgagcaagcggcttccccagttcctccag gtcccatcaaaccatgaacacattgaggtaacaagaatagatggcaccatagacagttct ccatgtctgaaagtcactcagaagtcctttggctctcagaacagcaacactgacatcatg ttttatcgcctgagcatgcccattgagtgtgctgaggtcttctcgaagacggtggcagga gggctccctggtgcaggcctctacgggcccaagaatgatctggaggattatgatgtggac tctgactttgaggttctgatgaagacagctcacggacatttggtgcctgaccgccttgac aaggacaaagaaaccccgaagccagagtttaataaccacaaagattatgctcaggaaaag ccttcacgcctaaagcaaagattcctgcttagaaggacaaagccagattatagcacaagc cattctgcgagactcactgaagatgtgctggctgatgaccgggatgactacgagtacctg atgcagacatccacgtactattactcagtgaggatctttcctggacaagagcctgctaac gtgtgggtgggctggatcacatctgacttccaccagtacgacacgggctttgatctggac agagtgcgcacagtgactgtcactctaggagatgaaaaaggaaaagtacacgagagcatc aaacgcagcaactgctatatggtgtgtgcaggagaaagcatgagccctgggcaaggacga aacaacagcaatggtctggagatcggctgcgtggtggatgctgccagcgggctgctcaca ttcattgccaacggcaaggagctaagtacatactatcaggtggagccaagcacaaagttg tttcctgcagtttttgcacaagctacaagtcccaatgtcttccagtttgagttgggcaga ataaagaatgtgatgcctctctcagcgggattgtttaaaagtgaacacaaaaaccctgtg ccccagtgtcccccacgtctgcacgtacagttcctgtcacatgttctgtggagccggatg cccaaccagttcttgaaggtggatgtctctcgaatcagtgaacgccaaggctggctggta cagtgtctggatcctctgcagttcatgtccctccatatccccgaggaaaacaggtctgtt gacatcctagaactgacagagcaggaggagttgctccagtttcactatcacaccctccgc ctctactccgctgtctgtgcccttgggaatcatcgggtggcccatgcgctctgcagccat gtggacgaacctcagctgctctatgccatcgagaacaagtacatgcctggcctgctgcgt gctggctactatgacctgctcattgacatccacctcagctcctatgccacagccaggctc atgatgaacaatgagttcattgtcccgatgacagaggagacaaagagcatcaccctcttc cccaatgagaacaagaaacatggtctcccaggcatcggcctcagcacgtctctccggccc cggatgcagttttcctctcctagttttgtgagcattagcagtgaatgttatcagtatagt ccagagtttccactggacatcctcaaggccaagaccatccagatgctcacagaagcagtg aaggagggcagcctccatgcgcgggaccctgtgggtgggaccaccgagttcctgtttgtg cctctcatcaagctcttctacaccctgctcattatgggtgtctttcacaatgaggatctg aaacacatcctgcagttgattgagcccagtgtgtttaaggaagctgcctctccagaggag gaaggaggagccccagagaaggaaatcagtgcagaagactctaagctggaaggaatgggt gaagaagaatccaaggggggcaagagacccaaggaaggcctgctccagatgaaactcccc gagccagttaaactacagatgtgcctcttgcttcagtacctctgtgactgccaggttcgg caccggatagaagccatagtagccttttcagatgactttgtagctaagcttcaagacaat caacggttcagatataatgaagttatgcaagccttaaacatgtccgctgcactcactgca cggaaaacgaaggagttccggtcaccaccgcaagagcagattaacatgcttctcaacttt aaggatgacaaaagtgaatgtccttgtcctgaagaaatccgagaccaactgctggatttc catgaggatctgatgactcactgtggaattgagctggatgaagatggatccctggatgga agtaatgacttaacaatcagaggacgtttgctgtccctggtagaaaaggtgacctacctg aagaagaaacaagctgaaaaaccagttgcaagcgactccagaaagccctccagtctccag caattgatttctgagactatggtgcggtgggctcaagagtctgtcatcgaggaccctgag ctggtgagggccatgtttgtgttgctgcatcgacagtatgatggcattgggggtctagtc cgggcactgccaaagacctacactatcaatggagtctctgtggaggataccatcaatctg cttgcatcacttggtcagatccgatctctgctgagtgtgaggatgggcaaagaagaagag aagctaatgatccgtggattgggggatatcatgaataacaaagtgttttaccagcacccc aatctcatgagggcccttggaatgcatgaaacagtgatggaagtcatggtgaatgtcctt