Mus pahari (shrew mouse): 110327193
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Entry
110327193 CDS
T05929
Symbol
Gclc
Name
(RefSeq) glutamate--cysteine ligase catalytic subunit isoform X1
KO
K11204
glutamate--cysteine ligase catalytic subunit [EC:
6.3.2.2
]
Organism
mpah
Mus pahari (shrew mouse)
Pathway
mpah00270
Cysteine and methionine metabolism
mpah00480
Glutathione metabolism
mpah01100
Metabolic pathways
mpah01240
Biosynthesis of cofactors
mpah04216
Ferroptosis
Module
mpah_M00118
Glutathione biosynthesis, glutamate => glutathione
Brite
KEGG Orthology (KO) [BR:
mpah00001
]
09100 Metabolism
09105 Amino acid metabolism
00270 Cysteine and methionine metabolism
110327193 (Gclc)
09106 Metabolism of other amino acids
00480 Glutathione metabolism
110327193 (Gclc)
09140 Cellular Processes
09143 Cell growth and death
04216 Ferroptosis
110327193 (Gclc)
Enzymes [BR:
mpah01000
]
6. Ligases
6.3 Forming carbon-nitrogen bonds
6.3.2 Acid-D-amino-acid ligases (peptide synthases)
6.3.2.2 glutamate---cysteine ligase
110327193 (Gclc)
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Motif
Pfam:
GCS
GCS2
Motif
Other DBs
NCBI-GeneID:
110327193
NCBI-ProteinID:
XP_021061614
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Position
10:72441322..72483162
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AA seq
637 aa
AA seq
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MGLLSQGSPLSWEETQRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDH
ENRKVQLLLNGGDVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTV
EANMRKRRKEATSVLGEHQALCTITSFPRLGCPGFTLPEHRPNPEEGGASKSLFFPDEAI
NKHPRFGTLTRNIRHRRGEKVVINVPIFKDKNTPSPFVETFPEDEEASKASQPDHIYMDA
MGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVI
SASVDDRTREERGLEPLKNNRFRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLE
EGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDI
GWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVL
QGMFYFRKDICKGGNAVVDGCSKAQTSSEPAAEEYTLMSIDTIINGKEGVFPGLIPILNS
YLESMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEINYS
LILKCNQIANELCECPELLGSGFRKAKYSGGKSDPSD
NT seq
1914 nt
NT seq
+upstream
nt +downstream
nt
atggggctgctgtcccaaggctcgccactgagctgggaagagacccagcgccacgccgac
cacgtgcggaggcacggcatcctccagttcctgcacatctatcacgcagtcaaggaccgg
cacaaggacgtgctcaagtggggtgacgaggtggagtacatgttggtgtccttcgatcat
gaaaatagaaaagtccagttgttgctgaatggaggagatgttcttgaaactctgcaggag
aagggggagaggacaaaccccaaccacccaaccctctggagaccggagtatgggagttac
atgatcgaagggacgcctggccagccctacggaggaacgatgtctgagttcaacacagtg
gaggccaacatgaggaaacgccggaaggaggctacttctgtactaggcgaacatcaggct
ctctgcaccatcacttcatttcccagactaggctgccctggattcacactgccagagcac
agacccaacccagaggaaggaggcgcatcaaagtccctcttctttccagatgaagccata
aacaagcacccccgctttggtactctaacaagaaacatccggcataggaggggagaaaag
gttgtcatcaatgtgccaatattcaaggacaagaatacaccatctccatttgtagaaaca
tttcctgaagatgaggaggcatcaaaggcttctcagccagaccatatctacatggatgcc
atgggattcgggatgggcaactgctgtctccaggtgacattccaagcctgcagcatatct
gaggcaagatacctttatgaccagctggccactatctgcccaattgttatggctttgagt
gctgcatctccattttaccgaggctacgtgtcagacattgattgtcgctggggagtgatt
tctgcatctgtagatgatagaacacgggaagagagaggcctggagcctctgaagaacaat
cgctttaggatcagtaaatctcggtatgactcaatagatagctacctgtctaagtgtggg
gagaagtacaatgacatcgacctgaccatcgataaggagatctacgagcagctcctggag
gaaggcattgatcatcttctggcacagcacgttgctcatctctttattagagacccactc
accctttttgaagagaaaatacacctggatgatgccaacgagtctgaccattttgagaat
attcagtccacaaactggcagacgatgaggtttaagcctcctcctccaaactcagatatt
ggatggagagtagagttccgaccaatggaggtgcagttaacagactttgagaactctgcc
tatgtggtatttgtggtactcctcactagggtgatcctctcgtacaaactagactttctc
atcccactttccaaggttgacgagaacatgaaagtggcccagaagcgagatgctgtcttg
caggggatgttttatttcaggaaagacatctgcaaaggcggcaacgctgtggtggatggg
tgcagcaaggcccagaccagctccgagccagctgcagaggagtacaccctgatgagcata
gacaccatcatcaatgggaaggaaggggtatttcctggactcatccccattctgaactcc
tatcttgagagcatggaagtcgatgtggacacccgatgcagtattctgaactacctaaag
ctaattaagaagagagcatctggagaactaatgactgttgccaggtggatgagagagttc
attgcaaaccatcctgactacaagcaagacagtgtaataactgatgaaatcaactatagc
ctcattttgaaatgcaaccaaattgcaaatgaattgtgtgaatgtccagagttacttgga
tcaggatttagaaaagcaaagtatagtggaggtaaaagtgacccttcagactag
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