Microtus oregoni (creeping vole): 121461505
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Entry
121461505 CDS
T08307
Symbol
Lrrk2
Name
(RefSeq) leucine-rich repeat serine/threonine-protein kinase 2 isoform X1
KO
K08844
leucine-rich repeat kinase 2 [EC:
2.7.11.1
]
Organism
morg
Microtus oregoni (creeping vole)
Pathway
morg05012
Parkinson disease
morg05022
Pathways of neurodegeneration - multiple diseases
Brite
KEGG Orthology (KO) [BR:
morg00001
]
09160 Human Diseases
09164 Neurodegenerative disease
05012 Parkinson disease
121461505 (Lrrk2)
05022 Pathways of neurodegeneration - multiple diseases
121461505 (Lrrk2)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
morg01001
]
121461505 (Lrrk2)
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:
morg04131
]
121461505 (Lrrk2)
09183 Protein families: signaling and cellular processes
04147 Exosome [BR:
morg04147
]
121461505 (Lrrk2)
Enzymes [BR:
morg01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.1 non-specific serine/threonine protein kinase
121461505 (Lrrk2)
Protein kinases [BR:
morg01001
]
Serine/threonine kinases: TKL group
LRRK family
121461505 (Lrrk2)
Membrane trafficking [BR:
morg04131
]
Exocytosis
Calcium ion-dependent exocytosis
Kinases and associated proteins
121461505 (Lrrk2)
Exosome [BR:
morg04147
]
Exosomal proteins
Exosomal proteins of other body fluids (saliva and urine)
121461505 (Lrrk2)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
ARM_LRRK2
Beta-prop_LRRK2
ANK_LRRK2
Pkinase
PK_Tyr_Ser-Thr
LRR_8
Roc
LRR_4
COR
Ras
LRR_1
LRR_14
WD40_CDC20-Fz
Beta-prop_RSE1_2nd
LRR_9
Beta-prop_EML_2
Arf
Ank_2
ARM_CUL7_CUL9
Beta-prop_EML
nSTAND3
LRR_NXF1-5
T2SSE
AAA_22
LRR_13
Beta-prop_WDR19_1st
ABC_tran
PduV-EutP
GTP_EFTU
AAA_7
Beta-prop_RIG_2nd
G-alpha
AAA_16
MMR_HSR1
MobB
Kdo
NACHT
cobW
TniB
AAA_29
Arm
TrwB_AAD_bind
FtsK_SpoIIIE
Gtr1_RagA
Beta-prop_HPS5
TsaE
AAA_18
Septin
AAA_15
AAA_23
SRP54
Motif
Other DBs
NCBI-GeneID:
121461505
NCBI-ProteinID:
XP_041528524
LinkDB
All DBs
Position
Unknown
AA seq
2527 aa
AA seq
DB search
MASGGSQSCEEEEEEALKKLIVRLNNIQEGKQMDTLLQLLEDMLVFTYSDRASKLFEGKN
FHVPLLIVLDSYMRVASVQQVGWSLLCKLIEVCPGTLPSLIGPQDIGNDWEVLGIHRLIL
KMLTFHQANVNLSTVGLKALDLLLDSGKITLLILDEECDVFLLIFDAMHKYSTNDEVQKL
GCKTLHVLFERVSEEQLIEFVENKDYMILLSALSSFKGDKEIVFHVLCCLHSLAVPCSNV
EVLMSGNVRCYNIVVEAMKAFPADEKIQEVSCSLLHRLTLGNFFNILVLNEVHVFVVRAV
LQYPENAALQISALSCLALLTETIFLNQDLEERSESQESNDEEDPEKLFWLEPCYKALTH
HRKNKHVQEAACWALNNLLMYQNSLHEKIGDEDGQFPAHREVMLSMLMHSSSKDVFQAAA
