Microtus oregoni (creeping vole): 121454099 Help Entry 121454099         CDS       T08307                                  Symbol Jak2 Name (RefSeq) tyrosine-protein kinase JAK2   KO K04447   Janus kinase 2 [EC:2.7.10.2] Organism morg  Microtus oregoni (creeping vole) Pathway morg01521   EGFR tyrosine kinase inhibitor resistance morg04062   Chemokine signaling pathway morg04081   Hormone signaling morg04148   Efferocytosis morg04151   PI3K-Akt signaling pathway morg04217   Necroptosis morg04550   Signaling pathways regulating pluripotency of stem cells morg04630   JAK-STAT signaling pathway morg04658   Th1 and Th2 cell differentiation morg04659   Th17 cell differentiation morg04725   Cholinergic synapse morg04917   Prolactin signaling pathway morg04920   Adipocytokine signaling pathway morg04933   AGE-RAGE signaling pathway in diabetic complications morg04935   Growth hormone synthesis, secretion and action morg05140   Leishmaniasis morg05145   Toxoplasmosis morg05152   Tuberculosis morg05161   Hepatitis B morg05164   Influenza A morg05167   Kaposi sarcoma-associated herpesvirus infection morg05168   Herpes simplex virus 1 infection morg05200   Pathways in cancer morg05207   Chemical carcinogenesis - receptor activation morg05235   PD-L1 expression and PD-1 checkpoint pathway in cancer morg05417   Lipid and atherosclerosis Brite KEGG Orthology (KO) [BR:morg00001]  09130 Environmental Information Processing   09132 Signal transduction    04630 JAK-STAT signaling pathway     121454099 (Jak2)    04151 PI3K-Akt signaling pathway     121454099 (Jak2)   09133 Signaling molecules and interaction    04081 Hormone signaling     121454099 (Jak2)  09140 Cellular Processes   09141 Transport and catabolism    04148 Efferocytosis     121454099 (Jak2)   09143 Cell growth and death    04217 Necroptosis     121454099 (Jak2)   09144 Cellular community - eukaryotes    04550 Signaling pathways regulating pluripotency of stem cells     121454099 (Jak2)  09150 Organismal Systems   09151 Immune system    04658 Th1 and Th2 cell differentiation     121454099 (Jak2)    04659 Th17 cell differentiation     121454099 (Jak2)    04062 Chemokine signaling pathway     121454099 (Jak2)   09152 Endocrine system    04920 Adipocytokine signaling pathway     121454099 (Jak2)    04917 Prolactin signaling pathway     121454099 (Jak2)    04935 Growth hormone synthesis, secretion and action     121454099 (Jak2)   09156 Nervous system    04725 Cholinergic synapse     121454099 (Jak2)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     121454099 (Jak2)    05207 Chemical carcinogenesis - receptor activation     121454099 (Jak2)    05235 PD-L1 expression and PD-1 checkpoint pathway in cancer     121454099 (Jak2)   09172 Infectious disease: viral    05161 Hepatitis B     121454099 (Jak2)    05164 Influenza A     121454099 (Jak2)    05168 Herpes simplex virus 1 infection     121454099 (Jak2)    05167 Kaposi sarcoma-associated herpesvirus infection     121454099 (Jak2)   