KEGG   Mus pahari (shrew mouse): 110327251
Entry
110327251         CDS       T05929                                 
Symbol
Pik3cb
Name
(RefSeq) phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1
  KO
K00922  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
Organism
mpah  Mus pahari (shrew mouse)
Pathway
mpah00562  Inositol phosphate metabolism
mpah01100  Metabolic pathways
mpah01521  EGFR tyrosine kinase inhibitor resistance
mpah01522  Endocrine resistance
mpah01524  Platinum drug resistance
mpah04012  ErbB signaling pathway
mpah04014  Ras signaling pathway
mpah04015  Rap1 signaling pathway
mpah04024  cAMP signaling pathway
mpah04062  Chemokine signaling pathway
mpah04066  HIF-1 signaling pathway
mpah04068  FoxO signaling pathway
mpah04070  Phosphatidylinositol signaling system
mpah04071  Sphingolipid signaling pathway
mpah04072  Phospholipase D signaling pathway
mpah04081  Hormone signaling
mpah04140  Autophagy - animal
mpah04150  mTOR signaling pathway
mpah04151  PI3K-Akt signaling pathway
mpah04152  AMPK signaling pathway
mpah04210  Apoptosis
mpah04211  Longevity regulating pathway
mpah04213  Longevity regulating pathway - multiple species
mpah04218  Cellular senescence
mpah04360  Axon guidance
mpah04370  VEGF signaling pathway
mpah04380  Osteoclast differentiation
mpah04510  Focal adhesion
mpah04550  Signaling pathways regulating pluripotency of stem cells
mpah04611  Platelet activation
mpah04613  Neutrophil extracellular trap formation
mpah04620  Toll-like receptor signaling pathway
mpah04625  C-type lectin receptor signaling pathway
mpah04630  JAK-STAT signaling pathway
mpah04650  Natural killer cell mediated cytotoxicity
mpah04660  T cell receptor signaling pathway
mpah04662  B cell receptor signaling pathway
mpah04664  Fc epsilon RI signaling pathway
mpah04666  Fc gamma R-mediated phagocytosis
mpah04668  TNF signaling pathway
mpah04670  Leukocyte transendothelial migration
mpah04722  Neurotrophin signaling pathway
mpah04725  Cholinergic synapse
mpah04750  Inflammatory mediator regulation of TRP channels
mpah04810  Regulation of actin cytoskeleton
mpah04910  Insulin signaling pathway
mpah04914  Progesterone-mediated oocyte maturation
mpah04915  Estrogen signaling pathway
mpah04917  Prolactin signaling pathway
mpah04919  Thyroid hormone signaling pathway
mpah04923  Regulation of lipolysis in adipocytes
mpah04926  Relaxin signaling pathway
mpah04929  GnRH secretion
mpah04930  Type II diabetes mellitus
mpah04931  Insulin resistance
mpah04932  Non-alcoholic fatty liver disease
mpah04933  AGE-RAGE signaling pathway in diabetic complications
mpah04935  Growth hormone synthesis, secretion and action
mpah04960  Aldosterone-regulated sodium reabsorption
mpah04973  Carbohydrate digestion and absorption
mpah05010  Alzheimer disease
mpah05017  Spinocerebellar ataxia
mpah05020  Prion disease
mpah05100  Bacterial invasion of epithelial cells
mpah05132  Salmonella infection
mpah05135  Yersinia infection
mpah05142  Chagas disease
mpah05146  Amoebiasis
mpah05160  Hepatitis C
mpah05161  Hepatitis B
mpah05162  Measles
mpah05163  Human cytomegalovirus infection
mpah05164  Influenza A
mpah05165  Human papillomavirus infection
mpah05166  Human T-cell leukemia virus 1 infection
