KEGG   Microtus oregoni (creeping vole): 121464321
Entry
121464321         CDS       T08307                                 
Symbol
Pik3cb
Name
(RefSeq) phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1
  KO
K00922  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
Organism
morg  Microtus oregoni (creeping vole)
Pathway
morg00562  Inositol phosphate metabolism
morg01100  Metabolic pathways
morg01521  EGFR tyrosine kinase inhibitor resistance
morg01522  Endocrine resistance
morg01524  Platinum drug resistance
morg04012  ErbB signaling pathway
morg04014  Ras signaling pathway
morg04015  Rap1 signaling pathway
morg04024  cAMP signaling pathway
morg04062  Chemokine signaling pathway
morg04066  HIF-1 signaling pathway
morg04068  FoxO signaling pathway
morg04070  Phosphatidylinositol signaling system
morg04071  Sphingolipid signaling pathway
morg04072  Phospholipase D signaling pathway
morg04081  Hormone signaling
morg04140  Autophagy - animal
morg04150  mTOR signaling pathway
morg04151  PI3K-Akt signaling pathway
morg04152  AMPK signaling pathway
morg04210  Apoptosis
morg04211  Longevity regulating pathway
morg04213  Longevity regulating pathway - multiple species
morg04218  Cellular senescence
morg04360  Axon guidance
morg04370  VEGF signaling pathway
morg04380  Osteoclast differentiation
morg04510  Focal adhesion
morg04550  Signaling pathways regulating pluripotency of stem cells
morg04611  Platelet activation
morg04613  Neutrophil extracellular trap formation
morg04620  Toll-like receptor signaling pathway
morg04625  C-type lectin receptor signaling pathway
morg04630  JAK-STAT signaling pathway
morg04650  Natural killer cell mediated cytotoxicity
morg04660  T cell receptor signaling pathway
morg04662  B cell receptor signaling pathway
morg04664  Fc epsilon RI signaling pathway
morg04666  Fc gamma R-mediated phagocytosis
morg04668  TNF signaling pathway
morg04670  Leukocyte transendothelial migration
morg04722  Neurotrophin signaling pathway
morg04725  Cholinergic synapse
morg04750  Inflammatory mediator regulation of TRP channels
morg04810  Regulation of actin cytoskeleton
morg04910  Insulin signaling pathway
morg04914  Progesterone-mediated oocyte maturation
morg04915  Estrogen signaling pathway
morg04917  Prolactin signaling pathway
morg04919  Thyroid hormone signaling pathway
morg04923  Regulation of lipolysis in adipocytes
morg04926  Relaxin signaling pathway
morg04929  GnRH secretion
morg04930  Type II diabetes mellitus
morg04931  Insulin resistance
morg04932  Non-alcoholic fatty liver disease
morg04933  AGE-RAGE signaling pathway in diabetic complications
morg04935  Growth hormone synthesis, secretion and action
morg04960  Aldosterone-regulated sodium reabsorption
morg04973  Carbohydrate digestion and absorption
morg05010  Alzheimer disease
morg05017  Spinocerebellar ataxia
morg05020  Prion disease
morg05100  Bacterial invasion of epithelial cells
morg05132  Salmonella infection
morg05135  Yersinia infection
morg05142  Chagas disease
morg05146  Amoebiasis
morg05160  Hepatitis C
morg05161  Hepatitis B
morg05162  Measles
morg05163  Human cytomegalovirus infection
morg05164  Influenza A
morg05165  Human papillomavirus infection
