Mustela putorius furo (domestic ferret): 101679745 Help Entry 101679745         CDS       T07239                                  Symbol RYR3 Name (RefSeq) ryanodine receptor 3 isoform X1   KO K04963   ryanodine receptor 3 Organism mpuf  Mustela putorius furo (domestic ferret) Pathway mpuf04020   Calcium signaling pathway mpuf04371   Apelin signaling pathway mpuf04713   Circadian entrainment mpuf04921   Oxytocin signaling pathway mpuf04970   Salivary secretion mpuf05010   Alzheimer disease mpuf05012   Parkinson disease mpuf05020   Prion disease mpuf05022   Pathways of neurodegeneration - multiple diseases Brite KEGG Orthology (KO) [BR:mpuf00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     101679745 (RYR3)    04020 Calcium signaling pathway     101679745 (RYR3)  09150 Organismal Systems   09152 Endocrine system    04921 Oxytocin signaling pathway     101679745 (RYR3)   09154 Digestive system    04970 Salivary secretion     101679745 (RYR3)   09159 Environmental adaptation    04713 Circadian entrainment     101679745 (RYR3)  09160 Human Diseases   09164 Neurodegenerative disease    05010 Alzheimer disease     101679745 (RYR3)    05012 Parkinson disease     101679745 (RYR3)    05020 Prion disease     101679745 (RYR3)    05022 Pathways of neurodegeneration - multiple diseases     101679745 (RYR3)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:mpuf04040]     101679745 (RYR3) Ion channels [BR:mpuf04040]  Voltage-gated cation channels   Ryanodine receptor    101679745 (RYR3) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 MIR SPRY Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_5 EF-hand_8 Motif Other DBs NCBI-GeneID:  101679745 NCBI-ProteinID:  XP_004751082 Ensembl:  ENSMPUG00000008052 LinkDB All DBs Position Unknown AA seq 4869 aa AA seqDB search MAEGGEGGEDEIQFLRTEDEVVLQCIANIHKEQRKFCLAAEGLGNRLCFLEPTSEAKYVP PDLCVCNFVLEQSLSVRALQEMLANTGENGGEGAAQGGGHRTLLYGHAILLRHSFSGMYL TCLTTSRSQTDKLAFDVGLRENATGEACWWTIHPASKQRSEGEKVRIGDDLILVSVSSER YLHLSVSNGNVQVDASFMQTLWNVHPTCSGSSVEEGYLLGGHVVRLFHGHDECLTIPSTD QNDAQHRRIFYEAGGAGTRARSLWRVEPLRISWSGSNIRWGQAFRLRHITTGHYLALTED QGLLLQDRTKSDTKSTAFSFRASKEIKEKLDSSHKRDIEGMGVPEIKYGDSVCFVQHIAS GLWVTYKAQDAKTSRLGPLKRKVILHQEGHMDDGLTLQRCQREESQAARIIRNTTALFSQ FVSGNNRAAAPVTLPIQEVLQTLQDLIAYFQPPEEEMQHEDKQNKLRSLKNRQNLFKEEG MLALVLNCIDRLNIYNSVAHFAGIAREESGMAWKEILNLLYKLLAALIRGNRNNCAQFSN NLDWLISKLDRLESSSGILEVLHCILIESPEALNLIAEGHIKSIISLLDKHGRNHKVLDV LCSLCLCNGVAVRANQNLICDNLLPRRNLLLQTRLINDVTSIRPNIFLGVAEGSAQYKKW YFELIIDQVDPFLTAEPTHLRVGWASSSGYAPYPGGGEGWGGNGVGDDLYSYGFDGLHLW SGRIPRAVASINQHLLRSDDVVSCCLDLGVPSISFRINGQPVQGMFENFNTDGLFFPVVS FSAGVKVRFLMGGRHGEFKFLPPSGYAPCYEALLPKEKMRLEPVKEYKRDAEGIRDLLGT TQSLSQASFIPCPIDTSQVVLPPHLEKIRDRLAENIHELWGMNKIELGWTFGKIRDDNKR