KEGG   Mustela putorius furo (domestic ferret): 101679345
Entry
101679345         CDS       T07239                                 
Symbol
PLCB4
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1
  KO
K05858  phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
mpuf  Mustela putorius furo (domestic ferret)
Pathway
mpuf00562  Inositol phosphate metabolism
mpuf01100  Metabolic pathways
mpuf04015  Rap1 signaling pathway
mpuf04020  Calcium signaling pathway
mpuf04022  cGMP-PKG signaling pathway
mpuf04062  Chemokine signaling pathway
mpuf04070  Phosphatidylinositol signaling system
mpuf04071  Sphingolipid signaling pathway
mpuf04072  Phospholipase D signaling pathway
mpuf04081  Hormone signaling
mpuf04082  Neuroactive ligand signaling
mpuf04261  Adrenergic signaling in cardiomyocytes
mpuf04270  Vascular smooth muscle contraction
mpuf04310  Wnt signaling pathway
mpuf04371  Apelin signaling pathway
mpuf04540  Gap junction
mpuf04611  Platelet activation
mpuf04613  Neutrophil extracellular trap formation
mpuf04621  NOD-like receptor signaling pathway
mpuf04713  Circadian entrainment
mpuf04720  Long-term potentiation
mpuf04723  Retrograde endocannabinoid signaling
mpuf04724  Glutamatergic synapse
mpuf04725  Cholinergic synapse
mpuf04726  Serotonergic synapse
mpuf04728  Dopaminergic synapse
mpuf04730  Long-term depression
mpuf04742  Taste transduction
mpuf04750  Inflammatory mediator regulation of TRP channels
mpuf04911  Insulin secretion
mpuf04912  GnRH signaling pathway
mpuf04915  Estrogen signaling pathway
mpuf04916  Melanogenesis
mpuf04918  Thyroid hormone synthesis
mpuf04919  Thyroid hormone signaling pathway
mpuf04921  Oxytocin signaling pathway
mpuf04922  Glucagon signaling pathway
mpuf04924  Renin secretion
mpuf04925  Aldosterone synthesis and secretion
mpuf04926  Relaxin signaling pathway
mpuf04927  Cortisol synthesis and secretion
mpuf04928  Parathyroid hormone synthesis, secretion and action
mpuf04929  GnRH secretion
mpuf04933  AGE-RAGE signaling pathway in diabetic complications
mpuf04934  Cushing syndrome
mpuf04935  Growth hormone synthesis, secretion and action
mpuf04961  Endocrine and other factor-regulated calcium reabsorption
mpuf04970  Salivary secretion
mpuf04971  Gastric acid secretion
mpuf04972  Pancreatic secretion
mpuf04973  Carbohydrate digestion and absorption
mpuf05010  Alzheimer disease
mpuf05016  Huntington disease
mpuf05017  Spinocerebellar ataxia
mpuf05022  Pathways of neurodegeneration - multiple diseases
mpuf05142  Chagas disease
mpuf05143  African trypanosomiasis
mpuf05146  Amoebiasis
mpuf05163  Human cytomegalovirus infection
mpuf05200  Pathways in cancer
mpuf05415  Diabetic cardiomyopathy
mpuf05417  Lipid and atherosclerosis
Module
mpuf_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:mpuf00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    101679345 (PLCB4)
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    101679345 (PLCB4)
   04310 Wnt signaling pathway
    101679345 (PLCB4)
   04371 Apelin signaling pathway
    101679345 (PLCB4)
   04020 Calcium signaling pathway
    101679345 (PLCB4)
