Entry |
|
Symbol |
Plcb2
|
Name |
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1
|
KO |
|
Organism |
mpah Mus pahari (shrew mouse)
|
Pathway |
mpah04070 | Phosphatidylinositol signaling system |
mpah04261 | Adrenergic signaling in cardiomyocytes |
mpah04613 | Neutrophil extracellular trap formation |
mpah04621 | NOD-like receptor signaling pathway |
mpah04723 | Retrograde endocannabinoid signaling |
mpah04750 | Inflammatory mediator regulation of TRP channels |
mpah04925 | Aldosterone synthesis and secretion |
mpah04928 | Parathyroid hormone synthesis, secretion and action |
mpah04933 | AGE-RAGE signaling pathway in diabetic complications |
mpah04935 | Growth hormone synthesis, secretion and action |
mpah04961 | Endocrine and other factor-regulated calcium reabsorption |
mpah04973 | Carbohydrate digestion and absorption |
mpah05022 | Pathways of neurodegeneration - multiple diseases |
|
Module |
mpah_M00130 | Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4 |
|
Brite |
KEGG Orthology (KO) [BR:mpah00001]
09100 Metabolism
09101 Carbohydrate metabolism
00562 Inositol phosphate metabolism
110318415 (Plcb2)
09130 Environmental Information Processing
09132 Signal transduction
04015 Rap1 signaling pathway
110318415 (Plcb2)
04310 Wnt signaling pathway
110318415 (Plcb2)
04371 Apelin signaling pathway
110318415 (Plcb2)
04020 Calcium signaling pathway
110318415 (Plcb2)
04070 Phosphatidylinositol signaling system
110318415 (Plcb2)
04072 Phospholipase D signaling pathway
110318415 (Plcb2)
04071 Sphingolipid signaling pathway
110318415 (Plcb2)
04022 cGMP-PKG signaling pathway
110318415 (Plcb2)
09133 Signaling molecules and interaction
04082 Neuroactive ligand signaling
110318415 (Plcb2)
04081 Hormone signaling
110318415 (Plcb2)
09140 Cellular Processes
09144 Cellular community - eukaryotes
04540 Gap junction
110318415 (Plcb2)
09150 Organismal Systems
09151 Immune system
04611 Platelet activation
110318415 (Plcb2)
04613 Neutrophil extracellular trap formation
110318415 (Plcb2)
04621 NOD-like receptor signaling pathway
110318415 (Plcb2)
04062 Chemokine signaling pathway
110318415 (Plcb2)
09152 Endocrine system
04911 Insulin secretion
110318415 (Plcb2)
04922 Glucagon signaling pathway
110318415 (Plcb2)
04929 GnRH secretion
110318415 (Plcb2)
04912 GnRH signaling pathway
110318415 (Plcb2)
04915 Estrogen signaling pathway
110318415 (Plcb2)
04921 Oxytocin signaling pathway
110318415 (Plcb2)
04926 Relaxin signaling pathway
110318415 (Plcb2)
04935 Growth hormone synthesis, secretion and action
110318415 (Plcb2)
04918 Thyroid hormone synthesis
110318415 (Plcb2)
04919 Thyroid hormone signaling pathway
110318415 (Plcb2)
04928 Parathyroid hormone synthesis, secretion and action
110318415 (Plcb2)
04916 Melanogenesis
110318415 (Plcb2)
04924 Renin secretion
110318415 (Plcb2)
04925 Aldosterone synthesis and secretion
110318415 (Plcb2)
04927 Cortisol synthesis and secretion
110318415 (Plcb2)
09153 Circulatory system
04261 Adrenergic signaling in cardiomyocytes
110318415 (Plcb2)
04270 Vascular smooth muscle contraction
110318415 (Plcb2)
09154 Digestive system
04970 Salivary secretion
110318415 (Plcb2)
04971 Gastric acid secretion
110318415 (Plcb2)
04972 Pancreatic secretion
110318415 (Plcb2)
04973 Carbohydrate digestion and absorption
110318415 (Plcb2)
09155 Excretory system
04961 Endocrine and other factor-regulated calcium reabsorption
110318415 (Plcb2)