QHPCLVEFSKLPETEKNYNLQMSTETLKTLLALGCHIAHVNPAAEEDLKKVKLPKNYMMS NGYKPAPLDLSDVKLLPPQEVLVDKLAENAHNVWAKDRIKQGWTYGIQQDLKNKRNPRLV PYALLDERTKKSNRDSLREAVRTFVGYGYNIEPSDQELADPAVEKVSIDKIRFFRVERSY AVRSGKWYFEFEVVTGGDMRVGWARPGCRPDIELGADDQAFVFEGSRGQRWHQGSGYFGR TWQPGDVVGCMINLDDASMIFTLNGELLITNKGSELAFADYEIENGFVPICSLGLSQIGR MNLGMDASTFKFYTMCGLQEGFEPFAVNMNRDVAMWFSKRLPTFVNVPKDHPHIEVVRID GTMDSPPCLKVTHKTFGTQNSNASMIYCRLSMPVECHSSFSHSPCLDSEAFQKRKQMQEI LSHTTTQCYYAIRIFAGQDPSCVWVGWVTPDYHLYSEKFDLNKNCTVTVTLGDERGRVHE SVKRSNCYMVWGGDIVATSQRSSRSNVDLEIGCLVDLAMGMLSFSANGRELGTCYQVEPN TKVFPAVFLQPTSTSLFQFELGKLKNAMPLSAAIFKSEEKNPVPQCPPRLDVQTIQPVLW SRMPSSFLKVETERVSERHGWAVQCLEPLQMMALHIPEENRCVDILELCEQEDLMQFHYH TLRLYSAVCALGNSRVAYALCGHVDLSQLFYAIDNKYLPGLLRSGFYDLLISIHLANAKE RKLMMKNEYIIPITSATRKIRLYPDESKRHGLPGVGLRTCLKPGFRFSTPCFVVTGEEHQ KQSPEIPLEILKTKALSMLTEAVQHSGAHIRDPVGGSVEFQFVPVLKLIGTLLVMGVFDD DDIRQILLLIDPSVFGEHSVETEDGAEKEEVTQVEEKAVEAGEKAGKEAPVRGLLQTRLP ESVKLQMCELLSYLCDCELQHRVEAIVAFGDIYVSKLQANQKSRYNELMQALNMSAALTA RKTREFRSPPQEQINMLLNFQLGENCPCPEEIREELYDFHEDLLIHCGVPLEEEEEEEED TSWAGKLRALVYKIKGPPKPEKEQPTEEEEKCPTTLKELISQTMIRWAQEDQIQDAELVR MMFSLLQRQYDSIGELLQALRKTYTISQASVSDTINLLAALGQIRCLFSVRMGKEEELLM INGLGDIMNNKVFYQHPNLMRVLGMHETVMEVMVNVLGAEKSQIAFPKMVASCCRFLCYF CRISRQNQKAMFEHLSYLLENSSVGLASPSMRGSTPLDVAASSVMDNNELALGLEEPDLE KVVTYLAGCGLQSCPMLLAKGYPDVGWNPIEGERYLSFLRFAVFVNSESVEENASVVVKL LIRRPECFGPALRGEGGNGLLAAMQGAIKISENPALDLPSQGYKREVMEDGEDEEIVHMG NAIMSFYSALIDLLGRCAPEMHLIQTGKGEAIRIRSILRSLVPTEDLVGIISIPLKLPSL NKDGSISEPDMAANFCPDHKAPMVLFLDRVYGIKDQTFLLHLLEVGFLPDLRASASLDTV SLSTTEAALALNRYLCSAVLPLLTRCAPLFAGTEHYTSLVDSTLQTIYRLSKGRSLTKAQ RDTIEECLLAICNHLRPSMLQQLLRRLVFDVPQLNEYCKMPLKLLTNHYEQCWKYYCLPS GWGSYGLAVEEELHLTEKLFWGIFDSLSHKKYDPDLFRMALPCLSAIAGALPPDYLDTRI SATLEKQISVDADGNFDPKPINTMNFSLPEKWEYIVTKYAEHSHDKWACDKSQNGWKYGI SLDENVKTHPLIRPFKTLTEKEKEIYRWPARESLKTMLAVGWSVERTKEGEAVVQQRENE KLRSVSQASQGNSYSPAPLDLSNVVLSRELQGMVEVVAENYHNIWAKKKKLELESKGGGS HPLLVPYDTLTAKEKFRDREKAQDLFKFLQVNGIVVSRGVKDMELDASSMEKRFAYKFLK KILKYVDSAQEFIAHLEAIVSSGKTEKSPHDQEIKFFAKVLLPLVDQYFTNHHLYFLSSP LKPLSSSGYASHKEKEMVASLFCKLAALVRHRISLFGSDSTTMVSCLHILAQTLDTRTVM KSGSELVKAGLRAFFENAAEDLEKTSENLKLGKFTHSRTQIKGVSQNINYTTVALLPILT SIFEHVAQHQFGVDLLLGDVQISCYHILCSLYSLGTGKNIYVERQRPALGECLASLAAAI PVAFLEPTLNRYNPLSVFNTKTPRERSILGMPDTVEEMCPDIPQLEGLMKEISDLAESGA RYTEMPHVIEVILPMLCNYLSYWWERGPEHLPPSTGPWCTKVTSEHLSVILGNILKIINN NLGIDEASWMKRIAVYAQPIISKARPDLLKSHFIPTLEKLKKKAVKTVQEEEQLKADTKG DTQEAELLILDEFAVLCRDLYAFYPMLIRYVDNNRSNWLKSPSADSDQLFRMVAEVFILW CKSHNFKREEQNFVIQNEINNLAFLTGDSKSKMSKAMQVKSGGQDQERKKTKRRGDLYSI QTSLIVAALKKMLPIGLNMCTPGDQELISLAKSRYSYRDTDEEVKEHLRNNLHLQEKSDD PAVKWQLNLYKDVLKSEEPFNAEKTIERVQRISAAVFHLEQVEQPLRSKKAVWHKLLSKQ RKRAVVACFRMAPLYNLPRHRSINLFLHGYQRFWIETEEYSFEEKLVQDLAKSPKVEEEE EEEMEKQPDPLHQIILHFSRNALTERSKLEDDPLYTSYSSMMAKSCQSGEDEEEEEDKEK