Entry |
|
Symbol |
Plcb1
|
Name |
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1
|
KO |
|
Organism |
mpah Mus pahari (shrew mouse)
|
Pathway |
mpah04070 | Phosphatidylinositol signaling system |
mpah04261 | Adrenergic signaling in cardiomyocytes |
mpah04613 | Neutrophil extracellular trap formation |
mpah04621 | NOD-like receptor signaling pathway |
mpah04723 | Retrograde endocannabinoid signaling |
mpah04750 | Inflammatory mediator regulation of TRP channels |
mpah04925 | Aldosterone synthesis and secretion |
mpah04928 | Parathyroid hormone synthesis, secretion and action |
mpah04933 | AGE-RAGE signaling pathway in diabetic complications |
mpah04935 | Growth hormone synthesis, secretion and action |
mpah04961 | Endocrine and other factor-regulated calcium reabsorption |
mpah04973 | Carbohydrate digestion and absorption |
mpah05022 | Pathways of neurodegeneration - multiple diseases |
|
Module |
mpah_M00130 | Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4 |
|
Brite |
KEGG Orthology (KO) [BR:mpah00001]
09100 Metabolism
09101 Carbohydrate metabolism
00562 Inositol phosphate metabolism
110319646 (Plcb1)
09130 Environmental Information Processing
09132 Signal transduction
04015 Rap1 signaling pathway
110319646 (Plcb1)
04310 Wnt signaling pathway
110319646 (Plcb1)
04371 Apelin signaling pathway
110319646 (Plcb1)
04020 Calcium signaling pathway
110319646 (Plcb1)
04070 Phosphatidylinositol signaling system
110319646 (Plcb1)
04072 Phospholipase D signaling pathway
110319646 (Plcb1)
04071 Sphingolipid signaling pathway
110319646 (Plcb1)
04022 cGMP-PKG signaling pathway
110319646 (Plcb1)
09140 Cellular Processes
09144 Cellular community - eukaryotes
04540 Gap junction
110319646 (Plcb1)
09150 Organismal Systems
09151 Immune system
04611 Platelet activation
110319646 (Plcb1)
04613 Neutrophil extracellular trap formation
110319646 (Plcb1)
04621 NOD-like receptor signaling pathway
110319646 (Plcb1)
04062 Chemokine signaling pathway
110319646 (Plcb1)
09152 Endocrine system
04911 Insulin secretion
110319646 (Plcb1)
04922 Glucagon signaling pathway
110319646 (Plcb1)
04929 GnRH secretion
110319646 (Plcb1)
04912 GnRH signaling pathway
110319646 (Plcb1)
04915 Estrogen signaling pathway
110319646 (Plcb1)
04921 Oxytocin signaling pathway
110319646 (Plcb1)
04926 Relaxin signaling pathway
110319646 (Plcb1)
04935 Growth hormone synthesis, secretion and action
110319646 (Plcb1)
04918 Thyroid hormone synthesis
110319646 (Plcb1)
04919 Thyroid hormone signaling pathway
110319646 (Plcb1)
04928 Parathyroid hormone synthesis, secretion and action
110319646 (Plcb1)
04916 Melanogenesis
110319646 (Plcb1)
04924 Renin secretion
110319646 (Plcb1)
04925 Aldosterone synthesis and secretion
110319646 (Plcb1)
04927 Cortisol synthesis and secretion
110319646 (Plcb1)
09153 Circulatory system
04261 Adrenergic signaling in cardiomyocytes
110319646 (Plcb1)
04270 Vascular smooth muscle contraction
110319646 (Plcb1)
09154 Digestive system
04970 Salivary secretion
110319646 (Plcb1)
04971 Gastric acid secretion
110319646 (Plcb1)
04972 Pancreatic secretion
110319646 (Plcb1)
04973 Carbohydrate digestion and absorption
110319646 (Plcb1)
09155 Excretory system
04961 Endocrine and other factor-regulated calcium reabsorption
110319646 (Plcb1)
09156 Nervous system
04724 Glutamatergic synapse
110319646 (Plcb1)
04725 Cholinergic synapse
110319646 (Plcb1)
04728 Dopaminergic synapse
