KEGG   Mustela putorius furo (domestic ferret): 101678347
Entry
101678347         CDS       T07239                                 
Symbol
PLCB1
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X2
  KO
K05858  phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
mpuf  Mustela putorius furo (domestic ferret)
Pathway
mpuf00562  Inositol phosphate metabolism
mpuf01100  Metabolic pathways
mpuf04015  Rap1 signaling pathway
mpuf04020  Calcium signaling pathway
mpuf04022  cGMP-PKG signaling pathway
mpuf04062  Chemokine signaling pathway
mpuf04070  Phosphatidylinositol signaling system
mpuf04071  Sphingolipid signaling pathway
mpuf04072  Phospholipase D signaling pathway
mpuf04081  Hormone signaling
mpuf04082  Neuroactive ligand signaling
mpuf04261  Adrenergic signaling in cardiomyocytes
mpuf04270  Vascular smooth muscle contraction
mpuf04310  Wnt signaling pathway
mpuf04371  Apelin signaling pathway
mpuf04540  Gap junction
mpuf04611  Platelet activation
mpuf04613  Neutrophil extracellular trap formation
mpuf04621  NOD-like receptor signaling pathway
mpuf04713  Circadian entrainment
mpuf04720  Long-term potentiation
mpuf04723  Retrograde endocannabinoid signaling
mpuf04724  Glutamatergic synapse
mpuf04725  Cholinergic synapse
mpuf04726  Serotonergic synapse
mpuf04728  Dopaminergic synapse
mpuf04730  Long-term depression
mpuf04742  Taste transduction
mpuf04750  Inflammatory mediator regulation of TRP channels
mpuf04911  Insulin secretion
mpuf04912  GnRH signaling pathway
mpuf04915  Estrogen signaling pathway
mpuf04916  Melanogenesis
mpuf04918  Thyroid hormone synthesis
mpuf04919  Thyroid hormone signaling pathway
mpuf04921  Oxytocin signaling pathway
mpuf04922  Glucagon signaling pathway
mpuf04924  Renin secretion
mpuf04925  Aldosterone synthesis and secretion
mpuf04926  Relaxin signaling pathway
mpuf04927  Cortisol synthesis and secretion
mpuf04928  Parathyroid hormone synthesis, secretion and action
mpuf04929  GnRH secretion
mpuf04933  AGE-RAGE signaling pathway in diabetic complications
mpuf04934  Cushing syndrome
mpuf04935  Growth hormone synthesis, secretion and action
mpuf04961  Endocrine and other factor-regulated calcium reabsorption
mpuf04970  Salivary secretion
mpuf04971  Gastric acid secretion
mpuf04972  Pancreatic secretion
mpuf04973  Carbohydrate digestion and absorption
mpuf05010  Alzheimer disease
mpuf05016  Huntington disease
mpuf05017  Spinocerebellar ataxia
mpuf05022  Pathways of neurodegeneration - multiple diseases
mpuf05142  Chagas disease
mpuf05143  African trypanosomiasis
mpuf05146  Amoebiasis
mpuf05163  Human cytomegalovirus infection
mpuf05200  Pathways in cancer
mpuf05415  Diabetic cardiomyopathy
mpuf05417  Lipid and atherosclerosis
Module
mpuf_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:mpuf00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    101678347 (PLCB1)
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    101678347 (PLCB1)
   04310 Wnt signaling pathway
    101678347 (PLCB1)
   04371 Apelin signaling pathway
    101678347 (PLCB1)
