Mycolicibacterium poriferae: MPOR_11910
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Entry
MPOR_11910 CDS
T07158
Symbol
hemD
Name
(GenBank) bifunctional uroporphyrinogen-III C-methyltransferase/uroporphyrinogen-III synthase
KO
K13542
uroporphyrinogen III methyltransferase / synthase [EC:
2.1.1.107
4.2.1.75
]
Organism
mpof
Mycolicibacterium poriferae
Pathway
mpof00860
Porphyrin metabolism
mpof01100
Metabolic pathways
mpof01110
Biosynthesis of secondary metabolites
mpof01120
Microbial metabolism in diverse environments
mpof01240
Biosynthesis of cofactors
Module
mpof_M00846
Siroheme biosynthesis, glutamyl-tRNA => siroheme
mpof_M00926
Heme biosynthesis, bacteria, glutamyl-tRNA => coproporphyrin III => heme
Brite
KEGG Orthology (KO) [BR:
mpof00001
]
09100 Metabolism
09108 Metabolism of cofactors and vitamins
00860 Porphyrin metabolism
MPOR_11910 (hemD)
Enzymes [BR:
mpof01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.1 Methyltransferases
2.1.1.107 uroporphyrinogen-III C-methyltransferase
MPOR_11910 (hemD)
4. Lyases
4.2 Carbon-oxygen lyases
4.2.1 Hydro-lyases
4.2.1.75 uroporphyrinogen-III synthase
MPOR_11910 (hemD)
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Gene cluster
GFIT
Motif
Pfam:
HEM4
TP_methylase
Motif
Other DBs
NCBI-ProteinID:
BBX50165
UniProt:
A0A6N4V5K0
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Position
1246595..1248274
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AA seq
559 aa
AA seq
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MRGRKGKPGRITFVGSGPGDPGLLTARARTVLAHAALVFTDPDVPEAVLGLVGAELPPQS
GPLPEAATKSDKSGGTDPSGAGAEQTADAVIPGGPDVRPALGDPAEVAKTLANEAKAGAD
VVRLVAGDPLSVDSVITEVNVVAKTQLVFEIVPGLPDTTAVPTYAGLPLGSAHTVADVRG
DVDWAALAAAPGPLILHATASHLPEAARTLIEYGLADTTPTVVTAHGTTCQQRSLETTLA
GLLDKNTLAAAATDTPPAGPLAGPLVVTIGRTVTNRAKLNWWESRSLYGWTVLVPRTKDQ
AGEMSDRLVGHGALPIEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTSTNAVRAVWE
KFNEFGLDARAFSGVKIACVGQATADRVRAFGINPELVPTGEQSSLGLLDEFPPYDDIFD
PVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPAHTREMIKTGGFDAVCF
TSSSTVRNLVGIAGKPHARTIVACIGPKTAETAAEFGLRVDVQPEVAAVGPLVEALAEHA
ARLRAEGALPPPRKKSRRR
NT seq
1680 nt
NT seq
+upstream
nt +downstream
nt
atgcgggggcgtaagggcaagcccggccgcatcactttcgtcggctccggacccggggac
ccgggtctgttgaccgcccgagcccgcaccgtgctggcgcacgccgccctggtgttcacc
gatcccgacgtacccgaggcggtgctgggcctcgtcggcgccgaactgccgccgcagtcg
ggtccgctgccggaggcggccaccaagagtgacaagtcgggcggcaccgacccgagcggg
gccggcgccgagcagaccgctgatgcggtcatcccgggcgggcccgacgtgcgccctgcc
ctcggtgaccccgccgaggtcgccaagacactggccaacgaggccaaggcaggcgccgac
gtcgtccgcctggtcgccggtgacccgctgtcggtggactcggtgatcaccgaggtcaac
gtggtggccaagacgcaactggtcttcgagatcgtgccgggcctgcccgacaccacagcg
gtgcccacctacgcgggcctgcctctgggttcggcgcacaccgtggccgacgtccgcggc
gacgtggactgggcggcgctcgccgctgctcccgggccgctgatcctgcacgcgacggcg
tcgcatctgcccgaggccgcgcgcaccctgatcgagtacgggctggccgacaccacgccc
accgtggtcaccgcccacggcaccacctgccagcagcgctcgctggagacgacgctggcc
gggctgctggacaagaacacgctcgctgccgcggcgaccgacaccccgcccgccggtccg
ctggccgggccgctggtcgtcacgatcggccgcaccgtcaccaaccgggccaagctgaac
tggtgggagagccgctcactgtacggctggacggtgctggtgccgcgcaccaaggaccag
gccggcgagatgagcgatcgcctggtcggccacggcgccctgcccatcgaggtgccgacc
atcgcggtcgagccgccccgcagccccgcccagatggaaagggccgtcaagggtttggtc
gacggacgcttccaatgggtggtgttcacctccaccaacgcggtgcgcgcggtgtgggag
aagttcaacgagttcgggctggacgcgcgggcgttctccggggtgaagatcgcctgtgtc
ggccaggccaccgccgatcgggtgcgggccttcggtatcaaccccgagctggtgcccacc
ggcgagcagtcctcgctggggctgctcgatgaattcccgccctacgacgacattttcgat
ccggtgaaccgggtgctgttgccacgcgccgacatcgccaccgagacgctggccgagggg
ctgcgcgaacgcggttgggagatcgaggacgtcaccgcctaccggaccgtgcgcgcggcg
ccgcccccggcgcacacccgcgagatgatcaagaccggcggcttcgacgcggtctgcttc
acctcgagctcgacggtgcgcaacctggtcgggatcgccgggaagccgcacgcccgcacg
atcgtggcgtgcatcgggcccaagaccgccgagaccgcagccgaattcgggttgcgcgtc
gacgtgcagccggaggtcgccgcggtgggcccgctggtggaggcgctggccgagcacgcc
gcgcggctgcgggccgagggggcgttgccgccgccgcggaagaagagccgccgccgctga
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