Mus pahari (shrew mouse): 110334252 Help Entry 110334252         CDS       T05929                                  Symbol Ryr2 Name (RefSeq) ryanodine receptor 2   KO K04962   ryanodine receptor 2 Organism mpah  Mus pahari (shrew mouse) Pathway mpah04020   Calcium signaling pathway mpah04024   cAMP signaling pathway mpah04260   Cardiac muscle contraction mpah04261   Adrenergic signaling in cardiomyocytes mpah04371   Apelin signaling pathway mpah04713   Circadian entrainment mpah04911   Insulin secretion mpah04921   Oxytocin signaling pathway mpah04972   Pancreatic secretion mpah05020   Prion disease mpah05022   Pathways of neurodegeneration - multiple diseases mpah05410   Hypertrophic cardiomyopathy mpah05412   Arrhythmogenic right ventricular cardiomyopathy mpah05414   Dilated cardiomyopathy mpah05415   Diabetic cardiomyopathy Brite KEGG Orthology (KO) [BR:mpah00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     110334252 (Ryr2)    04020 Calcium signaling pathway     110334252 (Ryr2)    04024 cAMP signaling pathway     110334252 (Ryr2)  09150 Organismal Systems   09152 Endocrine system    04911 Insulin secretion     110334252 (Ryr2)    04921 Oxytocin signaling pathway     110334252 (Ryr2)   09153 Circulatory system    04260 Cardiac muscle contraction     110334252 (Ryr2)    04261 Adrenergic signaling in cardiomyocytes     110334252 (Ryr2)   09154 Digestive system    04972 Pancreatic secretion     110334252 (Ryr2)   09159 Environmental adaptation    04713 Circadian entrainment     110334252 (Ryr2)  09160 Human Diseases   09164 Neurodegenerative disease    05020 Prion disease     110334252 (Ryr2)    05022 Pathways of neurodegeneration - multiple diseases     110334252 (Ryr2)   09166 Cardiovascular disease    05410 Hypertrophic cardiomyopathy     110334252 (Ryr2)    05412 Arrhythmogenic right ventricular cardiomyopathy     110334252 (Ryr2)    05414 Dilated cardiomyopathy     110334252 (Ryr2)    05415 Diabetic cardiomyopathy     110334252 (Ryr2)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:mpah04040]     110334252 (Ryr2)    04990 Domain-containing proteins not elsewhere classified [BR:mpah04990]     110334252 (Ryr2) Ion channels [BR:mpah04040]  Voltage-gated cation channels   Ryanodine receptor    110334252 (Ryr2) Domain-containing proteins not elsewhere classified [BR:mpah04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    110334252 (Ryr2) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY MIR Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_8 FYDLN_acid Motif Other DBs NCBI-GeneID:  110334252 NCBI-ProteinID:  XP_021071765 Ensembl:  MGP_PahariEiJ_G0019270 LinkDB All DBs Position 16:complement(16183290..16740541) Genome browser AA seq 4974 aa AA seqDB search MWNLTFLPVSFLQDDEVVLQCTATIHKEQQKLCLAAEGFGNRLCFLESTSNSKNVPPDLS ICTFVLEQSLSVRALQEMLANTVEKSEGQVDVEKWKFMMKTAQGGGHRTLLYGHAILLRH SYSGMYLCCLSTSRSSTDKLAFDVGLQEDTTGEACWWTIHPASKQRSEGEKVRVGDDLIL