mpah05167  Kaposi sarcoma-associated herpesvirus infection
mpah05168  Herpes simplex virus 1 infection
mpah05169  Epstein-Barr virus infection
mpah05170  Human immunodeficiency virus 1 infection
mpah05171  Coronavirus disease - COVID-19
mpah05200  Pathways in cancer
mpah05203  Viral carcinogenesis
mpah05205  Proteoglycans in cancer
mpah05206  MicroRNAs in cancer
mpah05207  Chemical carcinogenesis - receptor activation
mpah05208  Chemical carcinogenesis - reactive oxygen species
mpah05210  Colorectal cancer
mpah05211  Renal cell carcinoma
mpah05212  Pancreatic cancer
mpah05213  Endometrial cancer
mpah05214  Glioma
mpah05215  Prostate cancer
mpah05218  Melanoma
mpah05220  Chronic myeloid leukemia
mpah05221  Acute myeloid leukemia
mpah05222  Small cell lung cancer
mpah05223  Non-small cell lung cancer
mpah05224  Breast cancer
mpah05225  Hepatocellular carcinoma
mpah05226  Gastric cancer
mpah05230  Central carbon metabolism in cancer
mpah05231  Choline metabolism in cancer
mpah05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
mpah05415  Diabetic cardiomyopathy
mpah05417  Lipid and atherosclerosis
mpah05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:mpah00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    110327251 (Pik3cb)
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    110327251 (Pik3cb)
   04014 Ras signaling pathway
    110327251 (Pik3cb)
   04015 Rap1 signaling pathway
    110327251 (Pik3cb)
   04370 VEGF signaling pathway
    110327251 (Pik3cb)
   04630 JAK-STAT signaling pathway
    110327251 (Pik3cb)
   04668 TNF signaling pathway
    110327251 (Pik3cb)
   04066 HIF-1 signaling pathway
    110327251 (Pik3cb)
   04068 FoxO signaling pathway
    110327251 (Pik3cb)
   04070 Phosphatidylinositol signaling system
    110327251 (Pik3cb)
   04072 Phospholipase D signaling pathway
    110327251 (Pik3cb)
   04071 Sphingolipid signaling pathway
    110327251 (Pik3cb)
   04024 cAMP signaling pathway
    110327251 (Pik3cb)
   04151 PI3K-Akt signaling pathway
    110327251 (Pik3cb)
   04152 AMPK signaling pathway
    110327251 (Pik3cb)
   04150 mTOR signaling pathway
    110327251 (Pik3cb)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    110327251 (Pik3cb)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    110327251 (Pik3cb)
  09143 Cell growth and death
   04210 Apoptosis
    110327251 (Pik3cb)
   04218 Cellular senescence
    110327251 (Pik3cb)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    110327251 (Pik3cb)
   04550 Signaling pathways regulating pluripotency of stem cells
    110327251 (Pik3cb)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    110327251 (Pik3cb)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    110327251 (Pik3cb)
   04613 Neutrophil extracellular trap formation
    110327251 (Pik3cb)
   04620 Toll-like receptor signaling pathway
    110327251 (Pik3cb)
   04625 C-type lectin receptor signaling pathway
    110327251 (Pik3cb)
   04650 Natural killer cell mediated cytotoxicity
    110327251 (Pik3cb)
   04660 T cell receptor signaling pathway
    110327251 (Pik3cb)
   04662 B cell receptor signaling pathway
    110327251 (Pik3cb)
   04664 Fc epsilon RI signaling pathway