ggaggtggggagtccaaggagatcaccttccccaagatggtggccaactgttgccgtttt ctctgttacttctgtcgtattagtaggcagaatcagaaggccatgtttgatcatctcagt tatttactggaaaacagcagtgttggtcttgcttcaccagctatgagagggtcaactccc ctggacgtggctgcagcttcggtcatggacaacaatgaacttgccctcgctctccgggag ccagatctagagaaggtagttcgttatctggccggctgtgggctgcagagctgtcagatg ctggtgtctaaaggttaccctgacattgggtggaatccagttgaaggagagagatacctt gactttctcagatttgctgtcttctgtaacggggagagtgtggaagagaatgcaaacgtc gtggtgaggttgctcatcaggaggcccgagtgctttggtcctgccttgagaggggaaggt ggcaatggcctcctttcagccatggaagaagccataaaaatagctgaggatccttctaga gatggcccctccccaaccagtggatccagcaaaacccttgatacagaggaggaggaagat gacaccatccatatggggaatgccatcatgaccttctatgcagctttgattgacttgctc ggtcgctgtgctcctgaaatgcacttgattcatgctggaaagggagaagccattcgaatc aggtcaattttgcgatccctgattcccctgggagacttggtgggcgtaatcagcattgca tttcagatgccaacaatagccaaagatgggaaggtggtggagcctgacatgtctgcgggg ttttgcccagatcacaaggcagccatggttttgttccttgacagggtctatggaattgag gtgcaagatttcctcctccatctccttgaggttggctttctgccagatctccgagctgct gcctctctagacacggctgcactaagtgctacagacatggccttggccctcaatcggtac ctgtgcacagctgtcctgcctttgttaacgagatgtgctcccctgtttgctggaacagag caccatgcttccctcattgactctctgttgcatactgtatatagactgtctaagggatgc tccctcactaaagctcagcgtgactccatagaagtgtgcctgctctctatatgtggccaa ctacgaccttctatgatgcaacacctactcagaaggctggtatttgacgttccactgttg aatgagcatgcaaagatgcctcttaagcttctgacaaatcattatgaaagatgctggaaa tactactgcctgcctggagggtggggcaattttggtgctgcctcagaagaagaacttcat ttatcaagaaagttattttggggcatttttgatgctttgtctcaaaagaaatatgaacaa gaacttttcaaactggccctgccttgcctgagtgcagttgcgggagctttacctccagac tacatggagtcaaactatgtcagtatgatggaaaaacagtcatccatggattctgaaggg aactttaacccacaacctgttgatacctcaaacattacaattcctgagaagttggaatac ttcattaacaaatatgcagaacattcccacgataaatggtccatggacaagttggcgaat ggatggatttatggggaaatatattcagactcttctaaggtccagccgttaatgaagcca tataaactattgtctgaaaaggaaaaagaaatatatcgctggcccatcaaggaatcttta aaaacgatgcttgcttggggctggagaattgagagaacacgagagggagacagtatggct ctttataaccggactcgacgcatttctcagacaagccaggtgtctatagatgccgcgcat gggtatagccctcgtgctattgacatgagcaacgttacactatcccgggacctgcatgct atggcagaaatgatggctgaaaactaccacaacatatgggccaagaaaaagaaaatggag ctggaatccaaaggaggaggaaaccatcccttgttggtgccctatgacacactgacagcc aaagagaaagccaaggacagagagaaggctcaggatatcttcaagttcctgcagatcagt ggttatgctgtatccagagggtttaaggacctggatctggacacaccttccattgagaag cgatttgcctatagtttcctgcagcagctgatccgctatgtggacgaggctcatcagtac atcctggagtttgatggcggcagcagaagcaaaggagaacatttcccgtacgagcaagaa atcaagttctttgccaaagtcgttcttccgttaattgatcagtatttcaaaaaccaccgc ctgtacttcttgtccgcggcaagcaggcctctctgcactggaggacacgcatccaacaaa gagaaggagatggtgacgagcctgttctgcaaacttggagttcttgtcaggcataggatc tcactgtttgggaatgatgctacctcaattgtgaactgtcttcatattctggggcagact ttggatgcaaggactgtgatgaagacgggcctggacagtgtgaaaagtgctctcagggcc tttctggacaacgcagcagaggatctggaaaagacaatggaaaaccttaagcagggccag tttacccacacccggagccagcccaaaggggtgactcagatcatcaactacaccacggta gcactgttgcccatgctctcgtccctgtttgaacacatcggccagcatcagtttggagaa