VSVSSERYLHLSYGNSSWHVDAAFQQTLWSVAPISSGSEAAQGYLIGGDVLRLLHGHMDE CLTVPSGEHGEEQRRTVHYEGGAVSVHARSLWRLETLRVAWSGSHIRWGQPFRLRHVTTG KYLSLMEDKNLLLMDKEKADVKSTAFAFRSSKEKLDVGVRKEVDGMGTSEIKYGDSICYI QHVDTGLWLTYQAVDVKSARMGSIQRKAIMHHEGHMDDGLNLSRSQHEESRTARVIRSTV FLFNRFIRGLDALSKKVKLPTIDLPIESVSLSLQDLIGYFHPPDEHLEHEDKQNRLRALK NRQNLFQEEGMINLVLECIDRLHVYSSAAHFADVAGREAGESWKSILNSLYELLAALIRG NRKNCAQFSGSLDWLISRLERLEASSGILEVLHCVLVESPEALNIIKEGHIKSIISLLDK HGRNHKVLDVLCSLCVCHGVAVRSNQHLICDNLLPGRDLLLQTRLVNHVSSMRPNIFLGV SEGSAQYKKWYYELMVDHTEPFVTAEATHLRVGWASTEGYSPYPGGGEEWGGNGVGDDLF SYGFDGLHLWSGCIARTVSSPNQHLLRTDDVISCCLDLSAPSISFRINGQPVQGMFENFN IDGLFFPVVSFSAGIKVRFLLGGRHGEFKFLPPPGYAACYEAVLPKEKLKVEHSREYKQE RTYTRDLLGPTVSLTQAAFTPVPVDTSQIVLPPHLERIRERLAENIHELWVMNKIELGWQ YGPVRDDNKRQHPCLVEFCKLPEQERNYNLQMSLETLKTLLALGCHVGIADEHAEEKVKK MKLPKNYQLTSGYKPAPMDLSFIKLTPSQEAMVDKLAENAHNVWARDRIRQGWTYGIQQD VKNRRNPRLVPYTLLDDRTKKSNKDSLREAVRTLLGYGYHLEAPDQDHASRAEVCSGTGE RFRIFRAEKTYAVKAGRWYFEFEAVTAGDMRVGWSRPGCQPDLELGSDERAFAFDGFKAQ RWHQGNEHYGRSWQAGDVVGCMVDMNEHTMMFTLNGEILLDDSGSELAFKDFDVGDGFIP VCSLGVAQVGRMNFGKDVSTLKYFTICGLQEGYEPFAVNTNRDITMWLSKRLPQFLQVPS NHEHIEVTRIDGTIDSSPCLKVTQKSFGSQNSNTDIMFYRLSMPIECAEVFSKSVAGGLP GAGFYGPKNDLEDFDVDSDFEVLMKTAHGHLVPDRIDKDKETPKPEFNNHKDYAQEKPSR LKQRFLLRRTKPDYSTSHSARLTEDVLADDRDDYEYLMQTSTYYYSVRIFPGQEPANVWV GWITSDFHQYDTGFDLDRVRTVTVTLGDEKGKVHESIKRSNCYMVCAGESMSPGQGRNNS NGLEIGCVVDAASGLLTFIANGKELSTYYQVEPSTKLFPAVFAQATSPNVFQFELGRIKN VMPLSAGLFKSEHKNPVPQCPPRLHVQFLSHVLWSRMPNQFLKVDVSRISERQGWLVQCL DPLQFMSLHIPEENRSVDILELTEQEELLQFHYHTLRLYSAVCALGNHRVAHALCSHVDE PQLLYAIENKYMPGLLRAGYYDLLIDIHLSSYATARLMMNNEFIVPMTEETKGITLFPDE NKKHGLPGIGLSTSLRPRMRFSSPSFVSISNDCYQYSPEFPLDILKAKTIQMLTEAVKEG SLHARDPVGGTTEFLFVPLIKLFYTLLIMGIFHNEDLKHILQLIEPSVFKEAAVPEDEGG TPEKEMSIEDAKLEGEEETKGGKRPKEGLLQMKLPEPVKLQMCLLLQYLCDCQVRHRIEA IVAFSDDFVAKLQDNQRFRYNEVMQALNMSAALTARKTKEFRSPPQEQINMLLNFKDDKS ECPCPEEIRDQLLDFHEDLMTHCGIELDEDGSLDGSNDLTIRGRLLSLVEKVTYLKKKQA EKPVASDSRKSSSLQQLISETMVRWAQESVIEDPELVRAMFVLLHRQYDGIGGLVRALPK TYTINGVSVEDTINLLASLGQIRSLLSVRMGKEEEKLMIRGLGDIMNNKVFYQHPNLMRA LGMHETVMEVMVNVLGGGESKEITFPKMVANCCRFLCYFCRISRQNQKAMFDHLSYLLEN SSVGLASPAMRGSTPLDVAAASVMDNNELALALREPDLEKVVRYLAGCGLQSCQMLVSKG YPDIGWNPVEGERYLDFLRFAVFCNGESVEENANVVVRLLIRRPECFGPALRGEGGNGLL AAMEEAIKIAEDPSRDGPSPTSGSSKTLDIEEGEDDTIHMGNAIMTFYAALIDLLGRCAP EMHLIHAGKGEAIRIRSILRSLIPLGDLVGVISIAFQMPTIAKDGKVVEPDMSAGFCPDH KAAMVLFLDRVYGIEVQDFLLHLLEVGFLPDLRAAASLDTAALSATDMALALNRYLCTAV LPLLTRCAPLFAGTEHHASLIDSLLHTVYRLSKGCSLTKAQRDSIEVCLLSICGQLRPSM MQHLLRRLVFDVPLLNEHAKMPLKLLTNHYERCWKYYCLPGGWGNFGAASEEELHLSRKL FWGIFDALSQKKYEQELFKLALPCLSAVAGALPPDYMESNYVSMMEKQSSMDSEGNFNPQ PVDTSNITIPEKLEYFINKYAEHSHDKWSMDKLANGWIYGEIYSDSSKIQPLMKPYKLLS EKEKEIYRWPIKESLKTMLAWGWRIERTREGDSMALYNRTRRISQTSQVSIDAAHGYSPR AIDMSNVTLSRDLHAMAEMMAENYHNIWAKKKKLELESKGGGNHPLLVPYDTLTAKEKAK DREKAQDIFKFLQISGYVVSRGFKDLDLDTPSIEKRFAYSFLQQLIRYLDEAHQYILEFD GGSRSKGEHFPYEQEIKFFAKVVLPLIDQYFKNHRLYFLSAASRPLCTGGHASNKEKEMV