   04070 Phosphatidylinositol signaling system
    101679345 (PLCB4)
   04072 Phospholipase D signaling pathway
    101679345 (PLCB4)
   04071 Sphingolipid signaling pathway
    101679345 (PLCB4)
   04022 cGMP-PKG signaling pathway
    101679345 (PLCB4)
  09133 Signaling molecules and interaction
   04082 Neuroactive ligand signaling
    101679345 (PLCB4)
   04081 Hormone signaling
    101679345 (PLCB4)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    101679345 (PLCB4)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    101679345 (PLCB4)
   04613 Neutrophil extracellular trap formation
    101679345 (PLCB4)
   04621 NOD-like receptor signaling pathway
    101679345 (PLCB4)
   04062 Chemokine signaling pathway
    101679345 (PLCB4)
  09152 Endocrine system
   04911 Insulin secretion
    101679345 (PLCB4)
   04922 Glucagon signaling pathway
    101679345 (PLCB4)
   04929 GnRH secretion
    101679345 (PLCB4)
   04912 GnRH signaling pathway
    101679345 (PLCB4)
   04915 Estrogen signaling pathway
    101679345 (PLCB4)
   04921 Oxytocin signaling pathway
    101679345 (PLCB4)
   04926 Relaxin signaling pathway
    101679345 (PLCB4)
   04935 Growth hormone synthesis, secretion and action
    101679345 (PLCB4)
   04918 Thyroid hormone synthesis
    101679345 (PLCB4)
   04919 Thyroid hormone signaling pathway
    101679345 (PLCB4)
   04928 Parathyroid hormone synthesis, secretion and action
    101679345 (PLCB4)
   04916 Melanogenesis
    101679345 (PLCB4)
   04924 Renin secretion
    101679345 (PLCB4)
   04925 Aldosterone synthesis and secretion
    101679345 (PLCB4)
   04927 Cortisol synthesis and secretion
    101679345 (PLCB4)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    101679345 (PLCB4)
   04270 Vascular smooth muscle contraction
    101679345 (PLCB4)
  09154 Digestive system
   04970 Salivary secretion
    101679345 (PLCB4)
   04971 Gastric acid secretion
    101679345 (PLCB4)
   04972 Pancreatic secretion
    101679345 (PLCB4)
   04973 Carbohydrate digestion and absorption
    101679345 (PLCB4)
  09155 Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    101679345 (PLCB4)
  09156 Nervous system
   04724 Glutamatergic synapse
    101679345 (PLCB4)
   04725 Cholinergic synapse
    101679345 (PLCB4)
   04728 Dopaminergic synapse
    101679345 (PLCB4)
   04726 Serotonergic synapse
    101679345 (PLCB4)
   04720 Long-term potentiation
    101679345 (PLCB4)
   04730 Long-term depression
    101679345 (PLCB4)
   04723 Retrograde endocannabinoid signaling
    101679345 (PLCB4)
  09157 Sensory system
   04742 Taste transduction
    101679345 (PLCB4)
   04750 Inflammatory mediator regulation of TRP channels
    101679345 (PLCB4)
  09159 Environmental adaptation
   04713 Circadian entrainment
    101679345 (PLCB4)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    101679345 (PLCB4)
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    101679345 (PLCB4)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    101679345 (PLCB4)
   05142 Chagas disease
    101679345 (PLCB4)
   05143 African trypanosomiasis