HALSTLLEQNVNFRRILLAKGVYLNVLELMQKHSLVPEVAESGCKMLGHLFEGSNTSLDT
MAAVVPRIIAVMKTHETSLSVQLEALRAILHFVVPGIPEESRDDSQCKLNMFQKQYLRTD
IHKLVLAALDRFIGNPGVQKCGLKVLSSLTHLPDALEMLSLHGAVDSVLHALQMYPDDQE
IQCLGLHLTGCLITKKNFCIRTGHLLAKILVSSLQRFQDVPEVQTTGLQTILAILELSAS
FAKLLVHYSFDLVIFHQMSSSVMEQKDEQFINLCCKCFAKLAVDDELKSTMLERACDQNN
GIMVECLLLLGADANQSKGATSLIYQVCEKENSPKLVELLLNGGCREQDVRKALTISIQK
GDSQVISLLLRRLALDLANNSICLGGFCIRKIDPSWLGPLFPDKSSNLRKQTNTGSVLAR
KVLRYQMKNALQEGATSGSDGNFSEDALAKFGEWTFIPDSSMDSVFGHSDDLDSEAGSEN
SVLVKKKSNSISVGEFYRDPALQRCSANSQRHSSSLGPVLDHEDLLRRKRKILSSDECLR
PSKLQPHMRHSDSSSSLASEREYITSLDLSANELKDIDALSQKCCLSGHLEHLTKLELHQ
NALTGFPQQLCETLKCLTHLDLHSNKFTSFPSFLLKMACITNLDTSRNDIGPTVVLDPLV
KCPSLKHFNLSYNQLSSIPENLAQVVEKLEQLLLEGNKISGICSPLSLKELKILNLSKNH
IPSLPEDFLEACPKVETFSAQMNSLAAMPALPFSITSLKLSQNSFTCIPEAIFILPHLRS
LDMSHNSIEHLPGPAHWTSLNLRELFFSHNQITILNLSEKPHVWSRLEKLHLSHNKLKEI
PPEIGCLENLTSLDVSYNVELRSFPNEMGKLSKIWDLPLDGLHLNFDFKHIGCKAKDIIR
FLQQRLKKAVPYNRMKLMIVGNTGSGKTTLLQQLMKMKKSDLGMQSATVGIDVRDWPIQI
RGKRKKDLVLNVWDFAGREEFYSTHPHFMTQRALYLAVYDLSKGQAEVDAMKPWLFNIKA
RASSSPVILVGTHLDVSDEKQRKACISKITKELLNKRGFPTIRDYHFVNATEESDALAKL
RKTIINESLNFKIRDQPVVGQLIPDCYVELEKIILSERKAVPVEFPVINRKRLLQLVREH
QLQLDENELPHAVHFLNESGVLLHFQDPALQLSDLYFVEPKWLCKVMAQILTVKVEGCLK
YPKGIISRRDVEKFLSKKKRFPKNYMTQYFKLLEKFQIALPTGEEYLLVPSSLSDHRPVI
ELPHCENSEIIIRLYEMPYFPMGFWSRLINRLLEISPFMLSGRERALRPNRTYWRQGIYL
NWSPEAYCLVGSEVLDDRPESFLKITVPSCRKGCILLGQVVDHIDSLMEEWFPGLLEIDI
CGEGETLLKKWALYSFNDGEDHQKILLDELMKKAEEGDLLINPDQPRLTVPISQIAPDLI
LADLPRNIMLNNDELEFEEAPEFLLGDGSFGSVYRAAYEGEEVAVKIFNKHTSLRLLRQE
LVVLCHLHHPSLISLLAAGIRPRMLVMELASKGSLDRLLQQDKGSLTRTLQHRIALHVAD
GLRYLHSAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRA
PEVARGNVIYNQQADVYSFGLLLYDIWTTGGRIIEGLRFPNEFDELAIQGKLPDPVKEYG
CAPWPMVEKLIKKCLKENPQERPTSAQVFDILNSPELICLMRHILIPKNIVVECMVATNP
NSKSATLWLGCGNTEKGQLSFFDLNTERYSYEEVTDSRILCLALVHLPAEKESWVVCGTQ
SGDLLVINAEDEAKRHTLEKMTDSVTCLYCNSFAKQSKQSNFLLVGTADGNLVIFEDNTI
KCKGAAPLKTLRIGDVSTPLMCLSVSMNSSERHITWGGCGTKIFSFSSDFTIQKLIETRT
NQLFSYAAFSDSNIIAVAVDAALFIAKKNSPVVEVWDKKTEKLCELIDCVHFLKEVIVKV
NKESKHKLSYSGRVKALCLQKNTALWIGTGGGHILLLDLSTRRVIRTIHNFCDSVRAMSM
AQLGSLKNVMLVLGYKRKNTEGAQEQKEIQSCLSIWDINLPHEVQNLEKHIEVRTELAEK
MRRISVD
NT seq
7584 nt
NT seq
+upstream
nt +downstream
nt
atggccagtggcggctcgcagagctgcgaggaggaagaggaggaggctctgaagaagttg
atagtcaggctgaataatattcaggaaggcaagcagatggacacgttactccagctcctg
gaggacatgctggtgttcacctactccgacagagcctccaagttgtttgaaggtaaaaat
ttccacgtgcctctgttgatcgtcctggactcctacatgagagtcgccagcgtgcagcag
gtaggatggtcacttctgtgcaaattaatagaagtttgtccagggaccctgccaagctta