110319646 (Plcb1)
04726 Serotonergic synapse
110319646 (Plcb1)
04720 Long-term potentiation
110319646 (Plcb1)
04730 Long-term depression
110319646 (Plcb1)
04723 Retrograde endocannabinoid signaling
110319646 (Plcb1)
09157 Sensory system
04742 Taste transduction
110319646 (Plcb1)
04750 Inflammatory mediator regulation of TRP channels
110319646 (Plcb1)
09159 Environmental adaptation
04713 Circadian entrainment
110319646 (Plcb1)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
110319646 (Plcb1)
09172 Infectious disease: viral
05163 Human cytomegalovirus infection
110319646 (Plcb1)
09174 Infectious disease: parasitic
05146 Amoebiasis
110319646 (Plcb1)
05142 Chagas disease
110319646 (Plcb1)
05143 African trypanosomiasis
110319646 (Plcb1)
09164 Neurodegenerative disease
05010 Alzheimer disease
110319646 (Plcb1)
05016 Huntington disease
110319646 (Plcb1)
05017 Spinocerebellar ataxia
110319646 (Plcb1)
05022 Pathways of neurodegeneration - multiple diseases
110319646 (Plcb1)
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
110319646 (Plcb1)
05415 Diabetic cardiomyopathy
110319646 (Plcb1)
09167 Endocrine and metabolic disease
04933 AGE-RAGE signaling pathway in diabetic complications
110319646 (Plcb1)
04934 Cushing syndrome
110319646 (Plcb1)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:mpah04131]
110319646 (Plcb1)
Enzymes [BR:mpah01000]
3. Hydrolases
3.1 Acting on ester bonds
3.1.4 Phosphoric-diester hydrolases
3.1.4.11 phosphoinositide phospholipase C
110319646 (Plcb1)
Membrane trafficking [BR:mpah04131]
Exocytosis
Calcium ion-dependent exocytosis
Phospholipases
110319646 (Plcb1)
Endocytosis
Macropinocytosis
Phospholipase C
110319646 (Plcb1)
|
SSDB |
|
Motif |
|
Other DBs |
|
LinkDB |
|
Position |
3:117759176..118430582
|
AA seq |
1216 aa
MAGAQPGVHALQLKPVCVSDSLKKGTKFVKWDDDSTIVTPIILRTDPQGFFFYWTDQNKE
TELLDLSLVKDARCGKHAKAPKDPKLRELLDVGNIGHLEQRMITVVYGPDLVNISHLNLV
AFQEEVAKEWTNEVFSLATNLLAQNMSRDAFLEKAYTKLKLQVTPEGRIPLKNIYRLFSA
DRKRVETALEACSLPSSRNDSIPQEDFTPDVYRVFLNNLCPRPEIDNIFSEFGAKSKPYL
TVDQMMDFINLKQRDPRLNEILYPPLKQEQVQVLIEKYEPNSSLAKKGQMSVDGFMRYLS
GEENGVVSPEKLDLNEDMSQPLSHYFINSSHNTYLTAGQLAGNSSVEMYRQVLLSGCRCV
ELDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPFPILLSFENHVDSPKQ
QAKMAEYCRLIFGDALLMEPLEKYPLESGVPLPSPMDLMYKILVKNKKKSHKSSEGSGKK
RLSEQASNTYSDSSSVFEPSSPGAGEADTESDDDDDDDDCKKSSMDEGTAGSEAMATEEM
SNLVNYIQPVKFESFEISKKRNKSFEMSSFVETKGLEQLTKSPVEFVEYNKMQLSRIYPK
GTRVDSSNYMPQLFWNAGCQMVALNFQTVDLAMQINMGMYEYNGKSGYRLKPEFMRRPDK
HFDPFTEGIVDGIVANTLSVKIISGQFLSDKKVGTYVEVDMFGLPVDTRRKAFKTKTSQG
NAVNPVWEEEPIVFKKVVLPSLACLRIAAYEEGGKFIGHRILPVQAIRPGYHYICLRNER
NQPLMLPAVFVYIEVKDYVPDTYADVIEALSNPIRYVNLMEQRAKQLAALTLEDEEEVKK
EADPGETSSEAPSETRTTPAENGVNHTASLAPKPPSQAPHSQPAPGSVKAPAKTEDLIQS
VLTEVEAQTIEELKQQKSFVKLQKKHYKEMKDLVKRHHKKTTELIKEHTTKYNEIQNDYL
RRRAALEKSAKKDSKKKSEPSSPDHGSSAIEQDLAALDAEMTQKLIDLKDKQQQQLLNLR
QEQYYSEKYQKREHIKLLIQKLTDVAEECQSNQLKKLKEICEKEKKELKKKMDKKRQEKI
TEAKSKDKSQMEEEKTEMIRSYIQEVVQYIKRLEEAQSKRQEKLVEKHNEIRQQILDEKP
KLQMELEQEYQDKFKRLPLEVLEFVQEAMKGKISEDSNHGSAPPSLASDAAKVNLKSPSS
EEVERENPGREFDTPL |
NT seq |
3651 nt +upstreamnt +downstreamnt
atggctggggctcagcccggagtgcacgccttgcaactcaagcccgtgtgcgtgtccgac
agcctcaagaagggcaccaaattcgtcaagtgggatgatgactccactattgttactcca
attattttgaggactgatcctcagggatttttcttttactggacagaccagaataaggag
acggagctgttagatctcagccttgtcaaagatgccaggtgtgggaagcacgccaaagct
cccaaggaccccaagttgcgtgaacttctggatgttgggaacatcggacacttggaacag