   04020 Calcium signaling pathway
    101678347 (PLCB1)
   04070 Phosphatidylinositol signaling system
    101678347 (PLCB1)
   04072 Phospholipase D signaling pathway
    101678347 (PLCB1)
   04071 Sphingolipid signaling pathway
    101678347 (PLCB1)
   04022 cGMP-PKG signaling pathway
    101678347 (PLCB1)
  09133 Signaling molecules and interaction
   04082 Neuroactive ligand signaling
    101678347 (PLCB1)
   04081 Hormone signaling
    101678347 (PLCB1)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    101678347 (PLCB1)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    101678347 (PLCB1)
   04613 Neutrophil extracellular trap formation
    101678347 (PLCB1)
   04621 NOD-like receptor signaling pathway
    101678347 (PLCB1)
   04062 Chemokine signaling pathway
    101678347 (PLCB1)
  09152 Endocrine system
   04911 Insulin secretion
    101678347 (PLCB1)
   04922 Glucagon signaling pathway
    101678347 (PLCB1)
   04929 GnRH secretion
    101678347 (PLCB1)
   04912 GnRH signaling pathway
    101678347 (PLCB1)
   04915 Estrogen signaling pathway
    101678347 (PLCB1)
   04921 Oxytocin signaling pathway
    101678347 (PLCB1)
   04926 Relaxin signaling pathway
    101678347 (PLCB1)
   04935 Growth hormone synthesis, secretion and action
    101678347 (PLCB1)
   04918 Thyroid hormone synthesis
    101678347 (PLCB1)
   04919 Thyroid hormone signaling pathway
    101678347 (PLCB1)
   04928 Parathyroid hormone synthesis, secretion and action
    101678347 (PLCB1)
   04916 Melanogenesis
    101678347 (PLCB1)
   04924 Renin secretion
    101678347 (PLCB1)
   04925 Aldosterone synthesis and secretion
    101678347 (PLCB1)
   04927 Cortisol synthesis and secretion
    101678347 (PLCB1)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    101678347 (PLCB1)
   04270 Vascular smooth muscle contraction
    101678347 (PLCB1)
  09154 Digestive system
   04970 Salivary secretion
    101678347 (PLCB1)
   04971 Gastric acid secretion
    101678347 (PLCB1)
   04972 Pancreatic secretion
    101678347 (PLCB1)
   04973 Carbohydrate digestion and absorption
    101678347 (PLCB1)
  09155 Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    101678347 (PLCB1)
  09156 Nervous system
   04724 Glutamatergic synapse
    101678347 (PLCB1)
   04725 Cholinergic synapse
    101678347 (PLCB1)
   04728 Dopaminergic synapse
    101678347 (PLCB1)
   04726 Serotonergic synapse
    101678347 (PLCB1)
   04720 Long-term potentiation
    101678347 (PLCB1)
   04730 Long-term depression
    101678347 (PLCB1)
   04723 Retrograde endocannabinoid signaling
    101678347 (PLCB1)
  09157 Sensory system
   04742 Taste transduction
    101678347 (PLCB1)
   04750 Inflammatory mediator regulation of TRP channels
    101678347 (PLCB1)
  09159 Environmental adaptation
   04713 Circadian entrainment
    101678347 (PLCB1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    101678347 (PLCB1)
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    101678347 (PLCB1)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    101678347 (PLCB1)