TFEEKEMEKQKTLYQQARLHERGAAEMVLQMISASKGEMSPMVVETLKLGIAILNGGNAG VQQKMLDYLKEKKDAGFFQSLSGLMQSCSVLDLNAFERQNKAEGLGMVTEEGTLIVRERG EKVLQNDEFTRDLFRFLQLLCEGHNSDFQNFLRTQMGNTTTINVIISTVDYLLRLQESIS DFYWYYSGKDIIDESGQHNFSKALAVTKQIFNSLTEYIQGPCIGNQQSLAHSRLWDAVVG FLHVFANMQMKLSQDSSQIELLKELLDLLQDMVVMLLSLLEGNVVNGTIGKQMVDTLVES STNVEMILKFFDMFLKLKDLTSSDTFKEYDPDGKGIISKKEFQKAMEGQKQYTQSEIDFL LLCAEADENDMFNYIDFVDRFHEPAKDIGFNVAVLLTNLSEHMPNDSRLKCLLDPAGSVL NYFEPYLGRIEIMGGAKKIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGEQEKM ELFVNFCEDTIFEMQLASQISESDSAERPDEEEEEDEDSSYVLEIEGEEEDDKSFESASA FAMACASVKRNIANFLKKATLKNLRKQYRKVKKMTVKELVKVFFSFFWMLFVGLFRLFFT ILGGIFQILWNTVFGGGLVEGAKNIRVTKILGDMPDPTQFGIHDDALDAERAEVTEPGVP PELIHFVKGEKGDTDIMSDLFGLHPKKEGGLKHGPEVGLGDLSEIIGKDEPPTLESTVRK KRKAQAAEMKAAHEAEGKVEPEKTDLEDGEKEDTAKEEEQAEALWADVTKKKKRRRGQKV EKPEAFMANFFKGLEIYQTKLLHYLARNFYNLRFLALFVAFAINFILLFYKVTEEPAEEE TEDVANLWNSFTDEEEEEAMVFFVLQESTGYMAPALRALAIIHTVISLVCVVGYYCLKVP LVVFKREKEIARKLEFDGLYITEQPSEDDIKGQWDRLVINTPSFPNNYWDKFVKRKVINK YGDLYGAERIAELLGLDKNALDFSPVEESKAEAASLVSWLSSIDMKYHVWKLGVVFTDNS FLYLAWYTTMSVLGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVV YLYTVVAFNFFRKFYNKSEDDDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGDP YEMYRIVFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVREDMETKCFICGIGNDYF DTTPHGFETHTLQEHNLANYLFFLMYLINKDETEHTGQESYVWKMYQERCWDFFPAGDCF RKQYEDQLG NT seq 14610 nt NT seq  +upstreamnt  +downstreamnt atggccgaagggggagaaggaggcgaggacgagatccagttcctgcggactgaagatgag gtggttctccagtgcatcgcgaacattcacaaggagcaaaggaagttctgcctggcagcc gagggcctcgggaaccgcctgtgcttcttggagcccacttccgaagccaagtatgttcct ccagatctctgtgtctgcaattttgtgctggaacagtccctctctgtgagagccctgcag gaaatgcttgccaacacaggtgaaaatggcggtgaaggggcagcacaagggggtggccac aggaccctgctatatggccacgcgattctcctgcggcactccttcagcggaatgtatcta acatgtttgaccacatcaagatcccagacagataaacttgcctttgatgtaggtctacgg gaaaatgccacaggagaagcctgttggtggaccatacatccggcatccaaacagagatct gagggagagaaagttcgaattggtgatgacctcattctcgtcagcgtgtcctctgaaaga taccttcatctctcagtgtcaaacgggaacgtacaagtggacgcctcttttatgcagaca ctctggaatgtacatcctacgtgctcaggaagtagtgttgaagaaggatacctacttggt gggcacgtagtacgtctcttccatggtcatgatgagtgtttgactataccatctacagac cagaatgatgcccagcacaggaggatattctatgaagctgggggagctgggacacgagcc cgatctctgtggagagtggaaccccttcggataagttggagtggcagtaacatccgatgg ggccaggctttccggctccggcatatcaccacaggccactacctggccctgacagaggac caaggccttctactgcaggaccggacgaagtcagacaccaagtccaccgccttctctttc agggcttccaaggaaatcaaggagaaattggattccagtcacaagcgagatatagaaggc atgggcgttccagaaatcaagtatggagattctgtctgctttgtgcagcatatagccagc ggtctgtgggtgacctacaaagcacaagatgccaagacctcccgccttggacctctgaaa agaaaggtcatactccaccaggaaggccacatggatgacgggttaacactgcagagatgc cagcgcgaggagtcgcaggctgctcgcatcatccggaacacaaccgccttattcagccag