TSLFCKLGVLVRHRISLFGNDATSIVNCLHILGQTLDARTVMKTGLDSVKSALRAFLDNA AEDLEKTMENLKQGQFTHTRSQPKGVTQIINYTTVALLPMLSSLFEHIGQHQFGEDLILE DVQVSCYRILTSLYALGTSKSIYVERQRSALGECLAAFAGAFPIAFLETHLDKHNVYSIY NTRSSRERAALSLPANVEDVCPNIPSLEKLMTEIIELAESGIRYTQMPYMMEVVLPMLCS YMSRWWEHGPENHPERAEMCCTALNSEHMNTLLGNILKIIYNNLGIDEGAWMKRLAVFSQ PIINKVKPQLLKTHFLPLMEKLKKKAAMVVSEEDHLKAEARGDMSEAELLILDEFTTLAR DLYAFYPLLIRFVDYNRAKWLKEPNPEAEELFRMVAEVFIYWSKSHNFKREEQNFVVQNE INNMSFLITDTKSKMSKAAISDQERKKMKRKGDRYSMQTSLIVAALKRLLPIGLNICAPG DQELIALAKNRFSLKDTEEEVRDIIRSNIHLQGKLEDPAIRWQMALYKDLPNRTEDTSDP ERTVERVLDIANVLFHLEQKSKYTGRGYFSLGSTVEHPQRSKKAVWHKLLSKQRKRAVVA CFRMAPLYNLPRHRAVNLFLQGYEKSWIETEEHYFEDKLIEDLAKPGAELPEEDEAMKRV DPLHQLILLFSRTALTEKCKLEEDFLYMAYADIMAKSCHDEEDDDGEEEVKSFEVTGSQR SKEKEMEKQKLLYQQARLHDRGAAEMVLQTISASKGETGPMVAATLKLGIAILNGGNSTV QQKMLDYLKEKKDVGFFQSLAGLMQSCSVLDLNAFERQNKAEGLGMVTEEGSGEKVLQDD EFTCDLFRFLQLLCEGHNSDFQNYLRTQTGNNTTVNIIISTVDYLLRVQESISDFYWYYS GKDIIDEQGQRNFSKAIQVAKQVFNTLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAH MQMKLSQDSSQIELLKELMDLQKDMVVMLLSMLEGNVVNGTIGKQMVDMLVESSNNVEMI LKFFDMFLKLKDLTSSDTFKEYDPDGKGVISKRDFHKAMESHKHYTQSETEFLLSCAETD ENETLDYEEFVKRFHEPAKDIGFNVAVLLTNLSEHMPNDTRLQTFLELAESVLNYFQPFL GRIEIMGSAKRIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGEKEKMELFVNFC EDTIFEMQLAAQISESDLNERSANKEESEKERPEEQTPRMGFFSLLTIQSALFALRYNVL TLVRMLSLKSLKKQMKRIKKMTVKDMVLAFFSSYWSVFVTLLHFVASVCRGFFRIISSLL LGGSLVEGAKKIKVAELLANMPDPTQDEVRGDEEEGERKPLESALPSEDLTDLKELTEES DLLSDIFGLDLKREGGQYKLIPHNPNAGLSDLMTNPIPVPEVQEKFQEQKVKEEKEEKEE TKSEPEKAEGEDGEKEEKAKDDKSKQKSRQLHTHRYGEPEVPESAFWKKIIAYQQKLLNY FARNFYNMRMLALFVAFAINFILLFYKVSTSSVVEGKELPTRTSSDTAKVTTSLDSSPHR IIAVHYVLEESSGYMEPTLRILAILHTIISFFCIIGYYCLKVPLVIFKREKEVARKLEFD GLYITEQPSEDDIKGQWDRLVINTQSFPNNYWDKFVKRKVMDKYGEFYGRDRISELLGMD KAALDFSDAREKKKPKKDSSLSAVLNSIDVKYQMWKLGVVFTDNSFLYLAWYMTMSVLGH YNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFY NKSEDGDTPDMKCDDMLTCYMFHMYVGVRAGGGIGDEIEDPAGDEYEIYRIIFDITFFFF VIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGNDYFDTVPHGFETHTLQEH NLANYLFFLMYLINKDETEHTGQESYVWKMYQERCWEFFPAGDCFRKQYEDQLN NT seq 14925 nt NT seq  +upstreamnt  +downstreamnt atgtggaatctcacctttcttcctgtttcctttctgcaggatgatgaggtggttctgcag tgcacagcgaccatccacaaagagcagcagaagctgtgcttggcagcagaaggatttggc aacagactttgttttttggagtctacttccaattccaagaatgttcccccggacctgtct atctgcacctttgtgctggagcagtccctgtcagtacgggccctgcaggagatgctggcc aacacggtggaaaagtcagaagggcaggtggatgtggaaaaatggaagttcatgatgaag actgctcagggtggaggccaccggacactcctctatggacacgccatattgctacgccat tcctacagtggtatgtatctttgctgtctctccacttcccggtcttccactgacaaactg gccttcgatgttggtcttcaagaggataccacaggggaggcttgctggtggaccatacat cctgcctctaagcagagatcagaaggagaaaaagtacgtgttggagatgacctcatcttg gtcagcgtgtcctcagaaaggtacttgcacttgtcatatggcaacagcagctggcatgtg gatgccgccttccagcagaccctctggagcgtggcccctatcagctcaggaagtgaagca gcccaagggtatctcattggcggtgacgttctccggctgctgcacgggcacatggatgaa tgtctcactgtcccttcaggagagcatggcgaagaacagcggagaacagttcattatgaa