   05142 Chagas disease
    101678347 (PLCB1)
   05143 African trypanosomiasis
    101678347 (PLCB1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    101678347 (PLCB1)
   05016 Huntington disease
    101678347 (PLCB1)
   05017 Spinocerebellar ataxia
    101678347 (PLCB1)
   05022 Pathways of neurodegeneration - multiple diseases
    101678347 (PLCB1)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    101678347 (PLCB1)
   05415 Diabetic cardiomyopathy
    101678347 (PLCB1)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    101678347 (PLCB1)
   04934 Cushing syndrome
    101678347 (PLCB1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:mpuf04131]
    101678347 (PLCB1)
Enzymes [BR:mpuf01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     101678347 (PLCB1)
Membrane trafficking [BR:mpuf04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    101678347 (PLCB1)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    101678347 (PLCB1)
SSDB
Motif
Pfam: PI-PLC-X PLC-beta_C PI-PLC-Y PLCB1-4-like_EFh PH_14 EF-hand_like
Other DBs
NCBI-GeneID: 101678347
NCBI-ProteinID: XP_004751598
Ensembl: ENSMPUG00000006415
LinkDB
Position
Unknown
AA seq 1159 aa
MQETELLDLSLVKDARCGKHAKAPKDPKLRELLDVGNIGRLEHRMITVVYGPDLVNISHL
NLVAFQEEVAKEWTNEVFSLATNLLAQNMSRDAFLEKAYTKLKLQVTPEGRIPLKNIYRL
FSADRKRVETALEACSLPSSRNDSIPQEDFTPEVYRVFLNNLCPRPEIDNIFSEFGAKSK
PYLTVDQMMDFINLKQRDPRLNEILYPPLKQEQVQVLIEKYEPNNSLAKKGQISVDGFMR
YLSGEENGVVSPEKLDLNEDMSQPLSHYFINSSHNTYLTAGQLAGNSSVEMYRQVLLSGC
RCVELDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPFPILLSFENHVDS
PKQQAKMAEYCRLIFGDALLMEPLEKYPLESGVPLPSPMDLMYKILVKNKKKSHKSSEGS
GKKKLSEQASNTYSDSSSMFEPSSPGAGEADTESDDDDDDDDCKKSSMDEGTAGSEAMAT
EEMSNLVNYIQPVKFESFEISKKRNRSFEMSSFVETKGLEQLTKSPVEFVEYNKMQLSRI
YPKGTRVDSSNYMPQLFWNAGCQMVALNFQTVDLAMQINMGMYEYNGKSGYRLKPEFMRR
PDKHFDPFTEGIVDGIVANTLSVKIISGQFLSDKKVGTYVEVDMFGLPVDTRRKAFKTKT
SQGNAVNPVWEEEPIVFKKVVLPSLACLRIAVYEEGGKFIGHRILPVQAIRPGYHYICLR
NERNQPLMLPAVFVYIEVKDYVPDTYADVIEALSNPIRYVNLMEQRAKQLAALTLEDEEE
VKKEADPGETPSEAPSEARTTPAENGVNHTTSLAPKPPSQALHSQPAPGSVKAPVKTEDL
IQSVLTEVEAQTIEELKQQKSFVKLQKKHYKEMKDLVKRHHKKTTDLIKEHTTKYNEIQN
DYLRRRAALEKTAKKDSKKKSDPSSPDHGSSTIEQDLAALDAEMTQKLIDLKDKQQQQLL
NLRQEQYYSEKYQKREHIKLLIQKLTDVAEECQNNQLKKLKEICEKEKKELKKKMDKKRQ
EKITEAKSKDKSQMEEEKTEMIRSYIQEVVQYIKRLEEAQSKRQEKLVEKHKEIRQQILD
EKPKLQTDLEQEYQDKFKRLPLEILEFVQEAMKGKISEDSNHSSAPPSLASEPGKMNHRP
PSSDELEGDNPGKEFDTPL
NT seq 3480 nt   +upstreamnt  +downstreamnt
atgcaggagacggagctgttagatctcagccttgtcaaggatgccagatgtgggaagcat
gccaaagctcccaaggaccccaagttacgtgaacttttggatgtggggaacatcgggcgc
ctggagcatcgtatgataaccgtggtgtatgggcctgacttggttaacatctcccatttg
aatctcgtggctttccaagaagaagtagccaaggagtggacaaatgaggttttcagtttg
gcaacaaacctgctggcccaaaatatgtcaagagacgcatttctggaaaaagcctatact
aagcttaagctgcaagtcactccagaagggcgcattcctctcaaaaacatataccgcttg
ttctcagcagaccggaaacgagttgaaactgctttagaggcttgtagtcttccatcttca
aggaacgattcaatacctcaagaagatttcactccagaagtatacagagttttcctgaac
aacctttgccctcgacctgaaattgataacatcttttctgaatttggtgccaaaagcaaa