tttgtgagcgggaacaaccgcgcagcggcccctgtcaccctgccgatccaagaggtcctg cagaccttgcaggacttgattgcctactttcagcccccagaggaggagatgcagcacgag gacaaacagaacaaactccgctcgctcaaaaacagacagaatctcttcaaggaggaggga atgttggcccttgtgttaaactgcattgaccgcttaaatatctacaacagtgttgcacac tttgcggggatcgcaagggaggagagtggcatggcttggaaggaaatactgaacctcctc tacaaactgctcgctgctctcattcgtggaaacagaaacaactgcgctcagttctccaac aacctcgattggctaatcagcaaactggacagactagaatcttcctcaggtatcttggaa gttttgcactgcatcttgattgaaagcccagaagccttaaatctgatagccgagggccac atcaagtccatcatctccctgttggataagcatgggcggaatcacaaggttctggacgtg ctgtgttccctctgtctctgcaatggggttgctgtcagagccaaccagaatctgatttgt gacaacttgctgccccggaggaacttgctcctgcagacacggctaattaatgatgtgacc agcattcggcccaacatcttcctgggagttgccgagggctcggcgcagtacaagaagtgg tacttcgagctgattatcgaccaggtggatcccttcctaacagctgagcccacacacctg cgggtgggctgggcctcctcctccggctatgctccataccctggcgggggagaaggatgg ggaggcaatggtgtcggtgatgacctctactcctatggctttgatggacttcacctttgg tcaggccgcatacccagagccgtagcctccatcaaccagcacctcctgagatcagatgac gtggtgagctgttgcctcgaccttggagtgcccagcatctccttccgcatcaacgggcag cccgtgcaggggatgtttgagaacttcaacacagatgggctcttcttccctgtggtgagc ttctcagcaggtgtcaaagtgcgtttcctgatgggtggacgtcatggagaatttaagttc ctgcctccctctggctatgccccttgctatgaagccttacttccaaaagaaaagatgaga ttggagcctgtgaaagaatataaacgtgacgcagaaggcattagagatctgctgggtacc acccagtccctctcccaagcctccttcatcccatgccccatcgacaccagtcaggttgtt ttgccccctcacctagaaaagatccgagatagactggctgaaaacatccacgagctttgg ggaatgaataaaatagagcttggctggacttttggcaagatacgggatgacaataaaaga caacacccctgtcttgtggagttttcaaagctgcctgaaaccgagaagaattataaccta cagatgtcaactgaaaccttaaagaccctcctggccctagggtgccatattgctcatgtg aatccagctgctgaggaagatctcaagaaggtcaaattgcccaaaaactatatgatgtcc aatggctataagccagcccctttggatctgtctgatgtgaagctattacctcctcaagaa gttttagtggataagcttgcagaaaatgcacacaacgtttgggccaaagacagaataaaa caaggatggacctatggcatccaacaggatttaaagaataaaagaaatccccggctggtg ccatatgctttactggatgagcgtaccaagaagtccaatagggacagccttcgtgaagct gttcgcacatttgttggttatggctataacattgagccttcggaccaagaactggctgac ccagctgtggagaaagtcagcattgacaagattcgatttttccgggttgagcggtcttat gcagtgagatctggaaaatggtattttgagtttgaggtggtaactggaggagacatgcgc gttggctgggccaggccaggttgtcggcctgacattgagctgggggccgatgaccaagcc tttgtgtttgaaggcagcaggggccagcggtggcatcaaggcagtgggtattttggacgt acgtggcagccaggagacgtggttggatgtatgattaacttggatgatgcttcgatgatc ttcacactgaatggcgagctgctgatcaccaacaaaggctctgaactcgccttcgctgat tacgaaattgagaatggctttgtgcccatctgctctctgggactgtctcagatcggccgc atgaatctcgggatggatgccagcaccttcaagttttataccatgtgtggcctccaagag ggctttgagccttttgctgtcaacatgaaccgggacgttgcgatgtggttcagcaagcgc ctcccgacgtttgtcaacgtgccaaaggatcatccccatatagaggttgtgaggatcgat ggcaccatggacagtcctccatgcctcaaggtgacccacaagacatttggcacacagaat agcaatgccagcatgatctactgccgcctgagcatgcctgttgagtgccactcctccttc agccacagcccctgcctggacagtgaagccttccagaaaaggaaacagatgcaagaaata