morg05166  Human T-cell leukemia virus 1 infection
morg05167  Kaposi sarcoma-associated herpesvirus infection
morg05168  Herpes simplex virus 1 infection
morg05169  Epstein-Barr virus infection
morg05170  Human immunodeficiency virus 1 infection
morg05171  Coronavirus disease - COVID-19
morg05200  Pathways in cancer
morg05203  Viral carcinogenesis
morg05205  Proteoglycans in cancer
morg05206  MicroRNAs in cancer
morg05207  Chemical carcinogenesis - receptor activation
morg05208  Chemical carcinogenesis - reactive oxygen species
morg05210  Colorectal cancer
morg05211  Renal cell carcinoma
morg05212  Pancreatic cancer
morg05213  Endometrial cancer
morg05214  Glioma
morg05215  Prostate cancer
morg05218  Melanoma
morg05220  Chronic myeloid leukemia
morg05221  Acute myeloid leukemia
morg05222  Small cell lung cancer
morg05223  Non-small cell lung cancer
morg05224  Breast cancer
morg05225  Hepatocellular carcinoma
morg05226  Gastric cancer
morg05230  Central carbon metabolism in cancer
morg05231  Choline metabolism in cancer
morg05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
morg05415  Diabetic cardiomyopathy
morg05417  Lipid and atherosclerosis
morg05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:morg00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    121464321 (Pik3cb)
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    121464321 (Pik3cb)
   04014 Ras signaling pathway
    121464321 (Pik3cb)
   04015 Rap1 signaling pathway
    121464321 (Pik3cb)
   04370 VEGF signaling pathway
    121464321 (Pik3cb)
   04630 JAK-STAT signaling pathway
    121464321 (Pik3cb)
   04668 TNF signaling pathway
    121464321 (Pik3cb)
   04066 HIF-1 signaling pathway
    121464321 (Pik3cb)
   04068 FoxO signaling pathway
    121464321 (Pik3cb)
   04070 Phosphatidylinositol signaling system
    121464321 (Pik3cb)
   04072 Phospholipase D signaling pathway
    121464321 (Pik3cb)
   04071 Sphingolipid signaling pathway
    121464321 (Pik3cb)
   04024 cAMP signaling pathway
    121464321 (Pik3cb)
   04151 PI3K-Akt signaling pathway
    121464321 (Pik3cb)
   04152 AMPK signaling pathway
    121464321 (Pik3cb)
   04150 mTOR signaling pathway
    121464321 (Pik3cb)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    121464321 (Pik3cb)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    121464321 (Pik3cb)
  09143 Cell growth and death
   04210 Apoptosis
    121464321 (Pik3cb)
   04218 Cellular senescence
    121464321 (Pik3cb)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    121464321 (Pik3cb)
   04550 Signaling pathways regulating pluripotency of stem cells
    121464321 (Pik3cb)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    121464321 (Pik3cb)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    121464321 (Pik3cb)
   04613 Neutrophil extracellular trap formation
    121464321 (Pik3cb)
   04620 Toll-like receptor signaling pathway
    121464321 (Pik3cb)
   04625 C-type lectin receptor signaling pathway
    121464321 (Pik3cb)
   04650 Natural killer cell mediated cytotoxicity
    121464321 (Pik3cb)
   04660 T cell receptor signaling pathway
    121464321 (Pik3cb)
   04662 B cell receptor signaling pathway
    121464321 (Pik3cb)
