Mustela putorius furo (domestic ferret): 101680975
Help
Entry
101680975 CDS
T07239
Symbol
MAP2K1
Name
(RefSeq) dual specificity mitogen-activated protein kinase kinase 1 isoform X1
KO
K04368
mitogen-activated protein kinase kinase 1 [EC:
2.7.12.2
]
Organism
mpuf
Mustela putorius furo (domestic ferret)
Pathway
mpuf01521
EGFR tyrosine kinase inhibitor resistance
mpuf01522
Endocrine resistance
mpuf04010
MAPK signaling pathway
mpuf04012
ErbB signaling pathway
mpuf04014
Ras signaling pathway
mpuf04015
Rap1 signaling pathway
mpuf04022
cGMP-PKG signaling pathway
mpuf04024
cAMP signaling pathway
mpuf04062
Chemokine signaling pathway
mpuf04066
HIF-1 signaling pathway
mpuf04068
FoxO signaling pathway
mpuf04071
Sphingolipid signaling pathway
mpuf04072
Phospholipase D signaling pathway
mpuf04114
Oocyte meiosis
mpuf04140
Autophagy - animal
mpuf04148
Efferocytosis
mpuf04150
mTOR signaling pathway
mpuf04151
PI3K-Akt signaling pathway
mpuf04210
Apoptosis
mpuf04218
Cellular senescence
mpuf04270
Vascular smooth muscle contraction
mpuf04370
VEGF signaling pathway
mpuf04371
Apelin signaling pathway
mpuf04380
Osteoclast differentiation
mpuf04510
Focal adhesion
mpuf04517
IgSF CAM signaling
mpuf04519
Cadherin signaling
mpuf04540
Gap junction
mpuf04550
Signaling pathways regulating pluripotency of stem cells
mpuf04613
Neutrophil extracellular trap formation
mpuf04620
Toll-like receptor signaling pathway
mpuf04650
Natural killer cell mediated cytotoxicity
mpuf04660
T cell receptor signaling pathway
mpuf04662
B cell receptor signaling pathway
mpuf04664
Fc epsilon RI signaling pathway
mpuf04666
Fc gamma R-mediated phagosome formation
mpuf04668
TNF signaling pathway
mpuf04720
Long-term potentiation
mpuf04722
Neurotrophin signaling pathway
mpuf04725
Cholinergic synapse
mpuf04726
Serotonergic synapse
mpuf04730
Long-term depression
mpuf04810
Regulation of actin cytoskeleton
mpuf04910
Insulin signaling pathway
mpuf04912
GnRH signaling pathway
mpuf04914
Progesterone-mediated oocyte maturation
mpuf04915
Estrogen signaling pathway
mpuf04916
Melanogenesis
mpuf04917
Prolactin signaling pathway
mpuf04919
Thyroid hormone signaling pathway
mpuf04921
Oxytocin signaling pathway
mpuf04926
Relaxin signaling pathway
mpuf04928
Parathyroid hormone synthesis, secretion and action
mpuf04929
GnRH secretion
mpuf04934
Cushing syndrome
mpuf04935
Growth hormone synthesis, secretion and action
mpuf05010
Alzheimer disease
mpuf05022
Pathways of neurodegeneration - multiple diseases
mpuf05034
Alcoholism
mpuf05132
Salmonella infection
mpuf05135
Yersinia infection
mpuf05160
Hepatitis C
mpuf05161
Hepatitis B
mpuf05163
Human cytomegalovirus infection
mpuf05164
Influenza A
mpuf05165
Human papillomavirus infection
mpuf05166
Human T-cell leukemia virus 1 infection
mpuf05167
Kaposi sarcoma-associated herpesvirus infection
mpuf05170
Human immunodeficiency virus 1 infection
mpuf05200
Pathways in cancer
mpuf05205
Proteoglycans in cancer
mpuf05206
MicroRNAs in cancer
mpuf05207
Chemical carcinogenesis - receptor activation
mpuf05208
Chemical carcinogenesis - reactive oxygen species
mpuf05210
Colorectal cancer
mpuf05211
Renal cell carcinoma
mpuf05212
Pancreatic cancer
mpuf05213
Endometrial cancer
mpuf05214
Glioma
mpuf05215
Prostate cancer
mpuf05216
Thyroid cancer
mpuf05218
Melanoma
mpuf05219
Bladder cancer
mpuf05220
Chronic myeloid leukemia
mpuf05221
Acute myeloid leukemia
mpuf05223
Non-small cell lung cancer
mpuf05224
Breast cancer
mpuf05225
Hepatocellular carcinoma
mpuf05226
Gastric cancer
mpuf05230
Central carbon metabolism in cancer
mpuf05231
Choline metabolism in cancer
mpuf05235
PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:
mpuf00001
]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
101680975 (MAP2K1)
04012 ErbB signaling pathway
101680975 (MAP2K1)