ataggaccccaggatattggaaatgattgggaagtccttggtattcatcgactgattctt
aaaatgttaacttttcaccaagccaatgtcaacctctcaacagtcggactaaaagcctta
gatctcctcttagattcaggtaaaatcactttgctaatactggatgaagaatgtgatgtt
ttcttgctaatttttgatgccatgcacaaatattcaaccaatgatgaagttcagaaactt
ggatgcaagactttacatgtgctgtttgagagagtgtcagaggaacagctgattgagttt
gttgagaacaaagattacatgatactgttgagcgcactcagcagcttcaaaggggacaag
gaaattgtgtttcatgtgctctgctgccttcattccctggcagttccttgcagcaatgtt
gaagttctcatgagtgggaatgtcaggtgttacaatattgtggtagaagccatgaaagca
ttccctgccgatgagaaaattcaagaagtgagctgctccttgctccataggctaacacta
ggtaatttcttcaacatcttggtgttgaacgaagtacatgtctttgtggtgagagctgtc
ctgcagtatccagagaatgcagccttacagatttctgccctcagctgtttagcgctcctc
actgagaccattttcttaaaccaagacttggaggaaagaagtgagtctcaggaaagcaac
gatgaggaggaccctgagaagctgttctggttggaaccctgctacaaagccctgacgcac
catagaaagaacaagcatgtgcaggaagccgcgtgctgggcactaaataatctccttatg
taccagaacagtttgcacgagaagattggagacgaagatggccagttccctgcacacagg
gaagtgatgctgtccatgctgatgcattcttcctccaaagatgtcttccaagcagctgcg
catgcactgtccacgctcctggaacaaaatgttaatttcaggagaatcctgctagcaaaa
ggagtatacctgaatgtcttagagttgatgcagaagcactcccttgttcccgaggtggca
gagagtggatgcaagatgctgggtcacctgtttgaaggaagtaacacttccctggacaca
atggccgcagtggtccctagaataatagcagtgatgaaaacccacgagacttctctgtca
gtgcagctggaggcactgcgagccattttgcattttgtagttcctggaataccagaagaa
tccagggatgactctcaatgcaaactcaacatgttccagaaacagtatctcaggactgac
atccacaagctagttctagcagctctggataggttcattgggaatcctggggttcagaaa
tgtggactgaaagtattatcttctctgacacatcttcctgacgccttagagatgttgtcc
ttgcatggcgcagttgactccgtgcttcatgccctgcaaatgtatccagacgaccaagag
attcaatgcctgggcttacaccttacaggatgcttgattacaaagaagaatttctgcata
cggacagggcacctcctggcaaaaattctggtgtccagtttacagcgctttcaagatgtt
cctgaagtgcaaactacgggattgcagacaatcttggcaatccttgaattgtcagcgtct
ttcgccaagcttctggtacactactcatttgatttggtaatattccatcagatgtcctcc
agcgtgatggagcaaaaagatgagcagtttatcaatctgtgttgcaaatgttttgcaaag
ctagctgtggatgatgagctgaaaagcacaatgctagagagagcctgtgaccagaataat
ggcatcatggtggagtgtttgcttctgttgggagctgatgccaaccaatcaaagggggca
acgtctcttatttatcaggtatgtgagaaagagaacagtccaaaattggtggaactgttg
cttaatggtggatgccgtgaacaggatgtacgaaaagcactgacaataagcatccaaaag
ggcgacagccaggtcatcagcttgctcctaaggagacttgccctggacttggccaacaac
agtatttgccttggaggattttgcataaggaaaattgatccttcttggcttggtccttta
tttccagataagtcatctaatttaaggaaacaaacaaacaccggatctgtcttagcaaga
aaagtgctccgatatcagatgaaaaacgctttgcaagaaggagcaacttcaggcagtgat
ggcaacttttctgaagatgccctggcgaaatttggtgaatggaccttcattcctgactct
tctatggacagcgtgtttggccacagtgatgatttggatagcgaagcaggcagtgagaac
tcagttcttgtgaaaaagaagtcgaattcgattagtgtaggagaattttatagagatccg