ggtggtgctgtatccgttcatgcacgctccctctggagactagagaccctaagagtcgcg tggagtggaagccacataagatggggccagccattccgactccggcatgtcacaacagga aaatacttaagcctcatggaagacaagaaccttctactcatggacaaagagaaagccgat gtaaaatcaacagcgtttgccttccggtcttccaaggaaaaattggacgtgggggtgagg aaagaagtcgatggcatgggaacctcagaaatcaagtatggagactccatttgctacata caacatgtggatacaggcctgtggctaacctaccaggctgtggatgtgaaatcagcacga atgggctccatccagcgtaaggctatcatgcaccacgaaggccacatggacgatggtttg aatttatccagatcgcagcatgaggagtcccgcactgcccgcgtcatccggagcacagtg ttcctctttaataggttcataaggggcctggatgctctcagcaagaaagtaaagctgccc accattgacttgcccatcgagtctgtgagcctgagtttgcaggacctcatcggctacttc caccccccagatgagcacttggagcatgaggacaagcagaacaggctgcgagccctaaag aacaggcagaatctcttccaggaagagggaatgatcaacctagttctggagtgtattgac cgcctgcatgtctacagcagtgcagcccactttgcagacgtcgcaggacgagaagcaggg gagtcttggaaatccatcctgaattctctgtatgagttgctggcggctctaattagagga aatcgtaaaaactgtgctcaattttctggctccctcgactggctgatcagcagactggag agactggaagcatcctccggtatcctggaggtcctccactgtgtgttagtggagagccca gaagctctgaatatcatcaaagaagggcatatcaagtccattatctcacttttagacaag catgggagaaaccacaaggtcctggatgtgctgtgttctctctgtgtatgccatggagtt gctgtccgctctaatcagcacctcatctgcgataacctcctgccaggacgagatctctta ctgcagacccggcttgtgaatcatgtcagcagcatgaggcctaatattttcctgggtgtc agcgaaggatcagcacagtataagaagtggtactatgagctcatggtggaccacacggaa ccctttgtgacagcagaagccactcacctgcgagtgggctgggcttccaccgaagggtat tctccatacccaggtgggggtgaagagtggggtggcaatggcgttggtgacgacctcttc tcctatgggtttgatggacttcacctctggtcaggttgtatagctcgaaccgtgagctcc cccaaccagcacctgctgagaactgacgatgtcatcagttgttgcttagatctaagtgcc cccagcatctcgtttcgcattaatggacaaccggtacaagggatgtttgagaacttcaat atcgatggcctgttctttccagttgtcagtttctctgcaggaataaaggttcgctttttg cttggggggagacatggagaattcaagtttctccctccacctggctatgcagcttgctat gaagctgttctgcccaaagagaaattgaaggtggaacacagccgagaatataagcaagag aggacatacacacgagatctgctggggcctacagtgtccctgacccaagctgccttcaca cctgttcctgtggacaccagccagattgtgttgcctcctcacctggaaaggataagagaa agactggcagagaatatccacgagctctgggttatgaataaaattgagcttggctggcag tatggtccggttagagatgacaacaagagacagcacccatgtctggtggagttctgcaag cttccagaacaggaacgcaactataatttgcagatgtcgctcgaaaccctcaagaccttg ctggcactgggatgtcacgtgggtatagcggatgaacacgctgaagagaaggtgaagaaa atgaagctgcccaagaattaccagctgaccagcggatacaagcctgccccaatggatctg agctttataaaactaactccgtctcaggaagcaatggtggacaagttggctgaaaatgct cacaacgtgtgggcccgggaccgaatccggcaaggctggacttacggcatccagcaggat gtaaagaatagaagaaaccctcgcctcgtcccctacactcttctggatgacagaaccaag aagtccaacaaagacagtctccgagaggcagtgcgcacactactgggctatggctaccac ctggaagctcctgatcaggaccatgcctcgagagccgaggtgtgcagcggtactggggag aggttccgcatcttcagggcagagaagacctatgcggtgaaggctgggcgctggtacttt gaatttgaggctgtcaccgctggagacatgcgggtgggctggagcaggccaggctgccaa ccggacctggaactgggttctgatgaacgtgcctttgcttttgatggctttaaggcccag cggtggcaccagggcaatgaacactacggacgctcgtggcaagccggtgatgtcgtgggc tgcatggttgatatgaacgaacacaccatgatgttcactctgaacggcgagatcctgctg gatgactcgggctctgagctggcgttcaaggactttgatgttggtgatggattcatccct