   04664 Fc epsilon RI signaling pathway
    121464321 (Pik3cb)
   04666 Fc gamma R-mediated phagocytosis
    121464321 (Pik3cb)
   04670 Leukocyte transendothelial migration
    121464321 (Pik3cb)
   04062 Chemokine signaling pathway
    121464321 (Pik3cb)
  09152 Endocrine system
   04910 Insulin signaling pathway
    121464321 (Pik3cb)
   04923 Regulation of lipolysis in adipocytes
    121464321 (Pik3cb)
   04929 GnRH secretion
    121464321 (Pik3cb)
   04915 Estrogen signaling pathway
    121464321 (Pik3cb)
   04914 Progesterone-mediated oocyte maturation
    121464321 (Pik3cb)
   04917 Prolactin signaling pathway
    121464321 (Pik3cb)
   04926 Relaxin signaling pathway
    121464321 (Pik3cb)
   04935 Growth hormone synthesis, secretion and action
    121464321 (Pik3cb)
   04919 Thyroid hormone signaling pathway
    121464321 (Pik3cb)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    121464321 (Pik3cb)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    121464321 (Pik3cb)
  09156 Nervous system
   04725 Cholinergic synapse
    121464321 (Pik3cb)
   04722 Neurotrophin signaling pathway
    121464321 (Pik3cb)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    121464321 (Pik3cb)
  09158 Development and regeneration
   04360 Axon guidance
    121464321 (Pik3cb)
   04380 Osteoclast differentiation
    121464321 (Pik3cb)
  09149 Aging
   04211 Longevity regulating pathway
    121464321 (Pik3cb)
   04213 Longevity regulating pathway - multiple species
    121464321 (Pik3cb)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    121464321 (Pik3cb)
   05206 MicroRNAs in cancer
    121464321 (Pik3cb)
   05205 Proteoglycans in cancer
    121464321 (Pik3cb)
   05207 Chemical carcinogenesis - receptor activation
    121464321 (Pik3cb)
   05208 Chemical carcinogenesis - reactive oxygen species
    121464321 (Pik3cb)
   05203 Viral carcinogenesis
    121464321 (Pik3cb)
   05230 Central carbon metabolism in cancer
    121464321 (Pik3cb)
   05231 Choline metabolism in cancer
    121464321 (Pik3cb)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    121464321 (Pik3cb)
  09162 Cancer: specific types
   05210 Colorectal cancer
    121464321 (Pik3cb)
   05212 Pancreatic cancer
    121464321 (Pik3cb)
   05225 Hepatocellular carcinoma
    121464321 (Pik3cb)
   05226 Gastric cancer
    121464321 (Pik3cb)
   05214 Glioma
    121464321 (Pik3cb)
   05221 Acute myeloid leukemia
    121464321 (Pik3cb)
   05220 Chronic myeloid leukemia
    121464321 (Pik3cb)
   05218 Melanoma
    121464321 (Pik3cb)
   05211 Renal cell carcinoma
    121464321 (Pik3cb)
   05215 Prostate cancer
    121464321 (Pik3cb)
   05213 Endometrial cancer
    121464321 (Pik3cb)
   05224 Breast cancer
    121464321 (Pik3cb)
   05222 Small cell lung cancer
    121464321 (Pik3cb)
   05223 Non-small cell lung cancer
    121464321 (Pik3cb)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    121464321 (Pik3cb)
   05170 Human immunodeficiency virus 1 infection
    121464321 (Pik3cb)
   05161 Hepatitis B
    121464321 (Pik3cb)
   05160 Hepatitis C
    121464321 (Pik3cb)
   05171 Coronavirus disease - COVID-19
    121464321 (Pik3cb)
   05164 Influenza A
    121464321 (Pik3cb)
   05162 Measles
    121464321 (Pik3cb)