gctttgcagcgttgctcagcaaattctcagaggcattccagttccttgggtcccgttttg
gatcatgaagatttactgagaagaaaaagaaaaatactgtcttcagatgagtgtctcagg
ccatcgaagcttcagcctcacatgagacattcagatagttcttcttccctggcctctgag
agagaatacatcacatccttagacctttctgccaacgaactgaaagatattgatgccctg
agccagaagtgctgtctcagtggccacctggagcatcttaccaagctggaacttcaccag
aatgcactcactggctttcctcagcagctgtgtgagactctgaagtgcttgacgcatttg
gatttgcacagcaacaaattcacatccttcccctccttcttgttgaaaatggcatgcatc
accaacctcgacacctctcgaaatgacattggacccacagtagttttagaccccctggtg
aagtgtcccagcctcaaacactttaacctgtcctacaaccagctctcttccatcccagag
aacctcgcccaagtggtggagaaactggaacagctcctattggaaggaaacaaaatatct
gggatttgttctcccttgagcctgaaggaattgaagattttaaatcttagtaaaaaccat
attccatccctacctgaagactttcttgaggcttgtccaaaagtggagactttcagtgcc
cagatgaattctcttgctgcgatgcccgccttacctttttccataacgagtctaaaatta
tctcaaaacagtttcacgtgcattccagaagcgatattcattcttccacacttgcggtcc
ttggacatgagccacaacagcattgagcatctgccggggcctgcacactggacatctctg
aacttaagggaactcttctttagccataatcagatcaccatcttgaacctgagtgaaaag
ccacacgtgtggtcaagattagagaaactgcatctctctcataataaactgaaagagatt
cctcctgaaatcggctgtcttgaaaacctgacatctcttgatgtgagttacaacgtggaa
ctgaggtcctttccgaatgaaatggggaaattaagcaaaatatgggatcttcctttggat
ggactgcatctgaattttgactttaagcacataggatgcaaagccaaagacatcataagg
tttctccaacaacggctgaaaaaggcagtgccctacaaccgaatgaagcttatgattgtg
ggaaatactggcagcggaaagaccaccctgctgcagcagctcatgaaaatgaagaagtca
gatcttggcatgcagagcgccacagttggcatagacgtcagagattggcctatccaaata
cgagggaaaaggaaaaaggaccttgttctaaatgtgtgggactttgcaggtcgtgaggaa
ttctacagcacgcacccccacttcatgacccagcgagctctataccttgctgtgtatgac
ctcagcaaggggcaggcagaggtggatgccatgaagccctggctcttcaacatcaaggcc
cgtgcctcttcttctcccgtgattctggtgggcacacatttggatgtttctgatgagaag
cagcgcaaagcctgcataagcaaaatcaccaaggaactcctaaacaagcgaggattcccc
accatccgggactaccacttcgtaaatgccaccgaggagtcggatgcgctggcaaagctt
cggaaaaccatcataaatgagagccttaatttcaagatccgagatcagcctgtggttggg
cagttgattccagattgctacgtagaactggagaaaatcatcctgtcagagcgcaaggct
gtgccggtggagtttcctgtcattaaccggaagcgtctcttacaactcgtgcgagaacac
cagctgcagctggatgagaacgagctcccacacgccgttcatttcctaaacgagtcagga
gtccttctgcattttcaagaccctgcactgcagctaagcgacctgtattttgtggaaccc
aagtggctttgtaaagtcatggcacagattctgactgtgaaagtggagggctgtctgaaa
tatccaaagggcatcatttcacggagagacgtagaaaaattcctttcaaagaaaaagcga
ttcccaaaaaactacatgacacagtacttcaaactgctagaaaaattccagattgctttg
ccaacaggagaagagtatctgctggttccaagcagcttatctgaccacaggcctgtgata
gagctcccccactgtgagaactctgagatcatcattcggttatatgaaatgccatacttt
ccaatggggttttggtcaaggttgattaatcggttacttgaaatctcacctttcatgctt