gtgtgtagcctcggggtggcacaagtaggcaggatgaactttggaaaggacgtcagcact ttgaaatattttaccatctgtggcttacaagaaggctatgagccgtttgcagttaataca aatagggacatcaccatgtggctgagcaagcggcttccgcagttccttcaggtcccatca aaccacgaacacattgaggtgaccagaatagatggtaccatagacagttctccatgtctg aaggtcactcagaagtcctttggttctcagaacagcaacactgacatcatgttttaccgc ctgagtatgcccattgaatgtgccgaggtcttctcaaagtcggtggcaggagggcttcct ggtgccggcttctacgggcccaagaatgatttggaggactttgatgtggactccgacttt gaggttctgatgaagacagctcatggtcatcttgtgcctgaccgcatcgacaaggacaaa gagactcccaagccagagttcaataaccacaaagattatgctcaggaaaagccctcacga ctaaaacaaagattcttacttagaaggaccaagccagattacagcacaagccattctgca agactcactgaagatgtccttgctgatgaccgggatgactatgagtacctgatgcagaca tccacgtactattactcggtgaggatctttcctggacaagaaccagctaatgtctgggtg ggctggattacatctgacttccaccagtacgacacaggctttgatttggacagagtgcgc acagtgacggtcaccctaggagatgaaaaagggaaagtgcatgagagcatcaaacgcagc aactgctatatggtgtgtgcaggagagagcatgagccccgggcaaggacgaaacaacagc aacggcttggagattggctgtgtggtggatgctgccagcgggctgctcacattcatagcc aatggcaaggagctaagcacatactatcaggtggagccaagcacaaagttatttcctgcg gttttcgcgcaagctacaagtcccaatgttttccagtttgagttgggcagaataaagaat gtgatgcctctctctgcgggactgtttaagagcgagcacaaaaaccctgtgccccagtgt cctccacgtctgcatgtgcagttcctgtcacatgtcctgtggagccggatgcccaaccag ttcttgaaggtggacgtctctcgaatcagtgagcgccaaggctggctggttcagtgtcta gatcctctgcagtttatgtccctccatatacctgaggaaaacagatctgttgatatctta gagctgacagagcaggaggagttgttgcagtttcactatcacaccctccgcctctactct gctgtctgcgcccttgggaatcatcgggtggctcacgcgctgtgcagccacgtggacgaa cctcagctgctctatgccatcgagaacaagtacatgcctggcttgctgcgagctggctac tatgacctgctgattgacatccacctcagctcctatgccaccgccaggctcatgatgaac aacgagttcatcgtccctatgacagaggagaccaagggcatcaccctctttccggatgag aataagaaacacggcctcccaggcataggcctgagcacctcactccggcctcggatgcgc ttttcctctccgagtttcgtgagcattagcaacgactgttatcagtacagtcccgagttt cccctggacatcctcaaggccaagaccatccagatgctcacagaagcggtgaaggagggc agcctccatgctcgggatcctgtgggtgggaccacggagttcctctttgtgccccttatc aaactgttctataccctgctcatcatgggcatctttcacaatgaggatttgaaacacatc ctgcagttgattgagcccagtgtgtttaaggaagctgccgttccagaggacgaaggaggc accccagagaaggagatgagtatagaagatgccaaactggaaggcgaagaagaaaccaaa gggggcaaaaggcccaaggaaggcttgctccagatgaaactcccggagccagttaaacta cagatgtgcctcttgcttcagtacctctgcgactgccaggttaggcaccggatcgaagcc attgtagccttttcagatgactttgtagctaaactccaagacaaccaacggttcaggtac aatgaagtcatgcaagccttaaacatgtctgctgcactcactgccaggaaaaccaaggag ttccggtcaccaccacaggagcagattaacatgcttctcaattttaaggatgacaaaagt gaatgtccttgccctgaagaaatccgagaccaactcctagatttccatgaggacctgatg actcactgtggaattgaattggacgaggatggatccctagatggaagcaatgacttaaca atcagaggacgtctgctgtctctggtagaaaaggtgacctacctgaagaagaagcaagct gaaaagccagttgcaagtgactccagaaagtcctctagcctccagcaactcatctctgag actatggtgcggtgggctcaagagtctgtcattgaggaccctgagctggtgagggccatg ttcgtgctgctacatcggcagtatgatggcatcgggggtctagtccgagcgctgccaaag acctacacgatcaacggggtctctgtggaggacaccatcaatctgcttgcttcgctcggt cagatccgatctctgttgagtgtgaggatgggcaaagaagaggagaagctgatgattcgt ggactaggggatatcatgaataacaaagtgttttatcagcatcccaatctcatgagggcc