   05168 Herpes simplex virus 1 infection
    121464321 (Pik3cb)
   05163 Human cytomegalovirus infection
    121464321 (Pik3cb)
   05167 Kaposi sarcoma-associated herpesvirus infection
    121464321 (Pik3cb)
   05169 Epstein-Barr virus infection
    121464321 (Pik3cb)
   05165 Human papillomavirus infection
    121464321 (Pik3cb)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    121464321 (Pik3cb)
   05135 Yersinia infection
    121464321 (Pik3cb)
   05100 Bacterial invasion of epithelial cells
    121464321 (Pik3cb)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    121464321 (Pik3cb)
   05142 Chagas disease
    121464321 (Pik3cb)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    121464321 (Pik3cb)
   05017 Spinocerebellar ataxia
    121464321 (Pik3cb)
   05020 Prion disease
    121464321 (Pik3cb)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    121464321 (Pik3cb)
   05418 Fluid shear stress and atherosclerosis
    121464321 (Pik3cb)
   05415 Diabetic cardiomyopathy
    121464321 (Pik3cb)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    121464321 (Pik3cb)
   04932 Non-alcoholic fatty liver disease
    121464321 (Pik3cb)
   04931 Insulin resistance
    121464321 (Pik3cb)
   04933 AGE-RAGE signaling pathway in diabetic complications
    121464321 (Pik3cb)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    121464321 (Pik3cb)
   01524 Platinum drug resistance
    121464321 (Pik3cb)
   01522 Endocrine resistance
    121464321 (Pik3cb)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:morg04131]
    121464321 (Pik3cb)
Enzymes [BR:morg01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     121464321 (Pik3cb)
Membrane trafficking [BR:morg04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    121464321 (Pik3cb)
SSDB
Motif
Pfam: PI3_PI4_kinase PI3Ka PI3K_p85B PI3K_rbd PI3K_C2 Tom37_C DUF4381
Other DBs
NCBI-GeneID: 121464321
NCBI-ProteinID: XP_041533145
LinkDB
Position
Unknown
AA seq 1070 aa
MCLSSIMPPAMADILDIWAVDSQIASDGAISVDFLLPTGIYIQLEVPREATISSIKQMLW
KQVHNYPMFNLLMDIDSYMFACVNQTAVYEELEDETRRLCDVRPFLPVLKLVTRSCDPAE
KLDSKIGVLIGKGLHEFDALKDPEVNEFRRKMRKFSEDKIQSLVGLSWIDWLKHTYPPEH
EPSVLENLEDKLYGGKLIVAVHFENSQDVFSFQVSPNLTPIKINELAIQKRLTIHGKEDE
VSPYDCVLQVSGRVEYVFGEYPLIQFQYIRNCVMNRTLPHFILVECCKIKKMYEQEMIAI
EAAINRNSSNLPLPLPPKKTRVISHVWDNNNPFQIVLVKGNKLNTEETVKVHVRAGLFHG
TELLCKTVVSSEISGKNDHIWNEPLEFDINICDLPRMARLCFAVYAVLDKVKTKKSTKTI
NPSKYQTIRKAGKMHYPVAWVNTMVFDFKGQLRSGDVILHSWSSFPDELEEMLNPMGTVQ
TNPYAENATALHIKFPDNKKQPYYYPPFDKIIEKAAEIASGDSANVSSRGGKKFLAVLKE
ILDRDPLSQLCENEMDLIWTLRQDCRENFPQSLPKLLLSIKWNKLEDVAQLQALLQIWPK
LPPREALELLDFNYPDQYVREYAVGCLRQMSDEELSQYLLQLVQVLKYEPFLDCALSRFL
LERALDNRRIGQFLFWHLRSEVHIPAVSVQFGVILEAYCRGSVGHMKVLSKQVEALNKLK
TLNSLIKLNAVKLNRAKGKEAMHTCLKQNAYREALSDLQSPLNPCVILSELYVEKCKYMD
SKMKPLWLVYSSRGFGEDSVGVIFKNGDDLRQDMLTLQMLRLMDLLWKEAGLDLRMLPYG
CLATGDRSGLIEVVSTSETIADIQLNSSNVAATAAFNKDALLNWLKEYNSGDDLDRAIEE
FTLSCAGYCVASYVLGIGDRHSDNIMVKKTGQLFHIDFGHILGNFKSKFGIKRERVPFIL
TYDFIHVIQQGKTGNTEKFGRFRQCCEDAYLILRRHGNLFITLFALMLTAGLPELTSVKD
IQYLKDSLALGKSEEEALKQFKQKFDEALRESWTTKVNWMAHTVRKDYRS
NT seq 3213 nt   +upstreamnt  +downstreamnt
atgtgcctcagctctataatgcctcctgctatggcagacatccttgacatctgggcagtg
gattcacagatcgcatctgatggcgccatatctgtggatttccttctgcccactgggatt