cgcatgataactgtggtgtatggaccagacctggtgaacatttcccacttgaatcttgtg
gcttttcaagaggaagtggccaaggaatggacaaatgaggttttcagcttggcaacaaac
ctgctggctcagaacatgtccagggacgcatttctggagaaagcatatactaagctcaag
cttcaggtcaccccagagggccgcattcctctcaaaaacatctatcgattgttctcagca
gaccggaagcgagttgagactgcgctagaggcttgtagtcttccatcttcaaggaatgat
tccattccccaggaggacttcactccagatgtatacagagttttcctgaacaatctctgc
ccccgacctgaaattgataacatcttttccgaatttggtgccaaaagcaagccgtacctt
actgttgatcagatgatggattttatcaaccttaagcagagagatcctcggctaaatgaa
atactttacccacctctgaagcaggagcaggtccaagtgttgattgagaaatatgagccc
aacagcagcctcgccaagaaagggcagatgtcagtggatggattcatgcgctacctgagc
ggagaagaaaatggagtcgtttcacctgagaaactggatttgaacgaagacatgtctcag
cccctgtcacactatttcatcaattcctcgcacaacacctacctcacagctggccagttg
gctgggaactcgtctgtagagatgtatcgccaggtgcttctgtctggatgtcgctgtgtg
gagctggactgctggaagggaaggaccgctgaggaagagcccgtcatcacccacggattc
accatgacaacagaaatatccttcaaggaagtcatagaagccatcgcagagtgtgcgttc
aagacgtctcctttccccatcctcctttcttttgagaaccacgtggattccccaaagcaa
caagccaagatggccgagtattgccgattaatctttggtgatgccctccttatggaacca
ctggaaaaatacccactggaatctggggtacctcttccaagccctatggatttaatgtat
aaaatcttggtgaaaaacaagaagaagtcacacaagtcgtcagagggaagtggtaaaaag
cggctttctgagcaagcttccaacacctacagcgactcctccagcgtgttcgagccttcg
tctccaggagctggggaagcagatacggagagtgatgacgatgacgacgatgatgactgt
aaaaagtcttccatggatgaggggactgctggcagcgaagccatggccacggaagagatg
tctaacctggtgaactacattcagcctgtcaagtttgagtcctttgaaatttcaaaaaaa
agaaataaaagctttgaaatgtcttccttcgtggaaaccaaaggacttgaacaacttaca
aagtctccggtggaatttgtagaatacaacaagatgcaacttagcaggatatatcccaag
ggaacacgcgtggattcatccaactacatgcctcaactcttctggaatgctggctgtcag
atggtggcgctcaacttccagacagtggatctagctatgcagataaacatgggcatgtat
gaatacaacgggaagagtggctacaggctgaagccagaattcatgaggaggccggacaag
cattttgatccatttactgaaggaatcgtagatgggatagtggccaatactttatctgtt
aagattatttcaggtcagtttctctctgataagaaagttgggacttacgtggaagtggat
atgtttggcttgcctgtggacacaaggaggaaggcatttaaaaccaagacatcccaagga
aatgctgtaaaccctgtctgggaagaagaacctattgtattcaaaaaggtagttctacct
tctctggcctgtttgaggatagcagcatatgaagagggaggcaaatttattggccaccgg
atattgcctgtgcaggctatacggccaggctatcactacatctgcctgcggaatgagagg
aaccagcccctgatgctgccagctgtctttgtctacattgaagtcaaagactatgtgcca
gacacatacgcagatgtgatcgaagctctatcaaacccaatccgatatgtcaatctcatg
gaacagagagctaagcagctggctgcgttgacactggaggatgaagaggaagtaaagaag
gaggctgaccctggagaaacatcatctgaggctccaagcgaaaccaggacaacaccagca
gagaatggggtgaatcacaccgcctcccttgcccccaagcctccttcccaggctccacac
agccagcctgctccagggtctgtgaaggcacctgccaaaacagaagatctgatccagagc
gtgttaacagaagtagaggcgcaaaccatcgaagagctcaagcaacagaaatcgttcgtg
aaacttcaaaagaaacactacaaagaaatgaaagacctggtgaagagacaccacaagaaa
accacggagctcatcaaggagcacacgaccaagtacaatgagattcagaatgactacctg
agaaggagggcagccttggagaagtccgccaaaaaggacagcaagaagaaatctgaaccc
agcagccctgaccacggctcatcagccattgagcaagacctcgctgccctggatgcagaa
atgactcagaagttgatagacttgaaagacaagcaacaacagcagctgcttaatcttcgg
caagagcagtattacagcgagaagtaccagaagcgagaacacattaaactgcttattcag
aagttgacagatgttgcggaagagtgtcagagcaatcagttaaagaagctgaaagaaatc
tgtgagaaagagaagaaggaattaaagaagaaaatggacaagaaaaggcaggagaagata
acagaagccaagtccaaggacaagagccagatggaagaggagaagacagagatgatccga
tcatacatccaggaggtggtgcagtacatcaagaggttagaggaagcacaaagtaaaaga
caagaaaaacttgtggagaaacacaatgagatccgccagcagatcctagatgagaagccc
aagctgcagatggagctggaacaagaataccaagacaagttcaaaagactgcccctggag
gttctggagtttgttcaggaagccatgaaaggaaagatcagtgaggatagcaatcatggc
tctgcccctccctccttggcctcagacgctgcaaaggtgaacctcaagtctccctccagt
gaggaggtagaaagagagaacccaggaagagagtttgatactcctctgtga |