ctcgggatgcatgagacagtgatggaagtcatggtgaacgtccttggaggtggggagtcc aaggaaatcaccttccccaagatggtggccaactgctgccgttttctctgttacttctgt cgtataagtagacagaatcaaaaagccatgtttgatcatctcagttatttactggagaac agcagtgttggtcttgcatcaccagccatgagaggttcaactcctttagacgtggccgca gcttccgtgatggataacaatgagcttgcccttgctctacgagagcctgatctggagaag gtagttcgctatctggctggctgtggtctgcagagctgtcagatgctggtgtctaagggt tacccagacattgggtggaatcccgttgaaggagagcgataccttgactttctcagattt gcagtcttctgtaacggggagagtgtggaagagaatgcaaatgtcgtggtgaggttgctc attcggagacctgagtgctttggtcctgccttgagaggagaaggtggtaatggtctcctt gcagccatggaagaagccataaaaatagctgaggatccttctagagatggcccctctcca accagtggctccagcaaaacccttgatatagaagagggggaagatgataccatccacatg gggaacgcgatcatgaccttctacgcagctttgattgacctgcttggtcgctgtgctcct gaaatgcacttgattcacgctggaaagggagaagccatccgaatcaggtccattttgcga tctctgattccattgggagacttggtgggcgtcatcagcattgcatttcagatgccaaca atagccaaagatgggaaggtggtggagcctgacatgtccgcggggttttgcccagatcac aaggcagccatggttttgttccttgacagggtctatggaattgaggtgcaagatttcctc ctccatctccttgaggttggctttctgccagatcttcgagctgctgcctctctagacacg gctgcactaagtgctacagacatggccttggccctcaaccggtacctctgcacagctgtc ctacctttgttaacaaggtgtgctcctctgtttgctggaacagagcaccatgcttccctc attgactctctgctacatactgtatatagactctctaaaggatgctcccttaccaaagct cagcgggactccatagaagtgtgcctgctctctatctgtggccaactgagaccttctatg atgcaacacctactccgaaggctggtgtttgatgttccactgttgaatgagcatgcgaag atgcctctgaagctgctgaccaatcattatgaaagatgctggaaatattattgcctacct ggagggtggggcaactttggtgctgcctcagaagaagaacttcatttatcaagaaaatta ttttggggcatttttgatgctttgtctcaaaagaaatatgaacaagaacttttcaaactg gccctgccttgcctgagtgcagttgcgggagctttacctccagactacatggagtcaaac tatgtcagtatgatggaaaaacagtcatccatggattctgaagggaactttaacccacaa cctgttgatacctcaaacattacaattcccgagaagttggaatacttcattaacaaatac gcagaacattcccatgataaatggtccatggacaagttggcgaatggatggatttatggg gaaatatattcagactcttctaagatccaaccgctaatgaagccatataaactcttgtct gaaaaggaaaaagaaatttatcgttggccaatcaaggagtctttaaaaacaatgctggct tggggttggagaattgagagaacacgggagggggacagcatggccctttataaccggact cggcgcatttctcagacaagccaggtgtctatagatgctgcgcatgggtacagcccccgt gctattgacatgagtaatgtgacactctctcgagacctgcatgctatggcagagatgatg gctgaaaactaccacaacatatgggccaagaaaaagaaactggagctggaatccaaagga ggaggaaaccaccccctgctggtgccctatgacacactgacagccaaggagaaagccaag gacagagaaaaagcccaagacatcttcaagttcctacagatcagtggttatgtggtatcc agagggttcaaggacctagatctggacacaccttccattgagaagcgatttgcctatagt ttcctgcagcagctgatccgatatttggatgaggctcatcagtacatcctggagtttgat ggtggcagcagaagcaaaggagaacatttcccgtacgagcaagaaatcaagttctttgcc aaagttgttcttcctttaattgatcagtatttcaaaaaccaccgcctgtacttcttgtct gctgcaagcaggcctctctgcactggaggacatgcatccaacaaagagaaggagatggtg acaagcctgttctgcaaacttggagttcttgtcaggcataggatctcactgtttgggaat gatgccacctcgattgtgaactgtctgcacattttgggtcagactttggatgcaaggact gtgatgaagacgggcctagacagcgtgaaaagtgctctcagggcctttctggacaatgcg gcggaggatttggaaaagacaatggaaaacctgaagcagggccagtttactcacaccagg agccagcccaagggggtgactcagatcatcaactacaccaccgtggctctcctgcccatg