09156 Nervous system
04724 Glutamatergic synapse
110318415 (Plcb2)
04725 Cholinergic synapse
110318415 (Plcb2)
04728 Dopaminergic synapse
110318415 (Plcb2)
04726 Serotonergic synapse
110318415 (Plcb2)
04720 Long-term potentiation
110318415 (Plcb2)
04730 Long-term depression
110318415 (Plcb2)
04723 Retrograde endocannabinoid signaling
110318415 (Plcb2)
09157 Sensory system
04742 Taste transduction
110318415 (Plcb2)
04750 Inflammatory mediator regulation of TRP channels
110318415 (Plcb2)
09159 Environmental adaptation
04713 Circadian entrainment
110318415 (Plcb2)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
110318415 (Plcb2)
09172 Infectious disease: viral
05163 Human cytomegalovirus infection
110318415 (Plcb2)
09174 Infectious disease: parasitic
05146 Amoebiasis
110318415 (Plcb2)
05142 Chagas disease
110318415 (Plcb2)
05143 African trypanosomiasis
110318415 (Plcb2)
09164 Neurodegenerative disease
05010 Alzheimer disease
110318415 (Plcb2)
05016 Huntington disease
110318415 (Plcb2)
05017 Spinocerebellar ataxia
110318415 (Plcb2)
05022 Pathways of neurodegeneration - multiple diseases
110318415 (Plcb2)
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
110318415 (Plcb2)
05415 Diabetic cardiomyopathy
110318415 (Plcb2)
09167 Endocrine and metabolic disease
04933 AGE-RAGE signaling pathway in diabetic complications
110318415 (Plcb2)
04934 Cushing syndrome
110318415 (Plcb2)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:mpah04131]
110318415 (Plcb2)
Enzymes [BR:mpah01000]
3. Hydrolases
3.1 Acting on ester bonds
3.1.4 Phosphoric-diester hydrolases
3.1.4.11 phosphoinositide phospholipase C
110318415 (Plcb2)
Membrane trafficking [BR:mpah04131]
Exocytosis
Calcium ion-dependent exocytosis
Phospholipases
110318415 (Plcb2)
Endocytosis
Macropinocytosis
Phospholipase C
110318415 (Plcb2)
|
SSDB |
|
Motif |
|
Other DBs |
|
LinkDB |
|
Position |
3:complement(102116451..102135971)
|
AA seq |
1179 aa
MSLLNPVLLPPNVKAYLSQGERFIKWDDETSIASPVILRVDPKGYYLYWTHQNKEMEFLD
VTSIRDTRFGKFAKIPKSQKLREVFNMDFPDNHFLLKTLTVVSGPDMVDLTFHNFVSYKE
NVGKDWAEDVLALAKHPMTANAPRSTFLDKILVKLKMQLNPEGKIPVKNFFQMFPADRKR
VEAALGACHLAKGKNDAINPEDFPESVYKSFLMSLCPRPEIDEIFTSYHAKAKPYMTKEH
LTKFINQKQRDPRLNSLLFPPARPEQVQVLIDKYEPSGINVQRGQLSPEGMVWFLCGPEN
SVLAHDTLLTHQDMTQPLNHYFINSSHNTYLTAGQFSGLSSAEMYRQVLLSGCRCVELDC
WKGKPPDEEPIITHGFTMTTDILFKEAIEAIAESAFKTSPYPVILSFENHVDSPRQQAKM
AEYCRTMFGETLLTDPLENFPLKPGIPLPSPEDLRGKILIKNKKNQFSGPASPSKKPGGV
AEGSLPSNVPVEEDTGWTAEDRTEVEEEEEEEESGSLDEEEIKKMQSDEGTAGLEVTAYE
EMSSLVNYIQPTKFISFEFSAQKNRSYVVSSFTELKAYELLSKASMQFVDYNKRQMSRVY
PKGTRMDSSNYMPQMFWNAGCQMVALNFQTMDLPMQQNMAVFEFNGQSGYLLKHEFMRRL
DKQFNPFSVDRIDVVVATTLSITVISGQFLSERSVRTYVEVELFGLPGDPKRRYRTKLSP
TANSINPVWKEEPFIFEKILVPELASLRIAVMEEGNKFLGHRIIPINALHSGYHHLCLRS
ESNMPLTMPALFVFLEMKDYVPDTWADLTVALANPIKYFNAHDKKSVKLKEVTGSLPERL
FSSGTPVASQSNGAPVSAGNGSAAPGTKAKGEEAKKEVTEPQTASLEELRELKGVVKLQR
RHEKELRELERRGARRWEELLQRGAAQLAELQTPAAGSKLRPGKGSRKKRTLPCEETVLV
VAPSEPPDGADPRVQELKDRLEQELQQQGEEQYRSVLKRKEQHVTEQIAKMMELAREKQA
AELKTFKETSETDTKEMKKKLEAKRLERIQAMTKVTTDKVAQERLKREINNSHIQEVVQA
VKQMTETLERHQEKLEERQTACLGQIQAMEKQFQEKALAEYEAKMKGLEAEVKESVRACF
KVCFSAEAEDKPERPCEASEEPCSQEPLVSKADTQESRL |
NT seq |
3540 nt +upstreamnt +downstreamnt
atgtctttgctcaaccctgtcctgttgccccctaacgtgaaggcatatctgagccaaggg
gagcgcttcatcaagtgggacgatgaaacttcaatagcctctccagttatcctccgtgtg
gatcccaagggctattacttatactggacgcatcaaaataaggagatggaattcctggat