ctctctcataccacaacacagtgctactatgcaatccgcatctttgctggacaggacccc tcctgcgtctgggtcggatgggtgacaccagactatcacttatatagtgaaaagttcgac ctgaataaaaactgcacagttactgtcactctaggggatgaaagaggccgggtccatgaa agtgtgaaacgcagcaactgctacatggtctggggcggggatattgtggccacttcccaa agatcaagtcgaagcaacgtggacctggagattggctgcctcgtggatctggcgatgggc atgttgtctttttctgccaatgggagagaactcggcacctgctaccaggtggagcccaat accaaagtgtttccagcggttttcctacagcccacgagcacttccttgtttcagtttgaa cttgggaagctgaagaacgcgatgcccctgtcggcggccatctttaagagcgaagagaag aacccagttccacagtgtccgcctcggctggatgtccagaccatccagcccgtgctctgg agccgcatgcccagcagcttcctgaaggtggagacggagcgcgtgagcgagcgccacggc tgggcggtgcagtgcctggagcccctgcagatgatggcgctccacatcccggaggagaac aggtgtgtggacatcctggagctgtgtgagcaggaggacctgatgcagttccattaccac acgctccgactctacagcgccgtgtgcgccctgggaaacagcagggtggcctacgccctg tgcggccatgtggacctctcccagctcttctacgccattgataacaagtacctccctggc ctccttcgctccgggttctacgacctcctcatcagcatccacctggccaacgctaaggag aggaagctaatgatgaagaacgagtacatcattcccatcaccagtgccaccaggaaaatc cgcctgtacccagacgaatccaagaggcacgggctgccgggggtgggcctgagaacgtgc cttaagcccgggttcaggttctccaccccttgctttgttgtgactggcgaggagcaccag aagcagagccctgagatccccttggagattctcaagacgaaggcgctgagcatgctgacg gaggcggtgcagcacagcggggctcacatccgcgaccctgtgggtgggtctgtggagttc cagttcgtgcctgtgctgaaactcatcgggaccctgctggtcatgggggtgttcgatgac gatgacatccggcagatcctcctcctgattgatccctctgtgttcggggagcacagtgtg gagacggaggacggagcagagaaggaggaagtgactcaggtggaggagaaggcagtggag gccggggagaaggctggcaaggaggctcccgtcagaggcttgctgcagacccgactgcct gaatctgtcaagctgcagatgtgtgagctcctcagctatctctgtgactgtgagctgcag catcgagtggaggccattgtggcatttggcgacatttatgtctccaaactccaggcaaat cagaagtcccgctacaatgagctcatgcaggccttgaacatgtccgcagccctgactgcc cggaagaccagggagttccgctccccgccacaggagcagatcaacatgcttcttaacttc caactgggagaaaattgcccctgcccagaggagatccgggaggagctatatgacttccat gaggaccttctcattcactgtggcgttccactggaggaggaggaagaggaagaggaggac acgtcctgggctggaaaactccgtgccttggtgtataaaatcaaaggccctcccaagcct gagaaggaacagccaacagaagaggaagagaaatgccctaccaccttgaaggagctcatc tcacagaccatgatccgctgggcccaggaggaccagatccaggatgcggagttggtccga atgatgttcagcctccttcagagacagtacgacagcatcggggagctgctgcaggccctg cggaagacctacaccatcagccaggcctccgtgagtgacaccatcaacctgctggctgcg ctgggccagatccgctgcctgttcagtgtcaggatgggcaaggaggaggagctgctcatg atcaacgggctgggagacattatgaacaacaaggtgttttaccagcatcccaacctcatg cgagtccttggcatgcacgagacggtgatggaggtgatggtgaacgtgctgggcgcagag aagtctcagattgcttttcccaagatggttgctagctgttgccgcttcctctgctatttc tgtcgaattagcaggcaaaatcagaaggccatgtttgagcatctgagttacctgctggag aatagcagtgttggcctagcctccccttccatgaggggatctaccccactggacgtggca gcttcctctgtaatggacaacaatgagttagctctgggcttagaggaaccggacctcgag aaggtggtgacctacttggcaggctgtggcctgcagagctgccccatgcttctagccaaa ggataccctgatgtcggctggaaccccattgaaggggaacgttacctgtccttcctgagg tttgccgtctttgtgaacagtgaaagtgtggaagaaaatgctagtgtcgtggtcaagctg