gatctgatattggaggatgtgcaggtgtcttgttacagaattctgaccagcttgtatgcc ttgggaacaagcaagagcatctacgtggaaaggcagcgatctgcactcggagaatgccta gctgcctttgctgctgccttccctatagcctttttggaaacccacctggacaaacacaat gtttactccatctacaacacaaggtcttcacgggagagagcagctctcagtttaccagca aatgtggaggatgtctgcccaaatataccatccctggagaagctcatggctgagataata gagctggcagagtcaggtatccgctacactcagatgccacacatgatggaggttgtactg cccatgctgtgcagctacatgtcacgatggtgggagcacggtcctgagaaccatccagag agagctgagatgtgctgtacagctctcaactcagaacacatgaacacactgctgggcaac attctcaaaatcatctacaacaacctggggattgatgaaggagcctggatgaaacgctta gcagtgttttcgcagcctatcatcaacaaggtgaaaccacaactcttgaaaactcacttc ttgcccttgatggagaagctaaagaaaaaggctgccatggtagtgtctgaggaagaccac ctaaaagccgaggccagaggggacatgtctgaggctgagcttctaattttagatgagttc actacactggccagggatctctatgccttctacccactcttgatccgatttgtggactat aacagggcaaagtggctgaaggagcccaacccagaagcagaggagctctttcgaatggtg gctgaagttttcatcttctggtccaaatcccacaatttcaaaagagaagaacagaacttt gtggtgcaaaatgaaatcaacaacatgtccttcctcatcactgataccaagtccaagatg tccaaggcagccgtttctgatcaagagaggaagaaaatgaagcgcaaaggggaccgctat tctatgcagacatctctgattgtggcagctctgaagcgactgctgcccattgggctgaac atctgtgcccccggggaccaggagctcattgctctggccaaaaatcgatttagcttgaaa gacaccgaggaggaggtacaagatataatccgcagtaatatacacctacaaggcaagttg gaagatcctgcaatcaggtggcaaatggctctctacaaagacctgccaaacaggacagaa gacacctcagacccagagaagacagtggagcgtgtcctggatatagcaaatgtacttttt catcttgaacagaaatctaagtatactgagtatactggccggagatatttcagtctggtg gaacatcctcagagatcaaagaaggccgtatggcataaactactctctaagcagaggaaa agagctgtcgtcgcctgcttccggatggcccccttgtacaatctgccaaggcatcgggct gtcaatctttttcttcagggatatgaaaagtcttggattgaaacggaggagcattacttt gaggataaattgattgaagatttagcgaaaccaggtgctgaacctgcagaagaagacgaa gccacgaaaagagtcgatcctcttcaccagctcattcttctcttcagccgcacggccttg acggagaaatgcaaactggaggaagattttctatatatggcatatgcagatattatggca aagagttgtcacgatgaggaagacgatgacggtgaagaagaagtgaagagctttgaagtc acaggatcccaacgcagcaaggaaaaagaaatggagaagcagaaacttctctaccagcaa gccagactgcatgaccgtggggcagcagagatggtacttcagaccatcagtgccagcaaa ggagacactggaccaatggtggctgctactttgaaacttggcattgctattttaaatggt gggaactccacggtacagcagaagatgctggactacctgaaggaaaagaaggatgtaggc ttcttccagagcctggcaggtctcatgcagtcttgcagtgtccttgacctgaatgccttt gagaggcaaaacaaagcagaaggacttgggatggtgactgaggaaggatcaggagagaag gtactgcaggatgacgagttcacctgtgacctcttcagattcctgcagctgctctgtgag ggacacaactcagattttcagaattacctgagaactcagaccggcaacaatacaactgtc aatatcatcatctctactgtggactaccttctccgcgtgcaggagtccattagtgatttc tattggtactactctgggaaagacatcatagatgagcagggccagcgcaacttctccaaa gccatccaagtggcgaagcaggtgttcaacactctcaccgagtacatccagggtccttgt actggcaaccagcagagcctggcacacagcaggctgtgggacgctgttgtgggcttcctt catgtgtttgcccacatgcagatgaagctgtctcaggattccagccaaatcgagctcttg aaagaattgatggacctccagaaggacatggtggttatgctactgtccatgctagaaggt aatgttgtgaacggaaccataggcaaacagatggtggacatgcttgtggagtcttccaac aacgtggagatgatcctcaagttctttgacatgttcttgaagctaaaggacttgacgtcc tcagacacatttaaggagtatgaccctgacggcaaaggagtcatttctaagagagacttc