04014 Ras signaling pathway
101680975 (MAP2K1)
04015 Rap1 signaling pathway
101680975 (MAP2K1)
04370 VEGF signaling pathway
101680975 (MAP2K1)
04371 Apelin signaling pathway
101680975 (MAP2K1)
04668 TNF signaling pathway
101680975 (MAP2K1)
04066 HIF-1 signaling pathway
101680975 (MAP2K1)
04068 FoxO signaling pathway
101680975 (MAP2K1)
04072 Phospholipase D signaling pathway
101680975 (MAP2K1)
04071 Sphingolipid signaling pathway
101680975 (MAP2K1)
04024 cAMP signaling pathway
101680975 (MAP2K1)
04022 cGMP-PKG signaling pathway
101680975 (MAP2K1)
04151 PI3K-Akt signaling pathway
101680975 (MAP2K1)
04150 mTOR signaling pathway
101680975 (MAP2K1)
09133 Signaling molecules and interaction
04517 IgSF CAM signaling
101680975 (MAP2K1)
04519 Cadherin signaling
101680975 (MAP2K1)
09140 Cellular Processes
09141 Transport and catabolism
04140 Autophagy - animal
101680975 (MAP2K1)
04148 Efferocytosis
101680975 (MAP2K1)
09143 Cell growth and death
04114 Oocyte meiosis
101680975 (MAP2K1)
04210 Apoptosis
101680975 (MAP2K1)
04218 Cellular senescence
101680975 (MAP2K1)
09144 Cellular community - eukaryotes
04510 Focal adhesion
101680975 (MAP2K1)
04540 Gap junction
101680975 (MAP2K1)
04550 Signaling pathways regulating pluripotency of stem cells
101680975 (MAP2K1)
09142 Cell motility
04810 Regulation of actin cytoskeleton
101680975 (MAP2K1)
09150 Organismal Systems
09151 Immune system
04613 Neutrophil extracellular trap formation
101680975 (MAP2K1)
04620 Toll-like receptor signaling pathway
101680975 (MAP2K1)
04650 Natural killer cell mediated cytotoxicity
101680975 (MAP2K1)
04660 T cell receptor signaling pathway
101680975 (MAP2K1)
04662 B cell receptor signaling pathway
101680975 (MAP2K1)
04664 Fc epsilon RI signaling pathway
101680975 (MAP2K1)
04666 Fc gamma R-mediated phagosome formation
101680975 (MAP2K1)
04062 Chemokine signaling pathway
101680975 (MAP2K1)
09152 Endocrine system
04910 Insulin signaling pathway
101680975 (MAP2K1)
04929 GnRH secretion
101680975 (MAP2K1)
04912 GnRH signaling pathway
101680975 (MAP2K1)
04915 Estrogen signaling pathway
101680975 (MAP2K1)
04914 Progesterone-mediated oocyte maturation
101680975 (MAP2K1)
04917 Prolactin signaling pathway
101680975 (MAP2K1)
04921 Oxytocin signaling pathway
101680975 (MAP2K1)
04926 Relaxin signaling pathway
101680975 (MAP2K1)
04935 Growth hormone synthesis, secretion and action
101680975 (MAP2K1)
04919 Thyroid hormone signaling pathway
101680975 (MAP2K1)
04928 Parathyroid hormone synthesis, secretion and action
101680975 (MAP2K1)
04916 Melanogenesis
101680975 (MAP2K1)
09153 Circulatory system
04270 Vascular smooth muscle contraction
101680975 (MAP2K1)
09156 Nervous system
04725 Cholinergic synapse
101680975 (MAP2K1)
04726 Serotonergic synapse
101680975 (MAP2K1)
04720 Long-term potentiation
101680975 (MAP2K1)
04730 Long-term depression
101680975 (MAP2K1)
04722 Neurotrophin signaling pathway
101680975 (MAP2K1)
09158 Development and regeneration
04380 Osteoclast differentiation
101680975 (MAP2K1)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
101680975 (MAP2K1)
05206 MicroRNAs in cancer
101680975 (MAP2K1)
05205 Proteoglycans in cancer
101680975 (MAP2K1)
05207 Chemical carcinogenesis - receptor activation
101680975 (MAP2K1)
05208 Chemical carcinogenesis - reactive oxygen species
101680975 (MAP2K1)
05230 Central carbon metabolism in cancer
101680975 (MAP2K1)
05231 Choline metabolism in cancer
101680975 (MAP2K1)
05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
101680975 (MAP2K1)
09162 Cancer: specific types
05210 Colorectal cancer
101680975 (MAP2K1)
05212 Pancreatic cancer
101680975 (MAP2K1)
05225 Hepatocellular carcinoma
101680975 (MAP2K1)
05226 Gastric cancer
101680975 (MAP2K1)
05214 Glioma
101680975 (MAP2K1)
05216 Thyroid cancer
101680975 (MAP2K1)
05221 Acute myeloid leukemia