09171 Infectious disease: bacterial    05152 Tuberculosis     121454099 (Jak2)   09174 Infectious disease: parasitic    05145 Toxoplasmosis     121454099 (Jak2)    05140 Leishmaniasis     121454099 (Jak2)   09166 Cardiovascular disease    05417 Lipid and atherosclerosis     121454099 (Jak2)   09167 Endocrine and metabolic disease    04933 AGE-RAGE signaling pathway in diabetic complications     121454099 (Jak2)   09176 Drug resistance: antineoplastic    01521 EGFR tyrosine kinase inhibitor resistance     121454099 (Jak2)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:morg01001]     121454099 (Jak2) Enzymes [BR:morg01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.2  non-specific protein-tyrosine kinase      121454099 (Jak2) Protein kinases [BR:morg01001]  Non-receptor tyrosine kinases   JAK family [OT]    121454099 (Jak2) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  PK_Tyr_Ser-Thr Pkinase FERM_F2 FERM_F1 SH2_1 Jak1_Phl SH2 ABC1 FERM_C_FAK1 RIO1 Kinase-like FERM_M Motif Other DBs NCBI-GeneID:  121454099 NCBI-ProteinID:  XP_041517235 LinkDB All DBs Position Unknown AA seq 1132 aa AA seqDB search MGMACLTMTEMEATSTSPVHQNGDIPGNANSVKQIDPVLQVYLYHSLGKAEGDYLKFPIG EYVAEEICVAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNLLYRIRFYF PHWYCSGSNRTYRYGVSRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLG MAVLDMMRIAKEKDQTPLAVYNSISYKTFLPKCVRAKIQDYHILTRKRIRYRFRRFIQQF SQCKATARNLKLKYLINLETLQSAFYTEQFEVKESARGPSGEEIFATIIITGNGGIQWSR GRHKESETLAEQDLQLYCDFPDIIDVSIKQANQECSNESRIVTIHKQDGKILEIELSSLR EALSFVSLIDGYYRLTADAHHYLCKEVAPPSVLENMHSNCHGPISMDFAISKLKKAGNQT GLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLIMKNENREYNLSGTKKNFSNLKDLLNC YQMETVRSDSIIFQFTKCCPPKPKDKSNLLVFRTNGISDVQISPTLQRHNNVNQMVFHKI RNEDLVFNESLGQGTFTKIFKGIRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASM MSQLSHKHLVLNYGVCVCGEENILVQEFVKFGSLDTYLKKNKNSINILWKLGVAKQLAWA MHFLEEKSLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVP PECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDKHQLPAPKWTEL ANLINNCMDYEPDFRPAFRAVIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRD PTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIE ILKSLQHDNIVKYKGVCYSAGRRNLRLIMEYLPYGSLRDYLQKHKERIDHKKLLQYTSQI CKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFW YAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPVEFMRMIGNDKQGQMIVFHLIE LLKNNGRLPRPEGCPDEIYVIMTECWNNNVNQRPSFRDLALRVDQIWDSLAA NT seq 3399 nt NT seq  +upstreamnt  +downstreamnt atgggaatggcttgccttacaatgacagagatggaggcaacctccacatctcctgtacat cagaatggtgatattcctggaaatgctaattctgtgaagcagatagatccagtccttcaa gtatatctgtaccattctcttgggaaagctgaaggagactatctgaagtttccaattgga gagtatgttgcagaagaaatttgtgtggctgcttctaaagcttgtggtattacacctgtg tatcataatatgtttgctttaatgagtgaaacagaaagaatctggtatccacccaaccat gtcttccacatagatgagtcaaccaggcataatctactctacagaataagattttacttt cctcactggtattgcagtggcagcaatagaacctatagatacggagtatctcgtggggct gaagctcctcttcttgatgactttgtcatgtcttacctttttgctcagtggcggcatgat tttgtgcatgggtggataaaagtgcctgtgacccacgaaactcaagaagaatgtcttggg