ctcatcagacgcccggagtgcttcggcccagccctgcgaggtgaaggaggaaacggtctg ttggcggccatgcagggcgccattaagatctctgagaacccagccctcgaccttccctct cagggatacaagagagaagtcatggaggacggtgaagatgaagagatcgtacacatgggc aacgccattatgtctttttattcagctcttatagatctcctgggccgctgtgcgcctgaa atgcaccttatccagacaggaaagggagaagccatccggatcaggtcaatcctgcgctcc ctggtccccactgaggacctggttggcatcatcagcatccccttgaagctgccgtcccta aacaaagatgggtccatcagcgagccagatatggcagctaacttctgccctgaccacaag gcacccatggtgcttttcttggatcgtgtttatggcatcaaggaccaaacatttctgctc cacttgctggaggttggatttttacccgacttaagagcctctgcctctctagacacagtt tccctgagcaccacagaggctgcacttgccctaaataggtacttgtgttctgccgtgctc ccactcctcacaagatgcgccccgctctttgccggaacggagcactacacatctctcgtc gattctacgctgcagaccatataccggctttccaagggacgttccctcaccaaagctcag agggacaccatagaagaatgtttgctcgccatttgcaatcatttgaggccttccatgtta cagcagctcctgcgacgtctggtttttgatgtgccacagctcaacgagtactgcaaaatg ccccttaagcttctgacgaatcactatgaacagtgctggaagtattactgtctgccttca ggatgggggagctacgggctagctgtggaagaagaattgcacctgacggagaagctcttc tgggggattttcgactccctttcccataagaagtatgacccagaccttttccgaatggcc cttccttgtctcagtgctatagcgggggccctgccaccagattatttagacaccagaatc tcagccacgttggagaagcagatttcagtggatgcggatggcaactttgaccccaaaccc atcaacaccatgaatttctccttgcctgaaaaatgggaatacatcgtcaccaagtatgcg gagcattcacatgataaatgggcctgtgacaagagtcagaatggatggaaatacggaatt tccctggacgaaaatgtgaagacccatccactgatcaggcctttcaagacattaacagaa aaggagaaggaaatttaccgctggcccgcccgggagtccctgaaaaccatgctggctgtg ggctggtctgtggagaggaccaaagagggagaggccgtggttcaacagcgggaaaacgag aaacttcggagcgtgtctcaggccagccagggcaacagctacagccctgctcccctggac ctctctaacgtggtgctctccagggagcttcagggaatggtggaggtcgtggctgaaaac tatcacaacatctgggccaagaagaagaagctggaactggagagcaaaggtggtggcagt caccctctgttggtaccatatgataccctgacagccaaggagaagttcagggaccgagag aaggcacaggacctgtttaaattcctccaagtgaacggcatcgtggtttctagaggtgtg aaggatatggagctggatgcctcctccatggaaaagaggtttgcctataaatttttgaag aagatcctgaaatatgttgattccgcccaagagtttattgcccatttggaggccattgtc agcagtggaaaaacagaaaagtctccccacgaccaggagatcaaattctttgccaaagtt ctcctcccactggttgaccagtacttcaccaatcaccacctctacttcctgtcatcccct ctgaagccccttagcagcagcggctatgcctctcataaggagaaagaaatggtggccagc ctcttctgcaaactcgctgctcttgttcgacacaggatttccctctttgggagcgattct actacaatggtgagctgtcttcacatcttagctcagacacttgacacaaggactgtcatg aagtcaggctcagagctggtcaaggccgggttacgagcattctttgaaaatgctgcagaa gacttagagaagacttcggaaaacctgaagctggggaagtttacccattccagaacacag attaaaggcgtgtctcagaatattaactataccacggtggctctgctccccatcctgacg tccatctttgagcacgttgctcagcatcagttcggggtggatttactcttaggcgatgtg cagatttcatgctaccacatactgtgcagcctctactcccttgggactggaaagaatatc tacgttgaaaggcaacgtcctgcccttggagaatgtctggcctcactggcagctgccatc ccagtggcgttcctggagcccacgcttaatcgctacaatccactctcggtcttcaacacc aaaaccccccgggagaggtctattctgggcatgccggacacagtggaagagatgtgtcct