ccataccttactgttgatcagatgatggactttatcaaccttaagcagcgagatccccgg
ctaaatgaaatactttacccacctttaaagcaagaacaagtccaagtattgattgagaag
tatgaacccaacaatagtctcgccaaaaaaggacagatatcagtggatggctttatgcgc
tatctgagtggagaagaaaatggagtcgtttcacctgagaaactggatttgaatgaagat
atgtctcaacccctctctcactatttcatcaattcctcacacaacacctacctcacagct
ggccagttggctggaaactcctctgtcgagatgtatcgccaagtgcttctgtctggttgt
cgctgtgtggagttggactgctggaagggacggactgctgaagaggaaccagtcatcacc
cacgggtttaccatgacaaccgaaatatccttcaaggaagtgatagaagcaattgctgag
tgtgcatttaagacgtcaccttttccaattctgctttcatttgagaaccacgtagattcc
ccaaagcagcaagccaagatggcggagtattgccgactgatctttggagatgctcttctc
atggaaccactggaaaaatacccactggaatctggagttcctcttccaagccctatggat
ttaatgtacaaaattttggtgaaaaataagaagaaatcacataagtcgtcggaaggaagt
ggcaaaaagaagctctcagaacaagcctccaacacgtacagtgactcctccagcatgttc
gagccctcgtctcccggagccggggaagcggacactgagagtgacgacgacgacgatgat
gatgactgtaaaaaatcttcaatggatgaggggactgccgggagcgaggccatggccact
gaagagatgtctaacctggtgaactacattcagccagtcaagtttgagtcatttgaaatt
tcaaaaaaaagaaatagaagttttgaaatgtcttccttcgtggaaaccaaaggccttgag
caactgacgaagtctcccgtggaatttgtagaatataacaaaatgcagcttagcaggata
tatccgaaaggaacccgtgtggattcatcgaactacatgcctcagctcttctggaatgca
ggttgccaaatggttgcccttaattttcaaactgtggacctcgctatgcaaataaatatg
gggatgtacgaatacaatgggaaaagtggctacagattaaaaccagagttcatgaggaga
cctgacaagcattttgatcccttcaccgaaggcatcgtggatgggatagtggccaacact
ttatctgtcaagattatttcaggtcagtttctttccgataagaaagtcgggacttacgta
gaagtggatatgtttggtttgcctgtggacacgaggaggaaggcatttaagaccaaaaca
tcacaaggaaatgctgtaaatcccgtctgggaagaagagcccattgtgttcaaaaaggtg
gtccttccttctctggcctgtttgaggatagcagtttatgaagaaggaggtaaattcatt
ggtcaccggatcttgccagtacaagcaattcggccaggctatcactacatctgcctgagg
aatgaaaggaaccagcctctgatgctcccagctgtctttgtctacatagaggtgaaagac
tatgtcccagatacatatgcagatgtgattgaagctttgtcaaatccaatacgatatgtg
aatctcatggagcaaagagctaaacagttagctgctttgacactggaagatgaagaagaa
gtaaagaaagaggctgatcctggggaaacaccatcagaagctccaagtgaagccaggaca
actccagcagaaaacggagtgaatcacactacatccttggcacccaaaccaccatcccag
gctctccacagccaaccagctccaggttctgtaaaggcacctgtgaaaacagaagacctt
attcagagtgtcctaacagaagtggaagcccagactatcgaagagctaaagcagcagaaa
tcctttgtgaaacttcaaaagaagcactacaaagaaatgaaagacctggttaaaagacac
cacaagaaaaccactgaccttatcaaagaacacactacaaaatataatgagattcagaac
gactacttgagaaggagggcagctttggaaaagacagccaaaaaggatagtaagaaaaaa
tcagatcccagcagtcctgaccatggttcatcaacgattgaacaagatcttgctgcccta
gatgctgaaatgacccaaaagttaatagacttgaaagacaaacaacagcagcagctgctt
aatcttcgacaagagcagtattatagtgaaaaatatcagaagcgagaacatattaaactg
cttattcaaaaattgacggatgttgctgaagaatgtcagaataatcagctgaagaagctc
aaagaaatctgtgagaaagagaagaaggagttaaagaagaagatggacaaaaaaaggcag
gagaagataacagaagctaaatccaaagacaaaagtcaaatggaagaggaaaagacagag
atgatccgatcatacatccaagaggtggtgcagtacatcaagaggttagaagaggcccaa
agtaaacggcaagaaaaacttgtagagaaacacaaggagatacgtcaacagatcctggac
gaaaagcccaagctgcagacagacctggagcaagaataccaagacaagttcaaaagactg
cccctggagatcttggagttcgtgcaggaagccatgaaagggaagatcagcgaagacagc
aaccacagctctgcccctccctccctggcctcagagcctggaaaaatgaaccacaggcct
ccctccagtgacgagctggaaggagacaacccaggaaaagagttcgatactcctctgtga

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