ctctcctccctgttcgagcacatcggccagcatcagtttggagaagatctgatattggag gatgtgcaggtgtcttgttatagaattctgaccagcttgtatgccttgggaaccagcaag agcatttacgtggaaaggcaacgctctgcccttggggaatgcttagctgcctttgctggt gccttccctatcgcctttttggaaacccacctggacaaacataatgtttactccatctac aacaccaggtcttcacgagaaagagcagctctcagtttacctgcaaatgtggaggatgtc tgccccaatataccatccctagagaagctgatgactgagattatagagctggcagagtca ggaatccgctacactcagatgccatacatgatggaggttgtgctgcccatgttgtgcagc tacatgtcaaggtggtgggaacacggtcctgagaaccatccagagagggctgagatgtgc tgcacagccctcaactcagagcacatgaacacgctgctgggcaacattctcaaaatcatc tacaacaacctggggattgatgaaggagcctggatgaagcgcttggctgtgttttcacag cctatcatcaacaaagtgaaacctcagctcttgaaaactcatttcttacccttgatggag aagctaaagaaaaaggctgccatggtagtgtctgaggaagaccacctgaaagctgaagcc agaggggacatgtctgaggccgagctgctcattctagatgagttcaccacactggccagg gatctctacgccttctacccactcctcatccggtttgtggactataacagggcaaagtgg ctgaaggagcccaacccagaagcagaggagctatttcgaatggtggctgaagtcttcatc tactggtccaaatcccataatttcaaaagagaagaacagaactttgtggtacagaatgaa atcaacaacatgtccttcctcatcactgacacgaagtccaagatgtccaaggcagccatt tctgatcaagaaaggaagaaaatgaagcgcaaaggggaccggtattctatgcagacgtct ttgatcgtggcagctctgaagcgattactacctattgggctgaacatctgtgcccctggt gatcaagagctcattgctctggccaaaaatagatttagcttgaaagacaccgaggaggaa gtacgtgatataatccgcagtaatatacacttacaaggcaagctggaagaccctgcaatc aggtggcagatggctctctacaaagacttgccaaacaggacagaagacacctcagaccca gagaggacagtggagcgtgtcttggatatagcaaatgtgctttttcaccttgagcagaaa tctaagtatactggccggggatatttcagcctgggaagtacagtggaacatccccagaga tcaaagaaagctgtgtggcacaaactactctctaagcagagaaaaagagctgttgtggcc tgcttccggatggcccccttgtacaatctgccaaggcatcgggctgtcaatctttttctt cagggatatgaaaagtcttggattgaaacagaagagcattactttgaggataaattgatt gaagatttagcgaaaccaggggctgagctcccggaagaagacgaagccatgaaaagagtt gatcctctccatcagcttattcttctgttcagtcgcacggccctaacggagaaatgcaaa ctggaggaagattttctatacatggcatatgcagacattatggcaaagagttgtcatgat gaagaagatgacgatggtgaagaagaagtgaagagctttgaagtcacaggatcccaacgc agcaaggaaaaggaaatggaaaagcagaaacttctgtaccagcaagccagactgcacgac cgtggggcagccgagatggtacttcagaccatcagtgccagcaaaggggaaactggacca atggtggctgctactttgaagctgggcatcgctattttaaatggtggcaactccacggtg cagcagaagatgctggattacctgaaggagaaaaaggatgtaggcttcttccagagtctg gcaggcctcatgcagtcctgcagtgtcctggacctgaatgcctttgagaggcaaaacaaa gcagaaggacttgggatggtgactgaggaaggatcaggggagaaggttctgcaggatgat gagttcacctgtgatctcttccgattcctgcagctgctttgtgaggggcacaactcagat tttcagaattacctgagaactcagactggcaacaacaccacagttaatatcatcatctct accgtggactacctccttcgagtgcaggagtccattagtgatttctattggtactactct ggcaaggacatcatagatgagcaggggcagcgtaacttttccaaagccatccaagtggcg aagcaggtgttcaacacactcacggagtacatccagggcccttgtactggaaaccagcaa agcctagcacacagtaggctgtgggatgctgtggtgggcttccttcatgtatttgcacac atgcagatgaagctgtctcaggattccagccagattgagctcttaaaagaacttatggat ctccagaaggacatggtggtcatgctgctgtctatgctagaaggtaatgtggtgaacgga acaataggcaaacagatggtggacatgcttgtggagtcatccaacaatgtggagatgatc ctcaagttctttgacatgtttctgaagctgaaggacttgacatcctctgacacattcaaa