cacaaagccatggaaagccacaagcactacacacaatcagagactgagtttctgctgtca tgtgccgagacagacgaaaacgaaaccctggactatgaggagtttgtcaaaaggttccat gagcccgcgaaggacattggcttcaatgtcgctgtcctgttgaccaacctctcggagcac atgcccaatgacacgaggctgcagaccttcttagagttagccgagagtgtcctcaactat ttccaacctttcctgggtcgcattgagatcatgggcagtgccaagcgcatcgagagagtc tactttgagatcagcgagtccagccgaacccagtgggagaagccacaagtcaaggagtcc aaaagacagttcatattcgatgtggtcaatgagggtggggagaaggagaagatggagctc tttgtgaacttctgcgaggacaccatcttcgagatgcagctggcagctcagatctcagag tccgatctaaacgagcggtcagccaacaaagaagagagtgagaaggagagacctgaagag cagggcccacggatgggctttttctccctcctcaccatccagtcagccctgtttgctctc aggtacaacatcctaaccctggttaggacgctcagcctgaagaacctaaagaagcagatg aagagaatgaagaaaatgacggtgaaggacatggtcactgccttcttctcatcctactgg agtgtctttgtgaccctcttacacttcgtggccagtgtctgtaggggcttttttcgcatc gtctccagcctgctgcttgggggaagcctggtggaaggtgctaagaaaatcaaagtggcc gagcttctagccaacatgccagaccccactcaggatgaggtgcgaggagatgaggaagag ggagagaggaagtctttggagtcagcgctgccctctgaagatctgaccgacttaaaggaa ttgacagaggaaagtgaccttctctcggacatatttggcttagatctgaagagggaaggc gggcagtacaaactgattcctcataacccaaatgccggcctcagtgacctgatgaccaac cccatgcctgtccctgaggtacaagaaaagtttcaggagcagaaggctaaagaagagaag gaagaaaaagaagaaaccaagtctgaacctgaaaaggctgagggggaagatggagaaaaa gaagacaaagccaaagatgataagggcaagcagaagttgagacaacttcacacacatcgg tatggggaacctgaggtgccagagtcagcgttctggaagaaaatcatagcctatcagcag aagctgctgaactattttgctcgcaacttttacaacatgagaatgctggccttatttgtc gccttcgccatcaatttcatcctgctcttctacaaggtctccacttcgtctgtggttgaa ggaaaggagctgcctgcccgaagctccggtgacactgccaaagttcccaccagcctggac agcagcccacacagaatcatagcagtgcactatgtcctggaggagagcagtggctacatg gaacccacgctgcgcatcctagccatcttgcacactgtcatctctttcttttgcatcatt ggatactactgcctgaaagtccccttggtcatttttaagcgggagaaggaagtggcacgt aaattggagtttgacgggctttacattacagagcagccatcggaagatgatattaaaggc cagtgggacagactcgtgatcaacacacagtcatttcccaacaactactgggataaattt gttaaaagaaaggtgatggataagtatggagagttctatgggcgagacagaatcagtgag ttactgggcatggataaagctgccctggatttcagtgatgcgagagagaagaagaaaccc aagaaagacagctccttgtctgctgtcctgaactctattgatgtgaagtaccagatgtgg aagctcggagtcgtgttcacggacaactccttcctgtacctagcctggtatatgaccatg tccgttcttggacactataacaactttttttttgctgctcacctccttgacatcgcgatg ggattcaagaccttgagaaccatcctgtcctcagtcacccacaatggcaaacagctcgtg ttgactgtcggcttgttagctgtcgttgtgtacctgtacactgttgtggcgttcaatttc ttccggaagttctataataagagtgaagatggtgacacgccggacatgaaatgcgatgac atgctgacgtgttacatgttccacatgtatgtgggcgtccgtgctggagggggcattggg gatgaaattgaagacccagcgggagatgagtatgagatctaccgcatcatctttgacatc acgttcttcttctttgtgatcgtcatccttttggccatcatacaaggtttgatcatcgat gcttttggagaactcagagaccaacaagagcaagtcaaggaagacatggagaccaagtgc ttcatctgcgggataggcaatgactactttgatacggtgccacacggctttgaaacacat acgctccaggagcacaacctggccaactacctgtttttcctgatgtatctcataaacaag gatgaaacggaacacacgggacaggaatcttatgtctggaagatgtatcaagagaggtgt tgggagtttttcccagcaggggactgcttccggaaacagtatgaagaccagttgaattaa

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