tatatccagctggaagtacctcgggaagctaccatttcttctattaaacagatgttatgg
aagcaagttcacaattacccaatgtttaatctccttatggacattgactcctacatgttt
gcatgtgtgaatcaaactgctgtatacgaggaacttgaagatgaaactcgaagactttgt
gatgtcagaccttttcttcctgttctaaaactagtgacaagaagttgtgacccagcagaa
aaattggactcaaaaattggagtacttatagggaaaggtcttcatgaatttgatgccttg
aaggatcctgaagtgaatgagtttagaagaaaaatgcgcaaattcagtgaggacaagatt
cagtctctggtggggctgtcttggattgactggctgaagcacacgtacccacctgagcac
gagccgtccgtcctggagaacttggaggataaactttatggagggaagctgattgtggct
gtgcattttgaaaatagccaggatgtgtttagttttcaagtgtctcccaatttaactcct
ataaaaataaatgaattggcaatccagaaacgcttgactattcatggaaaggaagatgaa
gttagcccctatgactgtgtgttacaagtcagcgggagagtggagtatgtatttggagaa
tacccactaattcagttccagtatatccggaactgtgtgatgaataggaccctgccccat
ttcatcctcgtggaatgttgcaaaatcaagaaaatgtatgagcaagaaatgattgccata
gaggctgccatcaaccggaactcatctaaccttcctctgcccttaccaccaaagaaaacg
cgagttatttctcatgtctgggacaacaacaaccctttccaaattgtcttggtgaaagga
aataagcttaacacagaagaaactgtgaaagttcatgtcagagctggtctttttcatgga
actgagctcctgtgtaaaactgttgtaagctcggagatatcaggaaaaaacgaccatatt
tggaatgaaccactggaatttgatattaatatttgtgacttaccaagaatggctcgatta
tgttttgctgtttatgctgttttggataaagtaaaaacgaagaaatcaacaaaaactatt
aatccctctaaatatcagaccatcaggaaagctgggaaaatgcattatcctgtagcgtgg
gtaaatacgatggtttttgacttcaaaggacagctgagatctggagacgtcatactgcac
agttggtcgtcctttcctgatgagctggaagagatgctaaatcccatgggcactgtgcag
acgaacccatatgctgaaaatgcaactgccttgcatattaagttcccagataataaaaag
cagccttattattaccctcccttcgataagatcattgagaaggcagctgagattgccagt
ggcgacagtgctaacgtgtcaagtcgtggtggaaaaaaattccttgctgtactgaaagaa
atcttggacagggaccccctgtctcagctatgtgagaacgaaatggatcttatttggact
ctacggcaagattgccgagaaaatttcccacagtcactgccaaaactactcctgtcaatc
aagtggaataaacttgaagatgttgctcagcttcaggcactcctgcagatttggcccaaa
ctgccccccagggaagcactggagctcctggatttcaactatccagatcagtacgtccgg
gaatatgctgtgggctgcctgcgacagatgagtgatgaagagctctctcagtatcttcta
cagttggtgcaagttttgaaatatgagccttttcttgattgtgccctctctagattcctg
ctagaaagagcacttgataatcgaaggattgggcagttcctgttttggcatcttaggtca
gaagtacatattcccgccgtgtctgtccagtttggggtcatcctggaagcgtattgtcga
ggaagcgtagggcacatgaaagtgctttccaagcaggttgaagcactcaataagttaaaa
actttaaatagcttaatcaaattgaatgccgtgaagctcaacagagctaaaggaaaggag
gctatgcacacctgtttaaagcagaacgcttaccgggaggccctctctgaccttcagtcg
cctctgaacccgtgtgtcattctctcggaactctatgttgaaaagtgcaaatacatggat
tccaagatgaagcccttgtggctggtctacagcagcagaggttttggagaggactcggtt
ggagtgatctttaaaaatggtgatgatttgcggcaggacatgctgacgctgcagatgcta
cgcctgatggatctactctggaaagaggctggtttggaccttcggatgcttccctatggc
tgtttagcaacaggagatcgctctggcctcattgaggttgtgagcacctctgagacaatc
gctgacattcagctgaacagtagcaatgtggctgccacagcagccttcaacaaagacgca
ctcctgaactggcttaaggagtacaactctggggatgacctggaccgagcaattgaggag
ttcaccctgtcctgtgctggctactgtgtagcttcttatgtccttggcattggtgacagg
catagtgacaacatcatggtgaaaaaaacgggccagctcttccacatagattttggacat
attcttggaaatttcaaatctaaatttggcattaaaagagagcgagtaccttttatcctt
acttatgacttcattcatgtcattcagcaaggaaaaacaggaaatacagaaaaatttggc
aggtttcgccagtgctgtgaagatgcctatctgattttacggcggcatgggaacctcttc
atcactctcttcgcactgatgttgactgcagggcttcctgagcttacgtcagtcaaagat
atacagtatcttaaggactctcttgccttaggaaagagtgaagaagaagcactcaaacag
tttaagcagaaatttgatgaggccctcagggaaagctggactaccaaggtgaactggatg
gctcacacagttcgcaaagactacaggtcttag

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