gacatcccgcagctggaaggcctgatgaaggagatcagcgacctggctgagtcaggggcc cggtacacagagatgccccacgtcatcgaggtgatcttgcccatgctctgcaactacctg tcctactggtgggagcgggggcctgagcacctgccccccagcacagggccctggtgcacc aaggtcacatctgaacacctcagtgtcatcctgggaaacattctgaaaatcatcaacaac aacctgggcatcgatgaggcgtcctggatgaaacgtatcgcagtgtatgcccagccgatc atcagcaaagcccggccagacctgctgaaaagccacttcatcccaactctggagaagctg aagaaaaaggcggtaaagactgtgcaggaggaggagcagctgaaagccgacaccaaggga gacactcaggaggcggagctcctcatcctggatgagtttgcggtcctctgcagagacctc tatgccttctaccccatgctgatccgttatgtggacaacaacagatctaactggcttaaa agtcccagtgctgactctgaccagctcttccgcatggtggcagaggtcttcatcctgtgg tgtaaatctcacaacttcaagagggaagagcagaattttgtgattcagaatgaaattaat aatttggcatttttaactggagacagcaaaagcaagatgtcgaaagccatgcaagtaaag tctggaggacaggaccaggaacggaagaagacaaagcggaggggagacttgtattccatc cagacctctctcatcgtggccgcactcaagaaaatgctgcccattggtttgaatatgtgc acgccaggcgatcaggagctcatctccctggccaaatctcggtacagctatagggacaca gatgaagaggtgaaggaacatctgcggaataacttgcacctgcaggagaagtctgatgac ccagcagtaaagtggcaactgaacctctacaaagatgttctaaagagtgaagaacctttc aatgcagaaaagaccatagagcgtgtacagagaatttcagcagcggtgttccacctggag caggtggaacagcctttgaggtccaagaaggcggtctggcacaaactgttgtcaaagcag cggaaacgggcagtggtggcctgtttcaggatggcccctctctacaacctgcccaggcac cgctccattaacctcttcctccatggctatcagagattttggatagaaacagaggagtat tcctttgaagagaaactagtacaggatttggctaaatcccccaaggtggaagaggaggag gaggaggagatggaaaagcaaccagacccacttcatcagatcattctccattttagccgc aatgctctcacagagaggagcaaactggaagatgaccctttgtacacgtcctattccagc atgatggccaagagttgtcagagtggggaggacgaagaagaagaggaagacaaggagaaa acattcgaagagaaagagatggaaaagcagaaaaccctctaccaacaagcacggctgcat gagcggggagctgcagagatggtccttcagatgataagtgccagcaaaggtgagatgagc cccatggtggttgagactctgaagctgggcatcgccattctgaatgggggcaacgccggc gtgcagcagaaaatgctagattacctaaaggagaaaaaggatgctggattctttcaaagc ctttctggtcttatgcagtcttgcagtgtccttgatttgaatgcgtttgaaaggcagaat aaagcagaaggcctgggtatggttactgaggaaggaacactcattgtgcgtgagcgtggt gaaaaagtactccagaatgacgagtttactcgtgatctctttcggttcctgcagttactt tgtgaaggacataacagtgactttcagaacttcctgcggactcagatgggcaataccacc accataaacgtcatcatcagtaccgtggactacctcttgcgtctgcaggagtcaatcagt gatttctactggtattattcagggaaggacatcattgacgaatctggacagcacaatttt tccaaagctctggcagtcacgaagcagattttcaattctcttacggaatatatccagggc ccttgcattgggaaccagcagagcctggctcacagcaggctgtgggacgcggtggtcggc ttcctccatgtgtttgctaacatgcagatgaaactctctcaggattccagtcagatcgag ctgctgaaggaactcttggatctccttcaggacatggtggtgatgcttctgtccctcctg gaagggaatgtggtaaatggaactattggcaagcagatggttgacacactggtagaatca tctaccaatgtagaaatgatcttgaaattctttgacatgttcttgaaacttaaagaccta accagctcagacaccttcaaagaatatgacccagatggtaaagggattatctctaaaaaa gagttccaaaaggccatggaagggcagaaacagtacacacagtcagagattgactttctc cttttgtgcgcagaagctgatgagaatgatatgtttaattacattgattttgtagaccgg ttccatgagccggccaaggacatagggtttaatgtggcagtgttactgaccaatctctcc