atggcagtgctagatatgatgagaatagccaaagaaaaggaccaaactccactggctgtc tataactctatcagctacaaaacattcttaccaaagtgtgttcgagcaaagattcaagac tatcatattttaacccggaagcgaataaggtacagatttcgcagattcattcagcagttc agtcaatgcaaagccactgccagaaacctgaaacttaagtatcttataaacttggaaacc ctacagtctgccttctacacagagcaatttgaagtaaaagaatctgcaagaggtccttca ggtgaggagatttttgcaaccattataataactggaaacggtggaattcagtggtcaaga gggagacataaagaaagtgagacactggcagaacaggatttacagttatattgtgatttt cctgatattattgatgtcagtattaagcaagcaaaccaggaatgctcaaatgaaagtaga attgtaactatccataagcaagatggtaaaattttggaaatagagcttagctcgttaaga gaagccctgtcatttgtgtccttgattgacggctattaccgactcactgcagacgcacac cattacctctgtaaggaggtggcccctccgtctgtgctggagaacatgcacagcaactgc catggccccatctcaatggattttgccattagtaaactaaagaaggcagggaaccagacg ggactgtatgtacttcggtgtagccctaaggactttaacaaatactttctgacctttgct gttgagcgagaaaatgttattgaatataaacactgtttgattatgaagaatgaaaataga gagtacaatctcagtgggactaagaagaacttcagtaatcttaaggaccttttgaattgc taccagatggaaactgtgcgctcagacagtatcatcttccagtttactaaatgctgtccc cctaagccaaaagacaaatcaaaccttcttgtcttcagaaccaatggtatttctgatgtt cagatctcaccaacattacagaggcataataatgtgaaccagatggtgtttcacaaaatc agaaatgaagacttggtatttaatgaaagtcttggccaaggtacttttacaaaaatcttt aaaggtataagaagagaagttggagactatggtcaactgcatgaaacagaagttcttttg aaagttctggataaagcacataggaattattcagagtctttctttgaagcagcaagcatg atgagccagctttctcacaagcacttggttttgaattatggagtatgtgtctgtggagag gagaacattctggttcaagagtttgtaaaatttggatcactggatacatacctgaaaaaa aacaaaaattccataaatatattatggaaacttggagtggctaaacagttggcatgggcc atgcattttctagaagaaaaatcccttattcatgggaatgtgtgtgccaaaaatatcctg ctgatcagagaagaagacaggaaaacagggaatccacctttcatcaaacttagtgaccct ggcattagcattacagttctaccaaaggacattcttcaggagagaataccatgggtaccg cctgaatgcattgaaaatcctaaaaatctaaatctggcaacagacaagtggagttttggt actactctgtgggaaatctgcagcggaggagacaagcccctgagtgctctggactcgcaa aggaagttgcagttttatgaagataagcatcagcttcctgcacctaagtggacagaatta gcgaaccttataaacaattgcatggattatgagccagatttcaggcctgccttcagagcc gtcatccgtgatcttaatagcctgtttactccagattatgaactactaacagaaaatgac atgctaccaaatatgagaataggtgccttaggattttctggtgcttttgaagacagagac cctacacaatttgaagagagacacttgaaatttctacagcaacttggcaagggtaatttt gggagtgtggagatgtgccgctacgatcctctacaggacaacactggggaggtggtggct gttaaaaaactccagcacagcactgaagagcatctcagagacttcgaaagggagattgaa attctgaaatccttgcagcatgacaacattgtaaaatacaaaggagtgtgctacagtgct ggtcggcgcaacctaagattaattatggaatatttgccatatggaagtttacgagactat ctccaaaaacataaagaacgaatagatcacaaaaaacttctgcagtacacatctcagata tgcaagggcatggaatatcttggcacaaaaagatatatccatagggatttggcaacaaga aatatattggtggaaaatgagaacagagttaaaataggagattttggattaaccaaagtc ttgccacaggacaaagaatactacaaagtaaaagaaccaggcgaaagtcccatattctgg tatgctccagaatccctgacagagagcaagttttctgtggcctcggatgtatggagcttt ggcgtggttctgtatgagcttttcacatacattgagaagagcaaaagtcctccagtggaa tttatgcgaatgattggcaatgataaacaaggacagatgattgtgttccatttgatagaa cttctgaaaaacaatggaagactaccaagaccagaagggtgcccagatgagatttatgtg atcatgacagagtgctggaacaacaatgtaaatcagcgtccctctttcagggacctagca cttcgggtggatcagatctgggacagtctagctgcttga

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