    101679345 (PLCB4)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    101679345 (PLCB4)
   05016 Huntington disease
    101679345 (PLCB4)
   05017 Spinocerebellar ataxia
    101679345 (PLCB4)
   05022 Pathways of neurodegeneration - multiple diseases
    101679345 (PLCB4)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    101679345 (PLCB4)
   05415 Diabetic cardiomyopathy
    101679345 (PLCB4)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    101679345 (PLCB4)
   04934 Cushing syndrome
    101679345 (PLCB4)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:mpuf04131]
    101679345 (PLCB4)
Enzymes [BR:mpuf01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     101679345 (PLCB4)
Membrane trafficking [BR:mpuf04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    101679345 (PLCB4)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    101679345 (PLCB4)
SSDB
Motif
Pfam: PI-PLC-X PH_14 PI-PLC-Y PLCB1-4-like_EFh EF-hand_like C2 PLC-beta_C EF-hand_7 EF-hand_6
Other DBs
NCBI-GeneID: 101679345
NCBI-ProteinID: XP_004751601
Ensembl: ENSMPUG00000006431
UniProt: A0A8U0SV21
LinkDB
Position
Unknown
AA seq 1206 aa
MAKPYEFNWQKEVPSFLQEGAVFDRYEEESFVFEPNCLFKVDEFGFFLTWRSEGKEGQVL
ECSLINSIRLGATPKDPKILAALEAVGKSENDLEGRIVCVCSGTDLVNISFTYMVAENPE
VTKQWVEGLRSIIHNFRANNVSPMTCLKKHWMKLAFMTNTNGKIPVRSITRTFASGKTEK
VIFQALKELGLPSGKNDEIEPAAFTYEKFYELTQKICPRTDIEDLFKKINGDKTDYLTVD
QLVSFLNEHQRDPRLNEILFPFYDAKRAMQIIEMYEPDEDLKNKGLISSDGFCRYLMSDE
NAPVFLDRLELYQEMDHPLAHYFISSSHNTYLTGRQFGGKSSVEMYRQVLLAGCRCVELD
CWDGKGEDQEPIITHGKAMCTDILFKDVIQAIKETAFVTSEYPVILSFENHCSKYQQYKM
SKYCEDLFGDLLLKQALESHPLEPGRPLPSPNDLKRKILIKNKRLKPEVEKKQLEALKSM
MEAGESAAPVSILEDDNEEEIESADQEEEAHPEYKFGNELSADDLGHKEAVANSVKKASD
DLEHEINKKGLVTVEDEQAWMASYKYVGATTNIHPYLSTMINYAQPVKFQGFHVAEERNI
HYNMSSFNESVGLGYLKTHAIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQMVS
LNYQTPDLAMQLNQGKFEYNGSCGYLLKPDFMRRPDRTFDPFSETPVDGVIAATCSVQVI
SGQFLSDKKIGTYVEVDMYGLPTDTIRKEFRTRMVMNNGLNPVYNEESFVFRKVILPDLA
VLRIAVYDDNNRLIGQRILPLDGLQAGYRHISLRNEGNKPLSLPTIFCNIVLKTYVPDGF
GDIVDALSDPKKFLSITEKRADQMRAMGIETSDIADVPSDTSKNDKKGKANTAKANVTPQ
SSSELRPTTTAALGSGVEAKKGIELIPQVRIEDLKQMKAYLKHLKKQQKELNSLKKKHAK
EHSTMQKLHCTQVDKMVAQYDKEKSTHEKILEKAMKKKGGSNCLEMKKETEIKIQTLTSD
HKSKVKEIVAQHTKEWSEMINTHSAEEQEIRDLHLSQQCELLRKLLINAHEQQTQQLKMS
HDRESKEMRAHQAKISMENSKAISQDKSIKNKAERERRVRELNSSNTKKFLEERKRLAMK
QSKEMDQLKKVQLEHLEFLEKQNEQLLKSCHAVSQTQGEGDAADGEVGSRDGPQASNSSV
KLQNSN
NT seq 3621 nt   +upstreamnt  +downstreamnt
atggccaaaccttatgaatttaactggcagaaggaagttccttcctttttgcaagaagga
gccgtttttgacagatatgaagaggaatcctttgtgtttgaacccaactgcctcttcaaa
gtggatgaatttggcttctttctgacctggaggagtgaaggcaaggaaggacaagtgcta
gaatgttccctcatcaacagtattcgattgggagccacacccaaggatcccaaaatcctg
gccgctctcgaagctgttggaaagtcagagaatgatctggaagggcggatagtttgtgtt
tgcagcggcacagatctggtgaacatcagtttcacatacatggtggctgaaaatccagaa
gtaactaagcaatgggtagaaggactgagatcgatcatacacaacttcagggccaacaat
gtcagtccaatgacctgcctcaagaaacactggatgaaattggcatttatgaccaacaca
aatggtaaaattccagttaggagtattactagaacctttgcatcggggaaaacagaaaaa
gtgatctttcaagcactcaaggaattaggtcttcccagtggaaagaatgacgaaattgag
cctgcggcatttacttatgaaaagttctatgaactgacacaaaagatttgtcctcggaca