101680975 (MAP2K1)
05220 Chronic myeloid leukemia
101680975 (MAP2K1)
05218 Melanoma
101680975 (MAP2K1)
05211 Renal cell carcinoma
101680975 (MAP2K1)
05219 Bladder cancer
101680975 (MAP2K1)
05215 Prostate cancer
101680975 (MAP2K1)
05213 Endometrial cancer
101680975 (MAP2K1)
05224 Breast cancer
101680975 (MAP2K1)
05223 Non-small cell lung cancer
101680975 (MAP2K1)
09172 Infectious disease: viral
05166 Human T-cell leukemia virus 1 infection
101680975 (MAP2K1)
05170 Human immunodeficiency virus 1 infection
101680975 (MAP2K1)
05161 Hepatitis B
101680975 (MAP2K1)
05160 Hepatitis C
101680975 (MAP2K1)
05164 Influenza A
101680975 (MAP2K1)
05163 Human cytomegalovirus infection
101680975 (MAP2K1)
05167 Kaposi sarcoma-associated herpesvirus infection
101680975 (MAP2K1)
05165 Human papillomavirus infection
101680975 (MAP2K1)
09171 Infectious disease: bacterial
05132 Salmonella infection
101680975 (MAP2K1)
05135 Yersinia infection
101680975 (MAP2K1)
09164 Neurodegenerative disease
05010 Alzheimer disease
101680975 (MAP2K1)
05022 Pathways of neurodegeneration - multiple diseases
101680975 (MAP2K1)
09165 Substance dependence
05034 Alcoholism
101680975 (MAP2K1)
09167 Endocrine and metabolic disease
04934 Cushing syndrome
101680975 (MAP2K1)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
101680975 (MAP2K1)
01522 Endocrine resistance
101680975 (MAP2K1)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
mpuf01001
]
101680975 (MAP2K1)
Enzymes [BR:
mpuf01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.12 Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
2.7.12.2 mitogen-activated protein kinase kinase
101680975 (MAP2K1)
Protein kinases [BR:
mpuf01001
]
Serine/threonine kinases: STE group
STE7 family
101680975 (MAP2K1)
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
Pkinase
PK_Tyr_Ser-Thr
ABC1
Pkinase_fungal
Kinase-like
Haspin_kinase
Seadorna_VP7
Arabinose_bd
Motif
Other DBs
NCBI-GeneID:
101680975
NCBI-ProteinID:
XP_004758690
Ensembl:
ENSMPUG00000000363
UniProt:
M3XMR0
LinkDB
All DBs
Position
Unknown
AA seq
393 aa
AA seq
DB search
MPKKKPTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKV
GELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHE
CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYL
REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHY
SVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELVFGCPVEGDAAETPPRPRTPGRPLSSY
GMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAF
IKRSDGEEVDFAGWLCSTIGLNQPSTPTHAAGV
NT seq
1182 nt
NT seq
+upstream
nt +downstream
nt
atgcccaagaagaagccgacgcccatccagctgaacccggcccccgacggctccgcggtt
aacgggaccagctcggcggagaccaacctggaggccttacagaagaagcttgaggagctg
gagcttgatgagcagcagcggaagcgccttgaggcctttctcacccagaagcagaaggtc
ggggaattgaaggatgatgactttgagaagatcagtgagcttggcgcaggcaacggtggt
gtggtgttcaaggtctcccacaagccatcaggcctggtcatggccagaaagctcattcac
ctggagatcaaacctgcaatccggaaccagatcataagggagcttcaggtcctacacgag
tgcaactccccctacatcgtgggcttctacggtgcattctacagcgatggcgagatcagc
atctgcatggagcacatggatgggggttccttggatcaagtcctgaagaaagctggaaga
attcctgagcaaattttaggaaaagttagcattgctgtaataaaaggtctgacatacctg
agggagaagcacaagattatgcacagagatgtcaagccttccaacatcctcgtgaactcc
cgtggggagatcaagctctgtgactttggggtcagtgggcaactcatcgactccatggcc
aactcctttgtgggcacaaggtcctacatgtcgccggaaagactccaggggacccactac
tcagtgcagtcggacatctggagcatggggctgtctctggttgagatggcggtggggagg
tatcccatccctcccccagacgccaaggagctggagctggtgtttgggtgcccagtggag
ggagatgcggcggagacaccacccagacccaggactcctggaaggcccctcagctcttat
ggaatggacagccgacctcccatggcaatttttgagctgctggattacatagtcaatgag
cctcctccaaaactgcccagtggagtgttcagtctggaatttcaagattttgtgaataaa
tgcttaataaaaaacccagcagagagagcagatctgaagcaactcatggttcatgccttt
atcaagagatctgatggggaggaagtggattttgcaggttggctctgctccaccattggc
cttaaccagcccagcacaccgacccacgcagctggcgtttaa
DBGET
integrated database retrieval system