    110327251 (Pik3cb)
   04666 Fc gamma R-mediated phagocytosis
    110327251 (Pik3cb)
   04670 Leukocyte transendothelial migration
    110327251 (Pik3cb)
   04062 Chemokine signaling pathway
    110327251 (Pik3cb)
  09152 Endocrine system
   04910 Insulin signaling pathway
    110327251 (Pik3cb)
   04923 Regulation of lipolysis in adipocytes
    110327251 (Pik3cb)
   04929 GnRH secretion
    110327251 (Pik3cb)
   04915 Estrogen signaling pathway
    110327251 (Pik3cb)
   04914 Progesterone-mediated oocyte maturation
    110327251 (Pik3cb)
   04917 Prolactin signaling pathway
    110327251 (Pik3cb)
   04926 Relaxin signaling pathway
    110327251 (Pik3cb)
   04935 Growth hormone synthesis, secretion and action
    110327251 (Pik3cb)
   04919 Thyroid hormone signaling pathway
    110327251 (Pik3cb)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    110327251 (Pik3cb)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    110327251 (Pik3cb)
  09156 Nervous system
   04725 Cholinergic synapse
    110327251 (Pik3cb)
   04722 Neurotrophin signaling pathway
    110327251 (Pik3cb)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    110327251 (Pik3cb)
  09158 Development and regeneration
   04360 Axon guidance
    110327251 (Pik3cb)
   04380 Osteoclast differentiation
    110327251 (Pik3cb)
  09149 Aging
   04211 Longevity regulating pathway
    110327251 (Pik3cb)
   04213 Longevity regulating pathway - multiple species
    110327251 (Pik3cb)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    110327251 (Pik3cb)
   05206 MicroRNAs in cancer
    110327251 (Pik3cb)
   05205 Proteoglycans in cancer
    110327251 (Pik3cb)
   05207 Chemical carcinogenesis - receptor activation
    110327251 (Pik3cb)
   05208 Chemical carcinogenesis - reactive oxygen species
    110327251 (Pik3cb)
   05203 Viral carcinogenesis
    110327251 (Pik3cb)
   05230 Central carbon metabolism in cancer
    110327251 (Pik3cb)
   05231 Choline metabolism in cancer
    110327251 (Pik3cb)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    110327251 (Pik3cb)
  09162 Cancer: specific types
   05210 Colorectal cancer
    110327251 (Pik3cb)
   05212 Pancreatic cancer
    110327251 (Pik3cb)
   05225 Hepatocellular carcinoma
    110327251 (Pik3cb)
   05226 Gastric cancer
    110327251 (Pik3cb)
   05214 Glioma
    110327251 (Pik3cb)
   05221 Acute myeloid leukemia
    110327251 (Pik3cb)
   05220 Chronic myeloid leukemia
    110327251 (Pik3cb)
   05218 Melanoma
    110327251 (Pik3cb)
   05211 Renal cell carcinoma
    110327251 (Pik3cb)
   05215 Prostate cancer
    110327251 (Pik3cb)
   05213 Endometrial cancer
    110327251 (Pik3cb)
   05224 Breast cancer
    110327251 (Pik3cb)
   05222 Small cell lung cancer
    110327251 (Pik3cb)
   05223 Non-small cell lung cancer
    110327251 (Pik3cb)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    110327251 (Pik3cb)
   05170 Human immunodeficiency virus 1 infection
    110327251 (Pik3cb)
   05161 Hepatitis B
    110327251 (Pik3cb)
   05160 Hepatitis C
    110327251 (Pik3cb)
   05171 Coronavirus disease - COVID-19
    110327251 (Pik3cb)
   05164 Influenza A
    110327251 (Pik3cb)
   05162 Measles
    110327251 (Pik3cb)