gaacacatgccaaatgattctcgccttaagtgtctgttggacccagcaggaagtgtacta aattactttgaaccgtacctgggacgaattgagatcatgggtggggccaagaaaattgag cgtgtttatttcgagatcagtgaatccagtcgaactcagtgggagaagccccaagtgaag gagtcaaagcggcagttcatctttgatgtggtcaatgaagggggagagcaagaaaagatg gaactgtttgtgaacttctgtgaggataccatctttgaaatgcagttagcctctcagatc tccgaatctgactcagctgagaggcccgacgaggaggaggaagaagatgaagattcatct tatgtgttagaaattgagggtgaagaggaagacgacaagtctttcgagtcagcctctgca tttgccatggcctgtgcctcagtgaagagaaacattgccaactttctgaagaaggcaacc ctgaagaacctccggaaacagtacaggaaggtgaaaaagatgactgtgaaggagctggta aaagtgttcttctctttcttctggatgttgtttgtggggctcttccggttgttcttcacc atattgggaggaatcttccagatcctctggaacacagtgtttggaggcggcctcgtggaa ggggcaaagaacatcagagtgaccaagatcctgggtgacatgcctgaccccacccagttt ggtatccatgacgatgctctggatgctgagcgggcagaggtgactgagccaggggttcca cccgaactaattcacttcgtgaagggtgagaagggagatacagatattatgtcagatctc tttggattacacccgaagaaagaaggtggcttaaagcatgggcctgaagtgggtttgggt gacctttctgagattattggcaaggatgaaccccctacactagagagtactgtccggaag aaaaggaaagcacaggcagctgagatgaaagcagcacatgaagccgaagggaaagtggag cctgagaagacagacctagaagacggggagaaggaggatacggccaaagaggaagagcag gccgaggccctgtgggcagatgtgacaaagaagaagaagcgacggcggggccagaaagtc gagaagcctgaagccttcatggctaatttcttcaaagggctggaaatctatcagaccaag ttactgcattacctggccaggaatttctacaacctgaggttcctcgctctgttcgtagcc ttcgcgatcaacttcatcctactcttttataaggtcaccgaggaacctgcagaagaagag acagaagacgttgcaaatctgtggaattcctttaccgatgaggaagaagaagaagcgatg gtgttctttgtcctgcaggagagcactgggtacatggcacccgcattgcgggccttggcc attatccacaccgtcatctctttggtctgtgtggtgggctattactgcctgaaggtccct ctggtggtattcaaaagggaaaaagaaatcgccaggaagctggagtttgatggcctatat atcactgaacagccatctgaagatgacatcaaggggcagtgggaccgcctggtaatcaac acaccatcttttcctaataactactgggacaagtttgttaagagaaaggtgatcaacaag tacggcgacctctatggagcagaacgcattgcggaactcctgggtttggacaaaaatgcc ctggatttcagcccagtggaagagagcaaagcagaggcggcctctctggtgtcatggctg agttccatcgacatgaagtaccacgtctggaagctgggagttgtttttaccgacaactcc tttctctacctggcctggtataccaccatgtcagtcctgggccactacaacaacttcttc tttgctgctcatctgctggacatcgcgatgggcttcaagacgctgaggactattctgtca tctgtaactcacaatggcaagcagctggttctgactgttggtctcctggccgtggtggtt tacctctacaccgtggtggccttcaacttcttccgcaagttctacaacaaaagtgaagat gacgatgagcccgatatgaagtgtgatgacatgatgacgtgttacctgttccacatgtat gtgggagtgagagctggagggggcattggcgacgaaattgaagaccctgctggtgaccct tatgagatgtaccgcattgtctttgacattaccttcttcttcttcgtcattgtcatcttg ctggccatcattcaaggtcttattattgatgcttttggagagctaagagaccagcaggaa caagtgcgagaagatatggagactaaatgtttcatctgtgggattggcaatgactatttt gacacgactcctcatggctttgaaacacataccttacaggagcacaacttagccaactat ttgttcttcctgatgtacctgattaataaagatgagacagaacacacgggtcaggaatct tacgtctggaagatgtaccaagaaagatgttgggatttcttcccggctggtgactgcttt cggaaacaatatgaagatcagcttgggtaa

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