gtcacgagcatccgtgacactcgctttgggaagtttgcaaagatacccaagagccagaaa
ctccgtgaggtcttcaacatggactttccagacaaccacttcctgctaaaaacgctcaca
gtggtgtccggccctgacatggtggacctcaccttccacaactttgtctcttacaaggag
aacgtaggcaaggactgggctgaggacgtgctggctctcgccaaacacccgatgacagcc
aatgctccccgaagcacattcctggacaagatcctggtaaagcttaagatgcagctcaac
cctgaagggaagattcctgtgaagaactttttccagatgtttcctgctgatcgcaaacgg
gtggaagctgccctcggtgcctgtcaccttgcaaaaggcaaaaatgatgctatcaatcca
gaggacttccctgaatctgtgtacaagagcttcctcatgagcctatgtcctcggccagaa
atcgacgagatcttcacttcctaccacgctaaagctaaaccctatatgaccaaggagcac
ctgaccaaattcatcaatcagaagcaacgagaccctcgactcaactccttgctgttcccg
ccagcccggcctgagcaggtgcaggtgctcattgacaagtacgaacccagcggcatcaat
gtgcagaggggccagctgtcgccagaggggatggtctggtttctttgtggaccagagaac
agcgtgctggcccacgatacactgctgacccaccaagacatgacacagccactgaatcac
tacttcatcaattcctcacacaacacctacctgacagctggccagttctcaggcctctcc
tcggctgagatgtaccgccaggtgctgctgtcgggctgccgttgtgtagagctagactgt
tggaagggcaagccccccgacgaagagcccatcatcacccacggcttcaccatgaccaca
gatattttgttcaaggaagcaatcgaagccattgccgaaagtgcctttaagacctcccca
tatcccgtcatcctgtcatttgaaaaccacgtggactcaccccgccaacaggctaagatg
gctgagtactgcaggaccatgtttggagagaccttgctcacagatcccctggaaaatttt
cctctgaaacctggcatccctctgcccagccccgaggacctccggggtaagatcctcatt
aagaataagaagaaccagttttctgggccagcatcccccagcaagaagcctggtggggtg
gctgagggcagcctcccatctaatgtccctgtcgaagaggacacagggtggactgctgag
gaccggactgaggtggaagaggaggaggaagaggaggagtcaggaagcctggatgaagaa
gaaattaagaagatgcagtcggatgagggcacagcgggcctggaggtgacagcttatgag
gaaatgtccagccttgtcaattatatccagcccaccaagtttatctccttcgagttctct
gcacagaagaacagaagttacgttgtctcttccttcacggagctcaaggcctacgagctg
ctctccaaggcctccatgcagtttgtggactataataaacgccagatgagccgtgtgtac
cccaagggcacacgcatggactcttccaactacatgccccagatgttctggaatgctgga
tgtcagatggttgccctcaatttccagacaatggacctgcccatgcagcagaacatggca
gtgtttgagttcaacgggcagagtggctacctcctaaagcatgagttcatgcgcagactg
gacaagcagttcaaccccttctctgtggatcgaattgatgtggtggtagccaccaccctt
tccattacggtcatctctgggcagtttctgtcagagcgcagtgtgcgcacctatgtggaa
gtggaactgtttggtctcccaggggaccccaagaggcggtatcgtaccaagctgtcacct
actgctaactccatcaatcctgtctggaaagaggagccctttatctttgagaagatcctg
gtgcctgagctggcctccctcaggatagctgtgatggaagaaggcaacaaatttcttgga
caccgcatcatccccatcaatgccttacattctggataccaccatctgtgccttcgaagt
gagagcaacatgccccttaccatgcctgctctatttgtcttcctggagatgaaggactac
gtacctgacacgtgggcagatcttacagtggcccttgccaaccccatcaagtacttcaat
gcccatgataagaagtccgtgaagctcaaagaagtgacaggaagtctgcctgagaggctc
ttctcctctgggacacctgttgccagtcagtccaatggggcaccagtctcggcaggcaat
gggtcagcagcacccgggaccaaggccaagggggaagaagctaagaaagaagtgacagag
ccacagaccgccagcttggaagagctgcgggaactgaagggcgtggtgaagctgcagcgg
aggcacgagaaggagcttcgagagctggagcgccgtggagcccggcgttgggaggaactg
ctgcagcgtggcgccgcacagctggcggagctccagaccccggcagcgggcagcaagctc
cgcccgggcaagggctcccgcaagaagaggaccctgccctgtgaggagaccgtcctcgtc
gtggcgcctagcgagccccccgacggggcggacccgcgcgtgcaggagctgaaggacagg
ctggagcaggagctgcagcagcaaggcgaggagcagtaccgctctgtcctcaagcgcaag
gagcagcacgtgaccgagcaaatcgccaagatgatggagctggccagagagaaacaggct
gccgaactcaagaccttcaaggaaacctcggaaactgacaccaaagaaatgaagaaaaaa
ctggaggccaagaggctggaacggatccaagccatgaccaaggtcaccacagacaaggtg
gcccaggagaggctcaagagagaaattaacaattcccacatccaggaagtggtccaggct
gtcaagcagatgacagagaccctggagcgtcaccaggagaagctggaagagaggcagaca
gcctgcctggggcagatccaggcaatggaaaagcagttccaggagaaggcgctggcagag
tatgaggccaagatgaagggcctggaggctgaagtaaaggagtcggtgcgggcctgcttc
aaggtctgcttctctgctgaagcagaagacaagcccgagaggccctgtgaggcctctgag
gagccatgttcacaggaaccacttgtgagcaaggcagacacccaggagagccgcctctga |