gagtatgaccctgatggcaaaggggtcatttccaagagagacttccacaaagccatggag agccacaagcactacacccagtcagagactgagttcctgctgtcctgtgcagagacagat gaaaacgagacacttgactatgaagagtttgtcaaaaggttccatgagcctgccaaggac atcggcttcaacgtggctgttctgttgaccaacctctccgagcacatgcccaatgacacg aggctgcagaccttcctggaattagcagagagtgtcctcaactacttccaacctttcctg ggtcgtattgagatcatgggcagcgccaagcgcattgagagggtctattttgagatcagc gaatccagccgaacccagtgggagaagccccaggtcaaggagtccaagaggcagttcata ttcgatgtggtcaatgagggtggggagaaggagaagatggagctctttgtgaacttctgt gaggacaccatctttgagatgcagttggcagctcagatctcagagtctgatctgaacgag aggtcggcaaataaagaagagagtgagaaggagaggccagaggagcagaccccacggatg ggcttcttctccctcctcaccatccagtcggccttgtttgctcttaggtacaatgtccta accctcgtgaggatgctcagcctgaagagcctgaagaagcagatgaagaggataaagaag atgacagtgaaggacatggtcttggccttcttctcatcctactggagtgtgtttgtcacc ctcttgcacttcgtggccagcgtctgtaggggcttctttcgcattatctccagcctgttg ctggggggcagcctggtagaaggtgctaagaaaatcaaagtggcagaacttctagccaac atgccagaccccactcaggatgaggtgcgaggagatgaggaggagggagagaggaagccc ttagagtcagccctgccctctgaagacctgacagacttgaaggaactgacagaggagagt gaccttctttccgacatattcggcttggatctgaagagggaaggagggcagtacaaacta attcctcacaacccgaatgccggcctcagtgacctcatgaccaaccccatccctgtccct gaggtacaagaaaagtttcaggagcagaaggtgaaagaggaaaaggaagaaaaggaagaa accaagtctgaaccggagaaagctgaaggggaggatggagaaaaagaagaaaaagccaaa gacgataagagcaaacagaagtcgaggcagcttcatacacatcgctatggggagccggaa gtccctgagtcagcattctggaagaaaatcatagcctaccaacagaagctgctgaactat tttgctcgcaacttttacaacatgagaatgctggccttgtttgttgccttcgccatcaat ttcatcctgctcttctacaaggtctccacttcttctgtggttgaaggaaaggagctgcct acccgaacttccagcgataccgctaaagtgaccaccagcctggacagcagcccccatagg atcattgcggttcactacgtcctggaggagagcagtggttacatggaacccaccttgcgc atcttagccatcctccacaccatcatctccttcttttgcatcatcggatactactgcttg aaagtccccttggttatttttaagcgagagaaggaagtggcacggaagttggagtttgac ggtctttatataacggagcagccatcggaagatgatatcaaaggccagtgggacagactc gtgatcaacacacagtcatttcccaataactactgggataaatttgtgaaaagaaaggta atggataaatatggagagttttatgggagagacagaatcagtgagttactgggcatggat aaggctgcactggatttcagcgatgcaagagagaaaaagaagcccaagaaagacagctcc ttgtctgccgtattgaactctattgacgtgaagtaccagatgtggaaactaggagtcgtg ttcacagacaattccttcctctacctagcctggtatatgaccatgtctgttctcggacac tataacaactttttttttgctgctcatctccttgacatcgcgatgggcttcaagaccttg agaactatcctgtcctcggttacccataatggcaagcagctcgtgttaactgttggctta ttggctgttgttgtatacctgtacactgttgtggcgttcaatttcttccgaaaattctac aataaaagtgaggatggtgacacaccagacatgaagtgtgacgacatgttgacgtgttac atgttccacatgtatgtgggcgtccgtgctggagggggcatcggtgatgaaattgaagac ccagcaggagacgagtatgagatctaccgcatcatctttgacatcacattcttcttcttc gtgattgtcatccttttggcgatcatacaaggtttgatcattgatgcttttggagaactc cgagaccaacaagagcaagtcaaggaagacatggagaccaagtgcttcatctgtgggatt ggcaacgattattttgatacagtgccacatggctttgaaacccatactctacaggaacac aatctggccaactacctgttttttctgatgtatctcataaacaaggatgaaacagaacac acaggacaggaatcttatgtctggaagatgtaccaagagaggtgttgggaatttttccca gcaggggactgtttccggaaacaatatgaagatcagttaaattaa

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