tctggaagagagagagcactacgcccaaacagaacgtattggcgacagggcatctacctg
aattggtccccagaagcatattgtctggtgggatccgaagtgttagacgatcgaccagag
agtttcttgaaaattacagttccttcttgtagaaaaggttgtattctcttgggccaagtt
gtagatcacattgactcactcatggaagaatggtttcctgggctgctggagattgacatt
tgtggggaaggagaaactcttctgaagaaatgggcattgtacagttttaacgatggcgaa
gatcatcagaagatcctgcttgatgagttaatgaagaaagcagaagaaggagacctgcta
atcaatccagatcaaccaaggctcactgttcccatatcgcagattgctcctgacttgatt
ttagctgacctgcctagaaatattatgttgaacaatgatgagctggaatttgaagaagca
ccggagtttctcttaggtgatggaagttttggatcagtttatcgagctgcctatgaagga
gaggaagtggctgtgaagatttttaataaacatacatcacttaggctgttaagacaagag
ttggtggtcctttgccacctccaccacccaagcctgatatctttgctggcagctgggatt
cgtccgcggatgttggtgatggaattggcttccaagggttccttggatcgcttgctgcag
caggacaaaggcagtctcaccagaaccctccagcacaggattgccttgcatgtggccgat
ggcctgagatatctccactcagccatgatcatttatcgtgatctgaaaccccacaatgtg
ttgcttttcaccctctatcccaatgctgccatcattgccaagattgccgactacgggatt
gcacagtactgctgtagaatgggaataaagacctcagagggcaccccagggttccgggca
cctgaagttgccagaggaaatgtcatttataaccaacaggctgatgtttattcgttcggc
ttactgctttacgatatttggacaaccgggggtagaatcatagagggcttgaggtttcca
aatgagtttgatgaattagcaatacaagggaaattgccagatccagttaaagaatatggc
tgtgctccatggcctatggttgagaagttgatcaaaaagtgtttgaaagaaaatcctcaa
gaaaggcccacttctgcccaggtctttgacattttgaattcacctgaattaatttgtctc
atgcggcacattttaataccgaagaacattgttgttgaatgcatggttgctacaaatccc
aatagcaagagtgcgactctctggttgggctgtgggaacactgaaaaggggcagctctcc
ttctttgacttaaacacggaaagatacagctatgaggaagttactgatagtagaatattg
tgtctggctttggtacatctccctgctgagaaagagagctgggttgtgtgcggcacacag
tctggggatctcctggtcatcaatgctgaagacgaggcaaagaggcacactcttgaaaag
atgactgactctgttacttgcttgtattgcaattccttcgccaagcagagcaaacaaagt
aattttcttttggtgggaactgcagacggtaatctagtgatatttgaagataacaccatt
aagtgtaaaggagctgcccccttgaagacactacgcataggcgatgtcagtacgcccctg
atgtgcttgagtgtgtccatgaactcatctgaaaggcacatcacctggggagggtgtggt
acaaagatcttctcattttccagtgatttcaccattcagaaactcatagagacaagaacc
aaccagctcttttcttacgcagctttcagcgattctaacatcatagcggtggcagtagac
gcggctctctttattgccaagaagaacagccccgtggtggaggtgtgggacaagaaaacg
gagaagctctgtgaattgattgactgcgtgcacttcttaaaggaggtgattgtcaaagta
aacaaggagtccaaacacaagctgtcttactcggggagggtgaaagcgctctgcctgcag
aagaacacggctctctggataggaactggaggaggccacattttgctcctggacctctcc
acccgacgagtgatacgcaccattcacaacttctgtgactctgtgagagccatgtccatg
gcacagctaggaagccttaaaaatgtcatgctggttttggggtacaaaaggaagaataca
gaaggtgcccaagaacaaaaagaaatacagtcttgcttgtctatttgggacatcaatctt
ccacatgaagtacaaaatttagaaaaacacattgaagtgagaacagaattagctgagaaa
atgagaagaatatccgttgactag
DBGET
integrated database retrieval system