   05168 Herpes simplex virus 1 infection
    110327251 (Pik3cb)
   05163 Human cytomegalovirus infection
    110327251 (Pik3cb)
   05167 Kaposi sarcoma-associated herpesvirus infection
    110327251 (Pik3cb)
   05169 Epstein-Barr virus infection
    110327251 (Pik3cb)
   05165 Human papillomavirus infection
    110327251 (Pik3cb)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    110327251 (Pik3cb)
   05135 Yersinia infection
    110327251 (Pik3cb)
   05100 Bacterial invasion of epithelial cells
    110327251 (Pik3cb)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    110327251 (Pik3cb)
   05142 Chagas disease
    110327251 (Pik3cb)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    110327251 (Pik3cb)
   05017 Spinocerebellar ataxia
    110327251 (Pik3cb)
   05020 Prion disease
    110327251 (Pik3cb)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    110327251 (Pik3cb)
   05418 Fluid shear stress and atherosclerosis
    110327251 (Pik3cb)
   05415 Diabetic cardiomyopathy
    110327251 (Pik3cb)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    110327251 (Pik3cb)
   04932 Non-alcoholic fatty liver disease
    110327251 (Pik3cb)
   04931 Insulin resistance
    110327251 (Pik3cb)
   04933 AGE-RAGE signaling pathway in diabetic complications
    110327251 (Pik3cb)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    110327251 (Pik3cb)
   01524 Platinum drug resistance
    110327251 (Pik3cb)
   01522 Endocrine resistance
    110327251 (Pik3cb)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:mpah04131]
    110327251 (Pik3cb)
Enzymes [BR:mpah01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     110327251 (Pik3cb)
Membrane trafficking [BR:mpah04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    110327251 (Pik3cb)
SSDB
Motif
Pfam: PI3_PI4_kinase PI3Ka PI3K_rbd PI3K_p85B PI3K_C2 DUF4381
Other DBs
NCBI-GeneID: 110327251
NCBI-ProteinID: XP_021061719
Ensembl: MGP_PahariEiJ_G0015427
LinkDB
Position
10:complement(92395671..92493363)
AA seq 1064 aa
MPPAMADNLDIWAVDSQIASDGAISVDFLLPTGIYIQLEVPREATISYIKQMLWKQVHNY
PMFNLLMDIDSYMFACVNQTAVYEELEDETRRLCDVRPFLPVLKLVTRSCDPAEKLDSKI
GVLIGKGLHEFDALKDPEVNEFRRKMRKFSEDKIQSLVGLSWIDWLKHTYPPEHEPSVLE
NLEDKLYGGKLVVAVHFENSQDVFSFQVSPNLNPIKINELAIQKRLTIRGKEDEASPCDY
VLQVSGRVEYVFGDHPLIQFQYIRNCVMNRTLPHFILVECCKIKKMYEQEMIAIEAAINR
NSSNLPLPLPPKKTRVISHVWDNNNPFQIILVKGNKLNTEETVKVHVRAGIFHGTELLCK
TVVSSEISGKNDHIWNEQLEFDINICDLPRMARLCFAVYAVLDKVKTKKSTKTINPSKYQ
TIRKAGKVHYPVAWVNTMVFDFKGQLRSGDVILHSWSSFPDELEEMLNPMGTVQTNPYAE
NATALHIKFPENKKQPYYYPPFDKIIEKAAELASGDSANVSSRGGKKFLAVLKEILDRDP
LSQLCENEMDLIWTLRQDCRENFPQSLPKLLLSIKWNKLEDVAQLQALLQIWPKLPPREA
LELLDFNYPDQYVREYAVGCLRQMSDEELSQYLLQLVQVLKYEPFLDCALSRFLLERALD
NRRIGQFLFWHLRSEVHTPAVSIQFGVILEAYCRGSVGHMKVLSKQVEALNKLKTLNSLI
KLNAMKLNRAKGKEAMHTCLKQSAYREALSDLQSPLNPCVILSELYVEKCKYMDSKMKPL
WLVYSSRAFGEDSVGVIFKNGDDLRQDMLTLQMLRLMDLLWKEAGLDLRMLPYGCLATGD
RSGLIEVVSTSETIADIQLNSSNVAATAAFNKDALLNWLKEYNSGDDLDRAIEEFTLSCA
GYCVASYVLGIGDRHSDNIMVKKTGQLFHIDFGHILGNFKSKFGIKRERVPFILTYDFIH
VIQQGKTGNTEKFGRFRQCCEDAYLILRRHGNLFITLFALMLTAGLPELTSVKDIQYLKD
SLALGKTEEEALKQFKQKFDEALRESWTTKVNWMAHTVRKDYRS
NT seq 3195 nt   +upstreamnt  +downstreamnt
atgcctcctgctatggcagacaaccttgacatctgggcagtggactcacagattgcatcc