gatatagaggatctttttaaaaaaatcaatggagacaaaactgattatttaacggtagac
caattagtgagctttctaaatgaacatcagcgagaccctcgactgaatgaaattttattc
ccattttacgatgctaaaagggcaatgcagatcatcgagatgtatgagcccgatgaagat
ttgaagaacaaaggcctcatatcaagcgatgggttttgcagatacctgatgtcagatgaa
aatgccccagtcttcctggatcgtttagaactttaccaagaaatggaccatcctctggcc
cactacttcatcagttcttcccataacacctatctcacgggccgacagtttggcgggaaa
tcttcagtagaaatgtacagacaggttctcctggctggttgcagatgcgttgaacttgac
tgttgggatggaaaaggtgaagatcaagaaccgataataactcatggaaaagcaatgtgt
acagatatcctttttaaggatgttattcaagccatcaaggaaaccgcatttgtcacatcc
gaatatcctgtcattctctcctttgaaaatcactgcagcaaatatcagcagtacaagatg
tccaaatattgcgaagatctatttggggatctcctgttgaaacaagcacttgaatcacat
ccacttgaaccaggcagacccttaccatcccccaatgacctcaaaagaaaaatactcatc
aaaaataagcggctgaaacctgaggttgaaaaaaaacagctcgaggctttgaaaagcatg
atggaagctggagaatctgctgccccggttagcatcctagaggatgataatgaagaggaa
atagaaagtgctgaccaagaggaggaagctcaccccgaatacaaatttggaaacgaactt
tctgctgatgacttgggccacaaggaggctgttgcaaatagtgtcaagaaggcttcagat
gaccttgaacatgaaatcaacaaaaagggcctggtgactgtggaagacgaacaggcatgg
atggcgtcttataaatatgtaggtgctaccactaacatccatccgtatttgtctacaatg
atcaactatgcacaacccgtaaagtttcaaggtttccatgtggctgaagagcgcaatatt
cattataacatgtcttcttttaatgagtccgtcggcctgggctacttgaagacgcacgcc
attgaatttgtgaattataacaaacggcaaatgagccgcatttaccccaagggaggccgg
gtcgattccagtaattacatgcctcagattttctggaatgctggctgccagatggtttca
ctcaactatcaaaccccagatttagcgatgcaattgaatcagggaaaatttgagtataat
ggatcatgcgggtacctcctcaaaccagatttcatgagacggcccgatcgaacattcgat
cccttctctgaaactcctgtcgatggggttattgcagccacttgctcagtccaggtcata
tcaggtcagtttttatcagataagaaaattggtacatacgtagaagtggatatgtatggg
ttgcccaccgacaccatacgtaaggaattccgaactcgcatggtgatgaacaacggactc
aatccagtttacaatgaagaatcatttgtgttccggaaggtaatcctccctgacctggca
gtcttgagaatagcagtatatgacgacaacaacaggctcataggccagaggatccttcct
ctggatggcctccaagcaggctatcgacacatttcccttcgaaacgagggaaataaacca
ttatcactgccaaccattttctgcaatattgttcttaaaacatatgtgcctgatggattt
ggagatatcgtagatgctttatcagatccaaagaaatttctttccattacggaaaagaga
gcagaccaaatgagagccatgggcattgaaactagtgacatagcagatgtgcccagtgat
acttctaagaatgacaagaaaggaaaagccaacactgccaaagcaaacgtgaccccacag
agcagctctgagctcagaccaaccaccacggcggccctggggtctggcgtggaagcgaag
aaaggtatcgaacttatccctcaagtgaggatagaagatttgaagcagatgaaggcttac
ctgaagcacttaaagaaacagcagaaggagctaaattctttaaagaagaaacacgcaaag
gagcacagcacaatgcagaagttgcactgcacacaagttgacaagatggtggcacagtac
gacaaagagaagtcaacgcatgagaaaatcctagagaaagcgatgaagaagaaaggggga
agtaattgtctcgaaatgaaaaaagaaactgaaattaaaattcagacactgacatcagat
cacaaatctaaggtcaaagaaatagtggcccagcacacaaaggagtggtcagaaatgatc
aacacccacagtgctgaggagcaagaaatccgggacctacacctcagccagcagtgtgag
ctcctgagaaaactactgatcaatgcccatgagcagcaaacccagcagctgaaaatgtcc
catgacagggaaagcaaggaaatgcgagcacaccaggctaagatttctatggaaaacagc
aaagccatcagccaagataaatctatcaagaacaaagctgaacgggaaaggcgagtcagg
gagttaaatagcagcaacaccaaaaagtttctggaagaaagaaagagacttgcaatgaaa
cagtccaaagaaatggatcagttgaaaaaagtccagcttgaacacctcgagttcctagag
aaacagaatgagcagctattgaaatcctgccatgcagtgtcccaaacacaaggcgaagga
gatgcagcagatggtgaagttggaagccgagatggaccgcaggccagcaacagtagtgtg
aaactccaaaattcaaactga

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