gatggcgccatatccgtcgatttccttctgcccaccgggatttatatccagttggaagta
cctcgggaggctaccatttcttatattaaacagatgttatggaagcaagttcacaactac
ccgatgtttaacctcctcatggacattgactcctatatgtttgcatgtgtgaatcaaact
gccgtatatgaggaactggaagacgaaacacgaagactttgtgatgtcagaccttttctt
ccagttctcaaactagtgactagaagctgtgacccagcagaaaaattggactcaaaaatt
ggagttcttataggaaaaggtcttcatgagtttgatgccttgaaggatcccgaagtgaat
gaatttagaagaaaaatgcgcaaattcagtgaggacaagattcagtctctagtggggttg
tcttggattgactggctaaagcacacgtatccacctgagcatgagccgtctgtcctggag
aacttggaagataaactttatggaggaaagctggttgtagctgtgcactttgaaaatagc
caggatgtatttagttttcaagtgtctcccaatttgaatcctataaaaataaatgaattg
gcaatccagaaacgcctcactattcgtggaaaggaagatgaagctagcccctgtgactat
gtgttacaggtcagtgggagagtggagtatgtgtttggcgatcatccactaattcagttc
cagtacatccggaattgtgtgatgaataggaccctgccccacttcatccttgtggaatgt
tgtaagatcaagaaaatgtatgaacaagaaatgattgccatagaggctgccatcaaccga
aactcatccaaccttcctctccctttaccaccaaagaaaacacgagttatttctcatgtc
tgggacaacaacaaccctttccaaattatcttggtaaaaggaaataagcttaatacagaa
gaaactgtgaaagtccatgtccgagctgggatttttcacggaaccgagctcctgtgtaaa
accgtcgtaagctcggagatatcagggaagaacgaccatatttggaatgaacaactggaa
tttgatattaatatttgcgacttaccaagaatggctcgattatgttttgctgtttacgca
gttttggataaagtaaaaacgaagaaatcaacaaaaactattaatccctctaaatatcag
accatcaggaaagctgggaaagtgcattatcctgtcgcgtgggtaaataccatggttttt
gacttcaaaggacagctgaggtctggagacgtcatattgcacagctggtcttcgtttcct
gatgagctggaagaaatgctaaatcctatggggactgtgcagacgaacccgtatgctgag
aatgctactgccttgcatattaagttcccagagaataagaagcagccttattattacccc
cccttcgataagatcattgagaaggcagctgaacttgccagcggagacagtgctaatgtg
tcaagtcgtggtgggaaaaaatttcttgctgtactgaaagaaatcttggacagggacccc
ctgtctcagctgtgtgagaacgaaatggaccttatttggactctacggcaagactgccga
gaaaatttccctcagtcactgccaaaactcctcctgtcaatcaagtggaataaacttgaa
gatgttgctcagcttcaggcgctcctgcagatttggcccaaactgccccccagggaagcc
ctggaactcctggatttcaactatccagaccagtatgtccgggaatacgctgtcggctgc
ctccgacagatgagtgatgaagaactctctcagtatcttttacaattggtgcaagttttg
aaatatgagccttttcttgattgtgccctctccagattcctattagaaagagcacttgat
aatcggagaattgggcagttcctattttggcatcttaggtcagaggtgcacactcctgct
gtgtccatacagtttggtgtcattctggaagcatactgtcgaggaagtgtggggcacatg
aaagtgctttccaaacaggtcgaagcactcaataagttaaaaactttaaatagtttaatc
aaactgaatgccatgaagctgaacagagctaaaggaaaggaggccatgcacacgtgctta
aaacagagtgcttaccgggaggcgctctcggacctgcagtcgccgctgaacccgtgcgtt
atcctctcagagctctatgttgaaaagtgcaaatacatggactccaagatgaagcccctg
tggctggtctacagcagcagagcctttggagaggactcggttggagtgatctttaaaaat
ggtgacgatttgcggcaggacatgctgacgctgcagatgctgcgcctgatggatctgcta
tggaaagaagctggcttggacctgcggatgctcccctacggctgtttagcaacaggagat
cgctctggcctcattgaggttgtgagcacctctgagacaatcgctgacattcagctgaac
agtagtaatgtggctgccacagcagccttcaacaaagacgcactcctgaactggctcaag
gagtacaactctggggatgacctggaccgagcaattgaggagttcaccttgtcctgtgct
ggctactgtgtagcctcttatgtcctcggcattggtgacaggcacagcgacaacatcatg
gtgaagaaaacgggccagctcttccacatagattttgggcatattcttggaaatttcaaa
tctaaatttggcattaaaagggagcgagtaccttttattcttacttacgacttcattcat
gtcattcaacaaggaaaaactggaaacactgaaaaatttggcaggttccgccagtgctgt
gaagatgcgtacctgattttacggcggcatgggaacctcttcatcaccctgtttgcgctg
atgttgactgcagggctgcccgagctcacgtcggtcaaagatatacagtatcttaaggac
tctcttgccttagggaagactgaggaggaagcactgaagcagttcaagcagaagtttgac
gaggccctcagggaaagctggactactaaagtgaactggatggctcacacagtgcggaaa
gactacaggtcttag

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